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Volumn 120, Issue 1, 1998, Pages 23-29

Exploring the specificity pockets of two homologous SH3 domain using structure-based, split-pool synthesis and affinity-based selection

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE;

EID: 0032515410     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja972728u     Document Type: Article
Times cited : (36)

References (38)
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    • For reviews, see: (a) Chen, J. K.; Schreiber, S. L. Angew. Chem., Int. Ed. Engl. 1995, 34, 953-969. (a) Superti-Furga, G.; Courtnidge, S. A. BioEssays 1995, 17, 321-330.
    • (1995) BioEssays , vol.17 , pp. 321-330
    • Superti-Furga, G.1    Courtnidge, S.A.2
  • 13
    • 34249766325 scopus 로고
    • For a discussion on certain limitations of solid phase screening, see: (a) Madden, D.; Krchñák, V.; Lebl, M. Perspec. Drug Disc. Des. 1994, 2, 269-285 . For discussions on the effects of different linkers connecting ligands to solid support on ligand selection, see: (b) Parks, M. E.; Baird, E. E.; Dervan, P. B. J. Am. Chem. Soc. 1996, 118, 6147-6152. (c) Yu, Z.; Chu, Y.-H. Biorg. Med. Chem. Lett. 1997, 7, 95-98.
    • (1994) Perspec. Drug Disc. Des. , vol.2 , pp. 269-285
    • Madden, D.1    Krchñák, V.2    Lebl, M.3
  • 14
    • 0030567754 scopus 로고    scopus 로고
    • For a discussion on certain limitations of solid phase screening, see: (a) Madden, D.; Krchñák, V.; Lebl, M. Perspec. Drug Disc. Des. 1994, 2, 269-285 . For discussions on the effects of different linkers connecting ligands to solid support on ligand selection, see: (b) Parks, M. E.; Baird, E. E.; Dervan, P. B. J. Am. Chem. Soc. 1996, 118, 6147-6152. (c) Yu, Z.; Chu, Y.-H. Biorg. Med. Chem. Lett. 1997, 7, 95-98.
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 6147-6152
    • Parks, M.E.1    Baird, E.E.2    Dervan, P.B.3
  • 15
    • 0031013298 scopus 로고    scopus 로고
    • For a discussion on certain limitations of solid phase screening, see: (a) Madden, D.; Krchñák, V.; Lebl, M. Perspec. Drug Disc. Des. 1994, 2, 269-285 . For discussions on the effects of different linkers connecting ligands to solid support on ligand selection, see: (b) Parks, M. E.; Baird, E. E.; Dervan, P. B. J. Am. Chem. Soc. 1996, 118, 6147-6152. (c) Yu, Z.; Chu, Y.-H. Biorg. Med. Chem. Lett. 1997, 7, 95-98.
    • (1997) Biorg. Med. Chem. Lett. , vol.7 , pp. 95-98
    • Yu, Z.1    Chu, Y.-H.2
  • 20
    • 2842569383 scopus 로고    scopus 로고
    • Parallel synthesis involves the preparation of individual compounds in isolated reaction vessels (Hobbs Dewitt, S.; Czarnik, A. W. Acc. Chem. Res. 1996, 29, 114-122). It is differentiated from a split-pool synthesis that generates all combinations of coupling partners in a discrete manner, usually on solid support. In mixture synthesis, multiple components are used as mixtures in each reaction (Carell, T.; Wintner, E. A.; Sutherland, A. J.; Rebek, J., Jr.; Dunayevsky, Y. M.; Vouros, P. Chem. Biol. 1995, 2, 171-183). A large library of compounds can be synthesized with fewer individual steps by the split-pool and mixture synthesis methods than by parallel synthesis.
    • (1996) Acc. Chem. Res. , vol.29 , pp. 114-122
    • Hobbs Dewitt, S.1    Czarnik, A.W.2
  • 21
    • 0029257836 scopus 로고
    • Parallel synthesis involves the preparation of individual compounds in isolated reaction vessels (Hobbs Dewitt, S.; Czarnik, A. W. Acc. Chem. Res. 1996, 29, 114-122). It is differentiated from a split-pool synthesis that generates all combinations of coupling partners in a discrete manner, usually on solid support. In mixture synthesis, multiple components are used as mixtures in each reaction (Carell, T.; Wintner, E. A.; Sutherland, A. J.; Rebek, J., Jr.; Dunayevsky, Y. M.; Vouros, P. Chem. Biol. 1995, 2, 171-183). A large library of compounds can be synthesized with fewer individual steps by the split-pool and mixture synthesis methods than by parallel synthesis.
    • (1995) Chem. Biol. , vol.2 , pp. 171-183
    • Carell, T.1    Wintner, E.A.2    Sutherland, A.J.3    Rebek Jr., J.4    Dunayevsky, Y.M.5    Vouros, P.6
  • 26
    • 6844258592 scopus 로고    scopus 로고
    • note
    • 2 with the Src SH3 domain are 5.4 and 4.1 μM, respectively.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.