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Volumn 289, Issue 1 52-1, 2005, Pages

Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart

Author keywords

Glucose metabolism; High fat feeding; Insulin action; Lipid metabolism; Triglyceride

Indexed keywords

ACYL COENZYME A; FATTY ACID; HORMONE SENSITIVE LIPASE; INSULIN; TRIACYLGLYCEROL;

EID: 20544449419     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00251.2004     Document Type: Article
Times cited : (82)

References (60)
  • 1
    • 2642614548 scopus 로고    scopus 로고
    • Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro
    • Anthonsen MW, Ronnstrand L, and Wernstedt C. Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro. J Biol Chem 273: 213-221, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 213-221
    • Anthonsen, M.W.1    Ronnstrand, L.2    Wernstedt, C.3
  • 2
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG and Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911-917, 1959.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 3
    • 0034813837 scopus 로고    scopus 로고
    • Obesity, free fatty acids, and insulin resistance
    • Boden G. Obesity, free fatty acids, and insulin resistance. Curr Opin Endo Diabetes 8: 235-239, 2001.
    • (2001) Curr Opin Endo Diabetes , vol.8 , pp. 235-239
    • Boden, G.1
  • 4
    • 8844255630 scopus 로고    scopus 로고
    • Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and β-cell dysfunction
    • Boden G and Shulman GI. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and β-cell dysfunction. Eur J Clin Invest 32: 14-23, 2002.
    • (2002) Eur J Clin Invest , vol.32 , pp. 14-23
    • Boden, G.1    Shulman, G.I.2
  • 5
    • 0035405847 scopus 로고    scopus 로고
    • Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects
    • Boden G, Lebed B, Schatz M, Homko C, and Lemieux S. Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 50: 1612-1617, 2001.
    • (2001) Diabetes , vol.50 , pp. 1612-1617
    • Boden, G.1    Lebed, B.2    Schatz, M.3    Homko, C.4    Lemieux, S.5
  • 6
    • 0031753812 scopus 로고    scopus 로고
    • Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat
    • Chalkley SM, Hettiarachchi M, Chisholm DJ, and Kraegen EW. Five-hour fatty acid elevation increases muscle lipids and impairs glycogen synthesis in the rat. Metabolism 47: 1121-1126, 1998.
    • (1998) Metabolism , vol.47 , pp. 1121-1126
    • Chalkley, S.M.1    Hettiarachchi, M.2    Chisholm, D.J.3    Kraegen, E.W.4
  • 10
    • 0024026298 scopus 로고
    • The triumvirate: Beta-cell, muscle, liver. A collusion responsible for NIDDM
    • DeFronzo RA. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37: 667-687, 1988.
    • (1988) Diabetes , vol.37 , pp. 667-687
    • DeFronzo, R.A.1
  • 13
    • 0037417725 scopus 로고    scopus 로고
    • A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation of dietary fat content
    • Finck BN, Han X, Courtois M, Almond F, Nerbonne JM, Kovacs A, Gross RW, and Kelly DP. A critical role for PPARα-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation of dietary fat content. Proc Natl Acad Sci USA 100: 1226-1231, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1226-1231
    • Finck, B.N.1    Han, X.2    Courtois, M.3    Almond, F.4    Nerbonne, J.M.5    Kovacs, A.6    Gross, R.W.7    Kelly, D.P.8
  • 15
    • 0029176539 scopus 로고
    • Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: Implications for the control of fat storage and fat mobilization
    • Frayn KN, Coppack SW, Fielding BA, and Humphreys SM. Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization. Adv Enzyme Regul 35: 163-178, 1995.
    • (1995) Adv Enzyme Regul , vol.35 , pp. 163-178
    • Frayn, K.N.1    Coppack, S.W.2    Fielding, B.A.3    Humphreys, S.M.4
  • 16
    • 0029920693 scopus 로고    scopus 로고
    • Lipoprotein lipase and lipolysis: Central roles in lipoprotein metabolism and atherogenesis
    • Goldberg IJ. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J Lipid Res 37: 693-707, 1996.
    • (1996) J Lipid Res , vol.37 , pp. 693-707
    • Goldberg, I.J.1
  • 18
    • 0037066776 scopus 로고    scopus 로고
    • Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle
    • Haemmerle G, Zimmermann R, Strauss JG, Kratky D, Riederer M, Knipping G, and Zechner R. Hormone-sensitive lipase deficiency in mice changes the plasma lipid profile by affecting the tissue-specific expression pattern of lipoprotein lipase in adipose tissue and muscle. J Biol Chem 277: 12946-12952, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 12946-12952
    • Haemmerle, G.1    Zimmermann, R.2    Strauss, J.G.3    Kratky, D.4    Riederer, M.5    Knipping, G.6    Zechner, R.7
  • 19
    • 0036109168 scopus 로고    scopus 로고
    • Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice
    • Hajri T, Han XX, Bonen A, and Abumrad NA. Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice. J Clin Invest 109: 1381-1389, 2002.
    • (2002) J Clin Invest , vol.109 , pp. 1381-1389
    • Hajri, T.1    Han, X.X.2    Bonen, A.3    Abumrad, N.A.4
  • 21
    • 0033826850 scopus 로고    scopus 로고
    • Molecular mechanisms regulating hormone-sensitive lipase and lipolysis
    • Holm C, Osterlund T, Laurell H, and Contreras JA. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Annu Rev Nutr 20: 365-393, 2000.
    • (2000) Annu Rev Nutr , vol.20 , pp. 365-393
    • Holm, C.1    Osterlund, T.2    Laurell, H.3    Contreras, J.A.4
  • 23
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, and Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87-91, 1993.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 24
    • 0027953703 scopus 로고
    • Insulin action, diabetogenes, and the cause of type II diabetes
    • Kahn CR. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 43: 1066-1084, 1994.
    • (1994) Diabetes , vol.43 , pp. 1066-1084
    • Kahn, C.R.1
  • 25
    • 0033659881 scopus 로고    scopus 로고
    • Unraveling the mechanism of action of thiazolidinediones
    • Kahn CR, Chen L, and Cohen SE. Unraveling the mechanism of action of thiazolidinediones. J Clin Invest 106: 1305-1307, 2000.
    • (2000) J Clin Invest , vol.106 , pp. 1305-1307
    • Kahn, C.R.1    Chen, L.2    Cohen, S.E.3
  • 30
    • 0031796690 scopus 로고    scopus 로고
    • The putative role of the hormone-sensitive lipase gene in the pathogenesis of Type II diabetes mellitus and abdominal obesity
    • Klannemark M, Orho M, Langin D, Laurell H, Holm C, Reynisdottir S, Arner P, and Groop L. The putative role of the hormone-sensitive lipase gene in the pathogenesis of Type II diabetes mellitus and abdominal obesity. Diabetologia 41: 1516-1522, 1998.
    • (1998) Diabetologia , vol.41 , pp. 1516-1522
    • Klannemark, M.1    Orho, M.2    Langin, D.3    Laurell, H.4    Holm, C.5    Reynisdottir, S.6    Arner, P.7    Groop, L.8
  • 32
    • 0026468362 scopus 로고
    • What if Minkowski had been ageusic? An alternative angle on diabetes
    • McGarry JD. What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258: 766-770, 1992.
    • (1992) Science , vol.258 , pp. 766-770
    • McGarry, J.D.1
  • 34
    • 0026518355 scopus 로고
    • Increased lipolysis and its consequence on gluconeogenesis in non-insulin-dependent diabetes mellitus
    • Nurjhan N, Consoli A, and Gerich J. Increased lipolysis and its consequence on gluconeogenesis in non-insulin-dependent diabetes mellitus. J Clin Invest 89: 169-175, 1992.
    • (1992) J Clin Invest , vol.89 , pp. 169-175
    • Nurjhan, N.1    Consoli, A.2    Gerich, J.3
  • 37
    • 0035155272 scopus 로고    scopus 로고
    • Serine/threonine phosphorylation of IRS-1 triggers its degradation. Possible regulation by tyrosine phosphorylation
    • Pederson TM, Kramer DL, and Rondinone CM. Serine/threonine phosphorylation of IRS-1 triggers its degradation. Possible regulation by tyrosine phosphorylation. Diabetes 50: 24-31, 2001.
    • (2001) Diabetes , vol.50 , pp. 24-31
    • Pederson, T.M.1    Kramer, D.L.2    Rondinone, C.M.3
  • 39
    • 0034671645 scopus 로고    scopus 로고
    • Contrasting effects of 1RS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo
    • Previs SF, Withers DJ, Ren JM, White MF, and Shulman GI. Contrasting effects of 1RS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo. J Biol Chem 275: 38990-38994, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 38990-38994
    • Previs, S.F.1    Withers, D.J.2    Ren, J.M.3    White, M.F.4    Shulman, G.I.5
  • 40
    • 50549202600 scopus 로고
    • The glucose fatty acid cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • Randle PJ, Garland PB, Hales CN, and Newsholme EA. The glucose fatty acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1: 785-789, 1963.
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 41
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven GM. Role of insulin resistance in human disease. Diabetes 37: 1595-1607, 1988.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 43
    • 85047677635 scopus 로고
    • The diabetic heart: Metabolic causes for the development of a cardiomyopathy
    • Rodrigues B and McNeill JH. The diabetic heart: metabolic causes for the development of a cardiomyopathy. Cardiovasc Res 26: 913-922, 1992.
    • (1992) Cardiovasc Res , vol.26 , pp. 913-922
    • Rodrigues, B.1    McNeill, J.H.2
  • 44
    • 0035461405 scopus 로고    scopus 로고
    • A role for hormone-sensitive lipase in glucose-stimulated insulin secretion. A study in hormone-sensitive lipase-deficient mice
    • Roduit R, Masiello P, Wang SP, Li H, Mitchell GA, and Prentki M. A role for hormone-sensitive lipase in glucose-stimulated insulin secretion. A study in hormone-sensitive lipase-deficient mice. Diabetes 50: 1970-1975, 2001.
    • (2001) Diabetes , vol.50 , pp. 1970-1975
    • Roduit, R.1    Masiello, P.2    Wang, S.P.3    Li, H.4    Mitchell, G.A.5    Prentki, M.6
  • 46
    • 0015122097 scopus 로고
    • Studies on the hormone-sensitive lipase of adipose tissue
    • Schwartz JP and Jungas RL. Studies on the hormone-sensitive lipase of adipose tissue. J Lipid Res 12: 553-562, 1971.
    • (1971) J Lipid Res , vol.12 , pp. 553-562
    • Schwartz, J.P.1    Jungas, R.L.2
  • 48
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 106: 171-176, 2000.
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 50
    • 0021945547 scopus 로고
    • Defective energy metabolism of the heart in diabetes
    • Taegtmeyer H and Passmore JM. Defective energy metabolism of the heart in diabetes. Lancet 1: 139-141, 1985.
    • (1985) Lancet , vol.1 , pp. 139-141
    • Taegtmeyer, H.1    Passmore, J.M.2
  • 51
    • 0036706587 scopus 로고    scopus 로고
    • Association of the hormone sensitive lipase -60C > G variant with fasting insulin levels in healthy young men
    • Talmud PJ, Palmen J, Nicaud V, and Tiret L. Association of the hormone sensitive lipase -60C > G variant with fasting insulin levels in healthy young men. Nutr Metab Cardiovasc Dis 12: 173-177, 2002.
    • (2002) Nutr Metab Cardiovasc Dis , vol.12 , pp. 173-177
    • Talmud, P.J.1    Palmen, J.2    Nicaud, V.3    Tiret, L.4
  • 52
    • 0035969522 scopus 로고    scopus 로고
    • Variation in the promoter of the human hormone sensitive lipase gene shows gender specific effects on insulin and lipid levels: Results from the Ely study
    • Talmud PJ, Palmen J, Luan J, Flavell D, Byrne CD, Waterworth DM, and Wareham NJ. Variation in the promoter of the human hormone sensitive lipase gene shows gender specific effects on insulin and lipid levels: results from the Ely study. Biochim Biophys Acta 1537: 239-244, 2001.
    • (2001) Biochim Biophys Acta , vol.1537 , pp. 239-244
    • Talmud, P.J.1    Palmen, J.2    Luan, J.3    Flavell, D.4    Byrne, C.D.5    Waterworth, D.M.6    Wareham, N.J.7
  • 56
    • 0025273134 scopus 로고
    • Hormone-sensitive lipase-α multipurpose enzyme in lipid metabolism
    • Yeaman SJ. Hormone-sensitive lipase-α multipurpose enzyme in lipid metabolism. Biochim Biophys Acta 1052: 128-132, 1990.
    • (1990) Biochim Biophys Acta , vol.1052 , pp. 128-132
    • Yeaman, S.J.1
  • 58
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKK-beta
    • Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, and Shoelson SE. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of IKK-beta. Science 293: 1673-1677, 2001.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.W.5    Karin, M.6    Shoelson, S.E.7
  • 59
    • 0024325441 scopus 로고
    • Diabetic cardiomyopathy
    • Zarich SW and Nesto RW. Diabetic cardiomyopathy. Am Heart J 118: 1000-1012, 1989.
    • (1989) Am Heart J , vol.118 , pp. 1000-1012
    • Zarich, S.W.1    Nesto, R.W.2
  • 60
    • 0344667491 scopus 로고    scopus 로고
    • Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipase-deficient white adipose tissue
    • Zimmerman R, Haemmerle G, Wagner EM, Strauss JG, Kratky D, and Zechner R. Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipase-deficient white adipose tissue. J Lipid Res 44: 2089-2099, 2003.
    • (2003) J Lipid Res , vol.44 , pp. 2089-2099
    • Zimmerman, R.1    Haemmerle, G.2    Wagner, E.M.3    Strauss, J.G.4    Kratky, D.5    Zechner, R.6


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