(α/β+α)-peptide antagonists of BH3 domain/Bcl-x L recognition: Toward general strategies for foldamer-based inhibition of protein-protein interactions

Journal of the American Chemical Society

Volumn 129, Issue 1, 2007, Pages 139-154

  Sadowsky, Jack D ^a   Fairlie, W Douglas ^b   Hadley, Erik B ^a   Lee, Hee Seung ^a,e   Umezawa, Naoki ^a,f   Nikolovska Coleska, Zaneta ^c   Wang, Shaomeng ^c   Huang, David C S ^b   Tomita, York ^d   Gellman, Samuel H ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MICHIGAN   (United States)

^d GEORGETOWN UNIVERSITY   (United States)

^e Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^f NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOASSAY; ENZYME INHIBITION; FLUORESCENCE; MOLECULAR STRUCTURE; SURFACE CHEMISTRY;

FLUORESCENCE POLARIZATION (FP); HYDROPHILE SCANNING; PEPTIDES; PROTEIN PROTEIN INTERACTIONS;

AMINO ACIDS;

ALANINE; AMINO ACID; BH3 PROTEIN; BIM PROTEIN; CYTOCHROME C; LIGAND; OLIGOMER; PEPTIDE; PROTEIN BAD; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN NOXA;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; EMBRYO; ENZYME RELEASE; ESCHERICHIA COLI; FEMALE; FIBROBLAST; FLUORESCENCE POLARIZATION; HYDROPHILICITY; HYDROPHOBICITY; LIGAND BINDING; NONHUMAN; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; STOICHIOMETRY; STRUCTURE ANALYSIS; SURFACE PLASMON RESONANCE; ULTRACENTRIFUGATION;

ALANINE; AMINO ACID SEQUENCE; APOPTOSIS; BCL-X PROTEIN; CYTOCHROMES C; DRUG DESIGN; HUMANS; LIGANDS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846042156     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0662523     Document Type: Article

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