Deconstructing Myc

Genes and Development

Volumn 15, Issue 16, 2001, Pages 2023-2030

  Eisenman, R N ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; MYC PROTEIN; PROTEIN MAD1; PROTEIN MAD2;

ACETYLATION; CELL CYCLE; DEACETYLATION; GENE EXPRESSION; GENE REPRESSION; GENE TARGETING; ONCOGENE MYC; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ACETYLATION; ANIMALS; BACTERIAL PROTEINS; GENE EXPRESSION; HISTONES; HUMANS; PROTO-ONCOGENE PROTEINS C-MYC; RNA-BINDING PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 0035882058     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad928101     Document Type: Review

References (64)

1. Ordered recruitment of chromatin modifying and general transcription factors to the IFNβ promoter
2. Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max
3. Myc and the cell cycle
4. Function of the c-Myc oncoprotein in chromatin remodeling and transcription
5. A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation
6. Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3
7. Myc but not Fos rescue of a PDGF signalling block by kinase-inactive Src
8. Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events
9. Max: A helix-loop-helix zipper protein that forms a sequence-specific DNA binding complex with Myc
10. N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis
11. Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter
12. Myc versus USF: Discrimination at the cad gene is determined by core promoter elements
13. Coexamination of site-specific transcription factor binding and promoter activity in living cells
14. Solution structure of the interacting domains of the Mad-Sin3 complex: Implications for recruitment of a chromatin-modifying complex
15. c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets
16. The c-Myc transactivation domain is a direct modulator of apoptotic versus proliferative signals
17. c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for activation function
18. Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase
19. Regulation of c-myc expression by PDGF through Rho GTPases
20. The Myc oncoprotein: A critical evaluation of transactivation and target gene regulation
21. Expression analysis with oligonucleotide microarrays reveals Myc regulates genes involved in growth, cell cycle, signaling, and adhesion
22. Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter
23. Direct examination of histone acetylation on Myc target genes using chromatin immunoprecipitation
24. Disruption of the ARF-Mdm2-53 tumor suppressor pathway in Myc-induced lymphomagenesis
25. Structure and dynamic properties of a glucocorticoid receptor-induced chromatin transition
26. Binding of c-Myc to chromatin mediates mitogen-induced actylation of histone H4 and gene activation
27. Chromatin remodeling enzymes: Who's on first?
28. Myc represses the p21 (WAF1/CIP1) promoter and interacts with Sp1/Sp3
29. Myc target genes
30. The MYC/MAX/MAD network and the transcriptional control of cell behavior
31. Histone acetylation in chromatin structure and transcription
32. Identification of c-myc responsive genes using rat cDNA microarray
33. Histone acetyltransferase complexes stabilize SWI/SNF binding to promoter nucleosomes
34. Loss of FBP function arrests cellular proliferation and extinguishes c-myc expression
35. Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis
36. Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites
37. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis
38. c-Myc enhances protein synthesis and cell size during B lymphocyte development
39. Drosophila myc regulates growth during development
40. Sin meets NuRD and other tails of repression
41. Twenty-five years of the nucleosome, fundamental particle of the eukaryotic chromosome
42. The Myc and Max proteins possess distinct transcriptional activities
43. c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II
44. Phenotypes of c-myc-deficient rat fibroblasts isolated by targeted homologous recombination
45. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F onco-proteins
46. The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc
47. Connections between growth and the cell cycle
48. TGF-β flips the Myc switch
49. An alternative pathway for gene regulation by Myc
50. Tralp is a component of the yeast ada/spt transcriptional regulatory complexes
51. Destruction of myc by ubiquitin-mediated proteolysis: Cancer-associated and transforming mutations stabilize myc
52. The role of c-myc in cellular growth control
53. An amino-terminal domain of Mxil mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast repressor SIN3
54. Control of cell growth by c-Myc in the absence of cell division
55. The transcriptional program of a human B cell line in response to myc
56. Multiple ras-dependent phosphorylation pathways regulate myc protein stability
57. INK41B
58. Identification and characterization of specific DNA-binding complexes containing members of the myc/max/mad network of transcriptional regulators
59. INK4B expression by Myc through association with Miz-1
60. The language of covalent histone modifications
61. The 400 kda subunit of the PCAF histone acetylase complex belongs to the ATM superfamily
62. Diversity and specialization of mammalian SWI/SNF complexes
63. An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc
64. Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells