Failure to prolyl hydroxylate hypoxia-inducible factor α phenocopies VHL inactivation in vivo

EMBO Journal

Volumn 25, Issue 19, 2006, Pages 4650-4662

  Kim, William Y ^a   Safran, Michal ^a   Buckley, Marshall R M ^a   Ebert, Benjamin L ^a,b   Glickman, Jonathan ^a   Bosenberg, Marcus ^c   Regan, Meredith ^d,e   Kaelin Jr , William G ^a,f  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c UNIVERSITY OF VERMONT   (United States)

^d DANA FARBER CANCER INSTITUTE   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Hypoxia inducible factor; Prolyl hydroxylase; Von Hippel Lindau

Indexed keywords

CRE RECOMBINASE; GENE PRODUCT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION PROFILING; GENE LOCUS; GENETIC VARIABILITY; HYDROXYLATION; IN VIVO STUDY; LIVER; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SKIN; TUMOR SUPPRESSOR GENE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BLOOD VESSELS; BODY WEIGHT; CELL PROLIFERATION; EPIDERMIS; GENE EXPRESSION REGULATION; HELA CELLS; HEPATOCYTES; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER; MICE; MICE, INBRED BALB C; MICE, MUTANT STRAINS; ORGAN SIZE; PHENOTYPE; PROLINE; RECOMBINATION, GENETIC; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 33749344471     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601300     Document Type: Article

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