Promises and challenges of targeting Bcl-2 anti-apoptotic proteins for cancer therapy

Biochimica et Biophysica Acta - Reviews on Cancer

Volumn 1705, Issue 1, 2004, Pages 43-51

  O'Neill, Jason ^a   Manion, Michael ^a   Schwartz, Pam ^a   Hockenbery, David M ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Apoptosis; BCL 2; BCL X; BH3 domain; Mitochondria; Molecular target

Indexed keywords

1 NAPHTHALENEMETHYLENE; 2 METHOXYANTIMYCIN A; 3 [4 (CARBOXYMETHOXY) 3,2'' DIISOBUTYL 2' NAPHTHALEN 1 YLMETHYL[1,1':4'1''] TERPHENYL 4'' YL]PROPIONIC ACID; ANTIMYCIN A1; ANTISENSE OLIGODEOXYNUCLEOTIDE; BCL 2 PROTEIN INHIBITOR; BH 3 PROTEIN INHIBITOR 1; BH 3 PROTEIN INHIBITOR 2; BH3 PROTEIN; CARBENOID; CATECHIN; CHELERYTHRINE; CYTARABINE; CYTOTOXIC AGENT; EPICATECHIN 3 GALLATE; EPICATECHIN GALLATE; GOSSYPOL; HA 141; INHIBITOR OF APOPTOSIS PROTEIN; NSC 365400; POLYPHENOL DERIVATIVE; PROPIONIC ACID DERIVATIVE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN INHIBITOR; PURPUROGALLIN; TERPHENYL DERIVATIVE; THEAFLAVIN; TUMOR MARKER; UNCLASSIFIED DRUG;

APOPTOSIS; CANCER CELL; CANCER RESISTANCE; CANCER SURVIVAL; CANCER THERAPY; CELL SURVIVAL; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENTIATION; DRUG SELECTIVITY; DRUG TARGETING; HUMAN; MOLECULE; NONHUMAN; POINT MUTATION; POROSITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW; VALIDATION PROCESS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-X PROTEIN; CELL SURVIVAL; GENES, BCL-2; HUMANS; LIGANDS; NEOPLASMS; OLIGONUCLEOTIDES, ANTISENSE; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 9944244102     PISSN: 0304419X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbcan.2004.09.004     Document Type: Review

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