Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutSα mismatch-binding activity

Nucleic Acids Research

Volumn 30, Issue 9, 2002, Pages 1959-1966

  Christmann, Markus ^a   Tomicic, Maja T ^a   Kaina, Bernd ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; CASEIN KINASE II; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA; MUTAGENIC AGENT; PHOSPHATASE; PHOSPHATE; PROTEIN KINASE C; PROTEIN MSH2; PROTEIN MSH6; QUERCETIN;

ARTICLE; BINDING AFFINITY; CELL NUCLEUS; COMPLEX FORMATION; CONTROLLED STUDY; DNA PROTEIN COMPLEX; ENZYME INHIBITION; GENE TRANSLOCATION; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MISMATCH REPAIR; PHOSPHATE DEFICIENCY; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN METHYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; STRESS;

ACTIVE TRANSPORT, CELL NUCLEUS; BASE PAIR MISMATCH; CASEIN KINASE II; CELL NUCLEUS; DNA REPAIR; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; MACROMOLECULAR SUBSTANCES; MUTS HOMOLOG 2 PROTEIN; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS;

EID: 0036567603     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Mismatch repair in replication fidelity, genetic recombination and cancer biology
2. DNA-replication fidelity, mismatch repair and genome instability in cancer cells
3. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
4. GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells
5. Human MutSα recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine or the cisplatin d(GpG) adduct
6. Selective recognition of a cisplatin adduct by human mismatch repair proteins
7. Specific binding of human MSH2-MSH6 mismatch-repair protein heterodimers to DNA incorporating thymine- or uracil-containing UV light photoproducts opposite mismatched bases
8. Mismatch repair processing of carcinogen-DNA adducts triggers apoptosis
9. Human MutSα specifically binds to DNA containing aminofluorene and acetylaminofluorene adducts
10. A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells
11. Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents
12. 6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair compromised cells: Facts and models
13. 6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent
14. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
15. Clues to the pathogenesis of familial colorectal cancer
16. DNA mismatch binding defects, DNA damage tolerance and mutator phenotypes in human colorectal carcinoma cell lines
17. Cisplatin and adriamycin resistance are associated with MutSα and mismatch repair deficiency in an ovarian tumor cell line
18. 6-methylguanine-DNA methyltransferase expression in acquired resistance to methylating agents in human cells
19. Induction of two DNA mismatch repair proteins, MSH2 and MSH6 in differentiated human neuroblastoma SH-SY5Y cells exposed to doxorubicin
20. Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents
21. Phosphorylation of an N-terminal motif enhances DNA-binding activity of the human SRY protein
22. Inhibition of the DNA-binding and transcriptional repression activity of the Wilms' tumor gene product, WT1, by cAMP-dependent protein kinase-mediated phosphorylation of Ser-365 and Ser-393 in the zinc finger domain
23. Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B
24. Protein kinase C phosphorylates pp60src at a novel site
25. Regulation of WT1 by phosphorylation: Inhibition of DNA binding, alteration of transcriptional activity and cellular translocation
26. 6-alkylguanine-DNA alkyltransferase in human brain tumor cells
27. Phosphorylation of the DNA repair protein APE/Ref-1 by CKII affects redox regulation of AP-1
28. The DNA repair activity of human redox/repair protein APE/Ref-1 is inactivated by phosphorylation
29. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
30. Protein measurement with the Folin phenol reagent
31. hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSα
32. Activation of mammalian DNA ligase I through phosphorylation by casein kinase II
33. The PROSITE database, its status in 1999
34. Modulation of nuclear protein kinase activity and phosphorylation of histone H1 subspecies during the prereplicative phase of rat liver regeneration
35. Phosphorylation of the insect immunophilin FKBP46 by the Spodoptera frugiperda homolog of casein kinase II
36. Genetic and biochemical analysis of Msh2p-Msh6p: Role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition
37. Evolutionary origin, diversification and specialization of eukaryotic MutS homolog mismatch repair proteins
38. Nucleotide-promoted release of hMutSα from heteroduplex DNA is consistent with an ATP-dependent translocation mechanism
39. The human mismatch recognition complex hMSH2-hMSH6 functions as a novel molecular switch
40. Identification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNA
41. Stimulation of casein kinase II by epidermal growth factor: Relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit
42. Protein kinase CK2 ("casein kinase-2") and its implication in cell division and proliferation
43. Protein kinase CK2 and its role in cellular proliferation, development and pathology
44. Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase
45. Differential expression of protein kinase C isoforms in human colorectal cancers
46. Asymmetric expression of protein kinase CK2 subunits in human kidney tumors