Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 4, 1998, Pages 1635-1640

  Engelbergs, Jörg ^a   Thomale, Jürgen ^a   Galhoff, Anke ^a   Rajewsky, Manfred F ^a  

^a UNIVERSITY OF ESSEN MEDICAL SCHOOL   (Germany)

Author keywords

Ada transgenic rats; Mammary cancer; O6 alkylguanine DNA alkyltransferase; Overall and gene specific DNA repair

Indexed keywords

6 ETHYLGUANINE; 6-ETHYLGUANINE; DNA; DRUG DERIVATIVE; ETHYLNITROSOUREA; GUANINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLNITROSOUREA; 6 O METHYLGUANINE;

ALKYLATION; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DNA ADDUCT; DNA REPAIR; EXPERIMENTAL NEOPLASM; FEMALE; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; ONCOGENE RAS; POINT MUTATION; RAT; TRANSGENIC ANIMAL; UDDER; ANIMAL EXPERIMENT; BREAST ADENOCARCINOMA; BREAST CARCINOGENESIS; CANCER PREVENTION; DRUG EFFECT; GENE MUTATION; GENE TARGETING; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; ONCOGENE H RAS; PRIORITY JOURNAL;

ALKYLATION; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DNA ADDUCTS; DNA REPAIR; DNA, NEOPLASM; ETHYLNITROSOUREA; FEMALE; GENES, RAS; GUANINE; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, EXPERIMENTAL; METHYLNITROSOUREA; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; POINT MUTATION; RATS; TRANSCRIPTION, GENETIC;

EID: 0032539477     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.4.1635     Document Type: Article

References (59)

1. Goth, R. & Rajewsky, M. F. (1974) Proc. Natl. Acad. Sci. USA 74, 639-643.
2. Thomale, J., Huh, N., Nehls, P., Eberle, G. & Rajewsky, M. F. (1990) Proc. Natl. Acad. Sci. USA 87, 9883-9887.
3. Dumenco, L. L., Allay, E., Norton, K. & Gerson, S. L. (1993) Science 259, 219-222.
4. Nakatsuru, Y., Matsukuma, S., Nemoto, N., Sugano, H., Sekiguchi, M. & Ishikawa, T. (1993) Proc. Natl. Acad. Sci. USA 90, 6468-6472.
5. Bohr, V. A., Smith, C. A., Okumoto, D. S. & Hanawalt, P. C. (1985) Cell 40, 359-369.
6. Mellon, I., Spivak, G. & Hanawalt, P. C. (1987) Cell 51, 241-249.
7. Holmquist, G. P. & Gao, S. (1997) Mutat. Res. 386, 69-101.
8. Denissenko, M. F., Pao, A., Tang, M. & Pfeifer, G. P. (1996) Science 274, 430-432.
9. Tu, Y., Tornaletti, S. & Pfeifer, G. P. (1996) EMBO J. 15, 675-683.
10. Verhage, R. A., van Gool, A. J., de Groot, N., Hoeijmakers, J. H. J., van de Putte, P. & Brouwer, J. (1996) Mol. Cell. Biol. 16, 496-502.
11. Montesano, R., Hall, J. & Wild, C. P. (1992) in Relevance of Animal Studies to the Evaluation of Human Cancer Risk, eds. d'Amato, R., Slaga, T. J., Farland, W. H. & Henry, C. (Wiley-Liss, New York), pp. 175-196.
12. Beranek, D. T. (1990) Mutat. Res. 231, 11-30.
13. Gullino, P. M., Pettigrew, H. M. & Grantham, F. H. (1975) J. Natl. Cancer Inst. 54, 401-414.
14. Stoica, G., Koestner, A. & Capen, C. C. (1983) Am. J. Pathol. 110, 161-169.
15. Russo, J. & Russo, I. H. (1980) Cancer Res. 40, 2677-2687.
16. Zarbl, H., Sukumar, S., Arthur, A. V., Martin-Zanca, D. & Barbacid, M. (1985) Nature (London) 315, 382-385.
17. Kumar, R., Sukumar, S. & Barbacid, M. (1990) Science 248, 1101-1104.
18. Lindahl, T., Sedgwick, B., Sekiguchi, M. & Nakabeppu, Y. (1988) Annu. Rev. Biochem. 57, 133-157.
19. Fong, L. Y. Y., Jensen, D. A. & Magee, P. N. (1990) Carcinogrnesis 11, 411-417.
20. Parshad, R., Price, F. M., Bohr, V. A., Cowans, K. H., Zujewski, J. A. & Sanford, K. K. (1996) Br. J. Cancer 74, 1-5.
21. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY), 2nd Ed.
22. Thomale, J., Engelbergs, J., Seiler, F. & Rajewsky, M. F. (1996) in Technologies for Detection of DNA Damage and Mutations, ed. Pfeifer, G. P. (Plenum, New York), pp. 87-101.
23. Eberle, G. (1989) Ph.D. dissertation (University of Essen, Germany).
24. Thomale, J., Hochleitner, K. & Rajewsky, M. F. (1994) J. Biol. Chem. 269, 1681-1686.
25. Eckart, M. (1988) Ph.D. dissertation (University of Düsseldorf, Germany).
26. Rajewsky, M. F., Müller, R., Adamkiewicz, J. & Drosdziok, W. (1980) in Carcinogenesis: Fundamental Mechanisms and Environmental Effects, eds. Pullman, B., Ts'o, P. O. P. & Gelboin, H. (Reidel, Dordrecht, The Netherlands), pp. 207-218.
27. Ledeboer, A. M., Edens, L., Maat, J., Visser, C., Bos, J. W., Verrips, C. T., Janowicz, Z., Eckart, M., Roggenkamp, R. & Hollenberg, C. P. (1985) Nucleic Acids Res. 13, 3063-3082.
28. Waldstein, E. A. (1990) Carcinogenesis 11, 21-26.
29. Hogan, B., Constantini, F. & Lacy, A. (1986) Manipulating the Mouse Embryo: A Laboratory Manual (Cold Spring Harbor Lab. Press, Plainview, NY).
30. Nikitin, A. Yū., Jin, J. J., Papewalis, J., Prokopenko, S. N., Pozharisski, K. M., Winterhager, E., Flesken-Nikitin, A. & Rajewsky, M. F. (1996) Oncogene 12, 1309-1317.
31. Demple, B., Sedgwick, B., Robins, P., Totty, N., Waterfield, M. D. & Lindahl, T. (1985) Proc. Natl. Acad. Sci. USA 82, 2688-2692.
32. Bender, K., Federwisch, M., Loggen, U., Nehls, P. & Rajewsky, M. F. (1996) Nucleic Acids Res. 24, 2078-2094.
33. Pegg, A. E., Roberfroid, M., von Bahr, C., Foote, S. R., Mitra, S., Brésil, H., Likhachev, A. & Montesano, R. (1982) Proc. Natl. Acad. Sci. USA 79, 3862-3165.
34. Ruta, M., Wolford, R., Dhar, R., DeFeo-Jones, D., Ellis, R. W. & Scolnick, E. M. (1986) Mol. Cell. Biol. 6, 1706-1710.
35. Tahira, T., Hayashi, K., Ochiai, M., Tsuchida, N., Nagao, M. & Sugimura, T. (1986) Mol. Cell. Biol. 6, 1349-1351.
36. Suzui, M., Yoshimi, N., Tanaka, T. & Mori, H. (1995) Mol. Carcinogen. 14, 294-298.
37. Nikitin, A. Yū., Ballering, L. A. P., Lyons, J. & Rajewsky, M. F. (1991) Proc. Natl. Acad. Sci. USA 88, 9939-9943.
38. Lu, S. J., Milligan, J. R. & Archer, M. C. (1991) Mol. Carcinogen. 4, 261-264.
39. Pegg, A. E., Boosalis, M., Samson, L., Moschel, R. C., Byers, T. L., Swenn, K. & Dolan, M. E. (1993) Biochemistry 32, 11998-12006.
40. Zaidi, N. H., Pretlow, T. P., O'Riordan, M. A., Dumenco, L. L., Allay, E. & Gerson, S. L. (1995) Carcinogenesis 16, 451-456.
41. Becker, K., Dosch, J., Gregel, C. M., Martin, B. A. & Kaina, B. (1996) Cancer Res. 56, 3244-3249.
42. Guzman, R. C., Osborn, R. C., Swanson, S. M., Sakthivel, R., Hwang, S. I., Miyamoto, S. & Nandi, S. (1992) Cancer Res. 52, 5732-5737.
43. Swanson, S. M., Guzman, R. C., Tsukamoto, T., Huang, T. T., Dougherty, C. D. & Nandi, S. (1996) Cancer Lett. 102, 159-165.
44. Lu, S. J., Chaulk, E. J. & Archer, M. C. (1992) Carcinogenesis 13, 857-861.
45. Gerson, S. L., Trey, J. E., Miller, K. & Berger, N. A. (1986) Carcinogenesis 7, 745-749.
46. Anderson, C. H. & Beattie, C. W. (1992) Cancer Res. 52, 5076-5081.
47. Mientjes, E. J., Hochleitner, K., Luiten-Schuite, A., van Delft, J. H. M., Thomale, J., Berends, F., Rajewsky, M. F., Lohman, P. H. M. & Baan, R. A. (1996) Carcinogenesis 17, 2449-2454.
48. Jansen, J. G., Mohn, G. R., Vrieling, H., van Teijlingen, C. M. M., Lohman, P. H. M. & van Zeeland, A. A. (1994) Cancer Res. 54, 2478-2485.
49. Maher, V. M., Domoradzki, J., Bhattacharyya, N. P., Tsujimura, T., Corner, R. C. & McCormick, J. J. (1990) Mutat. Res. 233, 235-245.
50. Bronstein, S. M., Skopek, T. R. & Swenberg, J. A. (1992) Cancer Res. 52, 2008-2011.
51. Buschfort, C., Müller, M. R., Seeber, S., Rajewsky, M. F. & Thomale, J. (1997) Cancer Res. 57, 651-658.
52. Krane, I. M. & Leder, P. (1996) Oncogene 12, 1781-1788.
53. Samson, L., Thomale, J. & Rajewsky, M. F. (1988) EMBO J. 7, 2261-2267.
54. Morimoto, K., Dolan, M. E., Scicchitano, D. & Pegg, A. E. (1985) Carcinogenesis 6, 1027-1031.
55. Liem, L.-K., Lim, A. & Li, B. F. L. (1994) Nucleic Acids Res. 22, 1613-1619.
56. Bargmann, C. I., Huang, M.-C. & Weinberg, R. A. (1986) Cell 45, 649-657.
57. Perantoni, A. O., Rice, J. M., Reed, C. D., Watatani, M. & Wenk, M. L. (1987) Proc. Natl. Acad. Sci. USA 84, 6317-6321.
58. Guy, C. T., Webster, M. A., Schaller, M., Parsons, T. J., Cardiff, R. D. & Muller, W. J. (1992) Proc. Natl. Acad. Sci. USA 89, 10578-10582.
59. Cha, R. S., Thilly, W. G. & Zarbl, H. (1994) Proc. Natl. Acad. Sci. USA 91, 3749-3753.