Protective effect of O6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs

International Journal of Cancer

Volumn 65, Issue 4, 1996, Pages 506-512

  Preuss, Ilka ^a,b   Thust, Rudolf ^c   Kaina, Bernd ^a,b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROPEROXYIFOSFAMIDE; ANTINEOPLASTIC AGENT; CARMUSTINE; CHLORAMBUCIL; CISPLATIN; ELMUSTINE; LOMUSTINE; MAFOSFAMIDE; MELPHALAN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; NIMUSTINE; PROTECTIVE AGENT; STREPTOZOCIN; TRANSPLATIN; METHYLTRANSFERASE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG RESISTANCE; DRUG SENSITIVITY; GENOTOXICITY; HAMSTER; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE; ANIMAL; CELL SURVIVAL; CHO CELL; DRUG EFFECT; PHYSIOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; CHO CELLS; CRICETINAE; METHYLTRANSFERASES; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; SISTER CHROMATID EXCHANGE;

EID: 0029664534     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960208)65:4<506::AID-IJC19>3.0.CO;2-7     Document Type: Article

References (28)

1. 6-methylguanine in rat pulmonary cells. Carcinogenesis. 9, 2053-2058 (1988).
2. 6-Metbylguanine-DNA methyltransferase activity in human tumors. Carcinogenesis, 13, 1503-1507 (1992).
3. 6-Methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary. Cancer Res.. 51, 4131-4134 (1991).
4. DEHAND. J. and JORDANOV, J., Interaction of cis-diamminotolueneplatinum (II) with nucleosides: evidence for guanine O(6)-N(7) chelation by platinum. Chem. Comm., 473, 598-599 (1976).
5. 6-benzylguanine analogues on sensitivity of human tumor cells to the genotoxTc effects of alkylating agents. Cancer Res., 51, 3367-3372 (1991).
6. 6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc. nat. Acad. Sci. (Wash.), 87, 5368-5372 (1990).
7. EASTMAN, A., The formation, isolation and characterization of DNA adducts produced by anticancer platinum complexes. Pharmacol. Ther., 34, 155-166 (1987).
8. EISENBRAND, G., FIEBIG, H.H. and ZELLER, W.J., Some new congeners of the antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) synthesis of bifunctional analogues and water soluble derivatives and preliminary evaluation of their chemotherapeutic potential. Z. Krebsforsch.. 86, 279-286 (1976).
9. EISENBRAND, G.. MüLLER, N., DENKEL, E. and STERZEL, W., DNA adducts and DNA damage by antineoplastic and carcinogenic N-nitroso compounds. J. Cancer Res. clin. Oncol., 112, 196-204 (1986).
10. -/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains. J. biol. Chem., 268, 21102-21112 (1993).
11. 6-Alkylguanine-DNA alkyltransferase activity in human myeloid cells. J. clin. Invest., 76, 2106-2114 (1985).
12. GIBSON, N.W., ZLOTOGORSKI, C. and ERICKSON, L.C., Specific DNA repair mechanisms may protect some human tumor cells from DNA interstrand cross linking by chloroethylnitrosoureas but not from cross linking by other anti-tumor alkylating agents. Carcinogenesis, 6, 445-450 (1985).
13. HILTON, J., Deoxyribonucleic acid crosslinking by 4-hydroperoxy-cyctophosphamide in cyclophosphamide-sensitive and -resistant L1210 cells. Biochem. Pharmacol., 33, 1867-1872 (1984).
14. 6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines Environ, mol. Mutagenesis, 22, 283-292 (1993).
15. 6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents. Carcinogenesis, 12, 1857-1867 (1991).
16. KARRAN, P. and BIGNAMI, M., Self-destruction and tolerance in resistance of mammalian cells to alkylation damage. Nucl. Acids Res, 20, 2935-2940 (1992).
17. KAT, A., THILLY, W.G., FANG, W.-H., LONGLEY, M.J., LI, G.-M. and MODRICH, P., An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc. nat. Acad Sci. (Wash.), 90, 6424-6428 (1993).
18. LUDLUM, D.B., DNA alkylation by the haloethylnitrosoureas: nature of modifications produced and their enzymatic repair or removal. Mutation Res., 233, 117-126 (1990).
19. MITRA, S. and KAINA, B., Regulation of repair of alkylation damage in mammalian genomes. Progr. nucl. Acids Res. mol. Biol. 44, 109-142 (1993).
20. 6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res., 50, 6119-6129 (1990).
21. 6-Methylguanine-DNA methyltransferase activity in breast and brain tumors. Int. J. Cancer, 61, 321-326 (1995).
22. - human tumor cell line Mutation Res., 314, 99-113 (1994).
23. 6-methylguanine-DNA methyltransferase. Nucl. Acids. Res., 11, 7743-7758 (1983).
24. SCHEIN, P.S., O'CONNELL, M.J., BLOM, J., HUBBARD, S., MAGRATH, I.T., BERGEVIN, P., WIERNICK, P.H., ZIEGLER, L.J. and DEVITA, V.T., Clinical antitumor activity and toxicity of streptozotocin (NCS-86998). Cancer, 34, 993-1000 (1974).
25. STAHL, W. and EISENBRAND, G., Comparative study on the influence of two 2-chloroethylnitrosoureas with different carbamoylating potential towards glutathione and glutathione-related enzymes in different organs of the rat. Free Rad. Res. Comm., 14, 271-278 (1991).
26. TAKAYAMA, S. and SAKANISHI, S., Differential Giemsa staining of sister chromatids after extraction with acids. Chromosoma, 54, 109-116 (1977).
27. TONG, W.P., KOHN, K.W. and LUDLUM, D.B., Modifications of DNA by different haloethylnitrosoureas. Cancer Res.. 42, 4460-4464 (1982).
28. 6-alkylguanine-DNA atkyltransferase in HeLa cells by cisplatin. Carcinogenesis, 10, 1681-1684 (1989).