Enhanced metabolic stability and protein-binding properties of artificial α helices derived from a hydrogen-bond surrogate: Application to Bcl-xL

Angewandte Chemie - International Edition

Volumn 44, Issue 40, 2005, Pages 6525-6529

  Wang, Deyun ^a   Liao, Wei ^a   Arora, Paramjit S ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

Helical structures; Hydrogen bonds; Molecular recognition; Peptidomimetics; Protein protein interactions

Indexed keywords

BINDING ENERGY; CONFORMATIONS; CONSTRAINT THEORY; DEGRADATION; HYDROGEN BONDS; METABOLISM;

HELICAL STRUCTURES; MOLECULAR RECOGNITION; PEPTIDOMIMETICS; PROTEIN BINDING; PROTEIN-PROTEIN INTERACTIONS;

DNA;

PEPTIDE; PROTEIN BAK; PROTEIN BCL X;

AMINO ACID SEQUENCE; ARTICLE; BIOMIMETICS; CHEMICAL STRUCTURE; CHEMISTRY; HYDROGEN BOND; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SYNTHESIS;

AMINO ACID SEQUENCE; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-X PROTEIN; BIOMIMETICS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 27144476545     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200501603     Document Type: Article

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