MGMT: Key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents

DNA Repair

Volumn 6, Issue 8, 2007, Pages 1079-1099

  Kaina, Bernd ^a   Christmann, Markus ^a   Naumann, Steffen ^a   Roos, Wynand P ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Alkylating agents; Alkyltransferase; Carcinogenicity; Carmustine; Drug resistance; Genotoxicity; MGMT; Temozolomide; Tumor therapy

Indexed keywords

6 O CHLOROETHYLGUANINE; 6 O METHYLGUANINE; ALKYLATING AGENT; ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CHLOROZOTOCIN; DEXAMETHASONE; DOUBLE STRANDED DNA; FOTEMUSTINE; GLUCOCORTICOID; GUANINE; GUANINE DERIVATIVE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MITOZOLOMIDE; PROTEIN ALKB; PROTEIN P53; PROTEIN P73; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER THERAPY; CARCINOGENICITY; CELL METABOLISM; CELLULAR IMMUNITY; CHROMOSOME ABERRATION; CORRELATION ANALYSIS; CYTOTOXICITY; DNA CROSS LINKING; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA SYNTHESIS; DRUG SENSITIVITY; EXCISION REPAIR; FLOW CYTOMETRY; GENE EXPRESSION; GENE MUTATION; GENOTOXICITY; GLIOMA; GLIOMA CELL; HUMAN; INFLAMMATION; LYMPHOCYTE; MELANOMA CELL; METHYLATION; MISMATCH REPAIR; MODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; WESTERN BLOTTING;

ALKYLATING AGENTS; ALKYLATION; ANIMALS; APOPTOSIS; CHROMOSOME ABERRATIONS; DNA; DNA DAMAGE; DNA MISMATCH REPAIR; DNA MODIFICATION METHYLASES; DNA REPAIR; DNA REPAIR ENZYMES; GENE EXPRESSION; HUMANS; MODELS, BIOLOGICAL; MUTATION; NECROSIS; NEOPLASMS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; SISTER CHROMATID EXCHANGE; TUMOR SUPPRESSOR PROTEINS;

EID: 34447314728     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2007.03.008     Document Type: Article

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