-
1
-
-
0037020044
-
Identification of TOR signaling complexes: more TORC for the cell growth engine
-
Abraham R.T. Identification of TOR signaling complexes: more TORC for the cell growth engine. Cell 111 (2002) 9-12
-
(2002)
Cell
, vol.111
, pp. 9-12
-
-
Abraham, R.T.1
-
2
-
-
2342496712
-
FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
-
Accili D., and Arden K.C. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117 (2004) 421-426
-
(2004)
Cell
, vol.117
, pp. 421-426
-
-
Accili, D.1
Arden, K.C.2
-
3
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
Araki E., Lipes M.A., Patti M.E., Bruning J.C., Haag III B., Johnson R.S., and Kahn C.R. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372 (1994) 186-190
-
(1994)
Nature
, vol.372
, pp. 186-190
-
-
Araki, E.1
Lipes, M.A.2
Patti, M.E.3
Bruning, J.C.4
Haag III, B.5
Johnson, R.S.6
Kahn, C.R.7
-
5
-
-
0036192939
-
Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression
-
Belke D.D., Betuing S., Tuttle M.J., Graveleau C., Young M.E., Pham M., Zhang D., Cooksey R.C., McClain D.A., Litwin S.E., et al. Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J. Clin. Invest. 109 (2002) 629-639
-
(2002)
J. Clin. Invest.
, vol.109
, pp. 629-639
-
-
Belke, D.D.1
Betuing, S.2
Tuttle, M.J.3
Graveleau, C.4
Young, M.E.5
Pham, M.6
Zhang, D.7
Cooksey, R.C.8
McClain, D.A.9
Litwin, S.E.10
-
6
-
-
10744228630
-
Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets
-
Bell E., Cao X., Moibi J.A., Greene S.R., Young R., Trucco M., Gao Z., Matschinsky F.M., Deng S., Markman J.F., et al. Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets. Diabetes 52 (2003) 2731-2739
-
(2003)
Diabetes
, vol.52
, pp. 2731-2739
-
-
Bell, E.1
Cao, X.2
Moibi, J.A.3
Greene, S.R.4
Young, R.5
Trucco, M.6
Gao, Z.7
Matschinsky, F.M.8
Deng, S.9
Markman, J.F.10
-
7
-
-
0034705026
-
Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity
-
Bernal A., and Kimbrell D.A. Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity. Proc. Natl. Acad. Sci. USA 97 (2000) 6019-6024
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6019-6024
-
-
Bernal, A.1
Kimbrell, D.A.2
-
8
-
-
33645982255
-
From Mice to Men: Insights into the insulin resistance syndromes
-
Biddinger S.B., and Kahn C.R. From Mice to Men: Insights into the insulin resistance syndromes. Annu. Rev. Physiol. 68 (2006) 1-36
-
(2006)
Annu. Rev. Physiol.
, vol.68
, pp. 1-36
-
-
Biddinger, S.B.1
Kahn, C.R.2
-
9
-
-
0033603208
-
Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
-
Böhni R., Riesgo-Escovar J., Oldham S., Brogiolo W., Stocker H., Andruss B.F., Beckingham K., and Hafen E. Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell 97 (1999) 865-875
-
(1999)
Cell
, vol.97
, pp. 865-875
-
-
Böhni, R.1
Riesgo-Escovar, J.2
Oldham, S.3
Brogiolo, W.4
Stocker, H.5
Andruss, B.F.6
Beckingham, K.7
Hafen, E.8
-
10
-
-
0037025356
-
AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
-
Bolster D.R., Crozier S.J., Kimball S.R., and Jefferson L.S. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J. Biol. Chem. 277 (2002) 23977-23980
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 23977-23980
-
-
Bolster, D.R.1
Crozier, S.J.2
Kimball, S.R.3
Jefferson, L.S.4
-
11
-
-
0035916357
-
An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
-
Brogiolo W., Stocker H., Ikeya T., Rintelen F., Fernandez R., and Hafen E. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr. Biol. 11 (2001) 213-221
-
(2001)
Curr. Biol.
, vol.11
, pp. 213-221
-
-
Brogiolo, W.1
Stocker, H.2
Ikeya, T.3
Rintelen, F.4
Fernandez, R.5
Hafen, E.6
-
12
-
-
20044393471
-
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
-
Broughton S.J., Piper M.D., Ikeya T., Bass T.M., Jacobson J., Driege Y., Martinez P., Hafen E., Withers D.J., Leevers S.J., and Partridge L. Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc. Natl. Acad. Sci. USA 102 (2005) 3105-3110
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 3105-3110
-
-
Broughton, S.J.1
Piper, M.D.2
Ikeya, T.3
Bass, T.M.4
Jacobson, J.5
Driege, Y.6
Martinez, P.7
Hafen, E.8
Withers, D.J.9
Leevers, S.J.10
Partridge, L.11
-
13
-
-
0036629251
-
Cell cycle and death control: long live Forkheads
-
Burgering B.M., and Kops G.J. Cell cycle and death control: long live Forkheads. Trends Biochem. Sci. 27 (2002) 352-360
-
(2002)
Trends Biochem. Sci.
, vol.27
, pp. 352-360
-
-
Burgering, B.M.1
Kops, G.J.2
-
14
-
-
0034699544
-
IRS-2 pathways integrate female reproduction and energy homeostasis
-
Burks D.J., de Mora J.F., Schubert M., Withers D.J., Myers M.G., Towery H.H., Altamuro S.L., Flint C.L., and White M.F. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 407 (2000) 377-382
-
(2000)
Nature
, vol.407
, pp. 377-382
-
-
Burks, D.J.1
de Mora, J.F.2
Schubert, M.3
Withers, D.J.4
Myers, M.G.5
Towery, H.H.6
Altamuro, S.L.7
Flint, C.L.8
White, M.F.9
-
15
-
-
0035125526
-
IRS proteins and β-cell function
-
Burks D.J., and White M.F. IRS proteins and β-cell function. Diabetes 50 Suppl 1 (2001) S140-S145
-
(2001)
Diabetes
, vol.50
, Issue.SUPPL. 1
-
-
Burks, D.J.1
White, M.F.2
-
17
-
-
0347318052
-
The AMP-activated protein kinase cascade-a unifying system for energy control
-
Carling D. The AMP-activated protein kinase cascade-a unifying system for energy control. Trends Biochem. Sci. 29 (2004) 18-24
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 18-24
-
-
Carling, D.1
-
19
-
-
13444268937
-
Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy
-
Chiu H.C., Kovacs A., Blanton R.M., Han X., Courtois M., Weinheimer C.J., Yamada K.A., Brunet S., Xu H., Nerbonne J.M., et al. Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ. Res. 96 (2005) 225-233
-
(2005)
Circ. Res.
, vol.96
, pp. 225-233
-
-
Chiu, H.C.1
Kovacs, A.2
Blanton, R.M.3
Han, X.4
Courtois, M.5
Weinheimer, C.J.6
Yamada, K.A.7
Brunet, S.8
Xu, H.9
Nerbonne, J.M.10
-
20
-
-
0028088187
-
FlyBase - the Drosophila database
-
Fly Consortium
-
Fly Consortium. FlyBase - the Drosophila database. Nucleic Acids Res. 22 (1994) 3456-3458
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 3456-3458
-
-
-
22
-
-
0037134910
-
Hepatic amino acid-dependent signaling is under the control of AMP-dependent protein kinase
-
Dubbelhuis P.F., and Meijer A.J. Hepatic amino acid-dependent signaling is under the control of AMP-dependent protein kinase. FEBS Lett. 521 (2002) 39-42
-
(2002)
FEBS Lett.
, vol.521
, pp. 39-42
-
-
Dubbelhuis, P.F.1
Meijer, A.J.2
-
24
-
-
2342545519
-
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
-
Fingar D.C., and Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23 (2004) 3151-3171
-
(2004)
Oncogene
, vol.23
, pp. 3151-3171
-
-
Fingar, D.C.1
Blenis, J.2
-
25
-
-
3142749712
-
Long-lived Drosophila with overexpressed dFOXO in adult fat body
-
Giannakou M.E., Goss M., Junger M.A., Hafen E., Leevers S.J., and Partridge L. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305 (2004) 361
-
(2004)
Science
, vol.305
, pp. 361
-
-
Giannakou, M.E.1
Goss, M.2
Junger, M.A.3
Hafen, E.4
Leevers, S.J.5
Partridge, L.6
-
26
-
-
0942276379
-
Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling
-
Giraud J., Leshan R., Lee Y.H., and White M.F. Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling. J. Biol. Chem. 279 (2004) 3447-3454
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 3447-3454
-
-
Giraud, J.1
Leshan, R.2
Lee, Y.H.3
White, M.F.4
-
27
-
-
27844497945
-
FOXO transcription factors at the interface between longevity and tumor suppression
-
Greer E.L., and Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24 (2005) 7410-7425
-
(2005)
Oncogene
, vol.24
, pp. 7410-7425
-
-
Greer, E.L.1
Brunet, A.2
-
28
-
-
26944489689
-
Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila
-
Grönke S., Mildner A., Fellert S., Tennagels N., Petry S., Müller G., Jäckle H., and Kühnlein R.P. Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Cell Metab. 1 (2005) 323-330
-
(2005)
Cell Metab.
, vol.1
, pp. 323-330
-
-
Grönke, S.1
Mildner, A.2
Fellert, S.3
Tennagels, N.4
Petry, S.5
Müller, G.6
Jäckle, H.7
Kühnlein, R.P.8
-
29
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara K., Maruki Y., Long X., Yoshino K., Oshiro N., Hidayat S., Tokunaga C., Avruch J., and Yonezawa K. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110 (2002) 177-189
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
30
-
-
15044358594
-
New roles for the LKB1→AMPK pathway
-
Hardie D.G. New roles for the LKB1→AMPK pathway. Curr. Opin. Cell Biol. 17 (2005) 167-173
-
(2005)
Curr. Opin. Cell Biol.
, vol.17
, pp. 167-173
-
-
Hardie, D.G.1
-
31
-
-
0034463918
-
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
-
Haruta T., Uno T., Kawahara J., Takano A., Egawa K., Sharma P.M., Olefsky J.M., and Kobayashi M. A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol. Endocrinol. 14 (2000) 783-794
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 783-794
-
-
Haruta, T.1
Uno, T.2
Kawahara, J.3
Takano, A.4
Egawa, K.5
Sharma, P.M.6
Olefsky, J.M.7
Kobayashi, M.8
-
32
-
-
2942563805
-
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
-
Hwangbo D.S., Gershman B., Tu M.P., Palmer M., and Tatar M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429 (2004) 562-566
-
(2004)
Nature
, vol.429
, pp. 562-566
-
-
Hwangbo, D.S.1
Gershman, B.2
Tu, M.P.3
Palmer, M.4
Tatar, M.5
-
33
-
-
0037031147
-
Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila
-
Ikeya T., Galic M., Belawat P., Nairz K., and Hafen E. Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Curr. Biol. 12 (2002) 1293-1300
-
(2002)
Curr. Biol.
, vol.12
, pp. 1293-1300
-
-
Ikeya, T.1
Galic, M.2
Belawat, P.3
Nairz, K.4
Hafen, E.5
-
34
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K., Zhu T., and Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115 (2003) 577-590
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
35
-
-
0035861644
-
5′-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside
-
Jakobsen S.N., Hardie D.G., Morrice N., and Tornqvist H.E. 5′-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside. J. Biol. Chem. 276 (2001) 46912-46916
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 46912-46916
-
-
Jakobsen, S.N.1
Hardie, D.G.2
Morrice, N.3
Tornqvist, H.E.4
-
36
-
-
4544311861
-
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span
-
Jia K., Chen D., and Riddle D.L. The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span. Development 131 (2004) 3897-3906
-
(2004)
Development
, vol.131
, pp. 3897-3906
-
-
Jia, K.1
Chen, D.2
Riddle, D.L.3
-
37
-
-
0242539698
-
The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
-
Jünger M.A., Rintelen F., Stocker H., Wasserman J.D., Vegh M., Radimerski T., Greenberg M.E., and Hafen E. The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J. Biol. 2 (2003) 20-36
-
(2003)
J. Biol.
, vol.2
, pp. 20-36
-
-
Jünger, M.A.1
Rintelen, F.2
Stocker, H.3
Wasserman, J.D.4
Vegh, M.5
Radimerski, T.6
Greenberg, M.E.7
Hafen, E.8
-
38
-
-
27744511769
-
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
-
Kaeberlein M., Powers III R.W., Steffen K.K., Westman E.A., Hu D., Dang N., Kerr E.O., Kirkland K.T., Fields S., and Kennedy B.K. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310 (2005) 1193-1196
-
(2005)
Science
, vol.310
, pp. 1193-1196
-
-
Kaeberlein, M.1
Powers III, R.W.2
Steffen, K.K.3
Westman, E.A.4
Hu, D.5
Dang, N.6
Kerr, E.O.7
Kirkland, K.T.8
Fields, S.9
Kennedy, B.K.10
-
39
-
-
20844451123
-
AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism
-
Kahn B.B., Alquier T., Carling D., and Hardie D.G. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 1 (2005) 15-25
-
(2005)
Cell Metab.
, vol.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
40
-
-
3042648746
-
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
-
Kapahi P., Zid B.M., Harper T., Koslover D., Sapin V., and Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol. 14 (2004) 885-890
-
(2004)
Curr. Biol.
, vol.14
, pp. 885-890
-
-
Kapahi, P.1
Zid, B.M.2
Harper, T.3
Koslover, D.4
Sapin, V.5
Benzer, S.6
-
41
-
-
13944269223
-
The plasticity of aging: insights from long-lived mutants
-
Kenyon C. The plasticity of aging: insights from long-lived mutants. Cell 120 (2005) 449-460
-
(2005)
Cell
, vol.120
, pp. 449-460
-
-
Kenyon, C.1
-
42
-
-
0027771804
-
A C. elegans mutant that lives twice as long as wild type
-
Kenyon C., Chang J., Gensch E., Rudner A., and Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature 366 (1993) 461-464
-
(1993)
Nature
, vol.366
, pp. 461-464
-
-
Kenyon, C.1
Chang, J.2
Gensch, E.3
Rudner, A.4
Tabtiang, R.5
-
43
-
-
0041821468
-
Raptor and mTOR: subunits of a nutrient-sensitive complex
-
Kim D.H., and Sabatini D.M. Raptor and mTOR: subunits of a nutrient-sensitive complex. Curr. Top. Microbiol. Immunol. 279 (2004) 259-270
-
(2004)
Curr. Top. Microbiol. Immunol.
, vol.279
, pp. 259-270
-
-
Kim, D.H.1
Sabatini, D.M.2
-
44
-
-
0030813398
-
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
-
Kimura K.D., Tissenbaum H.A., Liu Y., and Ruvkun G. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277 (1997) 942-946
-
(1997)
Science
, vol.277
, pp. 942-946
-
-
Kimura, K.D.1
Tissenbaum, H.A.2
Liu, Y.3
Ruvkun, G.4
-
45
-
-
0037276069
-
A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
-
Kimura N., Tokunaga C., Dalal S., Richardson C., Yoshino K., Hara K., Kemp B.E., Witters L.A., Mimura O., and Yonezawa K. A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Genes Cells 8 (2003) 65-79
-
(2003)
Genes Cells
, vol.8
, pp. 65-79
-
-
Kimura, N.1
Tokunaga, C.2
Dalal, S.3
Richardson, C.4
Yoshino, K.5
Hara, K.6
Kemp, B.E.7
Witters, L.A.8
Mimura, O.9
Yonezawa, K.10
-
46
-
-
0036950665
-
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth
-
Kitamura T., Nakae J., Kitamura Y., Kido Y., Biggs III W.H., Wright C.V., White M.F., Arden K.C., and Accili D. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth. J. Clin. Invest. 110 (2002) 1839-1847
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1839-1847
-
-
Kitamura, T.1
Nakae, J.2
Kitamura, Y.3
Kido, Y.4
Biggs III, W.H.5
Wright, C.V.6
White, M.F.7
Arden, K.C.8
Accili, D.9
-
47
-
-
0036007421
-
Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K
-
Kozma S.C., and Thomas G. Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K. Bioessays 24 (2002) 65-71
-
(2002)
Bioessays
, vol.24
, pp. 65-71
-
-
Kozma, S.C.1
Thomas, G.2
-
48
-
-
2942689828
-
Expression of Drosophila FOXO regulates growth and can phenocopy starvation
-
Kramer J.M., Davidge J.T., Lockyer J.M., and Staveley B.E. Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev. Biol. 3 (2003) 5-18
-
(2003)
BMC Dev. Biol.
, vol.3
, pp. 5-18
-
-
Kramer, J.M.1
Davidge, J.T.2
Lockyer, J.M.3
Staveley, B.E.4
-
49
-
-
0033524937
-
Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes
-
Kulkarni R.N., Bruning J.C., Winnay J.N., Postic C., Magnuson M.A., and Kahn C.R. Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96 (1999) 329-339
-
(1999)
Cell
, vol.96
, pp. 329-339
-
-
Kulkarni, R.N.1
Bruning, J.C.2
Winnay, J.N.3
Postic, C.4
Magnuson, M.A.5
Kahn, C.R.6
-
50
-
-
9444234587
-
Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets
-
Kwon G., Marshall C.A., Pappan K.L., Remedi M.S., and McDaniel M.L. Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets. Diabetes 53 Suppl 3 (2004) S225-S232
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 3
-
-
Kwon, G.1
Marshall, C.A.2
Pappan, K.L.3
Remedi, M.S.4
McDaniel, M.L.5
-
51
-
-
0037466652
-
DAF-16 target genes that control C. elegans life-span and metabolism
-
Lee S.S., Kennedy S., Tolonen A.C., and Ruvkun G. DAF-16 target genes that control C. elegans life-span and metabolism. Science 300 (2003) 644-647
-
(2003)
Science
, vol.300
, pp. 644-647
-
-
Lee, S.S.1
Kennedy, S.2
Tolonen, A.C.3
Ruvkun, G.4
-
52
-
-
12344322710
-
Insulin receptor substrate proteins and diabetes
-
Lee Y.H., and White M.F. Insulin receptor substrate proteins and diabetes. Arch. Pharm. Res. 27 (2004) 361-370
-
(2004)
Arch. Pharm. Res.
, vol.27
, pp. 361-370
-
-
Lee, Y.H.1
White, M.F.2
-
53
-
-
0345447590
-
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan
-
Libina N., Berman J.R., and Kenyon C. Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan. Cell 115 (2003) 489-502
-
(2003)
Cell
, vol.115
, pp. 489-502
-
-
Libina, N.1
Berman, J.R.2
Kenyon, C.3
-
54
-
-
0030657540
-
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
-
Lin K., Dorman J.B., Rodan A., and Kenyon C. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278 (1997) 1319-1322
-
(1997)
Science
, vol.278
, pp. 1319-1322
-
-
Lin, K.1
Dorman, J.B.2
Rodan, A.3
Kenyon, C.4
-
55
-
-
0042322370
-
TOR action in mammalian cells and in Caenorhabditis elegans
-
Long X., Muller F., and Avruch J. TOR action in mammalian cells and in Caenorhabditis elegans. Curr. Top Microbiol. Immunol. 279 (2004) 115-138
-
(2004)
Curr. Top Microbiol. Immunol.
, vol.279
, pp. 115-138
-
-
Long, X.1
Muller, F.2
Avruch, J.3
-
56
-
-
24144492761
-
All roads lead to FoxO
-
Matsumoto M., and Accili D. All roads lead to FoxO. Cell Metab. 1 (2005) 215-216
-
(2005)
Cell Metab.
, vol.1
, pp. 215-216
-
-
Matsumoto, M.1
Accili, D.2
-
57
-
-
0036787462
-
Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic β-cells
-
McDaniel M.L., Marshall C.A., Pappan K.L., and Kwon G. Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic β-cells. Diabetes 51 (2002) 2877-2885
-
(2002)
Diabetes
, vol.51
, pp. 2877-2885
-
-
McDaniel, M.L.1
Marshall, C.A.2
Pappan, K.L.3
Kwon, G.4
-
58
-
-
0042631524
-
Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16
-
McElwee J., Bubb K., and Thomas J.H. Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2 (2003) 111-121
-
(2003)
Aging Cell
, vol.2
, pp. 111-121
-
-
McElwee, J.1
Bubb, K.2
Thomas, J.H.3
-
59
-
-
0034976004
-
The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila
-
Miron M., Verdu J., Lachance P.E., Birnbaum M.J., Lasko P.F., and Sonenberg N. The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nat. Cell Biol. 3 (2001) 596-601
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 596-601
-
-
Miron, M.1
Verdu, J.2
Lachance, P.E.3
Birnbaum, M.J.4
Lasko, P.F.5
Sonenberg, N.6
-
60
-
-
0037623473
-
Sirolimus changes lipid concentrations and lipoprotein metabolism in kidney transplant recipients
-
Morrisett J.D., Abdel-Fattah G., and Kahan B.D. Sirolimus changes lipid concentrations and lipoprotein metabolism in kidney transplant recipients. Transplant. Proc. 35 (2003) 143S-150S
-
(2003)
Transplant. Proc.
, vol.35
-
-
Morrisett, J.D.1
Abdel-Fattah, G.2
Kahan, B.D.3
-
61
-
-
0042092531
-
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
-
Murphy C.T., McCarroll S.A., Bargmann C.I., Fraser A., Kamath R.S., Ahringer J., Li H., and Kenyon C. Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424 (2003) 277-283
-
(2003)
Nature
, vol.424
, pp. 277-283
-
-
Murphy, C.T.1
McCarroll, S.A.2
Bargmann, C.I.3
Fraser, A.4
Kamath, R.S.5
Ahringer, J.6
Li, H.7
Kenyon, C.8
-
62
-
-
0036787607
-
Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1
-
Nakae J., Biggs III W.H., Kitamura T., Cavenee W.K., Wright C.V., Arden K.C., and Accili D. Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat. Genet. 32 (2002) 245-253
-
(2002)
Nat. Genet.
, vol.32
, pp. 245-253
-
-
Nakae, J.1
Biggs III, W.H.2
Kitamura, T.3
Cavenee, W.K.4
Wright, C.V.5
Arden, K.C.6
Accili, D.7
-
63
-
-
0030659557
-
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
-
Ogg S., Paradis S., Gottlieb S., Patterson G.I., Lee L., Tissenbaum H.A., and Ruvkun G. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389 (1997) 994-999
-
(1997)
Nature
, vol.389
, pp. 994-999
-
-
Ogg, S.1
Paradis, S.2
Gottlieb, S.3
Patterson, G.I.4
Lee, L.5
Tissenbaum, H.A.6
Ruvkun, G.7
-
64
-
-
0037306190
-
Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control
-
Oldham S., and Hafen E. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol. 13 (2003) 79-85
-
(2003)
Trends Cell Biol.
, vol.13
, pp. 79-85
-
-
Oldham, S.1
Hafen, E.2
-
65
-
-
0034312279
-
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
-
Oldham S., Montagne J., Radimerski T., Thomas G., and Hafen E. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev. 14 (2000) 2689-2694
-
(2000)
Genes Dev.
, vol.14
, pp. 2689-2694
-
-
Oldham, S.1
Montagne, J.2
Radimerski, T.3
Thomas, G.4
Hafen, E.5
-
66
-
-
20544449419
-
Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart
-
Park S.Y., Kim H.J., Wang S., Higashimori T., Dong J., Kim Y.J., Cline G., Li H., Prentki M., Shulman G.I., et al. Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart. Am. J. Physiol. Endocrinol. Metab. 289 (2005) E30-E39
-
(2005)
Am. J. Physiol. Endocrinol. Metab.
, vol.289
-
-
Park, S.Y.1
Kim, H.J.2
Wang, S.3
Higashimori, T.4
Dong, J.5
Kim, Y.J.6
Cline, G.7
Li, H.8
Prentki, M.9
Shulman, G.I.10
-
67
-
-
0036245337
-
Mechanisms of ageing: public or private?
-
Partridge L., and Gems D. Mechanisms of ageing: public or private?. Nat. Rev. Genet. 3 (2002) 165-175
-
(2002)
Nat. Rev. Genet.
, vol.3
, pp. 165-175
-
-
Partridge, L.1
Gems, D.2
-
68
-
-
0001437616
-
Bidirectional modulation of insulin action by amino acids
-
Patti M.E., Brambilla E., Luzi L., Landaker E.J., and Kahn C.R. Bidirectional modulation of insulin action by amino acids. J. Clin. Invest. 101 (1998) 1519-1529
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 1519-1529
-
-
Patti, M.E.1
Brambilla, E.2
Luzi, L.3
Landaker, E.J.4
Kahn, C.R.5
-
69
-
-
0034700456
-
Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
-
Pende M., Kozma S.C., Jaquet M., Oorschot V., Burcelin R., Le Marchand-Brustel Y., Klumperman J., Thorens B., and Thomas G. Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice. Nature 408 (2000) 994-997
-
(2000)
Nature
, vol.408
, pp. 994-997
-
-
Pende, M.1
Kozma, S.C.2
Jaquet, M.3
Oorschot, V.4
Burcelin, R.5
Le Marchand-Brustel, Y.6
Klumperman, J.7
Thorens, B.8
Thomas, G.9
-
70
-
-
30944458446
-
Extension of chronological life span in yeast by decreased TOR pathway signaling
-
Powers III R.W., Kaeberlein M., Caldwell S.D., Kennedy B.K., and Fields S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 20 (2006) 174-184
-
(2006)
Genes Dev.
, vol.20
, pp. 174-184
-
-
Powers III, R.W.1
Kaeberlein, M.2
Caldwell, S.D.3
Kennedy, B.K.4
Fields, S.5
-
71
-
-
0042161896
-
Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway
-
Puig O., Marr M.T., Ruhf M.L., and Tjian R. Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 17 (2003) 2006-2020
-
(2003)
Genes Dev.
, vol.17
, pp. 2006-2020
-
-
Puig, O.1
Marr, M.T.2
Ruhf, M.L.3
Tjian, R.4
-
72
-
-
0037052544
-
Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes
-
Rulifson E.J., Kim S.K., and Nusse R. Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296 (2002) 1118-1120
-
(2002)
Science
, vol.296
, pp. 1118-1120
-
-
Rulifson, E.J.1
Kim, S.K.2
Nusse, R.3
-
73
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
Saltiel A.R., and Kahn C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414 (2001) 799-806
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
74
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov D.D., Guertin D.A., Ali S.M., and Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 (2005) 1098-1101
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
75
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov D.D., Ali S.M., Sengupta S., Sheen J.-H., Hsu P.P., Bagley A.F., Markhard A.L., and Sabatini D.M. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell 22 (2006) 159-168
-
(2006)
Mol. Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.-H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
76
-
-
18244379033
-
Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice
-
Sharp Z.D., and Bartke A. Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice. J. Gerontol. A Biol. Sci. Med. Sci. 60 (2005) 293-300
-
(2005)
J. Gerontol. A Biol. Sci. Med. Sci.
, vol.60
, pp. 293-300
-
-
Sharp, Z.D.1
Bartke, A.2
-
77
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
Shaw R.J., Bardeesy N., Manning B.D., Lopez L., Kosmatka M., DePinho R.A., and Cantley L.C. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6 (2004) 91-99
-
(2004)
Cancer Cell
, vol.6
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
DePinho, R.A.6
Cantley, L.C.7
-
78
-
-
0032883802
-
The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes
-
Spradling A.C., Stern D., Beaton A., Rhem E.J., Laverty T., Mozden N., Misra S., and Rubin G.M. The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics 153 (1999) 135-177
-
(1999)
Genetics
, vol.153
, pp. 135-177
-
-
Spradling, A.C.1
Stern, D.2
Beaton, A.3
Rhem, E.J.4
Laverty, T.5
Mozden, N.6
Misra, S.7
Rubin, G.M.8
-
79
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
Tatar M., Bartke A., and Antebi A. The endocrine regulation of aging by insulin-like signals. Science 299 (2003) 1346-1351
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
80
-
-
23944525416
-
4E-BP functions as a metabolic brake used under stress conditions but not during normal growth
-
Teleman A.A., Chen Y.W., and Cohen S.M. 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev. 19 (2005) 1844-1848
-
(2005)
Genes Dev.
, vol.19
, pp. 1844-1848
-
-
Teleman, A.A.1
Chen, Y.W.2
Cohen, S.M.3
-
81
-
-
22944488274
-
Drosophila Melted modulates FOXO and TOR activity
-
Teleman A.A., Chen Y.W., and Cohen S.M. Drosophila Melted modulates FOXO and TOR activity. Dev. Cell 9 (2005) 271-281
-
(2005)
Dev. Cell
, vol.9
, pp. 271-281
-
-
Teleman, A.A.1
Chen, Y.W.2
Cohen, S.M.3
-
82
-
-
32644435565
-
Drosophila lacking microRNA miR-278 are defective in energy homeostasis
-
Teleman A.A., and Cohen S.M. Drosophila lacking microRNA miR-278 are defective in energy homeostasis. Genes Dev. 20 (2006) 417-422
-
(2006)
Genes Dev.
, vol.20
, pp. 417-422
-
-
Teleman, A.A.1
Cohen, S.M.2
-
83
-
-
23944507152
-
Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP
-
Tettweiler G., Miron M., Jenkins M., Sonenberg N., and Lasko P.F. Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes Dev. 19 (2005) 1840-1843
-
(2005)
Genes Dev.
, vol.19
, pp. 1840-1843
-
-
Tettweiler, G.1
Miron, M.2
Jenkins, M.3
Sonenberg, N.4
Lasko, P.F.5
-
85
-
-
24144446404
-
Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
-
Tremblay F., Krebs M., Dombrowski L., Brehm A., Bernroider E., Roth E., Nowotny P., Waldhausl W., Marette A., and Roden M. Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 54 (2005) 2674-2684
-
(2005)
Diabetes
, vol.54
, pp. 2674-2684
-
-
Tremblay, F.1
Krebs, M.2
Dombrowski, L.3
Brehm, A.4
Bernroider, E.5
Roth, E.6
Nowotny, P.7
Waldhausl, W.8
Marette, A.9
Roden, M.10
-
86
-
-
33644886769
-
Nutrients suppress PI3K/Akt signaling via raptor-dependent mTOR-mediated IRS1 phosphorylation
-
Tzatsos A., and Kandror K.V. Nutrients suppress PI3K/Akt signaling via raptor-dependent mTOR-mediated IRS1 phosphorylation. Mol. Cell. Biol. 26 (2006) 63-74
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 63-74
-
-
Tzatsos, A.1
Kandror, K.V.2
-
87
-
-
16844370268
-
Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway
-
Ueno M., Carvalheira J.B., Tambascia R.C., Bezerra R.M., Amaral M.E., Carneiro E.M., Folli F., Franchini K.G., and Saad M.J. Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway. Diabetologia 48 (2005) 506-518
-
(2005)
Diabetologia
, vol.48
, pp. 506-518
-
-
Ueno, M.1
Carvalheira, J.B.2
Tambascia, R.C.3
Bezerra, R.M.4
Amaral, M.E.5
Carneiro, E.M.6
Folli, F.7
Franchini, K.G.8
Saad, M.J.9
-
88
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
Um S.H., Frigerio F., Watanabe M., Picard F., Joaquin M., Sticker M., Fumagalli S., Allegrini P.R., Kozma S.C., Auwerx J., and Thomas G. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431 (2004) 200-205
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
Picard, F.4
Joaquin, M.5
Sticker, M.6
Fumagalli, S.7
Allegrini, P.R.8
Kozma, S.C.9
Auwerx, J.10
Thomas, G.11
-
89
-
-
0642367846
-
Genetics: influence of TOR kinase on lifespan in C. elegans
-
Vellai T., Takacs-Vellai K., Zhang Y., Kovacs A.L., Orosz L., and Muller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426 (2003) 620
-
(2003)
Nature
, vol.426
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
Muller, F.6
-
90
-
-
9644278037
-
Insulin regulation of heart function in aging fruit flies
-
Wessells R.J., Fitzgerald E., Cypser J.R., Tatar M., and Bodmer R. Insulin regulation of heart function in aging fruit flies. Nat. Genet. 36 (2004) 1275-1281
-
(2004)
Nat. Genet.
, vol.36
, pp. 1275-1281
-
-
Wessells, R.J.1
Fitzgerald, E.2
Cypser, J.R.3
Tatar, M.4
Bodmer, R.5
-
91
-
-
0034613164
-
Regulation of C. elegans life-span by insulinlike signaling in the nervous system
-
Wolkow C.A., Kimura K.D., Lee M.S., and Ruvkun G. Regulation of C. elegans life-span by insulinlike signaling in the nervous system. Science 290 (2000) 147-150
-
(2000)
Science
, vol.290
, pp. 147-150
-
-
Wolkow, C.A.1
Kimura, K.D.2
Lee, M.S.3
Ruvkun, G.4
-
92
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S., Loewith R., and Hall M. TOR signaling in growth and metabolism. Cell 124 (2006) 471-484
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.3
-
93
-
-
0034312315
-
Regulation of cellular growth by the Drosophila target of rapamycin dTOR
-
Zhang H., Stallock J.P., Ng J.C., Reinhard C., and Neufeld T.P. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev. 14 (2000) 2712-2724
-
(2000)
Genes Dev.
, vol.14
, pp. 2712-2724
-
-
Zhang, H.1
Stallock, J.P.2
Ng, J.C.3
Reinhard, C.4
Neufeld, T.P.5
|