Repair of DNA interstrand cross-links

Mutation Research - DNA Repair

Volumn 486, Issue 4, 2001, Pages 217-247

  Dronkert, M L G ^a   Kanaar, R ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

DNA damage repair; ERCC1; Fanconi anemia; RAD51 paralogs; Replicational bypass

Indexed keywords

ANTINEOPLASTIC AGENT; BRCA1 PROTEIN; BRCA2 PROTEIN; CELL CYCLE PROTEIN; CHLORMETHINE; DNA; FANCONI ANEMIA PROTEIN; MITOMYCIN C; NITROSOUREA DERIVATIVE; NUCLEOTIDE; PLATINUM DERIVATIVE; PROTEIN; PSORALEN DERIVATIVE; UNCLASSIFIED DRUG;

BACTERIUM; BREAST CARCINOMA; CANCER THERAPY; CELL CYCLE; CELL DEATH; CELL DIVISION; CHROMOSOME ABERRATION; CYTOTOXICITY; DNA CROSS LINKING; DNA DAMAGE; DNA RECOMBINATION; DNA REPAIR; DNA REPLICATION; EXCISION REPAIR; FANCONI ANEMIA; GENE MUTATION; HUMAN; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; YEAST CELL;

ANIMALS; CROSS-LINKING REAGENTS; DNA; DNA DAMAGE; DNA REPAIR; HUMANS; MODELS, BIOLOGICAL; MODELS, GENETIC; SACCHAROMYCES CEREVISIAE;

EID: 0035807079     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(01)00092-1     Document Type: Short Survey

References (274)

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61. The translocating RecBCD enzyme stimulates recombination by directing RecA protein onto ssDNA in a chi-regulated manner
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69. A yeast mutant specifically sensitive to bifunctional alkylation
70. Mutant gene snm2-1ts, conferring thermoconditional mutagen sensitivity in Saccharomyces cerevisiae is allelic with RAD5
71. Allelism between pso1-1 and rev3-1 mutants and between pso2-1 and snm1 mutants in Saccharomyces cerevisiae
72. Sensing and responding to DNA damage
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75. The DNA damage response: Putting checkpoints in perspective
76. Preferential incision of interstrand cross-links induced by 8-methoxypsoralen plus UVA in yeast during the cell cycle
77. Saccharomyces cerevisiae lacking snm1, rev3 or rad51 have a normal S phase but arrest permanently in G2 after cisplatin treatment
78. Cisplatin-DNA cross-links do not inhibit S phase and cause only a G2/M arrest in Saccharomyces cerevisiae
79. Repair of interstrand cross-links in DNA of Saccharomyces cerevisiae requires two systems for DNA repair: The RAD3 system and the RAD51 system
80. Preferential repair in Saccharomyces cerevisiae rad mutants after induction of interstrand cross-links by 8-methoxypsoralen plus UVA
81. Genetic control of excision of Saccharomyces cerevisiae interstrand DNA cross-links induced by psoralen plus near-UV light
82. Pulsed-field gel electrophoresis analysis of the repair of psoralen plus UVA-induced DNA photoadducts in Saccharomyces cerevisiae
83. Mitotic recombination and localized DNA double-strand breaks are induced after 8-methoxypsoralen and UVA irradiation in Saccharomyces cerevisiae
84. Repair of intermediate structures produced at DNA interstrand cross-links in Saccharomyces cerevisiae
85. Molecular mechanisms of DNA double-strand break repair
86. New aspects of the repair and genotoxicity of psoralen photoinduced lesions in DNA
87. Interactions among genes controlling sensitivity to radiation (RAD) and to alkylation by nitrogen mustard (SNM) in yeast
88. Interactions between mutations for sensitivity to psoralen photoaddition (pso) and to radiation (rad) in Saccharomyces cerevisiae
89. Genetic control of the bypass of mono-adducts and of the repair of cross-links photoinduced by 8-methoxypsoralen in yeast
90. Repair of exogenous (plasmid) DNA damaged by photoaddition of 8-methoxypsoralen in the yeast Saccharomyces cerevisiae
91. DNA polymerase zeta and the control of DNA damage induced mutagenesis in eukaryotes
92. The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free post-replication repair pathways
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94. The REV2 gene of Saccharomyces cerevisiae: Cloning and DNA sequence
95. Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair
96. Yeast DNA repair protein RAD5 that promotes instability of simple repetitive sequences is a DNA-dependent ATPase
97. Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities
98. REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a non-essential DNA polymerase
99. Deoxycytidyl transferase activity of yeast REV1 protein
100. Thymine-thymine dimer bypass by yeast DNA polymerase zeta
101. Genetic interactions between mutants of the error-prone repair group of Saccharomyces cerevisiae and their effect on recombination and mutagenesis
102. The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free post-replication repair mechanism
103. Repair of 8-methoxypsoralen photo-induced cross-links and mutagenesis: Role of the different repair pathways in yeast
104. Covalent cross-links introduced via a triple helix-forming oligonucleotide coupled to psoralen are inefficiently repaired
105. Analysis of damage tolerance pathways in Saccharomyces cerevisiae: A requirement for Rev3 DNA polymerase in translesion synthesis
106. Specificities of the Saccharomyces cerevisiae rad6, rad18, and rad52 mutators exhibit different degrees of dependence on the REV3 gene product, a putative non-essential DNA polymerase
107. Molecular structure of the DNA cross-link repair gene SNM1 (PSO2) of the yeast Saccharomyces cerevisiae
108. Mutagenesis induced by mono- and bi-functional alkylating agents in yeast mutants sensitive to photo-addition of furocoumarins (pso)
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110. The effects of three PSO genes on induced mutagenesis a novel class of mutationally defective yeast
111. Formation and stability of interstrand cross-links induced by cis- and trans-diamminedichloroplatinum(II) in the DNA of Saccharomyces cerevisiae strains differing in repair capacity
112. Induction in Saccharomyces cerevisiae of mitotic recombination by mono- and bi-functional agents: Comparison of the pso2-1 and rad52 repair-deficient mutants to the wild-type
113. Low glutathione pools in the original pso3 mutant of Saccharomyces cerevisiae are responsible for its pleiotropic sensitivity phenotype
114. The DNA repair gene PSO3 of Saccharomyces cerevisiae belongs to the RAD3 epistasis group
115. The PSO3 gene is involved in error-prone intragenic recombinational DNA repair in Saccharomyces cerevisiae
116. Involvement of the PSO3 gene of Saccharomyces cerevisiae in intrachromosomal mitotic recombination and gene amplification
117. Molecular cloning of WHI2, a gene involved in the regulation of cell proliferation in Saccharomyces cerevisiae
118. Filamentous growth of the budding yeast Saccharomyces cerevisiae induced by overexpression of the WHI2 gene
119. Allelism of PSO4 and PRP19 links pre-mRNA processing with recombination and error-prone DNA repair in Saccharomyces cerevisiae
120. PRP19: A novel spliceosomal component
121. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
122. Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease
123. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1 (supplement)
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125. Identification, chromosomal mapping and tissue-specific expression of hREV3 encoding a putative human DNA polymerase zeta
126. A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta
127. A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2
128. Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6
129. The human RAD18 gene product interacts with HRR6A and HHR6B
130. Dysfunction of human Rad18 results in defective post-replication repair and hypersensitivity to multiple mutagens
131. A surfeit of RAD51-like genes
132. Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23
133. Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C
134. The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta
135. Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta
136. Mutant rodent cell lines sensitive to ultraviolet light, ionizing radiation and cross-linking agents: A comprehensive survey of genetic and biochemical characteristics
137. Genetic analysis of mitomycin C-hypersensitive Chinese hamster cell mutants
138. Third-chromosome mutagen-sensitive mutants of Drosophila melanogaster
139. The hypermutability conferred by the mus308 mutation of Drosophila is not specific for cross-linking agents
140. A new DNA polymerase species from Drosophila melanogaster: A probable mus308 gene product
141. Molecular cloning of Drosophila mus308, a gene involved in DNA cross-link repair with homology to prokaryotic DNA polymerase I genes
142. Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase
143. Fanconi anemia, complementation group A, cells are defective in ability to produce incisions at sites of psoralen interstrand cross-links
144. Human endonucleolytic incision of DNA 3′ and 5′ to a site-directed psoralen monoadduct and interstrand cross-link
145. Initiation of DNA interstrand cross-link repair in humans: The nucleotide excision repair system makes dual incisions 5′ to the cross-linked base and removes a 22- to 28-nucleotide-long damage-free strand
146. DNA interstrand cross-links induce futile repair synthesis in mammalian cell extracts
147. Interstrand cross-links induce DNA synthesis in damaged and undamaged plasmids in mammalian cell extracts
148. Binding of nuclear proteins associated with mammalian DNA repair to the mitomycin C-DNA interstrand cross-link
149. Transcription-coupled repair of psoralen cross-links but not monoadducts in Chinese hamster ovary cells
150. Gene-specific DNA interstrand cross-links produced by nitrogen mustard in the human tumor cell line Colo320HSR
151. Gene-specific formation and repair of cisplatin intrastrand adducts and interstrand cross-links in Chinese hamster ovary cells
152. 8-Methoxypsoralen-induced mutations are highly targeted at cross-linkable sites of photoaddition on the non-transcribed strand of a mammalian chromosomal gene
153. The mutagenic processing of psoralen photolesions leaves a highly specific signature at an endogenous human locus
154. Involvement of nucleotide excision repair in a recombination-independent and error-prone pathway of DNA interstrand cross-link repair
155. ATM: The protein encoded by the gene mutated in the radiosensitive syndrome ataxia telangiectasia
156. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression
157. Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control
158. Lessons learned from BRCA1 and BRCA2
159. Nijmegen breakage syndrome: Consequences of defective DNA double strand break repair
160. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
161. Roles of BRCA1 and its interacting proteins
162. Lack of correlation between repair of DNA interstrand cross-links and hypersensitivity of hamster cells towards mitomycin C and cisplatin
163. Analysis of events associated with cell cycle arrest at G2 phase and cell death induced by cisplatin
164. The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin
165. Gross chromosomal rearrangements and genetic exchange between non-homologous chromosomes following BRCA2 inactivation
166. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway
167. Deficient gene specific repair of cisplatin-induced lesions in xeroderma pigmentosum and Fanconi's anemia cell lines
168. Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease
169. DNA structural elements required for ERCC1-XPF endonuclease activity
170. RAD1 and RAD10, but not other excision repair genes, are required for double-strand break-induced recombination in Saccharomyces cerevisiae
171. Role of the nucleotide excision repair gene ERCC1 in formation of recombination-dependent rearrangements in mammalian cells
172. Role of ERCC1 in removal of long non-homologous tails during targeted homologous recombination
173. Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence
174. Mice with DNA repair gene (ERCC1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning
175. Cells from ERCC1-deficient mice show increased genome instability and a reduced frequency of S phase-dependent illegitimate chromosome exchange but a normal frequency of homologous recombination
176. Phenotypic heterogeneity in nucleotide excision repair mutants of rodent complementation groups 1 and 4
177. Defining the roles of nucleotide excision repair and recombination in the repair of DNA interstrand cross-links in mammalian cells
178. Role of the human ERCC1 gene in gene-specific repair of cisplatin-induced DNA damage
179. Repair of an interstrand DNA cross-link initiated by ERCCl-XPF repair/recombination nuclease
180. Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair
181. Rad51 accumulation at sites of DNA damage and in post-replicative chromatin
182. Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes
183. Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation
184. Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination
185. Chromosome instability and defective recombinational repair in knockout mutants of the five rad51 paralogs
186. The Rad51 paralog Rad51B promotes homologous recombinational repair
187. BRCA2 is required for ionizine radiation-induced assembly of Rad51 complex in vivo
188. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
189. Association of BRCA1 with Rad51 in mitotic and meiotic cells
190. BRCA1-deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brcal transgene
191. Brcal controls homology-directed DNA repair
192. BRCA2 is required for homology-directed repair of chromosomal breaks
193. Triple-helix directed psoralen adducts induce a low frequency of recombination in an SV40 shuttle vector
194. Recombination induced by triple-helix-targeted DNA damage in mammalian cells
195. Molecular dosimetry for sister-chromatid exchange induction and cytotoxicity by monofunctional and bifunctional alkylating agents
196. Segregation of DNA polynucleotide strands into sister chromatids and the use of endoreduplicated cells to track sister-chromatid exchanges induced by cross-links, alkylations, or X-ray damage
197. Processing of psoralen adducts in an active human gene: Repair and replication of DNA containing monoadducts and interstrand cross-links
198. Sister-chromatid exchanges are mediated by homologous recombination in vertebrate cells
199. Mouse RAD54 affects DNA double-strand break repair and sister-chromatid exchange
200. The human Rad51 protein: Polarity of strand transfer and stimulation by hRP-A
201. Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein
202. Sequence of the RAD55 gene of Saccharomyces cerevisiae: Similarity of RAD55 to prokaryotic RecA and other RecA-like proteins
203. Nucleotide sequence of the RAD57 gene of Saccharomyces cerevisiae
204. Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase
205. Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family
206. Sequence analysis and expression of a novel mouse homolog of Escherichia coli recA gene
207. Isolation of human and mouse genes based on homology to REC2, a recombinational-repair gene from the fungus Ustilago maydis
208. Identification of a novel human RAD51 homolog RAD51B
209. Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes
210. Identification, characterization, and genetic mapping of Rad51D, a new mouse and human RAD51/RecA-related gene
211. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages
212. Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene
213. The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family
214. The XRCC2 DNA repair gene: Identification of a positional candidate
215. The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2
216. Evidence for simultaneous protein interactions between human Rad51 paralogs
217. Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation
218. The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells
219. Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which can be partially rescued in a p53 (-/-) background
220. Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice
221. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice
222. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53
223. Midgestation lethality in mice deficient for the RecA-related gene, Rad51D/Rad5113
224. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
225. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
226. XRCC3 is required for efficient repair of chromosome breaks by homologous recombination
227. Xrcc3 is required for assembly of Rad51 complexes in vivo
228. Isolation and cross-sensitivity of X-ray-sensitive mutants of V79-4 hamster cells
229. Localization to chromosome 7q36.1 of the human XRCC2 gene, determining sensitivity to DNA-damaging agents
230. The human ubiquitin-conjugating enzyme UbcH1 is involved in the repair of UV-damaged, alkylated and cross-linked DNA
231. Mutagenesis by third-strand-directed psoralen adducts in repair-deficient human cells: High frequency and altered spectrum in a xeroderma pigmentosum variant
232. Defective replication of psoralen adducts detected at the gene-specific level in xeroderma pigmentosum variant cells
233. Mutation specificity of 8-methoxypsoralen plus two doses of UVA irradiation in the hprt gene in diploid human fibroblasts
234. Psoralen adducts in a shuttle vector plasmid propagated in primate cells: High mutagenicity of DNA cross-links
235. Homologous and non-homologous recombination differentially affect DNA damage repair in mice
236. Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency
237. Fanconi anemia
238. Damage-resistant DNA synthesis in Fanconi anemia cells treated with a DNA cross-linking agent
239. Arrest of S phase progression is impaired in Fanconi anemia cells
240. Positional cloning of a novel Fanconi anemia gene: FANCD2
241. Cloning of cDNAs for Fanconi's anaemia by functional complementation
242. Localization of the Fanconi anemia complementation group D gene to a 200 kb region on chromosome 3p25.3
243. Positional cloning of the Fanconi anaemia group A gene: The Fanconi anaemia/breast cancer consortium
244. The Fanconi anaemia group G gene FANCG is identical with XRCC9
245. Evidence for at least eight Fanconi anemia genes
246. Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA
247. Isolation of a cDNA representing the Fanconi anemia complementation group E gene
248. The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM
249. Complementation analysis in Fanconi anemia: Assignment of the reference FA-H patient to group A
250. Association of complementation group and mutation type with clinical outcome in Fanconi anemia
251. Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene
252. Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia
253. Mice with a targeted disruption of the Fanconi anemia homolog fanca
254. Bone marrow failure in the Fanconi anemia group C mouse model after DNA damage
255. Assessment of mitomycin C sensitivity in Fanconi anemia complementation group C gene (Fac) knockout mouse cells
256. The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG
257. Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex
258. Resistance to mitomycin C requires direct interaction between the Fanconi anemia proteins FANCA and FANCG in the nucleus through an arginine-rich domain
259. The Fanconi anemia proteins FANCA and FANCG stabilize each other and promote the nuclear accumulation of the Fanconi anemia complex
260. The Fanconi anemia group C gene product is located in both the nucleus and cytoplasm of human cells
261. A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA
262. Carboxy terminal region of the Fanconi anemia protein, FANCG/XRCC9, is required for functional activity
263. The Fanconi anaemia proteins, FAA and FAC, interact to form a nuclear complex
264. The Fanconi anemia pathway requires FAA phosphorylation and FAA/FAC nuclear accumulation
265. Abnormal microsomal detoxification implicated in Fanconi anemia group C by interaction of the FAC protein with NADPH cytochrome P450 reductase
266. Human alpha spectrin II and the Fanconi anemia proteins FANCA and FANCC interact to form a nuclear complex
267. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF
268. Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation
269. Homologous recombination: From model organisms to human disease
270. Different genetic alterations underlie dual hypersensitivity of CHO mutant UV-1 to DNA methylating and cross-linking agents
271. Cellular and chromosomal hypersensitivity to DNA cross-linking agents and topoisomerase inhibitors in the radiosensitive Chinese hamster irs mutants: Phenotypic similarities to ataxia telangiectasia and Fanconi's anaemia cells
272. The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells
273. A CHO mutant, UV40, that is sensitive to diverse mutagens and represents a new complementation group of mitomycin C sensitivity