Regulation of expression of the DNA repair gene-O6-methylguanine-DNA methyltransferase via protein kinase C-mediated signaling

Cancer Research

Volumn 58, Issue 17, 1998, Pages 3950-3956

  Boldogh, Istvan ^a   Ramana, Chilakamarti V ^a,c   Chen, Zhenping ^a   Biswas, Tapan ^a   Hazra, Tapas K ^a   Grösch, Sabine ^b   Grombacher, Thomas ^b   Mitra, Sankar ^a,d   Kaina, Bernd ^b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c LERNER RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; DIACYLGLYCEROL; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CONTROLLED STUDY; DNA REPAIR; GENE ACTIVATION; GENE EXPRESSION REGULATION; HELA CELL; HUMAN; HUMAN CELL; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING;

ALKYLATING AGENTS; DNA REPAIR; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELA CELLS; HUMANS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; OKADAIC ACID; PROMOTER REGIONS (GENETICS); PROTEIN KINASE C; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1;

EID: 0032170560     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Mitra, S., and Kaina, B. Regulation of repair of alkylation damage in mammalian genomes. Prog. Nueleic Acids Res. Mol. Biol., 44: 109-142, 1993.
2. 6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res., 50: 6119-6129, 1990.
3. Erickson, L. C., Laurent, G., Sharkey, N. A., and Kohn, K. W. DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells. Nature (Lond.), 288: 727-729, 1980.
4. Ludlum, D. B. DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal. Mutat. Res., 233: 117-126, 1990.
5. 6-methylguanine-DNA methyltransferase. Nucleic Acids Res., 11: 7743-7758, 1983.
6. 6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs. Int. J. Cancer. 65: 506-512, 1996.
7. 6-methylguanine in DNA in inbred mice. Mech. Aging Dev., 48: 43-52, 1989.
8. 6-alkylguanine-DNA alkyltransferase activity in peripheral blood lymphocytes: relationship between this activity in lymphocytes and in lymphoblastoid lines from normal controls and from patients with Hodgkin's disease or non-Hodgkin's lym-phoma. Cancer Res., 49: 5339-5344, 1989.
9. Day, R. S., Ziolkowski, C. H. J., Seudiero, D. A., Meyer, S. A., Lubiniecki, A. S., Giardi, A. J., Galloway, S. M., and Bynum, G. D. Defective repair of alkylated DNA by human tumor and SV40-transformed human cell strains. Nature (Lond.), 288: 724-727, 1980.
10. 6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human. Proc. Natl. Acad. Sci. USA, 82: 2985-2989, 1985.
11. 6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents. Carcinogcnesis (Lond.), 12: 1857-1867, 1991.
12. 6-methylguanine-DNA methyltransferase associated with resistance to alkylated drugs in a mammalian cell line. J. Biol. Chem., 272: 13250-13254, 1997.
13. 6-methylguanine-DNA methyltransferase in mammalian cells by DNA-damaging treatments. Mol. Cell. Biol., 11: 4660-4668, 1991.
14. 6-methylguanine-DNA methyltransferases in liver of rats treated with dimethylnitrosamine. Am. J. Pathol., 148: 497-507, 1996.
15. 6-methylguanine-DNA methyltransferase mRNA in rat hepatoma cells. Biochim. Biophys. Acta, 1171: 35-40, 1992.
16. 6-methylguanine-DNA methyltransferase expression. Pharmacol. Ther., 74: 285-297, 1997.
17. 6-methylguanine-DNA methyltransferase (MGMT) gene CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol. Cell. Biol., 17: 5612-5619, 1997.
18. Patel, S. A., Graunke, D. M., and Pieper, R. O. Aberrant silencing of the CpG island-containing human gene is associated with the loss of nucleosome like positioning. Mol. Cell. Biol., 17: 5813-5822, 1997.
19. 6-methylguanine-DNA methyltransferase gene. Nucleic Acids Res., 19: 6163-6167, 1991.
20. 6-methylguanine DNA methyltransferase gene. Nucleic Acids Res., 22: 4614-4619, 1994.
21. Grombacher, T., Mitra, S., and Kaina, B. Induction of the alkyltransferase (MGMT) gene by DNA damaging agents and the glucocorticoid dexamethasone and comparison with the response of base excision repair genes. Carcinogenesis (Lond.), 17: 2329-2336, 1996.
22. 6-methylguanine DNA methyltransferase gene by glucocorticoid hormone. Oncogene, in press, 1998.
23. Herrlich, P., Ponta, H., and Ramsdorf, H. Y. DNA damage-induced gene expression: signal transduction and relation to growth factor signalling. Rev. Physiol. Biochem. Pharmacol., 119: 187-212, 1992.
24. Hunter, T. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signalling. Cell, 80: 225-236, 1995.
25. Chen, C. C. Protein kinase C α. δ, ∈ and ζ in C6 glioma cells. TPA induces translocation and down-regulation of conventional and new PKC isoforms but not atypical PKCζ. FEBS Lett., 332: 169-173, 1993.
26. Chambers, T. C., McAvoy, E. M., Jakobs, J. W., and Eilon, G. Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells. J. Biol. Chem., 265: 7679-7686, 1990.
27. Lee, S. A., Karaszkiewicz, J. W., and Anderson, W. B. Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells. Cancer Res., 52: 3750-3759, 1992.
28. Basu, A. The potential of protein kinase C and A target for anticancer treatment. Pharmacol. Ther., 59: 257-280, 1993.
29. Dphil, G. P. Anticancer drugs acting against signaling pathways. Curr. Opin. Oncol., 7: 554-559, 1995.
30. Chambers, T. C., Zheng, B., and Kuo, J. F. Regulation by phorbol ester and protein kinase C inhibitors and by protein phosphatase inhibitor (okadaik acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug resistance human KB cells. Mol. Pharmacol., 41: 1008-1015, 1992.
31. Sambrook, J., Fritsch, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual, Ed. 2. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
32. 6-alkylguanine. Proc. Natl. Acad. Sci. USA, 87: 686-690, 1990.
33. Bowman, L. H., Rabin, B., and Schlessinger, D. Multiple ribosomal RNA cleavage pathways in mammalian cells. Nucleic Acids Res., 9: 4951-4966, 1981.
34. Deng, W. P., and Nicholoff, J. A. Site-directed mutagenesis of virtually any plasmid by eliminating a unique site. Anal. Biochem., 200: 81-88, 1992.
35. 6-methylguanine-DNA methyltransferase (MGMT) and its relationship to cell death, mutation induction and chromosomal instability. Oncogene, 13: 1927-1935, 1996.
36. Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., and Nishizuka, Y. Direct activation of calcium-activated phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J. Biol. Chem., 257: 7847-7851, 1982.
37. Nishizuka, Y. The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature (Lond.), 308: 693-698, 1984.
38. Kishimoto, A., Takai, Y., Mori, T., Kikkawa, U., and Nishizuka, Y. Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. J. Biol. Chem., 255: 2273-2276, 1980.
39. Hidaka, H., Inagaki, M., Kawamoto, S., and Sasaki, Y. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry, 23: 5036-5041, 1984.
40. Suwanichkul, A., DePaolis, L. A., Lee, P. D., and Powell, D. R. Identification of a promoter element which participates in cAMP-stimulated expression of human insulin-like growth factor-binding protein-1. J. Biol. Chem., 268: 9730-9736, 1993.
41. Findik, D., Song, O., Hidaka, H., and Lavin, M. Protein kinase A inhibitors enhance radiation-induced apoptosis. J. Cell. Biochem., 57: 12-21, 1995.
42. Harrison, L., Galanopoulos, T., Ascione, A. G., Antoniades, H. N., and Demple, B. Regulated expression of APE apurinic endonuclease mRNA during wound healing in porcine epidermis. Carcinogenesis (Lond.), 17: 377-381, 1996.
43. Wilson, T. M., Rivkees, S. A., Deutsch, W. A., and Kelley, M. R. Differential expression of the apurinic/apyrimidinic endonuclease (APE/ref1) multifunctional DNA base excision repair gene during fetal development and in adult rat brain and testis. Mutat. Res., 362: 237-248, 1996.
44. Xu, Y., Moore, D. H., Broshears, J., Liu, L. F., Wilson, T. M., and Kelley, M. R. The apurinic/apyrimidinic endonuclease (APE-1/ref1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer. Anticancer Res., 17: 3713-3719, 1997.
45. 6-methylguanine-DNA methyltransferase and N-methylpurine-DNA glycosylase in rat liver cells exhibiting different status of differentiation. Biochim. Biophys. Acta, 1270: 63-72, 1995.
46. Boldogh, I., Abubakar, S., and Albrecht, T. Activation of proto-oncogenes: an immediate early event in human cytomegalovirus infection. Science (Washington DC), 247: 561-564, 1990.
47. Kaina, B., Haas, S., and Kappes, H. A general role for c-Fos in cellular protection against DNA-damaging carcinogens and cytostatic drugs. Cancer Res., 57: 2721-2731, 1997.
48. Ziegler, A., Knesel, J., Fabbro, D., and Nagamine, Y. Protein kinase C down-regulation enhances cAMP-mediated induction of urokinase-type plasminogen activator mRNA in LLC-PKI cells. J. Biol. Chem., 266: 21067-21074, 1991.
49. Huang, D., Hubbard, C. J., and Jungmann, R. A. Lactate dehydrogenase A subunit messenger stability is synergistically regulated via protein kinase A and C signal transduction pathways. Mol. Endocrinol., 9: 994-1004, 1995.
50. Levitzki, A. Signal-transduction therapy: a novel approach to disease management. Eur. J. Biochem., 226: 1-13, 1994.
51. 6-benzylguanine analogs on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents. Cancer Res., 51: 3367-3372, 1991.
52. 6-methylguanine DNA methyltransferase activity and mRNA levels in HT-29 cells in vitro. Cancer Res., 51: 1581-1585, 1991.
53. Erickson, L. C., Micetich, K. C., and Fisher, R. I. Preclinical and clinical experiences with drug combinations designed to inhibit DNA repair enzymes. In: P. Wooley and K. Tew (eds.), Mechanisms of Drug Resistance in Neoplastic Cells, pp. 173-183. New York: Academic Press, 1988.
54. 6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro. Cancer Res., 53: 4281-4286, 1993.