DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells

Biochemical Journal

Volumn 351, Issue 2, 2000, Pages 393-402

  Mullapudi, S R S ^a   Ali Osman, F ^a   Shou, J ^a   Srivenugopal, K S ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Base excision repair; Cancer chemotherapy; Drug resistance; O6 methylguanine; Post translational modification

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; CALMODULIN; CASEIN KINASE II; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA; MAGNESIUM ION; MANGANESE; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; RECOMBINANT PROTEIN; SEPHAROSE; SERINE; THREONINE; TYROSINE; TYRPHOSTIN;

AMINO ACID SEQUENCE; ARTICLE; BRAIN TUMOR; CANCER CHEMOTHERAPY; CELL FRACTIONATION; CONTROLLED STUDY; DNA REPAIR; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN TARGETING; TUMOR CELL;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; BRAIN NEOPLASMS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CASEIN KINASE II; CATIONS; CHROMATOGRAPHY, AGAROSE; CRICETINAE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; GENISTEIN; GUANOSINE TRIPHOSPHATE; HUMANS; MAGNESIUM; MANGANESE; MEDULLOBLASTOMA; MICE; MOLECULAR SEQUENCE DATA; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; PHOSPHATES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; RATS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; THREONINE; TUMOR CELLS, CULTURED; TYROSINE; TYRPHOSTINS;

EID: 0034667523     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3510393     Document Type: Article

References (42)

1. 6-alkylguanine-DNA alkyttransferase
2. Regulation of repair of alkytation damage in mammalian genomes
3. 6-enzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea
4. 6-alkylguanine-DNA alkyttransferase, a target for the modulation of drug resistance
5. 6-benzylguanine and its role in chemotherapy
6. 6-benzylguanine: A clinical trial establishing the biochemical modulatory dose in tumour tissue for alkyltransferase-directed DNA repair
7. 6-methylguanine-DNA methyltransferase mutants: Implications for drug resistance gene therapy
8. 6-alkylguanine-DNA alkyltransferase in human brain turnout cells
9. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
10. 6-benzylguanine
11. A novel strategy for production of a highly expressed recombinant protein in an active form
12. 6-enzylguanine
13. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
14. Partial purification and characterization of protein tyrosine kinases from normal tissues
15. Enrichment of yeast protein tyrosine kinase activity by substrate affinity chromatography
16. Chemical properties, isolation, and analysis of O-phosphates in proteins
17. A sensitive method for detection of calmodulin-dependent protein kinase II activity in sodium dodecyl sulfate-polyacrylamide gels
18. 6-methylguanine-DNA methyltransferase
19. 6-alkyiguanine-DNA alkyltransferase using newly developed monoclonal antibodies
20. Recombinant dengue virus type 1 NS3 protein exhibits specific viral RNA binding and NTPase activity regulated by the NS5 protein
21. Dual-specificity protein kinases: Will any hydroxyl do?
22. Structural and functional characteristics of Dyrk, a novel subfamily of protein kinases with dual specificity
23. CK2: A protein kinase in need of control
24. Effect of metal ions on the activity of casein kinase II from Xenopus laevis
25. Binding of polyamines to an autonomous domain of the regulatory subunit of protein kinase CK2 induces a conformational change in the holoenzyme. A proposed role for the kinase stimulation
26. Inhibition of casein kinase II by heparin
27. Casein kinase II is a selective target of HIV-1 transcriptional inhibitors
28. Protei tyrosine kinases: Structure, substrate specificity, and drug discovery
29. Signal-induced site-specific phosphorylation targets κBα to the ubiquitin-proteasome pathway
30. Ubiquitination of p27 is regulated Cdk-dependent phosphorytation and trimeric complex formation
31. Affinity purification of mammalian RNA polymerase I: Identification of an associated kinase
32. Casein kinase II copurities with yeast DNA topoisomerase II and reactivates the dephosphorylated enzyme
33. Tubulin-associated calmodulin-dependent kinase: Evidence for an endogenous complex of tubulin with a calcium-calmodulin-dependent kinase
34. 4 in human glioma cells followiing chloroethylnitrosourea-induced DNA damage
35. The PROSITE database, its status in 1999
36. 6-methylguanine-DNA methyltransferase binds DNA
37. 6-alkylguanine-DNA alkyltransferase
38. Nucleotide sequence analysis of human abl and bcr-abl cDNAs. Oncogene
39. Tyk2, prototype of a novel class of non-receptor tyrosine kinase genes
40. A family of F-box proteins
41. Regulation of protein transport to the nucleus: Central role of phosphorylation