The structure of dimeric ROCK I reveals the mechanism for ligand selectivity

Journal of Biological Chemistry

Volumn 281, Issue 1, 2006, Pages 260-268

  Jacobs, Marc ^a,b   Hayakawa, Koto ^a   Swenson, Lora ^a   Bellon, Steven ^a   Fleming, Mark ^a   Taslimi, Paul ^a   Doran, John ^a  

^a VERTEX PHARMACEUTICALS   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOELECTRIC POTENTIALS; CATALYSIS; CRYSTAL STRUCTURE; ENZYME INHIBITION; METABOLISM;

N-TERMINAL REGION; PLECKSTRIN HOMOLOGY; RHO-ASSOCIATED KINASE; RHO-DEPENDENT SIGNALING;

ENZYMES;

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ADENOSINE TRIPHOSPHATE; CYCLIC AMP; FASUDIL; RHO KINASE; 1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 METHYL 1 ((4 METHYL 5 ISOQUINOLINYL)SULFONYL)HOMOPIPERAZINE; 2-METHYL-1-((4-METHYL-5-ISOQUINOLINYL)SULFONYL)HOMOPIPERAZINE; AMIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DRUG DERIVATIVE; ENZYME INHIBITOR; HYDROXYFASUDIL; LIGAND; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; PYRIDINE DERIVATIVE; RHO-ASSOCIATED KINASE; SIGNAL PEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; DIMERIZATION; ENZYME ACTIVATION; PHOSPHORYLATION; PKA; PRIORITY JOURNAL; AMINO ACID SEQUENCE; BINDING COMPETITION; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; AMIDES; AMINO ACID SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIMERIZATION; ENZYME INHIBITORS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MOLECULAR SEQUENCE DATA; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33644857442     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M508847200     Document Type: Article

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