Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea

Biochemistry

Volumn 35, Issue 4, 1996, Pages 1328-1334

  Srivenugopal, Kalkunte S ^a,c   Yuan, Xiao Hua ^a   Friedman, Henry S ^b   Ali Osman, Francis ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O BENZYLGUANINE; ADENOSINE TRIPHOSPHATE; ANTIBODY; ANTINEOPLASTIC AGENT; CARMUSTINE; ENZYME ANTIBODY; GUANINE DERIVATIVE; MAGNESIUM ION; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; CELL MUTANT; CYTOTOXICITY; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME STABILITY; HUMAN; HUMAN CELL; IMMUNOAFFINITY CHROMATOGRAPHY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; TEMPERATURE SENSITIVE MUTANT; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOTTING, WESTERN; CARMUSTINE; CHROMATOGRAPHY, AFFINITY; ENERGY METABOLISM; GUANINE; HUMANS; KINETICS; MAGNESIUM; METHYLTRANSFERASES; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PRECIPITIN TESTS; RATS; TUMOR CELLS, CULTURED; UBIQUITINS;

EID: 0029670679     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9518205     Document Type: Article

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