Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload

Gastroenterology

Volumn 120, Issue 6, 2001, Pages 1412-1419

  Zoller, Heinz ^a   Koch, Robert O ^b   Theurl, Igor ^a   Obrist, Peter ^a   Pietrangelo, Antonello ^c   Montosi, Giuliana ^c   Haile, David J ^d   Vogel, Wolfgang ^d   Weiss, Günter ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^d UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; FERROPORTIN 1; IRON; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DISEASE ASSOCIATION; DUODENUM; FEMALE; HEMOCHROMATOSIS; HUMAN; IMMUNOHISTOCHEMISTRY; IRON ABSORPTION; IRON DEFICIENCY; IRON OVERLOAD; IRON TRANSPORT; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; TISSUE DISTRIBUTION; WESTERN BLOTTING;

EID: 0035049419     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2001.24033     Document Type: Article

References (36)

1. Iron absorption and transport
2. Iron transport across biologic membranes
3. Iron metabolism
4. Of metals, mice, and men: What animal models can teach us about body iron loading
5. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
6. Cloning and characterization of a mammalian proton-coupled metal-ion transporter
7. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse
8. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
9. A novel mammalian iron-regulated protein involved in intracellular iron metabolism
10. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
11. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress
12. Duodenal metal-transporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis
13. Genetic disorders affecting proteins of iron metabolism: Clinical implications
14. Diagnosis and management of hemochromatosis
15. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
16. Haemochromatosis and HLA-H
17. Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene
18. Rapid and simple determination of hereditary haemochromatosis mutations by multiplex PCR-SSCP: Detection of a new polymorphic mutation
19. "Real-time" polymerase chain reaction
20. Quantitative RT-PCR: Pitfalls and potential
21. Complete nucleotide sequence of human NRAMP2 cDNA
22. Characterization of tissue-expressed alpha subunits of the high conductance Ca(2+)-activated K+ channel
23. Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: Targeting to axons and nerve terminals
24. Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload
25. Understanding iron absorption and metabolism, aided by studies of hemochromatosis
26. Factors affecting iron balance
27. Regulation of intestinal iron absorption and mucosal iron kinetics in hereditary hemochromatosis
28. Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: Increased duodenal expression of the iron transporter DMT1
29. Nutritional anemias
30. Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane Of human intestinal Caco-2 cells
31. Overexpression of the ferritin iron-responsive element decreases the labile iron pool and abolishes the regulation of iron absorption by intestinal epithelial (Caco-2) cells
32. Intracellular iron regulates iron absorption and IRP activity in intestinal epithelial (Caco-2) cells
33. Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3′ untranslated region of the mRNA
34. Regulation of transferrin, transferrin receptor, and ferritin genes in human duodenum
35. Iron is hot: An update on the pathophysiology of hemochromatosis
36. Iron overload in Africa. Interaction between a gene and dietary iron content