Humnan MutSα recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 13, 1996, Pages 6443-6447

  Duckett, Derek R ^a   Drummond, James T ^a   Murchie, Alastair I H ^b   Reardon, Joyce T ^c   Sancar, Aziz ^c   Lilley, David M J ^b   Modrich, Paul ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

DNA alkylation; DNA repair; Mismatch repair

Indexed keywords

BACTERIA (MICROORGANISMS); MAMMALIA;

4 O METHYLTHYMINE; ADENOSINE TRIPHOSPHATASE; BACTERIAL PROTEIN; CISPLATIN; CISPLATIN DEOXY(GUANOSINE MONOPHOSPHATE GUANOSINE) ADDUCT; CISPLATIN-DEOXY(GUANOSINE MONOPHOSPHATE GUANOSINE) ADDUCT; DINUCLEOSIDE PHOSPHATE; DNA; DNA BINDING PROTEIN; DRUG DERIVATIVE; ESCHERICHIA COLI PROTEIN; GUANINE; MUTS PROTEIN, E COLI; O (6) METHYLGUANINE; O-(6)-METHYLGUANINE; O-4-METHYLTHYMINE; PROTEIN MUTS; THYMINE; 6 O METHYLGUANINE; THYMINE DERIVATIVE;

ARTICLE; CHEMISTRY; DNA BASE COMPOSITION; DNA DAMAGE; DNA REPAIR; HUMAN; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; BASE MISPAIRING; BASE PAIRING; CONTROLLED STUDY; DNA METHYLATION; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATASES; BACTERIAL PROTEINS; BASE COMPOSITION; BASE SEQUENCE; CISPLATIN; DINUCLEOSIDE PHOSPHATES; DNA; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; ESCHERICHIA COLI PROTEINS; GUANINE; HUMANS; MOLECULAR SEQUENCE DATA; MUTS DNA MISMATCH-BINDING PROTEIN; PROTEIN BINDING; THYMINE;

EID: 0029665878     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.13.6443     Document Type: Article

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