Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 9, 2005, Pages 2203-2207

  Miyazaki, Yasushi ^a   Matsunaga, Shinichiro ^a   Tang, Jun ^a   Maeda, Yutaka ^a   Nakano, Masato ^a   Philippe, Rocher J ^a,c   Shibahara, Megumi ^a   Liu, Wei ^b,d   Sato, Hideyuki ^a   Wang, Liping ^b   Nolte, Robert T ^b  

^a Development and Medical Affairs Division   (Japan)

^b GLAXOSMITHKLINE   (United States)

^c ADDEX PHARMACEUTICALS   (Switzerland)

^d MEDTRONIC INC   (United States)

Author keywords

Angiogenesis; Anticancer; Protein kinase; Tie 2; VEGFR2

Indexed keywords

4 AMINO 3 [4 [[2 FLUORO 5 (TRIFLUOROMETHYL)PHENYL]AMINOCARBONYLAMINO] PHENYL] 2 (4 METHOXYPHENYL)FURO[2,3 D]PYRIMIDINE; ANGIOPOIETIN 2 INHIBITOR; PROTEIN INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2 INHIBITOR;

ARTICLE; BROMINATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; X RAY DIFFRACTION;

EID: 20244380969     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.034     Document Type: Article

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