D-amino acid scan of γ-melanocyte-stimulating hormone: Importance of Trp8 on human MC3 receptor selectivity

Journal of Medicinal Chemistry

Volumn 43, Issue 26, 2000, Pages 4998-5002

  Grieco, P ^a,c   Balse, P M ^a,d   Weinberg, D ^b   MacNeil, T ^b   Hruby, V J ^a  

^a University of Arizona   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d American Peptide Company   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CYCLIC AMP; DEXTRO AMINO ACID; GAMMA INTERMEDIN; MELANOCORTIN RECEPTOR; TRYPTOPHAN;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HORMONE RECEPTOR INTERACTION; HUMAN; PEPTIDE SYNTHESIS; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RECEPTOR INTRINSIC ACTIVITY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; CYCLIC AMP; GAMMA-MSH; HUMANS; L CELLS (CELL LINE); LIGANDS; MICE; PEPTIDES; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, CORTICOTROPIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 0034727855     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000211e     Document Type: Article

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