Recent kinase and kinase inhibitor x-ray structures: Mechanisms of inhibition and selectivity insights

Current Medicinal Chemistry

Volumn 11, Issue 6, 2004, Pages 663-673

  Cherry, M ^a   Williams, David H ^a,b  

^a Millennium Pharmaceuticals Ltd   (United Kingdom)

^b Sareum Ltd   (United Kingdom)

Author keywords

ATP binding site; Inhibitor; Protein kinase; Regulation; Selectivity; X ray crystal structure

Indexed keywords

ABELSON KINASE; ADENOSINE TRIPHOSPHATE; ANGIOPOIETIN RECEPTOR; BRUTON TYROSINE KINASE; CASEIN KINASE; CASEIN KINASE I; CONNECTIN; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; DEATH ASSOCIATED PROTEIN KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; FIBROBLAST GROWTH FACTOR; GEFITINIB; IMATINIB; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; OLOMOUCINE; OXINDOLE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR; PURVALANOL; ROSCOVITINE; SOMATOMEDIN RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA; UNINDEXED DRUG; VATALANIB;

BREAST CANCER; CLINICAL TRIAL; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG CONFORMATION; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME REGULATION; ENZYME STRUCTURE; HUMAN; LUNG CANCER; LUNG NON SMALL CELL CANCER; PROTEIN LIPID INTERACTION; REVIEW; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN KINASES;

EID: 1642270826     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867043455792     Document Type: Review

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