Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice

Kidney International

Volumn 62, Issue 1, 2002, Pages 147-156

  Canonne Hergaux, François ^a   Gros, Philippe ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Anemia; Apical iron transporter; Brush border; Divalent cations transporter; Heme biosynthesis; Metabolic pathway; Proximal tubules

Indexed keywords

IRON; MESSENGER RNA; MUTANT PROTEIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2;

ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRUSH BORDER; CONTROLLED STUDY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC CODE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTESTINE; IRON RESPONSIVE ELEMENT; KIDNEY CORTEX; KIDNEY MEDULLA; KIDNEY MICROSOME; KIDNEY PROXIMAL TUBULE; MOUSE; NONHUMAN; NUTRITIONAL DEFICIENCY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION;

EID: 0036310725     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2002.00405.x     Document Type: Article

References (50)

1. Inherited iron overload disorders
2. Haemochromatosis: Novel gene discovery and the molecular pathophysiology of iron metabolism
3. Iron homeostasis: Insights from genetics and animal models
4. Chemistry and biology of eukaryotic iron metabolism
5. Iron transport across biologic membranes
6. The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes
7. Identification and characterization of a second mouse Nramp gene
8. Mycobacterium tuberculosis expresses a novel pH-dependent divalent cation transporter belonging to the Nramp family
9. Nramp defines a family of membrane proteins
10. Cloning and characterization of a mammalian proton-coupled metal-ion transporter
11. Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool
12. The G185R mutation disrupts function of the iron transporter Nramp2
13. Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells
14. Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport
15. The human Nramp2 gene: Characterization of the gene structure, alternative splicing, promoter region and polymorphisms
16. Heterologous expression, functional characterization and localization of two isoforms of the monkey iron transporter Nramp2
17. Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron
18. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
19. Red cell iron uptake in hereditary microcytic anemia
20. Defective iron uptake by the duodenum of Belgrade rats fed diets of different iron contents
21. The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border
22. Identification and localization of divalent metal transporter-1 (DMT-1) in term human placenta
23. Cellular distribution of ferric iron, ferritin, transferrin and divalent metal transporter 1 (DMT1) in substantia nigra and basal ganglia of normal and beta2-microglobulin deficient mouse brain
24. Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells
25. Manganese metabolism is impaired in the Belgrade laboratory rat
26. In vivo characterization of renal iron transport in the anaesthetized rat
27. Cellular localization of divalent metal transporter DMT-1 in rat kidney
28. Characterization of cell lines showing growth control isolated from both the wild type and a leucyl-tRNA synthetase mutant of Chinese hamster ovary cells
29. Functional complementation of the yeast divalent cation transporter family SMF by NRAMP2, a member of the mammalian natural resistance associated macrophage protein family
30. Membrane topology of P-glycoprotein as determined by epitope insertion: Transmembrane organization of the N-terminal domain of mdr3
31. Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities
32. + exchanger isoform of renal brush border
33. + exchange in the renal tubule: Localization and adaptation to the acid-base state
34. Basic mechanisms of urinary acidification
35. Potassium and acid-base
36. The hereditary hemochromatosis gene (HFE): A MHC class I-like gene that functions in the regulation of iron homeostasis
37. HFE gene knockout produces mouse model of hereditary hemochromatosis
38. Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders
39. Positional cloning of zebra fish ferroportin1 identifies a conserved vertebrate iron exporter
40. Cellular iron metabolism
41. Role of iron in progressive renal disease
42. Mechanisms of iron-induced proximal tubule injury in rat remnant kidney
43. Iron accumulation in human chronic renal disease
44. Iron depletion in the remnant kidney
45. Role of iron and oxygen radicals in the progression of chronic renal failure
46. Toxicity of holotransferrin but not albumin in proximal tubule cells in primary culture
47. Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells from normal and anemic mk mice
48. Natural resistance to infection with intracellular parasites: Molecular genetics identifies Nramp1 as the Bcg/Ity/Lsh locus
49. Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains