Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements

Nature Structural Biology

Volumn 6, Issue 10, 1999, Pages 953-960

  Ferrer, Marc ^a   Kapoor, Tarun M ^a   Strassmaier, Tim ^b   Weissenhorn, Winfried ^c,d   Skehel, John J ^e   Oprian, Dan ^b   Schreiber, Stuart L ^a,d   Wiley, Don C ^a,c,d   Harrison, Stephen C ^a,c,d  

^a HARVARD UNIVERSITY   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d Howard Hughes Medical Institute   (United Kingdom)

^e NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 41; LIGAND; PEPTIDE LIBRARY;

ALPHA HELIX; ARTICLE; CELL FUSION; COVALENT BOND; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN TARGETING; VIRUS INHIBITION;

AMINO ACID SEQUENCE; ANTI-HIV AGENTS; CELL FUSION; CELL LINE; COMBINATORIAL CHEMISTRY TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HIV ENVELOPE PROTEIN GP41; HIV-1; HUMANS; LIGANDS; MEMBRANE FUSION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT FUSION PROTEINS;

EID: 0032876381     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/13324     Document Type: Article

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