High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: Bound waters and natural ligand as guides for inhibitor design

Journal of Medicinal Chemistry

Volumn 39, Issue 23, 1996, Pages 4540-4546

  Schulze Gahmen, Ursula ^a   De Bondt, Hendrik L ^b   Kim, Sung Hou ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLIN DEPENDENT KINASE; MAGNESIUM ION; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CELL CYCLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME INHIBITOR COMPLEX; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN;

ADENOSINE TRIPHOSPHATE; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN BINDING; RECOMBINANT PROTEINS; WATER;

EID: 0029850471     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960402a     Document Type: Article

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