The raison d'être of constitutively active protein kinases: The lesson of CK2

Accounts of Chemical Research

Volumn 36, Issue 6, 2003, Pages 378-384

  Pinna, Lorenzo A ^a  

^a VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1,8 DIHYDROXY 4 NITROXANTHENONE; ANTINEOPLASTIC AGENT; CASEIN KINASE II; EMODIN; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE; TETRABROMOBENZOTRIAZOLE; UNCLASSIFIED DRUG;

CELL SURVIVAL; DRUG TARGETING; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYME SUBUNIT; PLEIOTROPY; PROTEIN TARGETING; REVIEW;

CASEIN KINASE II; ENZYME INHIBITORS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 0038340907     PISSN: 00014842     EISSN: None     Source Type: Journal    
DOI: 10.1021/ar020164f     Document Type: Review

References (53)

1. Venter, J. C.; Adams, M. D.; Myers, E. W.; Li, P. W.; Mural, R. J.; Sutton, G. G.; Smith, H. O.; Yandell, M.; Evans, C. A.; Holt, R. A.; et al. The sequence of the human genome. Science 2001, 1304-1351.
2. Blume-Jensen, P.; Hunter, T. Oncogenic kinase signaling. Nature 2001, 411, 355-365.
3. Konopa, J. B.; Watanabe, S. M.; Witte, O. N. An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity. Cell 1984, 37, 1035-1042.
4. Morris, S. W.; Kirstein, M. N.; Valentine, M. B.; Dittmer, K. G.; Shapiro, D. N.; Salman, D. L.; Look, A. T. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkins lymphoma. Science 1994, 263, 1281-1284.
5. Frame, M. C. Src on cancer: deregulation and consequences for cell behaviour. Biochim. Biophys. Acta 2002, 1602, 114-130.
6. Pinna, L. A. Casein kinase 2: an eminence grise in cellular regulation? Biochim. Biophys. Acta 1990, 1054, 267-284.
7. Allende, J. E.; Allende, C. C. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation. FASEB J. 1995, 9, 313-323.
8. Guerra, B.; Issinger, O.-G. Protein kinase CK2 and its role in cellular proliferation, development and pathology. Electrophoresis 1999, 20, 391-408.
9. Pinna, L. A. Protein kinase CK2: a challenge to canons J. Cell Sci. 2002, 115, 3873-3878.
10. Burnett, G.; Kennedy, E. P. The enzymatic phosphorylation of proteins J. Biol. Chem. 1954, 211, 969-980.
11. Ahmed, K.; Issinger, O.-G.; Marshak, D. R.; Pyerin, W. Editorial. Cell. Mol. Biol. Res. 1994, 40, 371-372.
12. Meggio F.; Pinna L. A. One-thousand-and-one substrates of protein kinase CK2? FASEB J. in press.
13. Niefind K.; Guerra B.; Pinna L. A.; Issinger O.-G.; Schomburg D. Chrystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 A resolution. EMBO J. 1998, 17, 2451-2462.
14. Sarno, S.; Ghisellini, P.; Pinna, L. A. Unique activation mechanism of protein kinase CK2: the N-terminal segment is essential for constitutive activity of the catalytic subunit but not of the holoenzyme. J. Biol. Chem. 2002, 277, 22509-22514.
15. Niefind, K.; Guerra, B.; Ermakowa, I.; Issinger, O.-G. Crystal structure of human protein kinase CK2: insights into basic properties of CK2 holoenzyme. EMBO J. 2001, 20, 5320-5331.
16. Litchfield, D. W.; Dobrowolska, G.; Krebs E. G. Regulation of casein kinase II by growth factors: a reevaluation. Cell Mol. Biol. Res. 1994, 40, 373-381.
17. Marin, O.; Sarno, S.; Boschetti, M.; Pagano, M. A.; Meggio, F.; Ciminale, V.; D'Agostino, D. M.; Pinna, L. A. Unique features of HIV-Rev protein phosphorylation by protein kinase CK2 ("casein kinase-2"). FEBS Lett. 2000, 481, 63-67.
18. Chambaz, E. M. Protein kinase CK2: functional properties in cell growth and neoplasia. Cancer Research Supported under BIOMED 1; Baig, S. S., Ed.; IOS Press: 1998; pp 122-132.
19. Ghavidel, A.; Schultz, M. C. TATA binding protein-associated CK2 transduces DNA damage signals to the RNA polymerase III transcription machinery. Cell 2001, 106, 575-584.
20. Pinna, L.A.; Ruzzene M. How do protein kinases recognize their substrates? Biochim. Biophys. Acta 1996, 1314, 191-225.
21. Marin, O.; Meggio, F.; Marchiori, F.; Borin, G.; Pinna, L. A. Site specificity of casein kinase-2 from rat liver cytosol. A study with model peptide substrates. Eur. J. Biochem. 1986, 160, 239-244.
22. Marin, O.; Meggio, F.; Draetta, G.; Pinna, L. A. The consensus sequences for cdc2 kinase and for casein kinase-2 are mutually incompatible. A study with peptides derived from the β-subunit of casein kinase-2. FEBS Lett. 1992, 301, 111-114.
23. Roach, P. J. Multisite and hierarchical protein phosphorylation. J. Biol. Chem. 1991, 266, 14139-14142.
24. Ficarro, S. B.; McCleland, M. L.; Stukenberg, P. T.; Burke, D. J.; Ross, M. M.; Shabanowotz, J.; Hunt, D. F.; White, F. M. Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae. Nat. Biotechnol. 2002, 19, 301-305.
25. Wilson, L. K.; Dhillon, N.; Thorner, J.; Martin, G. S. Casein kinase II catalyzes tyrosine phosphorylation of the yeast nucleolar immunophilin Fpr3. J. Biol. Chem. 1997, 272, 12961-12967.
26. Marin, O.; Meggio, F.; Sarno, S.; Cesaro, L.; Pagano, M. A.; Pinna, L. A. Tyrosine versus Serine/Threonine phosphorylation by protein kinase CK2. A study with peptide substrates derived from immunophilin Fpr3. J. Biol. Chem. 1999, 274, 29260-29265.
27. Sarno, S.; Vaglio, P.; Meggio, F.; Issinger, O.-G.; Pinna, L. A. Protein kinase CK2 mutants defective in substrate recognition. Purification and kinetic analysis. J. Biol. Chem. 1996, 271, 10595-10601.
28. Sarno, S.; Vaglio, P.; Marin, O.; Issinger, O.-G.; Ruffato, K.; Pinna, L. A. Mutational analysis of residues implicated in the interaction between protein kinase CK2 and peptide substrates. Biochemistry 1997, 36, 11717-11724.
29. Sarno, S.; Vaglio, P.; Cesaro, L.; Marin, O.; Pinna, L. A. A multifunctional network of basic residues confers unique properties to protein kinase CK2. Mol. Cell. Biochem. 1999, 191, 13-19.
30. Tawfic, S.; Yu, S.; Wang, H.; Faust, R.; Davis, A.; Ahmed, K. Protein kinase CK2 signal in neoplasia. Histol. Histopathol. 2001, 16, 573-582.
31. Seldin, D.; Leder, P. Casein kinase IIα transgene-induced murine lymphoma: relation to theilerosis in cattle. Science 1995, 267, 894-897.
32. Kelliher, M. A.; Seldin, D.; Leder, P. Tal-1 induces T cell acute limphoblastic leukemia accelerated by casein kinase IIα. EMBO J. 1996, 15, 5160-5166.
33. Landesman-Bollag, E.; Channavajhala, P. L.; Cardiff, R. D.; Seldin, D. C. p53 deficiency and misexpression of protein kinase CK2α collaborate in the development of thymic lymphomas in mice. Oncogene 1998, 16, 2965-2974.
34. Orlandini, M.; Semplici, F.; Ferruzzi, R.; Meggio, F.; Pinna, L. A.; Oliviero, S. Protein kinase CK2α′ is induced by serum as a delayed early gene and cooperates with Ha-ras in fibroblast transformation. J. Biol. Chem. 1998, 273, 21291-21297.
35. Li, D.; Dobrowolska, G.; Aicher, L. D.; Chen, M.; Wright, J. H.; Drueckes, P.; Dunphy, E. L.; Munar, E. S.; Krebs, E. G. Expression of the casein kinase 2 subunits in Chinese hamster ovary and 3T3 L1 cells provides information on the role of the enzyme in cell proliferation and the cell cycle. J. Biol. Chem. 1999, 274, 23988-32996.
36. Guo, C.; Yu, S.; Wang, H.; Davis, A. T.; Green, J. E.; Ahmed, K. A potential role of nuclear matrix-associated protein kinase CK2 in protection against drug-induced apoptosis in cancer cells. J. Biol. Chem. 2001, 276, 5992-5999.
37. Ahmed, K.; Gerber, D. A.; Cochet, C. Joining the cell survival squad: an emerging role for protein kinase CK2. Trends Cell Biology 2002, 12, 226-230.
38. Cohen, P. Protein kinases - the major drug targets of the twenty-first century? Nat. Rev./Drug Discov. 2002, 1, 309-315.
39. Fabbro, D.; Parkinson, D.; Matter A. Protein tysrosine kinase inhibitors: new treatment modalities? Curr. Opin. Pharmacol. 2002n, 2, 374-381.
40. Sawyers, C. L. Rational therapeutic intervention in cancer: kinases as drug targets. Curr. Opin. Genet. Dev. 2002, 12, 111-115.
41. Jain, M.; Arvanitis, C.; Chu, K.; Dewey, W.; Leonhardt, E.; Trinh, M.; Sundberg, C. D.; Bishop, J. M.; Felsher, D. W. Sustained loss of a neoplastic phenotype by brief inactivation of MYC. Science 2002, 297, 102-104.
42. Traxler, P.; Furet, P. Strategies toward the design of novel and selective protein tyrosine kinase inhibitors. Pharmacol. Ther. 1999, 82, 195-206.
43. Battistutta, R.; DeMoliner, E.; Sarno, S.; Zanotti, G.; Pinna, L. A. Structural features underlying selective inhibition of protein kinase CK2 by ATP-site directed trtrabromo-benzotriazole. Protein Sci. 2000, 10, 2200-2206.
44. Sarno, S.; Moro, S.; Meggio, F.; Zagotto, G.; Dal Ben, D.; Ghisellini, P.; Battistutta, R.; Zanotti, G.; Pinna, L. A. Toward the rational design of protein kinase CK2 inhibitors Pharmacol. Ther. 2002, 93, 159-168.
45. Sarno, S.; Reddy, H.; Meggio, F.; Ruzzene, M.; Davies, S. P.; Donella-Deana, A.; Shugar, D.; Pinna, L. A. Selectivity of 4,5,6,7-tetrabromotriazole, an ATP site-directed inhibitor of protein kinase CK2 ("casein kinase-2"). FEBS Lett. 2001, 496, 44-48.
46. Ruzzene, M.; Penzo, D.; Pinna, L. A. Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. Biochem. J. 2002, 364, 41-47.
47. Yim, H.; Lee, C. H.; Lee, S. K. Emodin, an antraquinone derivative isolated from the rhizomes of Rheum palmatum, selectively inhibits the activity of casein kinase II as a competitive inhibitor. Plant. Med. 1999, 65, 9-13.
48. Zhang, L.; Lau, Y-K.; Xi, L.; Hong, R-L.; Kim, D. S.; Chen, C-F.; Hortobagyi, G. N.; Chang, C.; Hung, M-C. Tyrosine kinase inhibitors, emodin and its derivative, repress HER-2/nau-induced cellular transformation and metastasis-associated properties. Oncogene 1998, 16, 2855-2863.
49. Battistutta, R.; Sarno, S.; De Moliner, E.; Papinutto, E.; Zanotti, G.; Pinna, L. A. The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2 J. Biol. Chem. 2000, 275, 29618-29622.
50. De Moliner, E.; Moro, S.; Sarno, S.; Zagotto, G.; Zanotti, G.; Pinna, L. A.; Battistutta, R. Inhibition of protein kinase CK2 by antraquinone related compounds: a structural insight. 2002 J. Biol. Chem. Nov. 4 (epub ahead of print).
51. Sayed, M.; Kim, S. O.; Salh, B. S.; Issinger, O.-G.; Pelech, S. L. Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase. J. Biol. Chem. 2000, 275, 16569-16573.
52. Homma, M. K.; Li, D.; Krebs, E. G.; Yuasa, Y.; Homma, Y. Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 5959-5964.
53. Duesbery, N. S.; Webb, C. P.; Leppla, S. H.; Gordon, V. M.; Klimpel, K. R.; Copeland, T. D.; Ahn, N. G.; Oskarsson, M. K.; Fukasawa, K.; Paull, K. D.; Vande Woude, G. F. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science 1998, 280, 734-737.