메뉴 건너뛰기




Volumn 118, Issue 15-16, 2006, Pages 442-462

Molecular and clinical aspects of iron homeostasis: From anemia to hemochromatosis

Author keywords

Anemia of chronic disease; Anemia of critical illness; Hemochromatosis; Iron deficiency; Secondary iron overload

Indexed keywords

CARRIER PROTEIN; CD163 ANTIGEN; CD71 ANTIGEN; CERULOPLASMIN; CYTOCHROME B; DEFERASIROX; DEFEROXAMINE; FERRIC HYDROXIDE SUCROSE; FERRITIN; FERROPORTIN 1; FERROUS GLUCONATE; HEMOJUVELIN; HEMOPROTEIN; HEPCIDIN; HFE PROTEIN; IRON; IRON CHELATING AGENT; IRON DEXTRAN; IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; LIPOCALIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; RECOMBINANT ERYTHROPOIETIN; TRANSFERRIN; TRANSFERRIN RECEPTOR 2;

EID: 33748764432     PISSN: 00435325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00508-006-0653-7     Document Type: Review
Times cited : (46)

References (191)
  • 1
    • 19044389821 scopus 로고    scopus 로고
    • Iron and immunity: A double-edged sword
    • Weiss G (2002) Iron and immunity: a double-edged sword. Eur J Clin Invest 32 [Suppl 1]: 70
    • (2002) Eur J Clin Invest , vol.32 , Issue.SUPPL. 1 , pp. 70
    • Weiss, G.1
  • 2
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: Molecular control of mammalian iron metabolism
    • Hentze MW, Muckenthaler MU, Andrews NC (2004) Balancing acts: molecular control of mammalian iron metabolism. Cell 117: 285
    • (2004) Cell , vol.117 , pp. 285
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 3
    • 33748804087 scopus 로고    scopus 로고
    • Regulation of Iron Metabolism
    • Weiss G VRG, Hershko C (eds). CRC Press, Taylor & Francis Group, Boca Raton
    • Pantopoulos K (2005) Regulation of Iron Metabolism. In: Weiss G VRG, Hershko C (eds) Anemia of chronic disease, Vol 30. CRC Press, Taylor & Francis Group, Boca Raton, p 1
    • (2005) Anemia of Chronic Disease , vol.30 , pp. 1
    • Pantopoulos, K.1
  • 4
  • 5
    • 2542560427 scopus 로고    scopus 로고
    • Hereditary hemochromatosis - A new look at an old disease
    • Pietrangelo A (2004) Hereditary hemochromatosis - a new look at an old disease. N Engl J Med 350: 2383
    • (2004) N Engl J Med , vol.350 , pp. 2383
    • Pietrangelo, A.1
  • 6
    • 3242887231 scopus 로고    scopus 로고
    • A significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: A multicenter, prospective, randomized, controlled trial in Japan
    • Yano M, Hayashi H, Yoshioka K, Kohgo Y, Saito H, Niitsu Y, et al (2004) A significant reduction in serum alanine aminotransferase levels after 3-month iron reduction therapy for chronic hepatitis C: a multicenter, prospective, randomized, controlled trial in Japan. J Gastroenterol 39: 570
    • (2004) J Gastroenterol , vol.39 , pp. 570
    • Yano, M.1    Hayashi, H.2    Yoshioka, K.3    Kohgo, Y.4    Saito, H.5    Niitsu, Y.6
  • 7
    • 1442350427 scopus 로고    scopus 로고
    • Clinical significance of hepatic iron deposition and serum iron values in patients with chronic hepatitis C infection
    • Metwally MA, Zein CO, Zein NN (2004) Clinical significance of hepatic iron deposition and serum iron values in patients with chronic hepatitis C infection. Am J Gastroenterol 99: 286
    • (2004) Am J Gastroenterol , vol.99 , pp. 286
    • Metwally, M.A.1    Zein, C.O.2    Zein, N.N.3
  • 8
    • 3943098598 scopus 로고    scopus 로고
    • Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3
    • Theurl I, Zoller H, Obrist P, Datz C, Bachmann F, Elliott RM, et al (2004) Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3. J Infect Dis 190: 819
    • (2004) J Infect Dis , vol.190 , pp. 819
    • Theurl, I.1    Zoller, H.2    Obrist, P.3    Datz, C.4    Bachmann, F.5    Elliott, R.M.6
  • 10
    • 0030778795 scopus 로고    scopus 로고
    • Body iron stores and the risk of carotid atherosclerosis: Prospective results from the Bruneck study
    • Kiechl S, Willeit J, Egger G, Poewe W, Oberhollenzer F (1997) Body iron stores and the risk of carotid atherosclerosis: prospective results from the Bruneck study. Circulation 96: 3300
    • (1997) Circulation , vol.96 , pp. 3300
    • Kiechl, S.1    Willeit, J.2    Egger, G.3    Poewe, W.4    Oberhollenzer, F.5
  • 11
    • 0032554685 scopus 로고    scopus 로고
    • Association between body iron stores and the risk of acute myocardial infarction in men
    • Tuomainen TP, Punnonen K, Nyyssonen K, Salonen JT (1998) Association between body iron stores and the risk of acute myocardial infarction in men. Circulation 97: 1461
    • (1998) Circulation , vol.97 , pp. 1461
    • Tuomainen, T.P.1    Punnonen, K.2    Nyyssonen, K.3    Salonen, J.T.4
  • 12
    • 0037132637 scopus 로고    scopus 로고
    • Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis
    • Gaenzer H, Marschang P, Sturm W, Neumayr G, Vogel W, Patsch J, et al (2002) Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis. J Am Coll Cardiol 40: 2189
    • (2002) J Am Coll Cardiol , vol.40 , pp. 2189
    • Gaenzer, H.1    Marschang, P.2    Sturm, W.3    Neumayr, G.4    Vogel, W.5    Patsch, J.6
  • 13
    • 0037704226 scopus 로고    scopus 로고
    • HFE mutation and dietary iron content interact to increase ischemia/reperfusion injury of the heart in mice
    • Turoczi T, Jun L, Cordis G, Morris JE, Maulik N, Stevens RG, et al (2003) HFE mutation and dietary iron content interact to increase ischemia/reperfusion injury of the heart in mice. Circ Res 92: 1240
    • (2003) Circ Res , vol.92 , pp. 1240
    • Turoczi, T.1    Jun, L.2    Cordis, G.3    Morris, J.E.4    Maulik, N.5    Stevens, R.G.6
  • 14
    • 0031811939 scopus 로고    scopus 로고
    • Patho-ecological implications of microbial acquisition of host iron
    • Weinberg ED (1998) Patho-ecological implications of microbial acquisition of host iron. Reviews in Medical Microbiology 9: 171
    • (1998) Reviews in Medical Microbiology , vol.9 , pp. 171
    • Weinberg, E.D.1
  • 16
    • 0037076925 scopus 로고    scopus 로고
    • Iron, infection and anemia - A classical triad
    • Weiss G (2002) Iron, infection and anemia - a classical triad. Wien Klin Wochenschr 114: 357
    • (2002) Wien Klin Wochenschr , vol.114 , pp. 357
    • Weiss, G.1
  • 17
    • 13144282684 scopus 로고    scopus 로고
    • The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
    • Feder JN, Penny DM, Irrinki A, Lee VK, Lebron JA, Watson N, et al (1998) The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA 95: 1472
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1472
    • Feder, J.N.1    Penny, D.M.2    Irrinki, A.3    Lee, V.K.4    Lebron, J.A.5    Watson, N.6
  • 18
  • 19
    • 0035793856 scopus 로고    scopus 로고
    • An iron-regulated ferric reductase associated with the absorption of dietary iron
    • McKie AT, Barrow D, Latunde-Dada GO, Rolfs A, Sager G, Mudaly E, et al (2001) An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 291: 1755
    • (2001) Science , vol.291 , pp. 1755
    • McKie, A.T.1    Barrow, D.2    Latunde-Dada, G.O.3    Rolfs, A.4    Sager, G.5    Mudaly, E.6
  • 21
    • 0030886381 scopus 로고    scopus 로고
    • Heme oxygenase 1 is required for mammalian iron reutilization
    • Poss KD, Tonegawa S (1997) Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci USA 94: 10919
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10919
    • Poss, K.D.1    Tonegawa, S.2
  • 22
    • 24744438847 scopus 로고    scopus 로고
    • The macrophage: A cellular factory at the interphase between iron and immunity for the control of infections
    • Theurl I, Fritsche G, Ludwiczek S, Garimorth K, Bellmann-Weiler R, Weiss G (2005) The macrophage: a cellular factory at the interphase between iron and immunity for the control of infections. Biometals 18: 359
    • (2005) Biometals , vol.18 , pp. 359
    • Theurl, I.1    Fritsche, G.2    Ludwiczek, S.3    Garimorth, K.4    Bellmann-Weiler, R.5    Weiss, G.6
  • 23
    • 0009429789 scopus 로고    scopus 로고
    • Iron acquisition by the reticuloendothelial system
    • Templeton D (ed). Marcel Dekker, New York
    • Weiss G (2002) Iron acquisition by the reticuloendothelial system. In: Templeton D (ed) Molecular and cellular iron transport. Marcel Dekker, New York, p 467
    • (2002) Molecular and Cellular Iron Transport , pp. 467
    • Weiss, G.1
  • 26
    • 0032160381 scopus 로고    scopus 로고
    • IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F
    • Muckenthaler M, Gray NK, Hentze MW (1998) IRP-1 binding to ferritin mRNA prevents the recruitment of the small ribosomal subunit by the cap-binding complex eIF4F. Mol Cell 2: 383
    • (1998) Mol Cell , vol.2 , pp. 383
    • Muckenthaler, M.1    Gray, N.K.2    Hentze, M.W.3
  • 27
    • 0028982262 scopus 로고
    • Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome
    • Guo B, Phillips JD, Yu Y, Leibold EA (1995) Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome. J Biol Chem 270: 21645
    • (1995) J Biol Chem , vol.270 , pp. 21645
    • Guo, B.1    Phillips, J.D.2    Yu, Y.3    Leibold, E.A.4
  • 29
    • 33644792074 scopus 로고    scopus 로고
    • Iron imports. III. Transfer of iron from the mucosa into circulation
    • Wessling-Resnick M (2006) Iron imports. III. Transfer of iron from the mucosa into circulation. Am J Physiol Gastrointest Liver Physiol 290: G1
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Wessling-Resnick, M.1
  • 31
    • 0035049419 scopus 로고    scopus 로고
    • Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload
    • Zoller H, Koch RO, Theurl I, Obrist P, Pietrangelo A, Montosi G, et al (2001) Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload. Gastroenterology 120: 1412
    • (2001) Gastroenterology , vol.120 , pp. 1412
    • Zoller, H.1    Koch, R.O.2    Theurl, I.3    Obrist, P.4    Pietrangelo, A.5    Montosi, G.6
  • 32
    • 18144406820 scopus 로고    scopus 로고
    • Calorimetric studies of melanotransferrin (p97) and its interaction with iron
    • Creagh AL, Tiong JW, Tian MM, Haynes CA, Jefferies WA (2005) Calorimetric studies of melanotransferrin (p97) and its interaction with iron. J Biol Chem 280: 15735
    • (2005) J Biol Chem , vol.280 , pp. 15735
    • Creagh, A.L.1    Tiong, J.W.2    Tian, M.M.3    Haynes, C.A.4    Jefferies, W.A.5
  • 33
    • 33645528381 scopus 로고    scopus 로고
    • Role of melanotransferrin in iron metabolism: Studies using targeted gene disruption in vivo
    • Sekyere EO, Dunn LL, Rahmanto YS, Richardson DR (2006) Role of melanotransferrin in iron metabolism: studies using targeted gene disruption in vivo. Blood 107: 2599
    • (2006) Blood , vol.107 , pp. 2599
    • Sekyere, E.O.1    Dunn, L.L.2    Rahmanto, Y.S.3    Richardson, D.R.4
  • 34
    • 0034070941 scopus 로고    scopus 로고
    • Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload
    • Trinder D, Oates PS, Thomas C, Sadleir J, Morgan EH (2000) Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload. Gut 46: 270
    • (2000) Gut , vol.46 , pp. 270
    • Trinder, D.1    Oates, P.S.2    Thomas, C.3    Sadleir, J.4    Morgan, E.H.5
  • 36
    • 18244399587 scopus 로고    scopus 로고
    • Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver
    • Gunshin H, Fujiwara Y, Custodio AO, Direnzo C, Robine S, Andrews NC (2005) Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J Clin Invest 115: 1258
    • (2005) J Clin Invest , vol.115 , pp. 1258
    • Gunshin, H.1    Fujiwara, Y.2    Custodio, A.O.3    Direnzo, C.4    Robine, S.5    Andrews, N.C.6
  • 37
    • 0033599057 scopus 로고    scopus 로고
    • Disorders of iron metabolism
    • Andrews NC (1999) Disorders of iron metabolism. N Engl J Med 341: 1986
    • (1999) N Engl J Med , vol.341 , pp. 1986
    • Andrews, N.C.1
  • 38
    • 0019855315 scopus 로고
    • Influence of dietary iron deficiency on hemoglobin, myoglobin, their respective reductases, and skeletal muscle mitochondrial respiration
    • Hagler L, Askew EW, Neville JR, Mellick PW, Coppes RI Jr, Lowder JF Jr (1981) Influence of dietary iron deficiency on hemoglobin, myoglobin, their respective reductases, and skeletal muscle mitochondrial respiration. Am J Clin Nutr 34: 2169
    • (1981) Am J Clin Nutr , vol.34 , pp. 2169
    • Hagler, L.1    Askew, E.W.2    Neville, J.R.3    Mellick, P.W.4    Coppes Jr., R.I.5    Lowder Jr., J.F.6
  • 39
    • 14544294358 scopus 로고    scopus 로고
    • Modification of iron regulation by the inflammatory response
    • Weiss G (2005) Modification of iron regulation by the inflammatory response. Best Pract Res Clin Haematol 18: 183
    • (2005) Best Pract Res Clin Haematol , vol.18 , pp. 183
    • Weiss, G.1
  • 40
    • 24344434227 scopus 로고    scopus 로고
    • Pathways for the regulation of body iron homeostasis in response to experimental iron overload
    • Theurl I, Ludwiczek S, Eller P, Seifert M, Artner E, Brunner P, et al (2005) Pathways for the regulation of body iron homeostasis in response to experimental iron overload. J Hepatol 43: 711
    • (2005) J Hepatol , vol.43 , pp. 711
    • Theurl, I.1    Ludwiczek, S.2    Eller, P.3    Seifert, M.4    Artner, E.5    Brunner, P.6
  • 41
    • 21644454100 scopus 로고    scopus 로고
    • Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis
    • Ludwiczek S, Theurl I, Bahram S, Schumann K, Weiss G (2005) Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis. J Cell Physiol 204: 489
    • (2005) J Cell Physiol , vol.204 , pp. 489
    • Ludwiczek, S.1    Theurl, I.2    Bahram, S.3    Schumann, K.4    Weiss, G.5
  • 42
    • 33744812973 scopus 로고    scopus 로고
    • Divalent metal transporter 1 in the kidney proximal tubule is expressed in late endosomes/lysosomal membranes: Implications for renal handling of protein-metal complexes
    • Abouhamed M, Gburek J, Liu W, Torchalski B, Wilhelm A, Wolff NA, et al (2006) Divalent metal transporter 1 in the kidney proximal tubule is expressed in late endosomes/lysosomal membranes: implications for renal handling of protein-metal complexes. Am J Physiol Renal Physiol 290: F1525
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Abouhamed, M.1    Gburek, J.2    Liu, W.3    Torchalski, B.4    Wilhelm, A.5    Wolff, N.A.6
  • 43
    • 0036310725 scopus 로고    scopus 로고
    • Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice
    • Canonne-Hergaux F, Gros P (2002) Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice. Kidney Int 62: 147
    • (2002) Kidney Int , vol.62 , pp. 147
    • Canonne-Hergaux, F.1    Gros, P.2
  • 44
    • 0034655418 scopus 로고    scopus 로고
    • In vivo characterization of renal iron transport in the anaesthetized rat
    • Wareing M, Ferguson CJ, Green R, Riccardi D, Smith CP (2000) In vivo characterization of renal iron transport in the anaesthetized rat. J Physiol 524 Pt 2: 581
    • (2000) J Physiol , vol.524 , Issue.PART 2 , pp. 581
    • Wareing, M.1    Ferguson, C.J.2    Green, R.3    Riccardi, D.4    Smith, C.P.5
  • 46
    • 9644307879 scopus 로고    scopus 로고
    • Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin
    • Mishra J, Mori K, Ma Q, Kelly C, Yang J, Mitsnefes M, et al (2004) Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol 15: 3073
    • (2004) J Am Soc Nephrol , vol.15 , pp. 3073
    • Mishra, J.1    Mori, K.2    Ma, Q.3    Kelly, C.4    Yang, J.5    Mitsnefes, M.6
  • 47
    • 4043163418 scopus 로고    scopus 로고
    • Neutrophil gelatinase-associated lipocalin: A novel early urinary biomarker for cisplatin nephrotoxicity
    • Mishra J, Mori K, Ma Q, Kelly C, Barasch J, Devarajan P (2004) Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol 24: 307
    • (2004) Am J Nephrol , vol.24 , pp. 307
    • Mishra, J.1    Mori, K.2    Ma, Q.3    Kelly, C.4    Barasch, J.5    Devarajan, P.6
  • 48
    • 20144388328 scopus 로고    scopus 로고
    • Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery
    • Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, et al (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365: 1231
    • (2005) Lancet , vol.365 , pp. 1231
    • Mishra, J.1    Dent, C.2    Tarabishi, R.3    Mitsnefes, M.M.4    Ma, Q.5    Kelly, C.6
  • 50
    • 33644862202 scopus 로고    scopus 로고
    • Iron imports. IV. Hepcidin and regulation of body iron metabolism
    • Ganz T, Nemeth E (2006) Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol 290: G199
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Ganz, T.1    Nemeth, E.2
  • 51
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, et al (2002) The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 110: 1037
    • (2002) J Clin Invest , vol.110 , pp. 1037
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3    Danan, J.L.4    Bigard, X.5    Devaux, I.6
  • 52
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, et al (2004) IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113: 1271
    • (2004) J Clin Invest , vol.113 , pp. 1271
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6
  • 54
    • 33645525540 scopus 로고    scopus 로고
    • Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice
    • Viatte L, Nicolas G, Lou DQ, Bennoun M, Lesbordes-Brion JC, Canonne-Hergaux F, et al (2005) Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice. Blood 107: 2952
    • (2005) Blood , vol.107 , pp. 2952
    • Viatte, L.1    Nicolas, G.2    Lou, D.Q.3    Bennoun, M.4    Lesbordes-Brion, J.C.5    Canonne-Hergaux, F.6
  • 55
    • 13444252281 scopus 로고    scopus 로고
    • Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin
    • Knutson MD, Oukka M, Koss LM, Aydemir F, Wessling-Resnick M (2005) Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin. Proc Natl Acad Sci USA 102: 1324
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1324
    • Knutson, M.D.1    Oukka, M.2    Koss, L.M.3    Aydemir, F.4    Wessling-Resnick, M.5
  • 56
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tattle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090
    • (2004) Science , vol.306 , pp. 2090
    • Nemeth, E.1    Tattle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6
  • 57
    • 22144484497 scopus 로고    scopus 로고
    • Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function
    • Detivaud L, Nemeth E, Boudjema K, Turlin B, Troadec MB, Leroyer P, et al (2005) Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood 106: 746
    • (2005) Blood , vol.106 , pp. 746
    • Detivaud, L.1    Nemeth, E.2    Boudjema, K.3    Turlin, B.4    Troadec, M.B.5    Leroyer, P.6
  • 58
    • 33646427702 scopus 로고    scopus 로고
    • TLR-4 dependent hepcidin expression by myeloid cells in response to bacterial pathogens
    • Peyssonnaux C, Zinkernagel AS, Datta V, Lauth X, Johnson RS, Nizet V (2006) TLR-4 dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 107: 3727
    • (2006) Blood , vol.107 , pp. 3727
    • Peyssonnaux, C.1    Zinkernagel, A.S.2    Datta, V.3    Lauth, X.4    Johnson, R.S.5    Nizet, V.6
  • 59
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, et al (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 38: 531
    • (2006) Nat Genet , vol.38 , pp. 531
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3    Xia, Y.4    Sidis, Y.5    Samad, T.A.6
  • 61
    • 23644444316 scopus 로고    scopus 로고
    • Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
    • Niederkofler V, Salie R, Arber S (2005) Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest 115: 2180
    • (2005) J Clin Invest , vol.115 , pp. 2180
    • Niederkofler, V.1    Salie, R.2    Arber, S.3
  • 62
    • 26244467650 scopus 로고    scopus 로고
    • Hemochromatosis: Genetic testing and clinical practice
    • Zoller H, Cox TM (2005) Hemochromatosis: genetic testing and clinical practice. Clin Gastroenterol Hepatol 3: 945
    • (2005) Clin Gastroenterol Hepatol , vol.3 , pp. 945
    • Zoller, H.1    Cox, T.M.2
  • 70
    • 0037151089 scopus 로고    scopus 로고
    • Human mitochondrial ferritin expressed in HeLa cells incorporates iron and affects cellular iron metabolism
    • Corsi B, Cozzi A, Arosio P, Drysdale J, Santambrogio P, Campanella A, et al (2002) Human mitochondrial ferritin expressed in HeLa cells incorporates iron and affects cellular iron metabolism. J Biol Chem 277: 22430
    • (2002) J Biol Chem , vol.277 , pp. 22430
    • Corsi, B.1    Cozzi, A.2    Arosio, P.3    Drysdale, J.4    Santambrogio, P.5    Campanella, A.6
  • 71
    • 0042324650 scopus 로고    scopus 로고
    • Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis
    • Zoller H, Theurl I, Koch RO, McKie AT, Vogel W, Weiss G (2003) Duodenal cytochrome b and hephaestin expression in patients with iron deficiency and hemochromatosis. Gastroenterology 125: 746
    • (2003) Gastroenterology , vol.125 , pp. 746
    • Zoller, H.1    Theurl, I.2    Koch, R.O.3    McKie, A.T.4    Vogel, W.5    Weiss, G.6
  • 72
    • 0344085880 scopus 로고    scopus 로고
    • Duodenal metal-transporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis
    • Zoller H, Pietrangelo A, Vogel W, Weiss G (1999) Duodenal metal-transporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis. Lancet 353: 2120
    • (1999) Lancet , vol.353 , pp. 2120
    • Zoller, H.1    Pietrangelo, A.2    Vogel, W.3    Weiss, G.4
  • 73
    • 0037111732 scopus 로고    scopus 로고
    • Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
    • Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC (2002) Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 100: 3776
    • (2002) Blood , vol.100 , pp. 3776
    • Weinstein, D.A.1    Roy, C.N.2    Fleming, M.D.3    Loda, M.F.4    Wolfsdorf, J.I.5    Andrews, N.C.6
  • 74
    • 28444436913 scopus 로고    scopus 로고
    • Non-HFE hemochromatosis
    • Pietrangelo A (2005) Non-HFE hemochromatosis. Semin Liver Dis 25: 450
    • (2005) Semin Liver Dis , vol.25 , pp. 450
    • Pietrangelo, A.1
  • 75
    • 0037343705 scopus 로고    scopus 로고
    • Transferrin receptor 2: A new molecule in iron metabolism
    • Trinder D, Baker E (2003) Transferrin receptor 2: a new molecule in iron metabolism. Int J Biochem Cell Biol 35: 292
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 292
    • Trinder, D.1    Baker, E.2
  • 76
    • 21044434748 scopus 로고    scopus 로고
    • First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin
    • Wallace DF, Summerville L, Lusby PE, Subramaniam VN (2005) First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin. Gut 54: 980
    • (2005) Gut , vol.54 , pp. 980
    • Wallace, D.F.1    Summerville, L.2    Lusby, P.E.3    Subramaniam, V.N.4
  • 78
    • 0037105376 scopus 로고    scopus 로고
    • Anemia and iron overload due to compound heterozygosity for novel ceruloplasmin mutations
    • Bosio S, De Gobbi M, Roetto A, Zecchina G, Leonardo E, Rizzetto M, et al (2002) Anemia and iron overload due to compound heterozygosity for novel ceruloplasmin mutations. Blood 100: 2246
    • (2002) Blood , vol.100 , pp. 2246
    • Bosio, S.1    De Gobbi, M.2    Roetto, A.3    Zecchina, G.4    Leonardo, E.5    Rizzetto, M.6
  • 79
    • 0042852936 scopus 로고    scopus 로고
    • Hemochromatosis - Neonatal and young subjects
    • Cox TM, Halsall DJ (2002) Hemochromatosis - neonatal and young subjects. Blood Cells Mol Dis 29: 411
    • (2002) Blood Cells Mol Dis , vol.29 , pp. 411
    • Cox, T.M.1    Halsall, D.J.2
  • 80
    • 28444449032 scopus 로고    scopus 로고
    • Clinical aspects of hemochromatosis
    • O'Neil J, Powell L (2005) Clinical aspects of hemochromatosis. Semin Liver Dis 25: 381
    • (2005) Semin Liver Dis , vol.25 , pp. 381
    • O'Neil, J.1    Powell, L.2
  • 81
    • 0035038147 scopus 로고    scopus 로고
    • Diagnosis and management of hemochromatosis
    • Tavill AS (2001) Diagnosis and management of hemochromatosis. Hepatology 33: 1321
    • (2001) Hepatology , vol.33 , pp. 1321
    • Tavill, A.S.1
  • 83
    • 0038187588 scopus 로고    scopus 로고
    • Patients with biochemical iron overload: Causes and characteristics of a cohort of 150 cases
    • Altes A, Remacha AF, Sureda A, Martino R, Briones J, Brunei S, et al (2003) Patients with biochemical iron overload: causes and characteristics of a cohort of 150 cases. Ann Hematol 82: 127
    • (2003) Ann Hematol , vol.82 , pp. 127
    • Altes, A.1    Remacha, A.F.2    Sureda, A.3    Martino, R.4    Briones, J.5    Brunei, S.6
  • 84
  • 85
    • 0347480378 scopus 로고    scopus 로고
    • Effective treatment of hereditary haemochromatosis with desferrioxamine in selected cases
    • Nielsen P, Fischer R, Buggisch P, Janka-Schaub G (2003) Effective treatment of hereditary haemochromatosis with desferrioxamine in selected cases. Br J Haematol 123: 952
    • (2003) Br J Haematol , vol.123 , pp. 952
    • Nielsen, P.1    Fischer, R.2    Buggisch, P.3    Janka-Schaub, G.4
  • 88
    • 33644873239 scopus 로고    scopus 로고
    • Ferroportin (Q248H) mutations in African families with dietary iron overload
    • McNamara L, Gordeuk VR, MacPhail AP (2005) Ferroportin (Q248H) mutations in African families with dietary iron overload. J Gastroenterol Hepatol 20: 1855
    • (2005) J Gastroenterol Hepatol , vol.20 , pp. 1855
    • McNamara, L.1    Gordeuk, V.R.2    MacPhail, A.P.3
  • 90
    • 10744232713 scopus 로고    scopus 로고
    • Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene
    • Gordeuk VR, Caleffi A, Corradini E, Ferrara F, Jones RA, Castro O, et al (2003) Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene. Blood Cells Mol Dis 31: 299
    • (2003) Blood Cells Mol Dis , vol.31 , pp. 299
    • Gordeuk, V.R.1    Caleffi, A.2    Corradini, E.3    Ferrara, F.4    Jones, R.A.5    Castro, O.6
  • 91
    • 0036893631 scopus 로고    scopus 로고
    • Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C
    • Bonkovsky HL, Troy N, McNeal K, Banner BF, Sharma A, Obando J, et al (2002) Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C. J Hepatol 37: 848
    • (2002) J Hepatol , vol.37 , pp. 848
    • Bonkovsky, H.L.1    Troy, N.2    McNeal, K.3    Banner, B.F.4    Sharma, A.5    Obando, J.6
  • 92
    • 0029051815 scopus 로고
    • Linkage of cell-mediated immunity to iron metabolism
    • Weiss G, Wachter H, Fuchs D (1995) Linkage of cell-mediated immunity to iron metabolism. Immunol Today 16: 495
    • (1995) Immunol Today , vol.16 , pp. 495
    • Weiss, G.1    Wachter, H.2    Fuchs, D.3
  • 97
    • 0345708218 scopus 로고    scopus 로고
    • Iron overload and its association with cancer risk in humans: Evidence for iron as a carcinogenic metal
    • Huang X (2003) Iron overload and its association with cancer risk in humans: evidence for iron as a carcinogenic metal. Mutat Res 533: 153
    • (2003) Mutat Res , vol.533 , pp. 153
    • Huang, X.1
  • 100
    • 0035127525 scopus 로고    scopus 로고
    • Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease
    • Fracanzani AL, Conte D, Fraquelli M, Taioli E, Mattioli M, Losco A, et al (2001) Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease. Hepatology 33: 647
    • (2001) Hepatology , vol.33 , pp. 647
    • Fracanzani, A.L.1    Conte, D.2    Fraquelli, M.3    Taioli, E.4    Mattioli, M.5    Losco, A.6
  • 101
    • 0142012132 scopus 로고    scopus 로고
    • Severe bacterial infection in transfusion-dependent patients with thalassemia major
    • Wang SC, Lin KH, Chern JP, Lu MY, Jou ST, Lin DT, et al (2003) Severe bacterial infection in transfusion-dependent patients with thalassemia major. Clin Infect Dis 37: 984
    • (2003) Clin Infect Dis , vol.37 , pp. 984
    • Wang, S.C.1    Lin, K.H.2    Chern, J.P.3    Lu, M.Y.4    Jou, S.T.5    Lin, D.T.6
  • 102
    • 33646414765 scopus 로고    scopus 로고
    • A Phase III study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with (beta)-thalassemia
    • Cappellini MD, Cohen A, Piga A, Bejaoui M, Perrotta S, Agaoglu L, et al (2005) A Phase III study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with (beta)-thalassemia. Blood 107: 3455
    • (2005) Blood , vol.107 , pp. 3455
    • Cappellini, M.D.1    Cohen, A.2    Piga, A.3    Bejaoui, M.4    Perrotta, S.5    Agaoglu, L.6
  • 103
    • 20344403788 scopus 로고    scopus 로고
    • Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia
    • Hershko C, Hoffbrand AV, Keret D, Souroujon M, Maschler I, Monselise Y, et al (2005) Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia. Haematologica 90: 585
    • (2005) Haematologica , vol.90 , pp. 585
    • Hershko, C.1    Hoffbrand, A.V.2    Keret, D.3    Souroujon, M.4    Maschler, I.5    Monselise, Y.6
  • 104
    • 0036308047 scopus 로고    scopus 로고
    • Pathogenesis and treatment of anaemia of chronic disease
    • Weiss G (2002) Pathogenesis and treatment of anaemia of chronic disease. Blood Rev 16: 87
    • (2002) Blood Rev , vol.16 , pp. 87
    • Weiss, G.1
  • 105
    • 28944446425 scopus 로고    scopus 로고
    • Benefits and risks of iron therapy for chronic anaemias
    • Weiss G, Gordeuk VR (2005) Benefits and risks of iron therapy for chronic anaemias. Eur J Clin Invest 35 [Suppl 3]: 36
    • (2005) Eur J Clin Invest , vol.35 , Issue.SUPPL. 3 , pp. 36
    • Weiss, G.1    Gordeuk, V.R.2
  • 107
    • 14644389345 scopus 로고    scopus 로고
    • Iron deficiency: A concise review
    • Umbreit J (2005) Iron deficiency: a concise review. Am J Hematol 78: 225
    • (2005) Am J Hematol , vol.78 , pp. 225
    • Umbreit, J.1
  • 109
    • 0035886304 scopus 로고    scopus 로고
    • Gastrointestinal causes of refractory iron deficiency anemia in patients without gastrointestinal symptoms
    • Annibale B, Capurso G, Chistolini A, D'Ambra G, DiGiulio E, Monarca B, et al (2001) Gastrointestinal causes of refractory iron deficiency anemia in patients without gastrointestinal symptoms. Am J Med 111: 439
    • (2001) Am J Med , vol.111 , pp. 439
    • Annibale, B.1    Capurso, G.2    Chistolini, A.3    D'Ambra, G.4    Digiulio, E.5    Monarca, B.6
  • 112
    • 17944362905 scopus 로고    scopus 로고
    • Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency
    • Han AP, Yu C, Lu L, Fujiwara Y, Browne C, Chin G, et al (2001) Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. Embo J 20: 6909
    • (2001) Embo J , vol.20 , pp. 6909
    • Han, A.P.1    Yu, C.2    Lu, L.3    Fujiwara, Y.4    Browne, C.5    Chin, G.6
  • 113
    • 0027523986 scopus 로고
    • Reversal of developmental delays in iron-deficient anaemic infants treated with iron
    • Idjradinata P, Pollitt E (1993) Reversal of developmental delays in iron-deficient anaemic infants treated with iron. Lancet 341: 1
    • (1993) Lancet , vol.341 , pp. 1
    • Idjradinata, P.1    Pollitt, E.2
  • 114
    • 0034095717 scopus 로고    scopus 로고
    • Erythrocytes: Better tolerance of iron polymaltose complex compared with ferrous sulphate in the treatment of anaemia
    • Jacobs P, Wood L, Bird AR (2000) Erythrocytes: better tolerance of iron polymaltose complex compared with ferrous sulphate in the treatment of anaemia. Hematol 5: 77
    • (2000) Hematol , vol.5 , pp. 77
    • Jacobs, P.1    Wood, L.2    Bird, A.R.3
  • 117
    • 0032722355 scopus 로고    scopus 로고
    • Reversal of iron deficiency anemia after helicobacter pylori eradication in patients with asymptomatic gastritis
    • Annibale B, Marignani M, Monarca B, Antonelli G, Marcheggiano A, Martino G, et al (1999) Reversal of iron deficiency anemia after helicobacter pylori eradication in patients with asymptomatic gastritis. Ann Intern Med 131: 668
    • (1999) Ann Intern Med , vol.131 , pp. 668
    • Annibale, B.1    Marignani, M.2    Monarca, B.3    Antonelli, G.4    Marcheggiano, A.5    Martino, G.6
  • 118
    • 13944278864 scopus 로고    scopus 로고
    • Iron-deficiency anemia and helicobacter pylori infection: A review of the evidence
    • DuBois S, Kearney DJ (2005) Iron-deficiency anemia and helicobacter pylori infection: a review of the evidence. Am J Gastroenterol 100: 453
    • (2005) Am J Gastroenterol , vol.100 , pp. 453
    • Dubois, S.1    Kearney, D.J.2
  • 119
    • 4644329078 scopus 로고    scopus 로고
    • Intravenous iron therapy in renal failure: Friend and foe?
    • Afzali B, Goldsmith DJ (2004) Intravenous iron therapy in renal failure: friend and foe? J Nephrol 17: 487
    • (2004) J Nephrol , vol.17 , pp. 487
    • Afzali, B.1    Goldsmith, D.J.2
  • 120
    • 3142751987 scopus 로고    scopus 로고
    • Prevalence and management of anaemia in haematologic cancer patients receiving cyclic nonplatinum chemotherapy: Results of a prospective national chart survey
    • Steurer M, Wagner H, Gastl G (2004) Prevalence and management of anaemia in haematologic cancer patients receiving cyclic nonplatinum chemotherapy: results of a prospective national chart survey. Wien Klin Wochenschr 116: 367
    • (2004) Wien Klin Wochenschr , vol.116 , pp. 367
    • Steurer, M.1    Wagner, H.2    Gastl, G.3
  • 121
    • 14644436419 scopus 로고    scopus 로고
    • Anemia of inflammation: The hepcidin link
    • Roy CN, Andrews NC (2005) Anemia of inflammation: the hepcidin link. Curr Opin Hematol 12: 107
    • (2005) Curr Opin Hematol , vol.12 , pp. 107
    • Roy, C.N.1    Andrews, N.C.2
  • 122
    • 0037926880 scopus 로고    scopus 로고
    • Cytokine-mediated regulation of iron transport in human monocytic cells
    • Ludwiczek S, Aigner E, Theurl I, Weiss G (2003) Cytokine-mediated regulation of iron transport in human monocytic cells. Blood 101: 4148
    • (2003) Blood , vol.101 , pp. 4148
    • Ludwiczek, S.1    Aigner, E.2    Theurl, I.3    Weiss, G.4
  • 123
    • 0037103231 scopus 로고    scopus 로고
    • Role of IL-10 for induction of anemia during inflammation
    • Tilg H, Ulmer H, Kaser A, Weiss G (2002) Role of IL-10 for induction of anemia during inflammation. J Immunol 169: 2204
    • (2002) J Immunol , vol.169 , pp. 2204
    • Tilg, H.1    Ulmer, H.2    Kaser, A.3    Weiss, G.4
  • 124
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T (2003) Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101: 2461
    • (2003) Blood , vol.101 , pp. 2461
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 125
    • 21544449756 scopus 로고    scopus 로고
    • Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages
    • Liu XB, Nguyen NB, Marquess KD, Yang F, Haile DJ (2005) Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages. Blood Cells Mol Dis 35: 47
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 47
    • Liu, X.B.1    Nguyen, N.B.2    Marquess, K.D.3    Yang, F.4    Haile, D.J.5
  • 126
    • 13844307889 scopus 로고    scopus 로고
    • Regulation of hepcidin transcription by interleukin-1 and interleukin-6
    • Lee P, Peng H, Gelbart T, Wang L, Beutler E (2005) Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci USA 102: 1906
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1906
    • Lee, P.1    Peng, H.2    Gelbart, T.3    Wang, L.4    Beutler, E.5
  • 127
    • 3042636759 scopus 로고    scopus 로고
    • The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes
    • Lee P, Peng H, Gelbart T, Beutler E (2004) The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes. Proc Natl Acad Sci USA 101: 9263
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 9263
    • Lee, P.1    Peng, H.2    Gelbart, T.3    Beutler, E.4
  • 128
    • 28944454784 scopus 로고    scopus 로고
    • Hyporesponsiveness to erythropoietic therapy due to chronic inflammation
    • Macdougall IC, Cooper AC (2005) Hyporesponsiveness to erythropoietic therapy due to chronic inflammation. Eur J Clin Invest 35 [Suppl 3]: 32
    • (2005) Eur J Clin Invest , vol.35 , Issue.SUPPL. 3 , pp. 32
    • Macdougall, I.C.1    Cooper, A.C.2
  • 129
    • 33646577477 scopus 로고    scopus 로고
    • Dysregulated monocyte iron homeostasis and erythropoeitin formation in patients with anemia of chronic disease
    • Theurl I, Mattle V, Seifert M, Mariani M, Marth C, Weiss G (2006) Dysregulated monocyte iron homeostasis and erythropoeitin formation in patients with anemia of chronic disease. Blood 107: 4142
    • (2006) Blood , vol.107 , pp. 4142
    • Theurl, I.1    Mattle, V.2    Seifert, M.3    Mariani, M.4    Marth, C.5    Weiss, G.6
  • 130
    • 0030976033 scopus 로고    scopus 로고
    • Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency
    • Punnonen K, Irjala K, Rajamaki A (1997) Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 89: 1052
    • (1997) Blood , vol.89 , pp. 1052
    • Punnonen, K.1    Irjala, K.2    Rajamaki, A.3
  • 131
    • 0141712327 scopus 로고    scopus 로고
    • Treatment of renal anemia with darbepoetin alfa: Results of an Austrian multicenter study
    • Horl WH, Holzer H, Mayer GJ (2002) Treatment of renal anemia with darbepoetin alfa: results of an Austrian multicenter study. Wien Klin Wochenschr 114: 967
    • (2002) Wien Klin Wochenschr , vol.114 , pp. 967
    • Horl, W.H.1    Holzer, H.2    Mayer, G.J.3
  • 132
    • 33748786692 scopus 로고    scopus 로고
    • Anemia of chronic disease
    • Cheson BD (ed). CRC Press, Taylor & Francis Group, Boca Raton
    • Weiss G VRG, Hershko C (2005) Anemia of chronic disease. In: Cheson BD (ed) Basic and clinical oncology, Vol 30. CRC Press, Taylor & Francis Group, Boca Raton
    • (2005) Basic and Clinical Oncology , vol.30
    • Weiss, G.V.R.G.1    Hershko, C.2
  • 133
    • 0036232280 scopus 로고    scopus 로고
    • Anemia management in chronic kidney disease: Role of factors affecting epoetin responsiveness
    • Eschbach JW (2002) Anemia management in chronic kidney disease: role of factors affecting epoetin responsiveness. J Am Soc Nephrol 13: 1412
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1412
    • Eschbach, J.W.1
  • 134
    • 0035864778 scopus 로고    scopus 로고
    • Anemia in critical illness
    • Eckardt KU (2001) Anemia in critical illness. Wien Klin Wochenschr 113: 84
    • (2001) Wien Klin Wochenschr , vol.113 , pp. 84
    • Eckardt, K.U.1
  • 135
    • 29844453671 scopus 로고    scopus 로고
    • Anemia during and at discharge from intensive care: The impact of restrictive blood transfusion practice
    • Walsh TS, Lee RJ, Maciver CR, Garrioch M, Mackirdy F, Binning AR, et al (2006) Anemia during and at discharge from intensive care: the impact of restrictive blood transfusion practice. Intensive Care Med 32: 100
    • (2006) Intensive Care Med , vol.32 , pp. 100
    • Walsh, T.S.1    Lee, R.J.2    Maciver, C.R.3    Garrioch, M.4    Mackirdy, F.5    Binning, A.R.6
  • 137
    • 9144245515 scopus 로고    scopus 로고
    • The CRIT Study: Anemia and blood transfusion in the critically ill - Current clinical practice in the United States
    • Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Abraham E, et al (2004) The CRIT Study: Anemia and blood transfusion in the critically ill - current clinical practice in the United States. Crit Care Med 32: 39
    • (2004) Crit Care Med , vol.32 , pp. 39
    • Corwin, H.L.1    Gettinger, A.2    Pearl, R.G.3    Fink, M.P.4    Levy, M.M.5    Abraham, E.6
  • 138
    • 24344483532 scopus 로고    scopus 로고
    • Iron metabolism, inflammation and anemia in critically ill patients. A cross-sectional study
    • Munoz M, Romero A, Morales M, Campos A, Garcia-Erce JA, Ramirez G (2005) Iron metabolism, inflammation and anemia in critically ill patients. A cross-sectional study. Nutr Hosp 20: 115
    • (2005) Nutr Hosp , vol.20 , pp. 115
    • Munoz, M.1    Romero, A.2    Morales, M.3    Campos, A.4    Garcia-Erce, J.A.5    Ramirez, G.6
  • 140
    • 0346256767 scopus 로고    scopus 로고
    • Red blood cell physiology in critical illness
    • Scharte M, Fink MP (2003) Red blood cell physiology in critical illness. Crit Care Med 31: S651
    • (2003) Crit Care Med , vol.31
    • Scharte, M.1    Fink, M.P.2
  • 142
    • 0036832772 scopus 로고    scopus 로고
    • Inhibition of erythropoietin gene expression signaling involves the transcription factors GATA-2 and NF-kappaB
    • La Ferla K, Reimann C, Jelkmann W, Hellwig-Burgel T (2002) Inhibition of erythropoietin gene expression signaling involves the transcription factors GATA-2 and NF-kappaB. Faseb J 16: 1811
    • (2002) Faseb J , vol.16 , pp. 1811
    • La Ferla, K.1    Reimann, C.2    Jelkmann, W.3    Hellwig-Burgel, T.4
  • 143
    • 0029135331 scopus 로고
    • Transforming growth factor beta (TGF-beta), a potent inhibitor of erythropoiesis: Neutralizing TGF-beta antibodies show erythropoietin as a potent stimulator of murine burst-forming unit erythroid colony formation in the absence of a burst-promoting activity
    • Dybedal I, Jacobsen SE (1995) Transforming growth factor beta (TGF-beta), a potent inhibitor of erythropoiesis: neutralizing TGF-beta antibodies show erythropoietin as a potent stimulator of murine burst-forming unit erythroid colony formation in the absence of a burst-promoting activity. Blood 86: 949
    • (1995) Blood , vol.86 , pp. 949
    • Dybedal, I.1    Jacobsen, S.E.2
  • 144
    • 0024589701 scopus 로고
    • In vivo hematopoietic effects of recombinant interleukin-1 alpha in mice: Stimulation of granulocytic, monocytic, megakaryocytic, and early erythroid progenitors, suppression of late-stage erythropoiesis, and reversal of erythroid suppression with erythropoietin
    • Johnson CS, Keckler DJ, Topper MI, Braunschweiger PG, Furmanski P (1989) In vivo hematopoietic effects of recombinant interleukin-1 alpha in mice: stimulation of granulocytic, monocytic, megakaryocytic, and early erythroid progenitors, suppression of late-stage erythropoiesis, and reversal of erythroid suppression with erythropoietin. Blood 73: 678
    • (1989) Blood , vol.73 , pp. 678
    • Johnson, C.S.1    Keckler, D.J.2    Topper, M.I.3    Braunschweiger, P.G.4    Furmanski, P.5
  • 145
    • 0028908945 scopus 로고
    • Interferon-gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development
    • Wang CQ, Udupa KB, Lipschitz DA (1995) Interferon-gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development. J Cell Physiol 162: 134
    • (1995) J Cell Physiol , vol.162 , pp. 134
    • Wang, C.Q.1    Udupa, K.B.2    Lipschitz, D.A.3
  • 149
    • 27144495422 scopus 로고    scopus 로고
    • Outcomes of acute coronary syndrome in a large Canadian cohort: Impact of chronic renal insufficiency, cardiac interventions, and anemia
    • Keough-Ryan TM, Kiberd BA, Dipchand CS, Cox JL, Rose CL, Thompson KJ, et al (2005) Outcomes of acute coronary syndrome in a large Canadian cohort: impact of chronic renal insufficiency, cardiac interventions, and anemia. Am J Kidney Dis 46: 845
    • (2005) Am J Kidney Dis , vol.46 , pp. 845
    • Keough-Ryan, T.M.1    Kiberd, B.A.2    Dipchand, C.S.3    Cox, J.L.4    Rose, C.L.5    Thompson, K.J.6
  • 152
    • 0032769737 scopus 로고    scopus 로고
    • Risk of bacterial infection associated with allogeneic blood transfusion among patients undergoing hip fracture repair
    • Carson JL, Altman DG, Duff A, Noveck H, Weinstein MP, Sonnenberg FA, et al (1999) Risk of bacterial infection associated with allogeneic blood transfusion among patients undergoing hip fracture repair. Transfusion 39: 694
    • (1999) Transfusion , vol.39 , pp. 694
    • Carson, J.L.1    Altman, D.G.2    Duff, A.3    Noveck, H.4    Weinstein, M.P.5    Sonnenberg, F.A.6
  • 153
    • 0028110311 scopus 로고
    • Blood transfusion-modulated tumor recurrence: First results of a randomized study of autologous versus allogeneic blood transfusion in colorectal cancer surgery
    • Heiss MM, Mempel W, Delanoff C, Jauch KW, Gabka C, Mempel M, et al (1994) Blood transfusion-modulated tumor recurrence: first results of a randomized study of autologous versus allogeneic blood transfusion in colorectal cancer surgery. J Clin Oncol 12: 1859
    • (1994) J Clin Oncol , vol.12 , pp. 1859
    • Heiss, M.M.1    Mempel, W.2    Delanoff, C.3    Jauch, K.W.4    Gabka, C.5    Mempel, M.6
  • 154
    • 0343360868 scopus 로고    scopus 로고
    • A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care
    • Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group
    • Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, et al (1999) A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 340: 409
    • (1999) N Engl J Med , vol.340 , pp. 409
    • Hebert, P.C.1    Wells, G.2    Blajchman, M.A.3    Marshall, J.4    Martin, C.5    Pagliarello, G.6
  • 155
    • 0037065340 scopus 로고    scopus 로고
    • Efficacy of recombinant human erythropoietin in critically ill patients: A randomized controlled trial
    • Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Shapiro MJ, et al (2002) Efficacy of recombinant human erythropoietin in critically ill patients: a randomized controlled trial. Jama 288: 2827
    • (2002) Jama , vol.288 , pp. 2827
    • Corwin, H.L.1    Gettinger, A.2    Pearl, R.G.3    Fink, M.P.4    Levy, M.M.5    Shapiro, M.J.6
  • 156
    • 11344262637 scopus 로고    scopus 로고
    • Effects of treatment with epoetin beta on outcomes in patients with anaemia and chronic heart failure
    • Silverberg DS, Wexler D, Blum M, Iaina A, Sheps D, Keren G, et al (2005) Effects of treatment with epoetin beta on outcomes in patients with anaemia and chronic heart failure. Kidney Blood Press Res 28: 41
    • (2005) Kidney Blood Press Res , vol.28 , pp. 41
    • Silverberg, D.S.1    Wexler, D.2    Blum, M.3    Iaina, A.4    Sheps, D.5    Keren, G.6
  • 157
    • 0037668617 scopus 로고    scopus 로고
    • Indications and practical management of parenteral iron therapy
    • Kosch M, Schaefer RM (2003) Indications and practical management of parenteral iron therapy. Wien Klin Wochenschr 115: 380
    • (2003) Wien Klin Wochenschr , vol.115 , pp. 380
    • Kosch, M.1    Schaefer, R.M.2
  • 158
    • 0030765635 scopus 로고    scopus 로고
    • Nramp1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages
    • Atkinson PG, Blackwell JM, Barton CH (1997) Nramp1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages. Biochem J 325: 779
    • (1997) Biochem J , vol.325 , pp. 779
    • Atkinson, P.G.1    Blackwell, J.M.2    Barton, C.H.3
  • 159
    • 0043136713 scopus 로고    scopus 로고
    • Nramp1 functionality increases inducible nitric oxide synthase transcription via stimulation of IFN regulatory factor 1 expression
    • Pritsche G, Dlaska M, Barton H, Theurl I, Garimorth K, Weiss G (2003) Nramp1 functionality increases inducible nitric oxide synthase transcription via stimulation of IFN regulatory factor 1 expression. J Immunol 171: 1994
    • (2003) J Immunol , vol.171 , pp. 1994
    • Pritsche, G.1    Dlaska, M.2    Barton, H.3    Theurl, I.4    Garimorth, K.5    Weiss, G.6
  • 161
    • 0141461407 scopus 로고    scopus 로고
    • L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy
    • Oudit GY, Sun H, Trivieri MG, Koch SE, Dawood F, Ackerley C, et al (2003) L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Nat Med 9: 1187
    • (2003) Nat Med , vol.9 , pp. 1187
    • Oudit, G.Y.1    Sun, H.2    Trivieri, M.G.3    Koch, S.E.4    Dawood, F.5    Ackerley, C.6
  • 162
    • 2342508341 scopus 로고    scopus 로고
    • Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice
    • Chen H, Attieh ZK, Su T, Syed BA, Gao H, Alaeddine RM, et al (2004) Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice. Blood 103: 3933
    • (2004) Blood , vol.103 , pp. 3933
    • Chen, H.1    Attieh, Z.K.2    Su, T.3    Syed, B.A.4    Gao, H.5    Alaeddine, R.M.6
  • 163
    • 0034677467 scopus 로고    scopus 로고
    • Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
    • Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, et al (2000) Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 403: 776
    • (2000) Nature , vol.403 , pp. 776
    • Donovan, A.1    Brownlie, A.2    Zhou, Y.3    Shepard, J.4    Pratt, S.J.5    Moynihan, J.6
  • 164
    • 0032716978 scopus 로고    scopus 로고
    • The hereditary hemochromatosis gene (HFE): A MHC class I-like gene that functions in the regulation of iron homeostasis
    • Feder JN (1999) The hereditary hemochromatosis gene (HFE): a MHC class I-like gene that functions in the regulation of iron homeostasis. Immunol Res 20: 175
    • (1999) Immunol Res , vol.20 , pp. 175
    • Feder, J.N.1
  • 166
    • 17644363328 scopus 로고    scopus 로고
    • Orchestration of iron homeostasis
    • Fleming RE, Bacon BR (2005) Orchestration of iron homeostasis. N Engl J Med 352: 1741
    • (2005) N Engl J Med , vol.352 , pp. 1741
    • Fleming, R.E.1    Bacon, B.R.2
  • 167
    • 27144507493 scopus 로고    scopus 로고
    • Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice
    • Gunshin H, Starr CN, Direnzo C, Fleming MD, Jin J, Greer EL, et al (2005) Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. Blood 106: 2879
    • (2005) Blood , vol.106 , pp. 2879
    • Gunshin, H.1    Starr, C.N.2    Direnzo, C.3    Fleming, M.D.4    Jin, J.5    Greer, E.L.6
  • 168
    • 0033861745 scopus 로고    scopus 로고
    • A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
    • McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, et al (2000) A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5: 299
    • (2000) Mol Cell , vol.5 , pp. 299
    • McKie, A.T.1    Marciani, P.2    Rolfs, A.3    Brennan, K.4    Wehr, K.5    Barrow, D.6
  • 169
    • 30144435054 scopus 로고    scopus 로고
    • CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin
    • Schaer DJ, Schaer CA, Buehler PW, Boykins RA, Schoedon G, Alayash AI, et al (2006) CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin. Blood 107: 373
    • (2006) Blood , vol.107 , pp. 373
    • Schaer, D.J.1    Schaer, C.A.2    Buehler, P.W.3    Boykins, R.A.4    Schoedon, G.5    Alayash, A.I.6
  • 170
    • 0038670716 scopus 로고    scopus 로고
    • Ferritin: At the crossroads of iron and oxygen metabolism
    • Theil EC (2003) Ferritin: at the crossroads of iron and oxygen metabolism. J Nutr 133: 1549S
    • (2003) J Nutr , vol.133
    • Theil, E.C.1
  • 171
    • 24744436353 scopus 로고    scopus 로고
    • Mechanisms of haem and non-haem iron absorption: Lessons from inherited disorders of iron metabolism
    • Anderson GJ, Frazer DM, McKie AT, Vulpe CD, Smith A (2005) Mechanisms of haem and non-haem iron absorption: lessons from inherited disorders of iron metabolism. Biometals 18: 339
    • (2005) Biometals , vol.18 , pp. 339
    • Anderson, G.J.1    Frazer, D.M.2    McKie, A.T.3    Vulpe, C.D.4    Smith, A.5
  • 173
    • 3042745199 scopus 로고    scopus 로고
    • Duodenal HFE expression and hepcidin levels determine body iron homeostasis: Modulation by genetic diversity and dietary iron availability
    • Ludwiczek S, Theurl I, Artner-Dworzak E, Chorney M, Weiss G (2004) Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability. J Mol Med 82: 373
    • (2004) J Mol Med , vol.82 , pp. 373
    • Ludwiczek, S.1    Theurl, I.2    Artner-Dworzak, E.3    Chorney, M.4    Weiss, G.5
  • 174
    • 20044395425 scopus 로고    scopus 로고
    • Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury
    • Mori K, Lee HT, Rapoport D, Drexler IR, Foster K, Yang J, et al (2005) Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest 115: 610
    • (2005) J Clin Invest , vol.115 , pp. 610
    • Mori, K.1    Lee, H.T.2    Rapoport, D.3    Drexler, I.R.4    Foster, K.5    Yang, J.6
  • 176
    • 0036800650 scopus 로고    scopus 로고
    • Rare causes of hereditary iron overload
    • Ponka P (2002) Rare causes of hereditary iron overload. Semin Hematol 39: 249
    • (2002) Semin Hematol , vol.39 , pp. 249
    • Ponka, P.1
  • 178
    • 0034964604 scopus 로고    scopus 로고
    • A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload
    • Kato J, Fujikawa K, Kanda M, Fukuda N, Sasaki K, Takayama T, et al (2001) A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload. Am J Hum Genet 69: 191
    • (2001) Am J Hum Genet , vol.69 , pp. 191
    • Kato, J.1    Fujikawa, K.2    Kanda, M.3    Fukuda, N.4    Sasaki, K.5    Takayama, T.6
  • 179
    • 12844260664 scopus 로고    scopus 로고
    • Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload
    • Mims MP, Guan Y, Pospisilova D, Priwitzerova M, Indrak K, Ponka P, et al (2005) Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload. Blood 105: 1337
    • (2005) Blood , vol.105 , pp. 1337
    • Mims, M.P.1    Guan, Y.2    Pospisilova, D.3    Priwitzerova, M.4    Indrak, K.5    Ponka, P.6
  • 180
    • 33646537173 scopus 로고    scopus 로고
    • Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload
    • Beaumont C, Delaunay J, Hetet G, Grandchamp B, de Montalembert M, Tchernia G (2006) Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload. Blood 107: 4168
    • (2006) Blood , vol.107 , pp. 4168
    • Beaumont, C.1    Delaunay, J.2    Hetet, G.3    Grandchamp, B.4    De Montalembert, M.5    Tchernia, G.6
  • 181
    • 30144443274 scopus 로고    scopus 로고
    • Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2)
    • Iolascon A, d'Apolito M, Servedio V, Cimmino F, Piga A, Camaschella C (2006) Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2). Blood 107: 349
    • (2006) Blood , vol.107 , pp. 349
    • Iolascon, A.1    D'Apolito, M.2    Servedio, V.3    Cimmino, F.4    Piga, A.5    Camaschella, C.6
  • 182
    • 0346847502 scopus 로고    scopus 로고
    • Aceruloplasminemia, an iron metabolic disorder
    • Miyajima H (2003) Aceruloplasminemia, an iron metabolic disorder. Neuropathology 23: 345
    • (2003) Neuropathology , vol.23 , pp. 345
    • Miyajima, H.1
  • 184
    • 0031030733 scopus 로고    scopus 로고
    • The relationship between iron overload, clinical symptoms, and age in 410 patients with genetic hemochromatosis
    • Adams PC, Deugnier Y, Moirand R, Brissot P (1997) The relationship between iron overload, clinical symptoms, and age in 410 patients with genetic hemochromatosis. Hepatology 25: 162
    • (1997) Hepatology , vol.25 , pp. 162
    • Adams, P.C.1    Deugnier, Y.2    Moirand, R.3    Brissot, P.4
  • 185
    • 0031941121 scopus 로고    scopus 로고
    • Genotypic/phenotypic correlations in genetic hemochromatosis: Evolution of diagnostic criteria
    • Adams PC, Chakrabarti S (1998) Genotypic/phenotypic correlations in genetic hemochromatosis: evolution of diagnostic criteria. Gastroenterology 114: 319
    • (1998) Gastroenterology , vol.114 , pp. 319
    • Adams, P.C.1    Chakrabarti, S.2
  • 188
    • 5044247615 scopus 로고    scopus 로고
    • Rust and corrosion in hematopoietic stem cell transplantation: The problem of iron and oxidative stress
    • Evens AM, Mehta J, Gordon LI (2004) Rust and corrosion in hematopoietic stem cell transplantation: the problem of iron and oxidative stress. Bone Marrow Transplant 34: 561
    • (2004) Bone Marrow Transplant , vol.34 , pp. 561
    • Evens, A.M.1    Mehta, J.2    Gordon, L.I.3
  • 189
    • 0032859434 scopus 로고    scopus 로고
    • Dysmetabolic iron overload syndrome
    • Fargion S (1999) Dysmetabolic iron overload syndrome. Haematologica 84: 97
    • (1999) Haematologica , vol.84 , pp. 97
    • Fargion, S.1
  • 191
    • 0021186059 scopus 로고
    • Acquired iron-deficiency anemia caused by an antibody against the transferrin receptor
    • Larrick JW, Hyman ES (1984) Acquired iron-deficiency anemia caused by an antibody against the transferrin receptor. N Engl J Med 311: 214
    • (1984) N Engl J Med , vol.311 , pp. 214
    • Larrick, J.W.1    Hyman, E.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.