Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitors

Journal of Medicinal Chemistry

Volumn 50, Issue 3, 2007, Pages 409-424

  Liao, Jeffrey Jie Lou ^a,b  

^a TransTech Pharma Inc   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 6 (2,6 DICHLOROPHENYL) 8 METHYL 2 (3 METHYLTHIOANILINO) 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; [4 [2 CYCLOPENTYL 9 (3 HYDROXYPHENETHYL)PURIN 6 YLAMINO]PHENYL]DIMETHYLPHOSPHINE OXIDE; AMINO ACID; CGP 77675; CYCLOPROPANECARBOXYLIC ACID [4 [4 (4 METHYL 1 PIPERAZINYL) 6 (5 METHYL 2H PYRAZOL 3 YLAMINO) 2 PYRIMIDINYLTHIO]PHENYL]AMIDE; DASATINIB; DORAMAPIMOD; ERLOTINIB; FASUDIL; GEFITINIB; H 1152P; HYDROXYFASUDIL; IMATINIB; LAPATINIB; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; N [5 (5 TERT BUTYL 2 OXAZOLYLMETHYLTHIO) 2 THIAZOLYL]ISONIPECOTAMIDE; PD 318088; PD 334581; PHA 680632; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PURVALANOL A; PYRIMIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; SORAFENIB; SUNITINIB; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME MECHANISM; MOLECULAR RECOGNITION; PROTEIN DOMAIN; REVIEW;

BINDING SITES; CATALYTIC DOMAIN; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN KINASES;

EID: 33846899405     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0608107     Document Type: Review

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