Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

Journal of Medicinal Chemistry

Volumn 44, Issue 25, 2001, Pages 4313-4324

  Enyedy, I J ^a,b,c   Huang, Y ^a   Long, Y Q ^c   Roller, P P ^c   Yang, D ^a   Wang, S ^a,c   Ling, Y ^a,b   Nacro, K ^a   Tomita, Y ^a   Wu, X ^a,d   Cao, Y ^b,d   Guo, R ^a   Li, B ^a   Zhu, X ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b BAYER CORPORATION   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN BCL 2; PROTEIN BCL 2 INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING SITE; CANCER; DRUG EFFECT; DRUG MECHANISM; GROWTH INHIBITION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; APOPTOSIS; AZOCINES; CELL DIVISION; CELL SURVIVAL; CYCLIC N-OXIDES; DATABASES, FACTUAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035818885     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010016f     Document Type: Article

References (44)

1. Bcl-2 family members and the mitochondria in apoptosis
2. The Bcl-2 protein family: Arbiters of cell survival
3. The role of the Bcl-2 family of apoptosis regulatory proteins in the immune system
4. Novel anticancer drug discovery
5. Bcl-2 family proteins: Strategies for overcoming chemoresistance in cancer
6. The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
7. Overcoming bcl-2- and p53-mediated resistance in prostate cancer
8. Induction of apoptosis in small-cell lung cancer cells by an antisense oligodexynucleotide targeting the BCl-2 coding sequence
9. BCl-2 antisense therapy in patients with nonhodgkin lymphoma
10. BCl-2 antisense therapy chemosensitizes human melanoma in SCID mice
11. Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-hodgkin's lymphoma
12. Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7
13. A phase I study of bcl-2 antisense G3139 (Genta) and weekly docetaxel in patients with advanced breast cancer and other solid tumors
14. Cell permeable bcl-2 binding peptides: A chemical approach to apoptosis induction in tumor cells
15. Structure-based discovery of a novel organic compound that binds to Bcl-2 protein and induces apoptosis of tumor cells
16. L
17. Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3
18. Solution structure of the antiapoptotic protein bcl-2
19. L, an inhibitor of programmed cell death
20. L. Implications for the function of the Bcl-2 protein family
21. L-Bak peptide complex: Recognition between regulators of apoptosis
22. Basic local alignment search tool
23. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
24. Evaluation of comparative protein modeling by MODELLER
25. Modeling mutations and homologous proteins
26. CHARMM: A program for macromolecular energy, minimization, and dynamics calculations
27. Regulation of apoptosis by BH3 domains in a cell-free system
28. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
29. L function and induce apoptosis through cytochrome c-independent activation of caspases
30. The NCI drug information system 3D database
31. Comparison of the NCI open database with seven large chemical structural databases
32. A geometric approach to macromolecule-ligand interactions
33. Critical evaluation of search algorithms for automated molecular docking and database screening
34. MOLMOL: A program for display and analysis of macromolecular structures
35. An efficient and cost-effective isotope labeling protocol for proteins expressed in Escherichia coli
36. High-level production of uniformly N-15- and C-13-enriched fusion proteins in Escherichia coli
37. 2O in protein NMR - Application to sensitivity enhancement and noe measurements
38. SAR by NMR as a novel tool for lead generation: Discovery of a potent series of non-peptide inhibitors of stromelysin (MMP-3)
39. NMRPipe: A multidimensional spectral processing system based on UNIX pipes
40. A common sense approach to peak picking in two-, three-, and four-dimensional double and triple-resonance heteronuclear magnetic resonance spectroscopy