메뉴 건너뛰기




Volumn 115, Issue 5, 2005, Pages 1258-1266

Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; IRON BINDING PROTEIN; IRON TRANSPORTER SLC11A2; UNCLASSIFIED DRUG;

EID: 18244399587     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI24356     Document Type: Article
Times cited : (342)

References (37)
  • 1
    • 0032959574 scopus 로고    scopus 로고
    • Transferrin receptor is necessary for development of erythrocytes and the nervous system
    • Levy, J.E., Jin, O., Fujiwara, Y., Kuo, F., and Andrews, N.C. 1999. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat. Genet. 21:396-399.
    • (1999) Nat. Genet. , vol.21 , pp. 396-399
    • Levy, J.E.1    Jin, O.2    Fujiwara, Y.3    Kuo, F.4    Andrews, N.C.5
  • 2
    • 0030755366 scopus 로고    scopus 로고
    • Cloning and characterization of a mammalian proton-coupled metal-ion transporter
    • Gunshin, H., et al. 1997. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 388:482-488.
    • (1997) Nature , vol.388 , pp. 482-488
    • Gunshin, H.1
  • 3
    • 0033564656 scopus 로고    scopus 로고
    • Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron
    • Canonne-Hergaux, F., Gruenheid, S., Ponka, P., and Gros, P. 1999. Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood. 93:4406-4437.
    • (1999) Blood , vol.93 , pp. 4406-4437
    • Canonne-Hergaux, F.1    Gruenheid, S.2    Ponka, P.3    Gros, P.4
  • 4
    • 0035895096 scopus 로고    scopus 로고
    • Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice
    • Canonne-Hergaux, F., Zhang, A.S., Ponka, P., and Gros, P. 2001. Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice. Blood. 98:3823-3830.
    • (2001) Blood , vol.98 , pp. 3823-3830
    • Canonne-Hergaux, F.1    Zhang, A.S.2    Ponka, P.3    Gros, P.4
  • 5
    • 0034070941 scopus 로고    scopus 로고
    • Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload
    • Trinder, D., Oates, P.S., Thomas, C., Sadleir, J., and Morgan, E.H. 2000. Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload. Gut. 46:270-276.
    • (2000) Gut , vol.46 , pp. 270-276
    • Trinder, D.1    Oates, P.S.2    Thomas, C.3    Sadleir, J.4    Morgan, E.H.5
  • 6
    • 0035875528 scopus 로고    scopus 로고
    • Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro
    • Gambling, L., et al. 2001. Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro. Biochem. J. 356:883-889.
    • (2001) Biochem. J. , vol.356 , pp. 883-889
    • Gambling, L.1
  • 7
    • 0033674229 scopus 로고    scopus 로고
    • Identification and localization of divalent metal transporter-1 (DMT-1) in term human placenta
    • Georgieff, M.K., Wobken, J.K., Welle, J., Burdo, J.R., and Connor, J.R. 2000. Identification and localization of divalent metal transporter-1 (DMT-1) in term human placenta. Placenta. 21:799-804.
    • (2000) Placenta , vol.21 , pp. 799-804
    • Georgieff, M.K.1    Wobken, J.K.2    Welle, J.3    Burdo, J.R.4    Connor, J.R.5
  • 8
    • 0027512915 scopus 로고
    • Characterization of transferrin-independent iron transport in K562 cells. Unique properties provide evidence for multiple pathways of iron uptake
    • Inman, R.S., and Wessling-Resnick, M. 1993. Characterization of transferrin-independent iron transport in K562 cells. Unique properties provide evidence for multiple pathways of iron uptake. J. Biol. Chem. 268:8521-8528.
    • (1993) J. Biol. Chem. , vol.268 , pp. 8521-8528
    • Inman, R.S.1    Wessling-Resnick, M.2
  • 9
    • 0028170059 scopus 로고
    • The mammalian transferrin-independent iron transport system may involve a surface ferrireductase activity
    • Jordan, I., and Kaplan, J. 1994. The mammalian transferrin-independent iron transport system may involve a surface ferrireductase activity. Biochem. J. 302:875-879.
    • (1994) Biochem. J. , vol.302 , pp. 875-879
    • Jordan, I.1    Kaplan, J.2
  • 10
    • 0025774978 scopus 로고
    • Regulation of the transferrin-independent iron transport system in cultured cells
    • Kaplan, J., Jordan, I., and Sturrock, A. 1991. Regulation of the transferrin-independent iron transport system in cultured cells. J. Biol. Chem. 266:2997-3004.
    • (1991) J. Biol. Chem. , vol.266 , pp. 2997-3004
    • Kaplan, J.1    Jordan, I.2    Sturrock, A.3
  • 11
    • 0028244452 scopus 로고
    • Uptake of non-transferrin bound iron by both reductive and non-reductive processes is modulated by intracellular iron
    • Randell, E.W., Parkes, J.G., Olivieri, N.F., and Templeton, D.M. 1994. Uptake of non-transferrin bound iron by both reductive and non-reductive processes is modulated by intracellular iron. J. Biol. Chem. 269:16046-16053.
    • (1994) J. Biol. Chem. , vol.269 , pp. 16046-16053
    • Randell, E.W.1    Parkes, J.G.2    Olivieri, N.F.3    Templeton, D.M.4
  • 12
    • 0025231790 scopus 로고
    • Characterization of a transferrin-independent uptake system for iron in HeLa cells
    • Sturrock, A., Alexander, J., Lamb, J., Craven, C.M., and Kaplan, J. 1990. Characterization of a transferrin-independent uptake system for iron in HeLa cells. J. Biol. Chem. 265:3139-3145.
    • (1990) J. Biol. Chem. , vol.265 , pp. 3139-3145
    • Sturrock, A.1    Alexander, J.2    Lamb, J.3    Craven, C.M.4    Kaplan, J.5
  • 13
    • 0032477866 scopus 로고    scopus 로고
    • Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport
    • Fleming, M.D., et al. 1998. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc. Natl. Acad. Sci. U. S. A. 95:1348-1153.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 1348-11153
    • Fleming, M.D.1
  • 14
    • 0030763856 scopus 로고    scopus 로고
    • Microcytic anemia mice have a mutation in Nramp2, a candidate iron transporter gene
    • Fleming, M.D., et al. 1997. Microcytic anemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat. Genet. 16:383-386.
    • (1997) Nat. Genet. , vol.16 , pp. 383-386
    • Fleming, M.D.1
  • 15
    • 0034548853 scopus 로고    scopus 로고
    • The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border
    • Canonne-Hergaux, F., et al. 2000. The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. Blood. 96:3964-3970.
    • (2000) Blood , vol.96 , pp. 3964-3970
    • Canonne-Hergaux, F.1
  • 16
    • 0032530922 scopus 로고    scopus 로고
    • The G185R mutation disrupts function of iron transporter Nramp2
    • Su, M.A., Trenor, C.C., Fleming, J.C., Fleming, M.D., and Andrews, N.C. 1998. The G185R mutation disrupts function of iron transporter Nramp2. Blood. 92:2157-2163.
    • (1998) Blood , vol.92 , pp. 2157-2163
    • Su, M.A.1    Trenor, C.C.2    Fleming, J.C.3    Fleming, M.D.4    Andrews, N.C.5
  • 17
    • 4444227596 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms underlying iron transport deficiency in microcytic anemia
    • Touret, N., et al. 2004. Molecular and cellular mechanisms underlying iron transport deficiency in microcytic anemia. Blood. 104:1526-1533.
    • (2004) Blood , vol.104 , pp. 1526-1533
    • Touret, N.1
  • 18
    • 19344369930 scopus 로고    scopus 로고
    • A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway
    • doi:10.1371/journal.pbio.0020050
    • Xu, H., Jin, J., DeFelice, L.J., Andrews, N.C., and Clapham, D.E. 2004. A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. PLoS Biol. 2:E50. doi:10.1371/journal.pbio.0020050.
    • (2004) PLoS Biol. , vol.2
    • Xu, H.1    Jin, J.2    DeFelice, L.J.3    Andrews, N.C.4    Clapham, D.E.5
  • 19
    • 12844260664 scopus 로고    scopus 로고
    • Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload
    • Mims, M.P., et al. 2005. Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload. Blood. 105:1337-1342.
    • (2005) Blood , vol.105 , pp. 1337-1342
    • Mims, M.P.1
  • 20
    • 0034572933 scopus 로고    scopus 로고
    • Iron homeostasis: Insights from genetics and animal models
    • Andrews, N.C. 2000. Iron homeostasis: insights from genetics and animal models. Nat. Rev. Genet. 1:208-217.
    • (2000) Nat. Rev. Genet. , vol.1 , pp. 208-217
    • Andrews, N.C.1
  • 21
    • 4043059169 scopus 로고    scopus 로고
    • Tissue-specific and inducible Cre-mediated recombination in the gut epithelium
    • el Marjou, F., et al. 2004. Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis. 39:186-193.
    • (2004) Genesis , vol.39 , pp. 186-193
    • El Marjou, F.1
  • 22
    • 0035865527 scopus 로고    scopus 로고
    • Expression of the DMT1 (NRAMP2) iron transporter in mice with genetic iron overload disorders
    • Canonne-Hergaux, F., et al. 2001. Expression of the DMT1 (NRAMP2) iron transporter in mice with genetic iron overload disorders. Blood. 97:1138-1140.
    • (2001) Blood , vol.97 , pp. 1138-1140
    • Canonne-Hergaux, F.1
  • 23
    • 0014804031 scopus 로고
    • Characterization and genetic studies of microcytic anemia in house mouse
    • Russell, E.S., et al. 1970. Characterization and genetic studies of microcytic anemia in house mouse. Blood. 35:838-850.
    • (1970) Blood , vol.35 , pp. 838-850
    • Russell, E.S.1
  • 24
    • 0014746040 scopus 로고
    • Low viability, skin lesions, and reduced fertility associated with microcytic anemia in the mouse
    • Russell, E.S., McFarland, E.C., and Kent, E.L. 1970. Low viability, skin lesions, and reduced fertility associated with microcytic anemia in the mouse. Transplant. Proc. 2:144-151.
    • (1970) Transplant. Proc. , vol.2 , pp. 144-151
    • Russell, E.S.1    McFarland, E.C.2    Kent, E.L.3
  • 25
    • 0034062537 scopus 로고    scopus 로고
    • Genes that modify the hemochromatosis phenotype in mice
    • Levy, J.E., Montross, L.K., and Andrews, N.C. 2000. Genes that modify the hemochromatosis phenotype in mice. J. Clin. Invest. 105:1209-1216.
    • (2000) J. Clin. Invest. , vol.105 , pp. 1209-1216
    • Levy, J.E.1    Montross, L.K.2    Andrews, N.C.3
  • 26
    • 0242579159 scopus 로고    scopus 로고
    • Transferrin receptor 1 is differentially required in lymphocyte development
    • Ned, R.M., Swat, W., and Andrews, N.C. 2003. Transferrin receptor 1 is differentially required in lymphocyte development. Blood. 102:3713-3718.
    • (2003) Blood , vol.102 , pp. 3713-3718
    • Ned, R.M.1    Swat, W.2    Andrews, N.C.3
  • 27
    • 0019268617 scopus 로고
    • An intestinal receptor for heme: Its parital characterization
    • Tenhunen, R., Grasbeck, R., Kouvonen, I., and Lundberg, M. 1980. An intestinal receptor for heme: its parital characterization. Int. J. Biochem. 12:713-716.
    • (1980) Int. J. Biochem. , vol.12 , pp. 713-716
    • Tenhunen, R.1    Grasbeck, R.2    Kouvonen, I.3    Lundberg, M.4
  • 28
    • 0036310725 scopus 로고    scopus 로고
    • Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice
    • Canonne-Hergaux, F., and Gros, P. 2002. Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice. Kidney Int. 62:147-156.
    • (2002) Kidney Int. , vol.62 , pp. 147-156
    • Canonne-Hergaux, F.1    Gros, P.2
  • 29
    • 0035025882 scopus 로고    scopus 로고
    • Cellular localization of divalent metal transporter DMT-1 in rat kidney
    • Ferguson, C.J., et al. 2001. Cellular localization of divalent metal transporter DMT-1 in rat kidney. Am. J. Physiol. Renal Physiol. 280:F803-F814.
    • (2001) Am. J. Physiol. Renal Physiol. , vol.280
    • Ferguson, C.J.1
  • 30
    • 0028109907 scopus 로고
    • Extracellular ferrireductase activity of K562 cells is coupled to transferrin-independent iron transport
    • Inman, R.S., Coughlan, M.M., and Wessling-Resnick, M. 1994. Extracellular ferrireductase activity of K562 cells is coupled to transferrin-independent iron transport. Biochemistry. 33:11850-11857.
    • (1994) Biochemistry , vol.33 , pp. 11850-11857
    • Inman, R.S.1    Coughlan, M.M.2    Wessling-Resnick, M.3
  • 31
    • 0036865552 scopus 로고    scopus 로고
    • The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition
    • Goetz, D.H., et al. 2002. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol. Cell. 10:1033-1043.
    • (2002) Mol. Cell. , vol.10 , pp. 1033-1043
    • Goetz, D.H.1
  • 32
    • 18744397511 scopus 로고    scopus 로고
    • An iron delivery pathway mediated by a lipocalin
    • Yang, J., et al. 2002. An iron delivery pathway mediated by a lipocalin. Mol. Cell. 10:1045-1056.
    • (2002) Mol. Cell. , vol.10 , pp. 1045-1056
    • Yang, J.1
  • 33
    • 0037184526 scopus 로고    scopus 로고
    • Mechanisms of cellular iron acquisition: Another iron in the fire
    • Kaplan, J. 2002. Mechanisms of cellular iron acquisition: another iron in the fire. Cell. 111:603-606.
    • (2002) Cell. , vol.111 , pp. 603-606
    • Kaplan, J.1
  • 34
    • 0141461407 scopus 로고    scopus 로고
    • L-type Ca(2+) channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy
    • Oudit, G.Y., et al. 2003. L-type Ca(2+) channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Nat. Med. 9:1187-1194.
    • (2003) Nat. Med. , vol.9 , pp. 1187-1194
    • Oudit, G.Y.1
  • 35
    • 0033168767 scopus 로고    scopus 로고
    • The C282Y mutation causing hereditary hemochromatosis does not produce a null allele
    • Levy, J.E., Montross, L.K., Cohen, D.E., Fleming, M.D., and Andrews, N.C. 1999. The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. Blood. 94:9-11.
    • (1999) Blood , vol.94 , pp. 9-11
    • Levy, J.E.1    Montross, L.K.2    Cohen, D.E.3    Fleming, M.D.4    Andrews, N.C.5
  • 37
    • 0018160469 scopus 로고
    • Simplified typing of mouse hemoglobin (Hbb) phenotypes using cystamine
    • Whitney, J.B., III. 1978. Simplified typing of mouse hemoglobin (Hbb) phenotypes using cystamine. Biochem. Genet. 16:667-672.
    • (1978) Biochem. Genet. , vol.16 , pp. 667-672
    • Whitney III, J.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.