Altered dietary iron intake is a strong modulator of renal DMT1 expression

American Journal of Physiology - Renal Physiology

Volumn 285, Issue 6 54-6, 2003, Pages

  Wareing, Mark ^a   Ferguson, Carole J ^a   Delannoy, Mathieu ^a   Cox, Alan G ^b   McMahon, Raymond F T ^a   Green, Roger ^a   Riccardi, Daniela ^a   Smith, Craig P ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Iron regulatory protein; Kidney; NRAMP2; Serum iron level; SLC11A2

Indexed keywords

IRON REGULATORY FACTOR; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); VESICULAR ACETYLCHOLINE TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; APICAL MEMBRANE; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; DMT1 GENE; DUODENUM MUCOSA; GENE; GENE MUTATION; IRON ABSORPTION; IRON INTAKE; IRON METABOLISM; IRON RESTRICTION; KIDNEY PROXIMAL TUBULE; MALE; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; RAT; URINARY EXCRETION;

EID: 0242582127     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00064.2003     Document Type: Article

References (30)

1. Abboud S and Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275: 19906-19912, 2000.
2. Alfrey AC and Hammond WS. Renal iron handling in the nephrotic syndrome. Kidney Int 37: 1409-1413, 1990.
3. Canonne-Hergaux F and Gros P. Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice. Kidney Int 62: 147-156, 2002.
4. Capassp G, Malnic G, Wang T, and Giebisch G. Acidification in mammalian cortical distal tubule. Kidney Int 45: 1543-1554, 1994.
5. Edwards JA and Hoke JE. Defect of intestinal mucosal iron uptake in mice with hereditary microcytic anemia. Proc Soc Exp Biol Med 141: 81-84, 1972.
6. Ferguson CJ, Wareing M, Ward DT, Green R, Smith CP, and Riccardi D. Cellular localization of divalent metal transporter DMT-1 in rat kidney. Am J Physiol Renal Physiol 280: F803-F814, 2001.
7. Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD, and Andrews NC. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci USA 95: 1148-1153, 1998.
8. Fleming MD, Trenor CC III, Su MA, Foernzler D, Beier DR, Dietrich WF, and Andrews NC. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16: 383-386, 1997.
9. Fleming RE, Migas MC, Zhou X, Jiang J, Britton RS, Brunt EM, Tomatsu S, Waheed A, Bacon BR, and Sly WS. Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1. Proc Natl Acad Sci USA 96: 3143-3148, 1999.
10. a. Ferguson CJ, Wareing M, Delannoy M, Fenton R, Mclarnon SJ, Ashton N, Cox AG, McMahon RFT, Garrick LM, Green R, Smith PC, and Riccardi D. Iron handling and gene expression of the divalent metal transporter, DMT1 in the kidney of the anemic Belgrade (b) rat. Kidney Int. In press.
11. Gambling L, Danzeisen R, Gair S, Lea RG, Charania Z, Solanky N, Joory KD, Srai SK, and McArdle HJ. Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro. Biochem J 356: 883-889, 2001.
12. Garrick LM, Dolan KG, Romano MA, and Garrick MD. Non-transferrin-bound iron uptake in Belgrade and normal rat erythroid cells. J Cell Physiol 178: 349-358, 1999.
13. Gruenheid S, Canonne-Hergaux F, Gauthier S, Hackam DJ, Grinstein S, and Gros P. The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. J Exp Med 189: 831-841, 1999.
14. Gruenheid S, Cellier M, Vidal S, and Gros P. Identification and characterization of a second mouse Nramp gene. Genomics 25: 514-525, 1995.
15. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, and Hediger MA. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388: 482-488, 1997.
16. Hubert N and Hentze MW. Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci USA 99: 12345-12350, 2002.
17. Lee PL, Gelbart T, West C, Halloran C, and Beutler E. The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms. Blood Cells Mol Dis 24: 199-215, 1998.
18. Oates PS, Jeffrey GP, Basclain KA, Thomas C, and Morgan EH. Iron excretion in iron-overloaded rats following the change from an iron-loaded to an iron-deficient diet. J Gastroenterol Hepatol 15: 665-674, 2000.
19. Oates PS and Morgan EH. Defective iron uptake by the duodenum of Belgrade rats fed diets of different iron contents. Am J Physiol Gastrointest Liver Physiol 270: G826-G832, 1996.
20. Oates PS and Morgan EH. Effects of dietary iron loading with carbonyl iron and of iron depletion on intestinal growth, morphology, and expression of transferrin receptor in the rat. Anat Rec 246: 364-371, 1996.
21. Picard V, Govoni G, Jabado N, and Gros P. Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool. J Biol Chem 275: 35738-35745, 2000.
22. Roth JA, Horbinski C, Feng L, Dolan KG, Higgins D, and Garrick MD. Differential localization of divalent metal transporter 1 with and without iron response element in rat PC12 and sympathetic neuronal cells. J Neurosci 20: 7595-7601, 2000.
23. Sladic-Simic D, Zivlovic N, Marinkovic D, Martinovic J, and Martinovic PN. Hereditary hypochromic microcytic anemia in the laboratory rat. Genetics 53: 1079-1089, 1966.
24. Su MA, Trenor CC, Fleming JC, Fleming MD, and Andrews NC. The G185R mutation disrupts function of the iron transporter Nramp2. Blood 92: 2157-2163, 1998.
25. Tabuchi M, Yoshimori T, Yamaguchi K, Yoshida T, and Kishi F. Human NRAMP2/DMT1, which mediates iron transport across endosomal membranes, is localized to late endosomes and lysosomes in HEp-2 cells. J Biol Chem 275: 22220-22228, 2000.
26. Tandy S, Williams M, Leggett A, Lopez-Jimenez M, Dedes M, Ramesh B, Srai SK, and Sharp P. Nramp2 expression is associated with pH-dependent iron uptake across the apical membrane of human intestinal Caco-2 cells. J Biol Chem 275: 1023-1029, 2000.
27. Trinder D, Oates PS, Thomas C, Sadleir J, and Morgan EH. Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload. Gut 46: 270-276, 2000.
28. Wareing M, Ferguson CJ, Green R, Riccardi D, and Smith CP. In vivo characterization of renal iron transport in the anaesthetized rat. J Physiol 524: 581-586, 2000.
29. Worthington MT, Browne L, Battle EH, and Luo RQ. Functional properties of transfected human DMT1 iron transporter. Am J Physiol Gastrointest Liver Physiol 279: G1265-G1273, 2000.
30. Yeh KY, Yeh M, Watkins JA, Rodriguez-Paris J, and Glass J. Dietary iron induces rapid changes in rat intestinal divalent metal transporter expression. Am J Physiol Gastrointest Liver Physiol 279: G1070-G1079, 2000.