메뉴 건너뛰기




Volumn 512, Issue 2-3, 2002, Pages 121-134

Genotoxicity of Streptozotocin

Author keywords

Genotoxicity; Streptozocin; Streptozotocin

Indexed keywords

ANTIOXIDANT; BARBITAL; CYCLOSPORIN A; DOXORUBICIN; FLUOROURACIL; FREE RADICAL; METAL CHELATE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROCARBAZINE; SEMUSTINE; STREPTOZOCIN; TIOGUANINE; VINCRISTINE;

EID: 0036898999     PISSN: 13835742     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5742(02)00044-3     Document Type: Review
Times cited : (340)

References (136)
  • 1
    • 0011960173 scopus 로고
    • Streptozotocin, a new antibiotic. In vitro and in vivo evaluation
    • Lewis C., Barbiers A.R. Streptozotocin, a new antibiotic. In vitro and in vivo evaluation. Antibiot. Ann. 7:1959/1960;247-254.
    • (1959) Antibiot. Ann. , vol.7 , pp. 247-254
    • Lewis, C.1    Barbiers, A.R.2
  • 4
    • 0014623881 scopus 로고
    • A preparative synthesis of Streptozotocin
    • Hardegger E., Meier A., Stoos A. A preparative synthesis of Streptozotocin. Helv. Chim. Acta. 52:1969;2555-2560.
    • (1969) Helv. Chim. Acta , vol.52 , pp. 2555-2560
    • Hardegger, E.1    Meier, A.2    Stoos, A.3
  • 5
    • 0014707937 scopus 로고
    • Improved synthesis of Streptozotocin
    • Hessler E.J., Jahnke H.K. Improved synthesis of Streptozotocin. J. Org. Chem. 35:1970;245-246.
    • (1970) J. Org. Chem. , vol.35 , pp. 245-246
    • Hessler, E.J.1    Jahnke, H.K.2
  • 7
    • 0002385099 scopus 로고
    • Alkylating Agents
    • B.A. Chabner, J.M. Collins (Eds.), J.B. Lippincott, Philadelphia
    • M. Colvin, B.A. Chabner, Alkylating Agents, in: B.A. Chabner, J.M. Collins (Eds.), Cancer Chemotherapy Principies and Practice, J.B. Lippincott, Philadelphia, 1990, pp. 276-313.
    • (1990) Cancer Chemotherapy Principies and Practice , pp. 276-313
    • Colvin, M.1    Chabner, B.A.2
  • 8
    • 0025275635 scopus 로고
    • Nitrosoureas from chemist to physician: Classification and recent approaches to drug design
    • McConnick J.E., McElhinney R.S. Nitrosoureas from chemist to physician: classification and recent approaches to drug design. Eur. J. Cancer. 26:1990;207-221.
    • (1990) Eur. J. Cancer , vol.26 , pp. 207-221
    • McConnick, J.E.1    McElhinney, R.S.2
  • 10
    • 0031558241 scopus 로고    scopus 로고
    • Inhibition of DNA repair as a means of increasing the antitumor activity of DNA reactive agents
    • Dolan M.E. Inhibition of DNA repair as a means of increasing the antitumor activity of DNA reactive agents. Adv. Drug Del. Rev. 26:1997;105-118.
    • (1997) Adv. Drug Del. Rev. , vol.26 , pp. 105-118
    • Dolan, M.E.1
  • 12
    • 0022971473 scopus 로고
    • Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation of methylnitrosourea and N-methyl-N′-nitro-N-nitrosoguanidine
    • Goldmaker V.S., Cuzich R.A., Thilly W.G. Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation of methylnitrosourea and N-methyl-N′-nitro-N-nitrosoguanidine. J. Biol. Chem. 261:1986;12462-12471.
    • (1986) J. Biol. Chem. , vol.261 , pp. 12462-12471
    • Goldmaker, V.S.1    Cuzich, R.A.2    Thilly, W.G.3
  • 13
    • 45949118113 scopus 로고
    • Characterization of a CHO variant in respect to alkylating agent-induced biological effects and DNA repair
    • Goth-Goldstein R., Hughes M. Characterization of a CHO variant in respect to alkylating agent-induced biological effects and DNA repair. Mutat. Res. 184:1987;139-146.
    • (1987) Mutat. Res. , vol.184 , pp. 139-146
    • Goth-Goldstein, R.1    Hughes, M.2
  • 14
    • 0023900145 scopus 로고
    • Cytotoxicity and induction of sister chromatid exchanges in human and rodent brain tumor cells treated with alkylating chemotherapeutic agents
    • Tokuda K., Bodell W.J. Cytotoxicity and induction of sister chromatid exchanges in human and rodent brain tumor cells treated with alkylating chemotherapeutic agents. Cancer Res. 48:1988;3100-3105.
    • (1988) Cancer Res. , vol.48 , pp. 3100-3105
    • Tokuda, K.1    Bodell, W.J.2
  • 15
    • 0025195404 scopus 로고
    • 6-alkylguanine-DNA-alkyltransferase: Regulation and importance in response to alkylating carcinogenic and therapeutic agents
    • 6-alkylguanine-DNA-alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res. 50:1990;6119-6129.
    • (1990) Cancer Res. , vol.50 , pp. 6119-6129
    • Pegg, A.E.1
  • 16
    • 0028983225 scopus 로고
    • Streptozotocin-induced genotoxic effects in Chinese hamster cells: The resistant phenotype of V79 cells
    • Capucci M.S., Hoffmann M.E., Natarajan A.T. Streptozotocin-induced genotoxic effects in Chinese hamster cells: the resistant phenotype of V79 cells. Mutat. Res. 347:1995a;79-85.
    • (1995) Mutat. Res. , vol.347 , pp. 79-85
    • Capucci, M.S.1    Hoffmann, M.E.2    Natarajan, A.T.3
  • 18
    • 0029929429 scopus 로고    scopus 로고
    • The secondary leukernias: Cha1lenges and research directions
    • Smith M.A., McCaffrey R.P., Karp J.E. The secondary leukernias: cha1lenges and research directions. J. Natl. Cancer Inst. 88:1996;407-418.
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 407-418
    • Smith, M.A.1    McCaffrey, R.P.2    Karp, J.E.3
  • 19
    • 0019991327 scopus 로고
    • The combination of methyl-CCNU, vincristine, 5-fluorouracil and Streptozotocin in the treatment of advanced colo-rectal adenocarcinoma
    • Togni P., Sessa C., Varini M., Cavalli F. The combination of methyl-CCNU, vincristine, 5-fluorouracil and Streptozotocin in the treatment of advanced colo-rectal adenocarcinoma. Schweiz Med. Wochenschr. 112:1982;930-933.
    • (1982) Schweiz Med. Wochenschr. , vol.112 , pp. 930-933
    • Togni, P.1    Sessa, C.2    Varini, M.3    Cavalli, F.4
  • 20
    • 0021021353 scopus 로고
    • Methyl-CCNU, 5-fluoouracil, vincristine, and Streptozotocin in metastatic colo-rectal carcinoma
    • Weltz M.D., Perry D.J., Blom J., Butler W.M. Methyl-CCNU, 5-fluoouracil, vincristine, and Streptozotocin in metastatic colo-rectal carcinoma. J. Clin. Oncol. 1:1983;135-137.
    • (1983) J. Clin. Oncol. , vol.1 , pp. 135-137
    • Weltz, M.D.1    Perry, D.J.2    Blom, J.3    Butler, W.M.4
  • 21
    • 0021613148 scopus 로고
    • Phase II study of methyl-CCNU, vincristine, 5-fluorouracil, and Streptozotocin in advanced colorectal cancer by the Gastrointestinal Tumor Study Group
    • Gastrointestinal Tumor Study Group. Phase II study of methyl-CCNU, vincristine, 5-fluorouracil, and Streptozotocin in advanced colorectal cancer by the Gastrointestinal Tumor Study Group, J. Clin. Oncol. 2 (1984) 770-773.
    • (1984) J. Clin. Oncol. , vol.2 , pp. 770-773
  • 22
    • 0023605653 scopus 로고
    • Phase 2 trial of Streptozotocin by continuous infusion for metastatic colorectal carcinoma
    • Clamon G., Riggs C., Stegink L., Traves M. Phase 2 trial of Streptozotocin by continuous infusion for metastatic colorectal carcinoma. Cancer Drug Deliv. 4:1987;43-46.
    • (1987) Cancer Drug Deliv. , vol.4 , pp. 43-46
    • Clamon, G.1    Riggs, C.2    Stegink, L.3    Traves, M.4
  • 23
    • 0026095149 scopus 로고
    • Chemotherapy with 5-fluorouracil and Streptozotocin in carcinoid tumors of gastrointestinal origin: Experiences with 13 patients
    • Ridolfi R., Amaducci L., Derni S., Fabbri L., Innocenti M.P., Vignutelli P. Chemotherapy with 5-fluorouracil and Streptozotocin in carcinoid tumors of gastrointestinal origin: experiences with 13 patients. J. Chemother. 3:1991;328-331.
    • (1991) J. Chemother. , vol.3 , pp. 328-331
    • Ridolfi, R.1    Amaducci, L.2    Derni, S.3    Fabbri, L.4    Innocenti, M.P.5    Vignutelli, P.6
  • 25
    • 0032450572 scopus 로고    scopus 로고
    • Multiple pulmonary chemodectomas in a child: Results of four different therapeutic regimens
    • Chow S.N., Seear M., Anderson R., Magee F. Multiple pulmonary chemodectomas in a child: results of four different therapeutic regimens. J. Pediatr. Hematol. Oncol. 20:1998;583-586.
    • (1998) J. Pediatr. Hematol. Oncol. , vol.20 , pp. 583-586
    • Chow, S.N.1    Seear, M.2    Anderson, R.3    Magee, F.4
  • 28
    • 0019981647 scopus 로고
    • Streptozotocin: A review of its pharmacology, efficacy, and toxicity
    • Weiss R.B. Streptozotocin: a review of its pharmacology, efficacy, and toxicity. Cancer Treat. Rep. 66:1982;427-438.
    • (1982) Cancer Treat. Rep. , vol.66 , pp. 427-438
    • Weiss, R.B.1
  • 29
    • 0020953916 scopus 로고
    • Streptozotocin: Distribution, metabolism and mechanisms of action
    • Tjälve H. Streptozotocin: distribution, metabolism and mechanisms of action. Uppsala J. Med. Sci. Suppl. 39:1983;145-157.
    • (1983) Uppsala J. Med. Sci. Suppl. , vol.39 , pp. 145-157
    • Tjälve, H.1
  • 30
    • 0019501634 scopus 로고
    • Alkylation of DNA in rat tissues following administration of Streptozotocin
    • Bennett R.A., Pegg A.E. Alkylation of DNA in rat tissues following administration of Streptozotocin. Cancer Res. 41:1981;2786-2790.
    • (1981) Cancer Res. , vol.41 , pp. 2786-2790
    • Bennett, R.A.1    Pegg, A.E.2
  • 33
    • 0023070001 scopus 로고
    • 6-methylguanine in human cell killing, sister chromatid exchange induction and mutagenesis: A review
    • 6-methylguanine in human cell killing, sister chromatid exchange induction and mutagenesis: a review. J. Cell Sci. 6(Suppl.):1987;333-353.
    • (1987) J. Cell Sci. , vol.6 , Issue.SUPPL. , pp. 333-353
    • Day, R.S.1    Babich, M.A.2    Yarosh, D.B.3    Scudiero, D.A.4
  • 34
    • 0000017747 scopus 로고
    • Biological consequences of reactions with DNA: Role of specific lesions
    • C.S. Cooper, P.L. Grover (Eds.), Springer, Berlin
    • G.P. Margison, P.J. O'Connor, Biological consequences of reactions with DNA: role of specific lesions, in: C.S. Cooper, P.L. Grover (Eds.), Handbook of Experimental Pharmacology 94/1, Springer, Berlin, 1990, pp. 547-571.
    • (1990) Handbook of Experimental Pharmacology , vol.94 , Issue.1 , pp. 547-571
    • Margison, G.P.1    O'Connor, P.J.2
  • 38
    • 0022037404 scopus 로고
    • Apurinic sites as mutagenic intermediates
    • Loeb L.A. Apurinic sites as mutagenic intermediates. Cell. 40:1985;483-484.
    • (1985) Cell , vol.40 , pp. 483-484
    • Loeb, L.A.1
  • 39
    • 0018074304 scopus 로고
    • Measurements of DNA damage in Chinese hamster cells treated with equitoxic and equimutagenic doses of nitrosoureas
    • Erickson L.C., Bradley M.O., Kohn K.W. Measurements of DNA damage in Chinese hamster cells treated with equitoxic and equimutagenic doses of nitrosoureas. Cancer Res. 38:1978;3379-3384.
    • (1978) Cancer Res. , vol.38 , pp. 3379-3384
    • Erickson, L.C.1    Bradley, M.O.2    Kohn, K.W.3
  • 40
    • 0018193831 scopus 로고
    • Detection of DNA damage induced in vivo following exposure of rats to carcinogens
    • Petzold G.L., Swenberg J.A. Detection of DNA damage induced in vivo following exposure of rats to carcinogens. Cancer Res. 38:1978;1589-1594.
    • (1978) Cancer Res. , vol.38 , pp. 1589-1594
    • Petzold, G.L.1    Swenberg, J.A.2
  • 41
    • 0019812690 scopus 로고
    • Streptozotocin and alloxan induced DNA strand breaks and poly(ADP-ribose)synthetase in pancreatic islets
    • Yamamoto H., Uchigata Y., Okamoto H. Streptozotocin and alloxan induced DNA strand breaks and poly(ADP-ribose)synthetase in pancreatic islets. Nature. 294:1981;284-286.
    • (1981) Nature , vol.294 , pp. 284-286
    • Yamamoto, H.1    Uchigata, Y.2    Okamoto, H.3
  • 42
    • 0012011384 scopus 로고
    • Protection by superoxide dismutase, catalase and poly(ADP-ribose)synthetase inhibitors against alloxan- and Streptozotocin-induced islet DNA strand breaks and against proinsulin synthesis inhibition
    • K.G. Alberti, T. Ogada, J.A.A. Alouch, E.N. Mngola (Eds.), Excerpta Medica, Amsterdam
    • H. Okamoto, H. Yarnamoto, Y. Uchigata, Protection by superoxide dismutase, catalase and poly(ADP-ribose)synthetase inhibitors against alloxan- and Streptozotocin-induced islet DNA strand breaks and against proinsulin synthesis inhibition, in: K.G. Alberti, T. Ogada, J.A.A. Alouch, E.N. Mngola (Eds.), Proceedings of 11th Congress International Diabetes Federation, Excerpta Medica, Amsterdam, 1982, p. 13.
    • (1982) Proceedings of 11th Congress International Diabetes Federation , pp. 13
    • Okamoto, H.1    Yarnamoto, H.2    Uchigata, Y.3
  • 43
    • 0020315923 scopus 로고
    • Protection by superoxide dismutase, catalase, and poly(ADP-ribose)synthetase inhibitors against alloxan- and Streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis
    • Uchigata Y., Yamamoto H., Kavamura A., Okamoto H. Protection by superoxide dismutase, catalase, and poly(ADP-ribose)synthetase inhibitors against alloxan- and Streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J. Biol. Chem. 257:1982;6084.
    • (1982) J. Biol. Chem. , vol.257 , pp. 6084
    • Uchigata, Y.1    Yamamoto, H.2    Kavamura, A.3    Okamoto, H.4
  • 44
    • 0022472816 scopus 로고
    • Mechanisms of nitrosourea-induced β-cell damage. Alterations in DNA
    • LeDoux S.P., Woodley S.E., Patton N.J., Wilson G.L. Mechanisms of nitrosourea-induced β-cell damage. Alterations in DNA. Diabetes. 35:1986;866-872.
    • (1986) Diabetes , vol.35 , pp. 866-872
    • LeDoux, S.P.1    Woodley, S.E.2    Patton, N.J.3    Wilson, G.L.4
  • 45
    • 0023191188 scopus 로고
    • Dose-response curves for liver DNA fragmentation induced in rats by 16 N-nitroso compounds as measured by viscometric and alkaline elution analyses
    • Brambilla G., Carlo P., Finollo R., Sciaba L. Dose-response curves for liver DNA fragmentation induced in rats by 16 N-nitroso compounds as measured by viscometric and alkaline elution analyses. Cancer Res. 47:1987;3485-3491.
    • (1987) Cancer Res. , vol.47 , pp. 3485-3491
    • Brambilla, G.1    Carlo, P.2    Finollo, R.3    Sciaba, L.4
  • 46
    • 0022492515 scopus 로고
    • DNA damage and cytotoxicity of 2-chloroethyl (methyllsulfonyl) methanesulfonate (NSC 338947) produced in human colon carcinoma cells with methylating agent pretreatment
    • Hartley J.A., Gibson N.W. DNA damage and cytotoxicity of 2-chloroethyl (methyllsulfonyl) methanesulfonate (NSC 338947) produced in human colon carcinoma cells with methylating agent pretreatment. Cancer Res. 46:1986;3871-3875.
    • (1986) Cancer Res. , vol.46 , pp. 3871-3875
    • Hartley, J.A.1    Gibson, N.W.2
  • 48
    • 0022654311 scopus 로고
    • Comparative interactions of Streptozotocin and chlorozotocin with DNA of an insulin-secreting cell line (RINr)
    • Mossman B.T., Ireland C.M., Filipak M., LeDoux S., Wilson G.L. Comparative interactions of Streptozotocin and chlorozotocin with DNA of an insulin-secreting cell line (RINr). Diabetologia. 29:1986;186-191.
    • (1986) Diabetologia , vol.29 , pp. 186-191
    • Mossman, B.T.1    Ireland, C.M.2    Filipak, M.3    LeDoux, S.4    Wilson, G.L.5
  • 49
    • 0025757259 scopus 로고
    • Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea Streptozotocin
    • Pettepher C.C., LeDoux S.P., Bohr V.A., Wilson G.L. Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea Streptozotocin. J. Biol. Chem. 266:1991;3113-3117.
    • (1991) J. Biol. Chem. , vol.266 , pp. 3113-3117
    • Pettepher, C.C.1    LeDoux, S.P.2    Bohr, V.A.3    Wilson, G.L.4
  • 50
    • 0024439383 scopus 로고
    • DNA repair mechanisms affecting cytotoxicity by Streptozotocin in E. coli
    • Fram R.J., Mack S.L., George M., Marinus M.G. DNA repair mechanisms affecting cytotoxicity by Streptozotocin in E. coli. Mutat. Res. 218:1989;125-133.
    • (1989) Mutat. Res. , vol.218 , pp. 125-133
    • Fram, R.J.1    Mack, S.L.2    George, M.3    Marinus, M.G.4
  • 51
    • 0028271775 scopus 로고
    • Tissue-specific induction of mutations by Streptozotocin in vivo
    • Schmezer P., Eckert C., Liegibel U.M. Tissue-specific induction of mutations by Streptozotocin in vivo. Mutat. Res. 307:1994;495-499.
    • (1994) Mutat. Res. , vol.307 , pp. 495-499
    • Schmezer, P.1    Eckert, C.2    Liegibel, U.M.3
  • 52
    • 0029566291 scopus 로고
    • Extent and persistence of Streptozotocin-induced DNA damage and cell proliferation in rat kidney as determined by in vivo alkaline elution and BrdUrd labeling assays
    • Kraynak A.R., Storer R.D., Jensen R.D., Kloss M.W., Soper K.A., Clair J.H., DeLuca J.G., Nichols W.W., Eydelloth R.S. Extent and persistence of Streptozotocin-induced DNA damage and cell proliferation in rat kidney as determined by in vivo alkaline elution and BrdUrd labeling assays. Toxicol. Appl. Pharmacol. 135:1995;279-286.
    • (1995) Toxicol. Appl. Pharmacol. , vol.135 , pp. 279-286
    • Kraynak, A.R.1    Storer, R.D.2    Jensen, R.D.3    Kloss, M.W.4    Soper, K.A.5    Clair, J.H.6    DeLuca, J.G.7    Nichols, W.W.8    Eydelloth, R.S.9
  • 53
    • 0033561597 scopus 로고    scopus 로고
    • Site-specific DNA methylation and apoptosis: Induction by diabetogenic Streptozotocin
    • Murata M., Takahashi A., Saito I., Kawanishi S. Site-specific DNA methylation and apoptosis: induction by diabetogenic Streptozotocin. Biochem. Pharmacol. 57:1999;881-887.
    • (1999) Biochem. Pharmacol. , vol.57 , pp. 881-887
    • Murata, M.1    Takahashi, A.2    Saito, I.3    Kawanishi, S.4
  • 54
    • 0022400099 scopus 로고
    • Measurement of unscheduled DNA synthesis in rat kidney cells following in vivo treatment with genotoxic agents
    • Tyson C.K., Mirsalis J.C. Measurement of unscheduled DNA synthesis in rat kidney cells following in vivo treatment with genotoxic agents. Environ. Mutagen. 7:1985;889-899.
    • (1985) Environ. Mutagen. , vol.7 , pp. 889-899
    • Tyson, C.K.1    Mirsalis, J.C.2
  • 55
    • 0025534481 scopus 로고
    • Genotoxicity of pancreatic chemical carcinogens to propagable cultured normal pancreatic epithelial cells
    • Shepherd J., Tsao M.S., Duguid W.P. Genotoxicity of pancreatic chemical carcinogens to propagable cultured normal pancreatic epithelial cells. Exp. Mol. Pathol. 53:1990;203-210.
    • (1990) Exp. Mol. Pathol. , vol.53 , pp. 203-210
    • Shepherd, J.1    Tsao, M.S.2    Duguid, W.P.3
  • 56
    • 0027238867 scopus 로고
    • Genotoxic agents increase expression of growth arrest and DNA damage - Inducible genes gadd 153 and gadd 45 in rat pancreatic islets
    • Eizirik D.L., Bjorklund A., Cagliero E. Genotoxic agents increase expression of growth arrest and DNA damage - inducible genes gadd 153 and gadd 45 in rat pancreatic islets. Diabetes. 42:1993;738-745.
    • (1993) Diabetes , vol.42 , pp. 738-745
    • Eizirik, D.L.1    Bjorklund, A.2    Cagliero, E.3
  • 57
    • 0021092027 scopus 로고
    • Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro
    • Sandler S., Swenne I. Streptozotocin, but not alloxan, induces DNA repair synthesis in mouse pancreatic islets in vitro. Diabetologia. 25:1983;444-447.
    • (1983) Diabetologia , vol.25 , pp. 444-447
    • Sandler, S.1    Swenne, I.2
  • 58
    • 0022212920 scopus 로고
    • DNA repair synthesis in the pancreatic islets of Streptozotocin-treated mice
    • Sandler S., Swenne I. DNA repair synthesis in the pancreatic islets of Streptozotocin-treated mice. Diabetes Res. 2:1985;255-258.
    • (1985) Diabetes Res. , vol.2 , pp. 255-258
    • Sandler, S.1    Swenne, I.2
  • 59
    • 0024365136 scopus 로고
    • Effects of Streptozotocin exposure in vitro on the replication and repair of DNA in fetal rat pancreatic islet cells
    • Sandler S., Swenne I. Effects of Streptozotocin exposure in vitro on the replication and repair of DNA in fetal rat pancreatic islet cells. Pancreas. 4:1989;53-58.
    • (1989) Pancreas , vol.4 , pp. 53-58
    • Sandler, S.1    Swenne, I.2
  • 60
    • 0028657016 scopus 로고
    • Treatment of cultured pancreatic β cells with Streptozotocin induces cell death by apoptosis
    • Morgan N.G., Cable H.C., Newcombe N.R., Williams G.T. Treatment of cultured pancreatic β cells with Streptozotocin induces cell death by apoptosis. Biosci. Rep. 14:1994;243-250.
    • (1994) Biosci. Rep. , vol.14 , pp. 243-250
    • Morgan, N.G.1    Cable, H.C.2    Newcombe, N.R.3    Williams, G.T.4
  • 61
    • 0029812292 scopus 로고    scopus 로고
    • Streptozotocin at low doses induces apoptosis and at high doses causes necrosis in a murine pancreatic β-cell line, INS-1
    • Saini K.S., Thompson C., Winterford C.M., Walker N.I., Cameron D.P. Streptozotocin at low doses induces apoptosis and at high doses causes necrosis in a murine pancreatic β-cell line, INS-1. Biochem. Mol. Biol. Int. 39:1996;1229-1236.
    • (1996) Biochem. Mol. Biol. Int. , vol.39 , pp. 1229-1236
    • Saini, K.S.1    Thompson, C.2    Winterford, C.M.3    Walker, N.I.4    Cameron, D.P.5
  • 62
    • 0037081753 scopus 로고    scopus 로고
    • Sensitivity of HaCat keratinocytes to diabetogenic toxins
    • Harel A., Bloch O., Vardi P., Bloch K. Sensitivity of HaCat keratinocytes to diabetogenic toxins. Biochem. Pharmacol. 63:2002;171-178.
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 171-178
    • Harel, A.1    Bloch, O.2    Vardi, P.3    Bloch, K.4
  • 64
    • 0027054676 scopus 로고
    • New hypotheses for the mechanisms of Streptozotocin and alloxan inducing diabetes mellitus
    • Kawada J. New hypotheses for the mechanisms of Streptozotocin and alloxan inducing diabetes mellitus. Yakugaku Zasshi. 112:1992;773-791.
    • (1992) Yakugaku Zasshi , vol.112 , pp. 773-791
    • Kawada, J.1
  • 66
    • 0028951141 scopus 로고
    • Hydroxyl radical formation in diabetic rats induced by Streptozotocin
    • Ohkuwa T., Sato Y., Naoi M. Hydroxyl radical formation in diabetic rats induced by Streptozotocin. Life Sci. 56:1995;1789-1798.
    • (1995) Life Sci. , vol.56 , pp. 1789-1798
    • Ohkuwa, T.1    Sato, Y.2    Naoi, M.3
  • 67
    • 0029863131 scopus 로고    scopus 로고
    • N-monomethyl-arginine and nicotinamide prevent Streptozotocin-induced double strand DNA break formation in pancreatic rat islets
    • Bedoya F.J., Solano F., Lucas M. N-monomethyl-arginine and nicotinamide prevent Streptozotocin-induced double strand DNA break formation in pancreatic rat islets. Experientia. 52:1996;344-547.
    • (1996) Experientia , vol.52 , pp. 344-547
    • Bedoya, F.J.1    Solano, F.2    Lucas, M.3
  • 68
    • 0029257151 scopus 로고
    • Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage
    • Kroncke K.D., Fehsel K., Sommer A., Rodriguez M.L., Kolb-Bachofen V. Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage. Biol. Chem. Hoppe Seyler. 376:1995;179-185.
    • (1995) Biol. Chem. Hoppe Seyler. , vol.376 , pp. 179-185
    • Kroncke, K.D.1    Fehsel, K.2    Sommer, A.3    Rodriguez, M.L.4    Kolb-Bachofen, V.5
  • 69
    • 0035461380 scopus 로고    scopus 로고
    • Overexpression of metallothionein in pancreatic β cell reduces Streptozotocin-induced DNA damage and diabetes
    • Chen H., Carlson E.C., Pellet L., Moritz J.T., Epstein P.N. Overexpression of metallothionein in pancreatic β cell reduces Streptozotocin-induced DNA damage and diabetes. Diabetes. 50:2001;2040-2046.
    • (2001) Diabetes , vol.50 , pp. 2040-2046
    • Chen, H.1    Carlson, E.C.2    Pellet, L.3    Moritz, J.T.4    Epstein, P.N.5
  • 70
    • 18244412346 scopus 로고
    • Protective role of superoxide dismutase against diabetogenic drugs
    • Gandy S.E., Buse M.G., Crouch R.K. Protective role of superoxide dismutase against diabetogenic drugs. Clin. Res. 30:1982;392a.
    • (1982) Clin. Res. , vol.30
    • Gandy, S.E.1    Buse, M.G.2    Crouch, R.K.3
  • 71
    • 0018838435 scopus 로고
    • Protection against Streptozotocin-induced diabetes by superoxide dismutase
    • Robbins M.J., Sharp R.A., Slonim A.E., Burr I.M. Protection against Streptozotocin-induced diabetes by superoxide dismutase. Diabetologia. 18:1980;55.
    • (1980) Diabetologia , vol.18 , pp. 55
    • Robbins, M.J.1    Sharp, R.A.2    Slonim, A.E.3    Burr, I.M.4
  • 72
    • 0020643905 scopus 로고
    • Attenuation of Streptozotocin diabetes with superoxide dismutase-1ike copper (nX3,5-diisopropylsalicylate) in the rat
    • Gandy S.E., Buse M.G., Sorenson J.R.J., Crouch R.K. Attenuation of Streptozotocin diabetes with superoxide dismutase-1ike copper (nX3,5-diisopropylsalicylate) in the rat. Diabetologia. 24:1983;437.
    • (1983) Diabetologia , vol.24 , pp. 437
    • Gandy, S.E.1    Buse, M.G.2    Sorenson, J.R.J.3    Crouch, R.K.4
  • 73
    • 0019968492 scopus 로고
    • The partial protection effect of the hydroxyl radical scavenger dimethylurea on Streptozotocin-induced diabetes in vivo and in vitro
    • Sandler S., Andersson A. The partial protection effect of the hydroxyl radical scavenger dimethylurea on Streptozotocin-induced diabetes in vivo and in vitro. Diabetologia. 23:1982;374.
    • (1982) Diabetologia , vol.23 , pp. 374
    • Sandler, S.1    Andersson, A.2
  • 74
    • 0020576982 scopus 로고
    • Modification of chernically induced diabetes in rats by Vitamin E: Supplementation minimizes and depletion enhances development of diabetes
    • Slonim A.E., Surber M.E., Page D.E., Sharp R.A., Burr I.M. Modification of chernically induced diabetes in rats by Vitamin E: supplementation minimizes and depletion enhances development of diabetes. J. Clin. Invest. 71:1983;1282.
    • (1983) J. Clin. Invest. , vol.71 , pp. 1282
    • Slonim, A.E.1    Surber, M.E.2    Page, D.E.3    Sharp, R.A.4    Burr, I.M.5
  • 75
    • 0000855771 scopus 로고
    • Action of Streptozotocin, an antileukemic antibiotic, on L1210 cells
    • P. Farnes (Ed.), Baltimore, The Williams and Wilkins Co.
    • B.K. Bhuyan, Action of Streptozotocin, an antileukemic antibiotic, on L1210 cells, in: P. Farnes (Ed.), In Vitro Vol. 4, Baltimore, The Williams and Wilkins Co., 1969, p. 154.
    • (1969) In Vitro , vol.4 , pp. 154
    • Bhuyan, B.K.1
  • 76
    • 0015083032 scopus 로고
    • The effects of N-methyl-N-nitro-N-nitrosoguanidine and Streptozotocin on mammalian cell cultures
    • Kelly F., Legator M. The effects of N-methyl-N-nitro-N-nitrosoguanidine and Streptozotocin on mammalian cell cultures. Mutat. Res. 12:1971;183-190.
    • (1971) Mutat. Res. , vol.12 , pp. 183-190
    • Kelly, F.1    Legator, M.2
  • 77
    • 0028888633 scopus 로고
    • Streptozotocin-induced chromosomal aberrations, SCEs and mutations in CHO-9 parental cells and in EM-C11 mutant cell line
    • Capucci M.S., Hoffmann M.E., Zdzienicka M.Z., Natarajan A.T. Streptozotocin-induced chromosomal aberrations, SCEs and mutations in CHO-9 parental cells and in EM-C11 mutant cell line. Mutat. Res. 326:1995c;227-234.
    • (1995) Mutat. Res. , vol.326 , pp. 227-234
    • Capucci, M.S.1    Hoffmann, M.E.2    Zdzienicka, M.Z.3    Natarajan, A.T.4
  • 78
    • 0031727913 scopus 로고    scopus 로고
    • Effects of antioxidants on Streptozotocin-induced clastogenesis in mammalian and insect cells
    • Bolzán A.D., Bianchi N.O., Bianchi M.S. Effects of antioxidants on Streptozotocin-induced clastogenesis in mammalian and insect cells. Mutat. Res. 418:1998;35-42.
    • (1998) Mutat. Res. , vol.418 , pp. 35-42
    • Bolzán, A.D.1    Bianchi, N.O.2    Bianchi, M.S.3
  • 79
    • 0343963164 scopus 로고    scopus 로고
    • The effect of 1,10-phenanthroline on the chromosome damage and sister-chromatid exchanges induced by Streptozotocin in mammalian and insect cells
    • Bolzán A.D., González M.C., Bianchi M.S. The effect of 1,10-phenanthroline on the chromosome damage and sister-chromatid exchanges induced by Streptozotocin in mammalian and insect cells. Mutat. Res. 447:2000;221-226.
    • (2000) Mutat. Res. , vol.447 , pp. 221-226
    • Bolzán, A.D.1    González, M.C.2    Bianchi, M.S.3
  • 80
    • 0037134766 scopus 로고    scopus 로고
    • Chromosomal response of human lymphocytes to Streptozotocin
    • Bolzán A.D., Bianchi M.S. Chromosomal response of human lymphocytes to Streptozotocin. Mutat. Res. 503:2002;63-68.
    • (2002) Mutat. Res. , vol.503 , pp. 63-68
    • Bolzán, A.D.1    Bianchi, M.S.2
  • 81
    • 0014821362 scopus 로고
    • The action of Streptozotocin on mammalian cells
    • Bhuyan B.K. The action of Streptozotocin on mammalian cells. Cancer Res. 30:1970;2017-2023.
    • (1970) Cancer Res. , vol.30 , pp. 2017-2023
    • Bhuyan, B.K.1
  • 82
    • 0000659450 scopus 로고
    • Correction of alkylation hypersensitivity of CHO-W27-1 by transfection with human DNA
    • Kaina B. Correction of alkylation hypersensitivity of CHO-W27-1 by transfection with human DNA. Carcinogenesis. 11:1987;1209-1212.
    • (1987) Carcinogenesis , vol.11 , pp. 1209-1212
    • Kaina, B.1
  • 83
    • 0031589755 scopus 로고    scopus 로고
    • 6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair comprornised cells: Facts and models
    • 6-methylguanine in Mex-, Mex+ and methylation-tolerant mismatch repair comprornised cells: facts and models. Mutat. Res. 381:1997;227-241.
    • (1997) Mutat. Res. , vol.381 , pp. 227-241
    • Kaina, B.1    Ziouta, A.2    Ochs, K.3    Coquerelle, T.4
  • 84
    • 0027340278 scopus 로고
    • 6-alkylguanine and N-alkyIpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: New insights gained from studies of genetically engineered mammalian cell lines
    • 6-alkylguanine and N-alkyIpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines. Environ. Mol. Mutagen. 22:1993;283-292.
    • (1993) Environ. Mol. Mutagen. , vol.22 , pp. 283-292
    • Kaina, B.1    Fritz, G.2    Coquerelle, T.3
  • 86
    • 0026471037 scopus 로고
    • Clastogenicity to the mouse bone marrow of the mouse germ cell genotoxin Streptozotocin
    • Liegibel U., Tinwell H., Callander R.D., Schmezer P., Ashby J. Clastogenicity to the mouse bone marrow of the mouse germ cell genotoxin Streptozotocin. Mutagenesis. 7:1992;471-474.
    • (1992) Mutagenesis , vol.7 , pp. 471-474
    • Liegibel, U.1    Tinwell, H.2    Callander, R.D.3    Schmezer, P.4    Ashby, J.5
  • 88
    • 0028987786 scopus 로고
    • A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells
    • Galloway S.M., Greenwood S.K., Hill R.B., Bradt C.I., Bean C.L. A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells. Mutat. Res. 346:1995;231-245.
    • (1995) Mutat. Res. , vol.346 , pp. 231-245
    • Galloway, S.M.1    Greenwood, S.K.2    Hill, R.B.3    Bradt, C.I.4    Bean, C.L.5
  • 89
    • 0020967477 scopus 로고
    • Pretreatrnent of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone
    • Zlotogorski C., Erickson L.C. Pretreatrnent of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone. Carcinogenesis. 4:1983;759-763.
    • (1983) Carcinogenesis , vol.4 , pp. 759-763
    • Zlotogorski, C.1    Erickson, L.C.2
  • 90
    • 0022612382 scopus 로고
    • More than additive toxicity of the combination of 1-methyl-1-nitrosourea plus 1,3-bis(2-chloroethyl)-I-nitrosourea in the rat
    • Zeller W.J., Berger M.R., Henne T., Weber E. More than additive toxicity of the combination of 1-methyl-1-nitrosourea plus 1,3-bis(2-chloroethyl)-I-nitrosourea in the rat. Cancer Res. 46:1986;1714-1716.
    • (1986) Cancer Res. , vol.46 , pp. 1714-1716
    • Zeller, W.J.1    Berger, M.R.2    Henne, T.3    Weber, E.4
  • 91
    • 0024825701 scopus 로고
    • Inhibition of a specific DNA repair system and nitrosourea cytotoxicity in resistant human cancer cells
    • Futscher B.W., Micetich K.C., Barnes D.M., Fisher R.I., Erickson L.C. Inhibition of a specific DNA repair system and nitrosourea cytotoxicity in resistant human cancer cells. Cancer Commun. 1:1989;65-73.
    • (1989) Cancer Commun. , vol.1 , pp. 65-73
    • Futscher, B.W.1    Micetich, K.C.2    Barnes, D.M.3    Fisher, R.I.4    Erickson, L.C.5
  • 92
    • 0025828948 scopus 로고
    • 6-methylguanine DNA methyltransferase activity and mRNA levels in HT-29 cells in vitro
    • 6-methylguanine DNA methyltransferase activity and mRNA levels in HT-29 cells in vitro. Cancer Res. 51:1991;1581-1585.
    • (1991) Cancer Res. , vol.51 , pp. 1581-1585
    • Pieper, R.O.1    Futscher, B.W.2    Dong, Q.3    Erickson, L.C.4
  • 93
    • 0026887984 scopus 로고
    • Effect of pretreatment with N-methyl-N-nitrosourea or Streptozotocin on the cytotoxicity and the induction of sister chromatid exchanges in human and rodent brain tumor cells treated with chloroethylnitrosourea
    • Tokuda K. Effect of pretreatment with N-methyl-N-nitrosourea or Streptozotocin on the cytotoxicity and the induction of sister chromatid exchanges in human and rodent brain tumor cells treated with chloroethylnitrosourea. Hokkaido Igaku Zasshi. 67:1992;462-474.
    • (1992) Hokkaido Igaku Zasshi , vol.67 , pp. 462-474
    • Tokuda, K.1
  • 94
    • 0024338624 scopus 로고
    • 6-alkylguanine-DNA alkyltransferase by Streptozotocin in vivo
    • 6-alkylguanine-DNA alkyltransferase by Streptozotocin in vivo. Cancer Res. 49:1989;3134-3138.
    • (1989) Cancer Res. , vol.49 , pp. 3134-3138
    • Gerson, S.L.1
  • 95
    • 0026554643 scopus 로고
    • Phase I study of Streptozotocin- and carmustine-sequenced administration in patients with advanced cancer
    • Micetich K.C., Futscher B., Koch D., Fisher R.I., Erickson L.C. Phase I study of Streptozotocin- and carmustine-sequenced administration in patients with advanced cancer. J. Natl. Cancer Inst. 84:1992;256-260.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 256-260
    • Micetich, K.C.1    Futscher, B.2    Koch, D.3    Fisher, R.I.4    Erickson, L.C.5
  • 99
    • 0023391912 scopus 로고
    • 6-methylguanine-DNA-methyltransferase activity and are hypermutable by alkylating agents
    • 6-methylguanine-DNA-methyltransferase activity and are hypermutable by alkylating agents. Carcinogenesis (London). 8:1987;1109-1113.
    • (1987) Carcinogenesis (London) , vol.8 , pp. 1109-1113
    • Ishida, R.1    Takahashi, T.2
  • 100
    • 0023294561 scopus 로고
    • Alkylation repair and the induction of cell death and sister chromatid exchange in human cells
    • Samson L., Linn S. Alkylation repair and the induction of cell death and sister chromatid exchange in human cells. Carcinogenesis (London). 8:1987;227-230.
    • (1987) Carcinogenesis (London) , vol.8 , pp. 227-230
    • Samson, L.1    Linn, S.2
  • 101
    • 0024394466 scopus 로고
    • Tolerance to methylniytosourea-induced DNA damage is associated with 6-thioguanine resístanse in CHO cells
    • Aquilina G., Zijno A., Moscufo N., Dogliotti N.E., Bignami M. Tolerance to methylniytosourea-induced DNA damage is associated with 6-thioguanine resístanse in CHO cells. Carcinogenesis. 10:1989;1219-1223.
    • (1989) Carcinogenesis , vol.10 , pp. 1219-1223
    • Aquilina, G.1    Zijno, A.2    Moscufo, N.3    Dogliotti, N.E.4    Bignami, M.5
  • 103
    • 0025350382 scopus 로고
    • Differences in induction of sister chromatid exchange in MNNG-resistant HeLa S3-Mer-cell lines
    • Ishida R., Utsumi K.R. Differences in induction of sister chromatid exchange in MNNG-resistant HeLa S3-Mer-cell lines. Carcinogenesis. 11:1990;1209-1212.
    • (1990) Carcinogenesis , vol.11 , pp. 1209-1212
    • Ishida, R.1    Utsumi, K.R.2
  • 104
    • 0022244540 scopus 로고
    • Protection of mammalian cells by o-phenanthroline from lethal and DNA-damaging effects produced by active oxygen species
    • Mello-Filho A., Meneghini R. Protection of mammalian cells by o-phenanthroline from lethal and DNA-damaging effects produced by active oxygen species. Biochim. Biophys. Acta. 847:1985;82-89.
    • (1985) Biochim. Biophys. Acta , vol.847 , pp. 82-89
    • Mello-Filho, A.1    Meneghini, R.2
  • 105
    • 0022917625 scopus 로고
    • 1,10 Phenanthroline, a metal chelator, protects against alloxan- but not Streptozotocin-induced diabetes
    • Eizirik D.L., de Lucio M.A., Boschero A.C., Hoffmann M.E. 1,10 Phenanthroline, a metal chelator, protects against alloxan- but not Streptozotocin-induced diabetes. J. Free Radic. Biol. Med. 2:1986;189-192.
    • (1986) J. Free Radic. Biol. Med. , vol.2 , pp. 189-192
    • Eizirik, D.L.1    De Lucio, M.A.2    Boschero, A.C.3    Hoffmann, M.E.4
  • 106
    • 0032480042 scopus 로고    scopus 로고
    • Critical steps in alkylation-induced aberration formation
    • Kaina B. Critical steps in alkylation-induced aberration formation. Mutat. Res. 404:1998;119-124.
    • (1998) Mutat. Res. , vol.404 , pp. 119-124
    • Kaina, B.1
  • 107
    • 0014357667 scopus 로고
    • Mutagenic activity of Streptozotocin
    • Kolbye S.M., Legator M.S. Mutagenic activity of Streptozotocin. Mutat. Res. 6:1968;387-389.
    • (1968) Mutat. Res. , vol.6 , pp. 387-389
    • Kolbye, S.M.1    Legator, M.S.2
  • 108
    • 0015089931 scopus 로고
    • A microbial assay for detecting chemical mutagens in tissue homogenates
    • Ficsor G., Muthiani E. A microbial assay for detecting chemical mutagens in tissue homogenates. Mutat. Res. 12:1971;335-337.
    • (1971) Mutat. Res. , vol.12 , pp. 335-337
    • Ficsor, G.1    Muthiani, E.2
  • 109
    • 0001406666 scopus 로고
    • Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals
    • McCann J., Choi E., Yamasaki E., Ames B.N. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. Proc. Natl. Acad. Sci. U.S.A. 72:1975;5135-5139.
    • (1975) Proc. Natl. Acad. Sci. U.S.A. , vol.72 , pp. 5135-5139
    • McCann, J.1    Choi, E.2    Yamasaki, E.3    Ames, B.N.4
  • 110
    • 0017180450 scopus 로고
    • Mutagenicity of Streptozotocin and several other nitrosourea compounds in Salmonella typhimurium
    • Zimmer D.M., Bhuyan B.K. Mutagenicity of Streptozotocin and several other nitrosourea compounds in Salmonella typhimurium. Mutat. Res. 40:1976;281-288.
    • (1976) Mutat. Res. , vol.40 , pp. 281-288
    • Zimmer, D.M.1    Bhuyan, B.K.2
  • 111
    • 0018179951 scopus 로고
    • Mutagenicity testing of benomyl, methyl-2-benzimidazole carbamate, Streptozotocin and N-methyl-N′-nitro-N-nitrosoguanidine in Salmonella typhimurium in vitro and in rodent host-mediated assays
    • Ficsor G., Bordas S., Stewart S.J. Mutagenicity testing of benomyl, methyl-2-benzimidazole carbamate, Streptozotocin and N-methyl-N′-nitro-N-nitrosoguanidine in Salmonella typhimurium in vitro and in rodent host-mediated assays. Mutat. Res. 51:1978;151-164.
    • (1978) Mutat. Res. , vol.51 , pp. 151-164
    • Ficsor, G.1    Bordas, S.2    Stewart, S.J.3
  • 113
    • 0022812124 scopus 로고
    • Mutagenesis and repair of DNA damage caused by nitrogen mustard, N,N′-bis(2-chloroethyl)-N-nitrosourea (BCNU), Streptozotocin and mitomycin C in E. coli.
    • Fram R.J., Sullivan J., Marinus M.G. Mutagenesis and repair of DNA damage caused by nitrogen mustard, N,N′-bis(2-chloroethyl)-N-nitrosourea (BCNU), Streptozotocin and mitomycin C in E. coli. Mutat. Res. 66:1986;299-342.
    • (1986) Mutat. Res. , vol.66 , pp. 299-342
    • Fram, R.J.1    Sullivan, J.2    Marinus, M.G.3
  • 114
    • 0031052951 scopus 로고    scopus 로고
    • Comparison of the induction of SOS repair in Escherichia coli PQ37 and PQ243 by antineoplastic agents
    • Marczewska J., Koziorowska J. Comparison of the induction of SOS repair in Escherichia coli PQ37 and PQ243 by antineoplastic agents. Acta Pol. Pharm. 54:1997;35-41.
    • (1997) Acta Pol. Pharm. , vol.54 , pp. 35-41
    • Marczewska, J.1    Koziorowska, J.2
  • 115
    • 0018973399 scopus 로고
    • Characterisation of mutants of Escherichia coli K12, selected by resistance to Streptozotocin
    • Lengeler J. Characterisation of mutants of Escherichia coli K12, selected by resistance to Streptozotocin. Mol. Gen. Genet. 179:1980;49-54.
    • (1980) Mol. Gen. Genet. , vol.179 , pp. 49-54
    • Lengeler, J.1
  • 116
    • 0023768804 scopus 로고
    • Sequence specificity of Streptozotocin-induced mutations
    • Mack S.L., Fram R.J., Marinus M.G. Sequence specificity of Streptozotocin-induced mutations. Nucleic Acids Res. 16:1988;9811-9820.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 9811-9820
    • Mack, S.L.1    Fram, R.J.2    Marinus, M.G.3
  • 117
    • 0014663132 scopus 로고
    • Microbial mutagenicity of Streptozotocin in animal-mediated assays
    • Gabridge M.G., Denunzio A., Legator M.S. Microbial mutagenicity of Streptozotocin in animal-mediated assays. Nature. 221:1969;68-70.
    • (1969) Nature , vol.221 , pp. 68-70
    • Gabridge, M.G.1    Denunzio, A.2    Legator, M.S.3
  • 118
    • 0017253731 scopus 로고
    • Cytotoxicity, mutations and DNA damage produced in Chinese hamster cells treated with Streptozotocin, its analogs, and N-methyl-N′-nitro-N-nitrosoguanidine
    • Bhuyan B.K., Peterson A.R., Heidelberger C. Cytotoxicity, mutations and DNA damage produced in Chinese hamster cells treated with Streptozotocin, its analogs, and N-methyl-N′-nitro-N-nitrosoguanidine. Chem. Biol. Interact. 13:1976;173-179.
    • (1976) Chem. Biol. Interact. , vol.13 , pp. 173-179
    • Bhuyan, B.K.1    Peterson, A.R.2    Heidelberger, C.3
  • 119
    • 0011932627 scopus 로고
    • Mutagenicity of various chemicals and their metabolites in Drosophila
    • [abstract]
    • Browning L.S. Mutagenicity of various chemicals and their metabolites in Drosophila. Genetics. 74:1973;33. [abstract].
    • (1973) Genetics , vol.74 , pp. 33
    • Browning, L.S.1
  • 120
    • 0028210029 scopus 로고
    • Metabolic activation of four drugs in the eye mosaic assay measuring principally mitotic recombination in Drosophila melanogaster: Differences in strain susceptibility and route of exposure
    • Rodríguez-Arnaiz R., Aranda J.H. Metabolic activation of four drugs in the eye mosaic assay measuring principally mitotic recombination in Drosophila melanogaster: differences in strain susceptibility and route of exposure. Mutat. Res. 305:1994;157-163.
    • (1994) Mutat. Res. , vol.305 , pp. 157-163
    • Rodríguez-Arnaiz, R.1    Aranda, J.H.2
  • 121
    • 0014209501 scopus 로고
    • Induction of renal tumour by Streptozotocin in rats
    • Arison R.N., Feudale E.L. Induction of renal tumour by Streptozotocin in rats. Nature. 214:1967;1254-1255.
    • (1967) Nature , vol.214 , pp. 1254-1255
    • Arison, R.N.1    Feudale, E.L.2
  • 124
    • 0017228370 scopus 로고
    • Modification of renal tumorigenic effect of Streptozotocin by nicotinarnide: Spontaneous reversibiJity of Streptozotocin diabetes
    • Rakieten N., Gordon B.S., Beaty A., Cooney D.A., Schein P.S. Modification of renal tumorigenic effect of Streptozotocin by nicotinarnide: spontaneous reversibiJity of Streptozotocin diabetes. Proc. Soc. Exp. Biol. Med. 151:1976;356-361.
    • (1976) Proc. Soc. Exp. Biol. Med. , vol.151 , pp. 356-361
    • Rakieten, N.1    Gordon, B.S.2    Beaty, A.3    Cooney, D.A.4    Schein, P.S.5
  • 125
    • 0024954920 scopus 로고
    • Liver, kidney and is let cell tumors in spontaneously hypertensive and normotensive rats treated with Streptozotocin
    • Iwase M., Nunoi K., Sadoshima S., Kikuchi M., Fujishima M. Liver, kidney and is let cell tumors in spontaneously hypertensive and normotensive rats treated with Streptozotocin. Tohoku J. Exp. Med. 159:1989;83-90.
    • (1989) Tohoku J. Exp. Med. , vol.159 , pp. 83-90
    • Iwase, M.1    Nunoi, K.2    Sadoshima, S.3    Kikuchi, M.4    Fujishima, M.5
  • 126
    • 0014691063 scopus 로고
    • Potential carcinogenic effect of Streptozotocin
    • Sibay T.M., Hayes J.A. Potential carcinogenic effect of Streptozotocin. Lancet. 2:1969;912.
    • (1969) Lancet , vol.2 , pp. 912
    • Sibay, T.M.1    Hayes, J.A.2
  • 128
    • 0015865776 scopus 로고
    • Effect of Streptozotocin in the Chinese hamster (Cricetulus griseus)
    • Berman L.D., Hayes J.A., Sibay T.M. Effect of Streptozotocin in the Chinese hamster (Cricetulus griseus). J. Natl. Cancer Inst. 51:1973;1287-1294.
    • (1973) J. Natl. Cancer Inst. , vol.51 , pp. 1287-1294
    • Berman, L.D.1    Hayes, J.A.2    Sibay, T.M.3
  • 129
    • 0029887466 scopus 로고    scopus 로고
    • DNA damage induced by seven N-nitroso compounds in primary cultures of human and rat kidney cells
    • Robbiano L., Mereto E., Corbu C., Brambilla G. DNA damage induced by seven N-nitroso compounds in primary cultures of human and rat kidney cells. Mutat. Res. 368:1996;41-47.
    • (1996) Mutat. Res. , vol.368 , pp. 41-47
    • Robbiano, L.1    Mereto, E.2    Corbu, C.3    Brambilla, G.4
  • 130
    • 0027157233 scopus 로고
    • Neoplastic transformation of propagable cultured rat pancreatic duct epithelial cells by azaserine and Streptozotocin
    • Shepherd J.G., Chen J.R., Tsao M.S., Duguid W.P. Neoplastic transformation of propagable cultured rat pancreatic duct epithelial cells by azaserine and Streptozotocin. Carcinogenesis. 14:1993;1027-1033.
    • (1993) Carcinogenesis , vol.14 , pp. 1027-1033
    • Shepherd, J.G.1    Chen, J.R.2    Tsao, M.S.3    Duguid, W.P.4
  • 131
    • 0025980542 scopus 로고
    • Potentiation of renal tumorigenicity by cyclosporin A in Streptozotocin diabetic rats
    • Reddi A.S., Jyothirmayi G.N., Halka K., Khan M.Y. Potentiation of renal tumorigenicity by cyclosporin A in Streptozotocin diabetic rats. Cancer Lett. 56:1991;109-115.
    • (1991) Cancer Lett. , vol.56 , pp. 109-115
    • Reddi, A.S.1    Jyothirmayi, G.N.2    Halka, K.3    Khan, M.Y.4
  • 132
    • 0025689372 scopus 로고
    • Amelioration of sodium barbital-induced nephropathy and regenerative tubular hyperplasia after a single injection of Streptozotocin does not abolish the renal tumor promoting effect of barbital sodium in male F344/NCr rats
    • Konishi N., Diwan B.A., Ward J.M. Amelioration of sodium barbital-induced nephropathy and regenerative tubular hyperplasia after a single injection of Streptozotocin does not abolish the renal tumor promoting effect of barbital sodium in male F344/NCr rats. Carcinogenesis. 11:1990;2149-2156.
    • (1990) Carcinogenesis , vol.11 , pp. 2149-2156
    • Konishi, N.1    Diwan, B.A.2    Ward, J.M.3
  • 133
    • 0018189942 scopus 로고
    • Tumorigenic action of Streptozotocin on the pancreas and kidney in male Wistar rats
    • Kazumi T., Yoshino G., Fujii S., Baba S. Tumorigenic action of Streptozotocin on the pancreas and kidney in male Wistar rats. Cancer Res. 38:1978;2144-2147.
    • (1978) Cancer Res. , vol.38 , pp. 2144-2147
    • Kazumi, T.1    Yoshino, G.2    Fujii, S.3    Baba, S.4
  • 134
    • 0020994797 scopus 로고
    • DNA strand breaks and poly(ADP-ribose) synthetase activation in pancreatic islets - A new aspect to development of insulin-dependent diabetes and pancreatic β-cell tumors
    • Okamoto H., Yamamoto H. DNA strand breaks and poly(ADP-ribose) synthetase activation in pancreatic islets - a new aspect to development of insulin-dependent diabetes and pancreatic β-cell tumors. Princess Takamatsu Symp. 13:1983;297-308.
    • (1983) Princess Takamatsu Symp. , vol.13 , pp. 297-308
    • Okamoto, H.1    Yamamoto, H.2
  • 136
    • 0011988763 scopus 로고
    • International Agency for Research on Cancer (IARC). Monographs, (Suppl. 7) 1987, p. 72.
    • (1987) Monographs , Issue.SUPPL. 7 , pp. 72


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.