2-Amino-O4-benzylpteridine derivatives: Potent inactivators of O6-alkylguanine-DNA alkyltransferase

Journal of Medicinal Chemistry

Volumn 47, Issue 15, 2004, Pages 3887-3891

  Nelson, Michael E ^a   Loktionova, Natalia A ^b   Pegg, Anthony E ^b   Moschel, Robert C ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 O BENZYL 6 FORMYLPTERIDINE; 2 AMINO 4 O BENZYL 6 HYDROXYMETHYLPTERIDINE; 2 AMINO 4 O BENZYL 6,7 DIMETHYLPTERIDINE; 2 AMINO 4 O BENZYLPTERIDINE 6 CARBOXYLIC ACID; 2 AMINO 4 O BENZYLPTERIDINE DERIVATIVE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE INHIBITOR; 6 O BENZYLGUANINE; CARMUSTINE; DNA; FOLIC ACID DERIVATIVE; O 4 BENZYLFOLIC ACID; PTERIDINE DERIVATIVE; UNCLASSIFIED DRUG; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE;

ARTICLE; CANCER ADJUVANT THERAPY; CANCER CELL CULTURE; CELL KILLING; CELL STRAIN A549; CELL STRAIN HT29; CELL STRAIN KB; COLON TUMOR; CONTROLLED STUDY; DNA REPAIR; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SOLUBILITY; ENZYME INACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG TUMOR; NASOPHARYNX TUMOR; ADJUVANT CHEMOTHERAPY; CHEMISTRY; DRUG ANTAGONISM; DRUG SCREENING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

CELL LINE, TUMOR; CHEMOTHERAPY, ADJUVANT; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PTERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3142652522     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049758+     Document Type: Article

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