Potent and selective inhibitors of the Abl-kinase: Phenylaminopyrimidine (PAP) derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 2, 1997, Pages 187-192

  Zimmermann, Jürg ^a   Buchdunger, Elisabeth ^a   Mett, Helmut ^a   Meyer, Thomas ^a   Lydon, Nicholas B ^a  

^a CIBA GEIGY LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CHRONIC MYELOID LEUKEMIA; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; PROTEIN PHOSPHORYLATION; REACTION ANALYSIS;

EID: 0031026055     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00601-4     Document Type: Article

References (13)

1. Clark, S.; Crist, W.; Witte, O. Annu. Rev. Med 1989, 40, 113-122.
2. Lugo, T.; Pendergast, A.; Muller, A.; Witte, O.; Science 1990, 247, 1079-1082.
3. Heisterkamp, N.; Jenster, G.; Ten Hoeve, J.; Zovich, D.; Pattengale, P.; Groffen, J. Nature 1990, 344, 251-253.
4. Szczylik, C.; Skorski, T.; Nicolaides, N.; Manzella, L.; Malaguarnera, L., Venturelli, D.; Gewirtz, A.; Calabretta, B.; Science 1991, 253, 562-56 5.
5. Buzetti, F.; Brasca, M.G.; Crugnola, A.; Fustinoni, S.; Longo, A.; Penco, S. Il Farmaco 1993, 48, 615-636.
6. Spada, A.P.; Myers, M.R. Exp. Opin. Ther. Patents, 1995, 5, 805-817.
7. Levitzki, A. FASEB J. 1992, 6, 3275-3282 and Anafi, M.; Gazit, A.; Zehavi, A.; Ben-Neriah, A.; Levitzki, A. Blood 1993, 82, 3524-3529.
8. Levitzki, A. FASEB J. 1992, 6, 3275-3282 and Anafi, M.; Gazit, A.; Zehavi, A.; Ben-Neriah, A.; Levitzki, A. Blood 1993, 82, 3524-3529.
9. Geissler, J.F.; Roesel, J.L.; Meyer, Th.; Trinks, U.P.; Traxler, P.; Lydon, N.B. Cancer Research 1992, 52, 4492-4498.
10. Paul, R.; Hallett, W.A.; Hanifin, J.W.; Reich, M.F.; Johnson, B.D.; Lenhard, R.H.; Dusza, J.P.; Kerwar, S.S.; Li, J.Y.; Pickett, W.C.; Seifert, C.M.; Torley, L.-W.; Tarrant, M.E.; Wrenn, S. J. Med. Chem.1993, 36, 2716-2725.
11. Buchdunger, E.; Zimmermann, J.; Mett, H., Meyer, Th.; Müller, M.; Regenass, U.; Lydon, N.B. Proc. Natl. Acad. Sci. USA 1995, 92, 2558-2562.
12. Buchdunger, E.; Zimmermann, J.; Mett, H.; Meyer, Th.; Müller, M.; Druker, B.J.; Lydon, N.B. Cancer Res. 1996, 56, 100-104.
13. Druker, B.J.; Tamura, S.; Buchdunger, E.; Ohno, S.; Segal, G.M.; Fanning, S.; Zimmermann, J.; Lydon, N.B. Nat. Med. (N. Y) 1996, 2, 561-566