Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets

Diabetes

Volumn 53, Issue SUPPL. 3, 2004, Pages

  Kwon, Guim ^a   Marshall, Connie A ^a   Pappan, Kirk L ^a   Remedi, Maria S ^a   McDaniel, Michael L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; AMINO ACID; ANTIDIABETIC AGENT; CALCIUM ION; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; DIAZOXIDE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; EXENDIN 4; GLIBENCLAMIDE; GLUCAGON LIKE PEPTIDE 1 AGONIST; GLUCOSE; GROWTH FACTOR; INSULIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; NIFEDIPINE; OXIDOREDUCTASE; POTASSIUM CHANNEL; PROINSULIN; S6 KINASE; S6 KINASE 1; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG;

CELL GROWTH; CELL PROLIFERATION; CONFERENCE PAPER; DNA SYNTHESIS; DRUG MECHANISM; ENZYME INHIBITION; HORMONE ACTION; HYPOTHESIS; INSULIN SYNTHESIS; NONHUMAN; NUTRIENT; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CYCLIC AMP; DIAZOXIDE; FORSKOLIN; GROWTH SUBSTANCES; HUMANS; INSULIN; ISLETS OF LANGERHANS; NUTRITION PHYSIOLOGY; PHOSPHORYLATION; PROTEIN KINASES; SIGNAL TRANSDUCTION;

EID: 9444234587     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.suppl_3.S225     Document Type: Conference Paper

References (30)

1. Harris TE, Lawrence Jr JC: TOR signaling. Sci STKE 212:re15:1-17, 2003
2. Beretta L, Gingras AC, Svitkin YV, Hall MN, Sonenberg N: Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J 15:658-664, 1996
3. Meyuhas O: Synthesis of the translational apparatus is regulated at the translational level. Eur J Biochem 267:6321-6330, 2000
4. Lawrence JC Jr, Abraham RT: PHAS/4E-BPs as regulators of mRNA translation and cell proliferation. Trends Biochem Sci 22:345-349, 1997
5. Morley SJ: Intracellular signaling pathways regulating initiation factor eIF4E phosphoiylation during the activation of cell growth. Biochem Soc Trans 25:503-509
6. Gingras AC, Raught B, Sonenberg N: eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 68:913-963, 1999
7. Cutlar NS, Heitman J, Cardenas ME: TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals. Mol Cell Endocrinol 155:135-142, 1999
8. McDaniel ML, Marshall CA, Pappan KL, Kwon GK: Metabolic and autocrine regulation of the mammalian target of rapamycin by pancreatic β-cells. Diabetes 51:2877-2885, 2002
9. Xu G, Marshall CA, Lin T-A, Kwon G, Munivenkatappa RB, Hill JR, Lawrence JC Jr, McDaniel ML: Insulin mediates glucose stimulated phosphorylation of PHAS-I by pancreatic β-cells: an insulin-receptor mechanism for autoregulation of protein synthesis by translation. J Biol Chem 273:4485-4491, 1998
10. Xu G, Kwon G, Marshall CA, Lin T-A, Lawrence JC Jr, McDaniel ML: Branched-chain amino acids are essential in the regulation of PHAS-I and p70S6 kinase by pancreatic β-cells: a possible role in protein translation and mitogenic signaling. J Biol Chem 273:28178-28184, 1998
11. Xu G, Kwon G, Cruz WS, Marshall CA, McDaniel ML: Metabolic regulation by leucine of translation initiation through the mTOR-signaling pathway by pancreatic β-cells. Diabetes 50:353-360, 2001
12. Pende M, Kozma SC, Jaquet M, Oorschot V, Burcelin R, Le Marchand-Brustel Y, Kmmperman J, Thorens B, Thomas G: Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice. Nature 408:994-997, 2002
13. Mayo KE, Miller LJ, Bataille D, Dalle S, Goke B, Thorens B, Drucker DJ: International Union of Pharmacology. XXXV. The Glucagon Receptor Family. Pharmacol Rev 55:167-194, 2003
14. Drucker DJ: Glucagon-like peptides: Regulators of cell proliferation, differentiation, and apoptosis. Mol Endocrinol 17:161-171, 2003
15. Holz GG, Chepurny OG: Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus. Curr Med Chem 10:2471-2483, 2003
16. Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H, Bertolotto C, Di Mario U, Harlan DM, Perfetti R: Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology 144:5149-5158, 2003
17. Xu G, Stoffers DA, Habener JF, Bonner-Wejr S: Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48:2270-2276, 1999
18. Tourrel C, Bailbe D, Lacorne M, Meile MJ, Kergoat M, Portha B: Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4. Diabetes 51:1443-1452, 2002
19. Leech CA, Holz GG, Chepurny O, Habener JF: Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic β-cells. Biochem Biophys Res Commun 278:44-47, 2003
20. Fineman MS, Bicsak TA, Shen LZ, Taylor K, Gaines E, Varns A, Kim D, Baron AD: Effect of glycemic control of Exenatide (synthetic Exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes. Diabetes Care 26:2370-2377, 2003
21. Kashima Y, Miki T, Shibasaki T, Ozaki N, Miyazaki M, Yano H, Seino S: Critical role of cAMP-GEFII.Rim2 complex in incretin-potentiated insulin secretion. J Biol Chem 276:46046-46053, 2001
22. 2+ signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1. J Biol Chem 270:17749-17757, 1995
23. 2+ signaling system simulated by the insulinotropic hormone glucagon-like peptide-1 (7-37). J Biol Chem 274: 14147-14156, 1999
24. + channels in an insulin-secreting cell line. J Membr Biol 99:215-224, 1987
25. Desai BN, Myers BR, Schreiber SL: FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc Natl Acad Sci U S A 99:4319-4324, 2002
26. Arsham AM, Howell JJ, Simon MC: A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J Biol Chem 278:29655-29669, 2003
27. Dennis PB, Jaesschke A, Saitoh M, Fowler B, Kozma SC, Thomas G: mTOR: a homeostatic ATP sensor. Science 294:1102-1105, 2001
28. 2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 β-cells. Biochem J 369:287-299, 2003
29. Briaud I, Lingohr MK, Dickson LM, Wrede CE, Rhodes CJ: Differential activation mechanisms of erk-1/2 and p70s6k by glucose in pancreatic β-cells. Diabetes 52:974-983, 2003
30. Kwon GK, Pappan KL, Marshall CA, Schaffer JE, McDaniel ML: Cyclic AMP dose-dependently prevents palmitate-induced apoptosis by both PKA- and cAMP-GEF-dependent pathways in β-cells. J Biol Chem 279:8938-8945, 2004