A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 8, 1998, Pages 1219-1226

  Liu, Y ^a   Shah, K ^a   Yang, F ^a   Witucki, L ^a   Shokat, K M ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

ATP analogue; Kinase; Rational design; Src

Indexed keywords

ADENOSINE TRIPHOSPHATE DERIVATIVE; CATECHOL; LIGAND; PROTEIN TYROSINE KINASE; RAPAMYCIN;

ARTICLE; BINDING SITE; DRUG SYNTHESIS; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; GENETIC ENGINEERING; MOLECULAR RECOGNITION;

ADENOSINE TRIPHOSPHATE; BINDING SITES; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; MUTATION; ONCOGENE PROTEIN PP60(V-SRC); SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; SUBSTRATE SPECIFICITY;

FELIS CATUS;

EID: 0031709073     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(98)00099-6     Document Type: Article

References (26)

1. Pawson, T.; Scott, J. D. Science 1997, 278, 2075.
2. Cohen, G. B.; Reb, R.; Baltimore, D. Cell 1995, 80, 237.
3. Hunter, T.; Plowman, G. D. Trends Biochem. Sci. 1997, 22, 18.
4. Hunter, T. Biochem. Soc. Trans. 1996, 24, 307.
5. Shah, K.; Liu, Y.; Deirmengian, C.; Shokat, K. M. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 3565.
6. Liu, Y.; Shah, K.; Yang, F.; Witucki, L.; Shokat, K. M. Chem. Biol. 1998, 5, 91.
7. Liberles, S. D.; Diver, S. T.; Austin, D. J.; Schreiber, S. L. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 7825.
8. Belshaw, P. J.; Schreiber, S. L. J. Am. Chem. Soc. 1997, 119, 1805.
9. Amara, J. F.; Clackson, T.; Rivera, V. M.; Guo, T.; Keenan, T.; Natesan, S.; Pollen, R.; Yanf, W.; Courage, N. L.; Holt, D. A.; Gilman, M. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 10618.
10. Belshaw, P. J.; Schoepfer, J. G.; Liu, K. Q.; Morrison, K. L.; Schreiber, S. L. Angew. Chem. Int. Ed. Engl. 1995, 34, 2129.
11. Weijland, A.; Parmeggiani, A. Science 1993, 259, 1311.
12. Hwang, Y. W.; Miller, D. L. J. Biol. Chem. 1987, 262, 1081.
13. Yu, B.; Slepak, V. Z.; Simon, M. I. J. Biol. Chem. 1997, 272, 18015.
14. Smith, G. K.; Banks, S.; Blumenkopf, T. A.; Cory, M.; Humphreys, J.; Laethem, R.; Miller, J.; Moxham, C.P.; Mullin, R.; Ray, P. H.; Walton, L. M.; Wolfe III, L. A. J. Bio. Chem. 1997, 272, 15804.
15. Noren, C. J.; Anthony-Cahill, S. J.; Griffith, M. C.; Schultz, P. G. Science 1989, 244, 182.
16. Mendel, D.; Cornish, V. W.; Schultz, P. G. Ann. Rev. Biophys. Biomol. Struct. 1995, 24, 435.
17. Saks, M. E.; Sampson, J. R.; Nowak, M. W.; Kearney, P. C.; Du, F.; Abelson, J. N.; Lester, H. A.; Dougherty, D. A.; J. Biol. Chem. 1996, 271, 23169.
18. England, P. M.; Lester, H. A.; Davidson, N.; Dougherty, D. A. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 11025.
19. Liu, D. R.; Magliery, T. J.; Pastrnak, M.; Schultz, P. G. Proc. Natl. Acad. Sci. U.S.A. 1997, 94, 10092.
20. Liu, D. R.; Magliery, T. J.; Schultz, P. G. Chem. Biol. 1997, 4, 685.
21. Zheng, J.; Knighton, D. R.; Ten Eyck, L. F.; Karlson, R.; Zuong, N.-H.; Taylor, S. S.; Sowadski, J. M. Biochemistry 1993, 32, 2154.
22. Jeffrey, P. D.; Russo, A. A.; Polak, K.; Gibbs, E.; Hurwitz, J.; Massague, J.; Pavletich, N. P. Nature 1995, 376, 313.
23. Xu, W.; Harrison, S. C.; Eck, M. J. Nature 1997, 385, 595.
24. Sicheri, F.; Moarefi, I.; Kuriyan, J. Nature 1997, 385, 602.
25. Yamaguchi, H.; Hendrickson, W. A. Nature 1996, 384, 484.
26. Kikugawa, K.; Iizuka, K.; Ichino, M. J. Med. Chem. 1973, 16, 358.