Design and application of an α-helix-mimetic scaffold based on an oligoamide-foldamer strategy: Antagonism of the Bak BH3/Bcl-xL complex

Angewandte Chemie - International Edition

Volumn 42, Issue 5, 2003, Pages 535-539

  Ernst, Justin T ^a   Becerril, Jorge ^a   Park, Hyung Soon ^a   Yin, Hang ^a   Hamilton, Andrew D ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

Amides; Helical structures; Peptidomimetics; Protein models; Proteins

Indexed keywords

ASSAYS; CELLS; COMPLEXATION; PROTEINS; TUMORS;

PROGRAMMED CELL DEATH;

SCAFFOLDS;

POLYAMIDE; PROTEIN BAK; PROTEIN BCL XL;

ALPHA HELIX; ARTICLE; CELL DEATH; COMPLEX FORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SYNTHESIS;

BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-X PROTEIN; BIOMIMETIC MATERIALS; DIMERIZATION; ETHYLAMINES; FLUORESCENCE POLARIZATION; MEMBRANE PROTEINS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037415861     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200390154     Document Type: Article

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23. The protein-binding experiments were carried out by diluting a solution of the helix mimetic in DMSO into an aqueous buffer solution (25°, 10 mM PBS, pH 7.4) of Bcl-xL and the fluorescently labeled Bak peptide.