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Volumn 6, Issue 5, 2006, Pages 347-359

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; IMATINIB; NOTCH1 RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN;

EID: 33646366173     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1880     Document Type: Review
Times cited : (354)

References (175)
  • 2
    • 7044263031 scopus 로고    scopus 로고
    • Outcome of treatment in adults with acute lymphoblastic leukemia: Analysis of the LALA-94 trial
    • Thomas, X. et al. Outcome of treatment in adults with acute lymphoblastic leukemia: analysis of the LALA-94 trial. J. Clin. Oncol. 22, 4075-4086 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 4075-4086
    • Thomas, X.1
  • 3
    • 0036464686 scopus 로고    scopus 로고
    • Treatment of adult acute lymphoblastic leukemia (ALL): Long-term follow-up of the GIMEMA ALL 0288 randomized study
    • Annino, L. et al. Treatment of adult acute lymphoblastic leukemia (ALL): long-term follow-up of the GIMEMA ALL 0288 randomized study. Blood 99, 863-871 (2002).
    • (2002) Blood , vol.99 , pp. 863-871
    • Annino, L.1
  • 4
    • 0037092959 scopus 로고    scopus 로고
    • Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia
    • Linker, C., Damon, L., Ries, C. & Navarro, W. Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukemia. J. Clin. Oncol. 20, 2464-2471 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 2464-2471
    • Linker, C.1    Damon, L.2    Ries, C.3    Navarro, W.4
  • 5
    • 8644242365 scopus 로고    scopus 로고
    • Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high-dose therapy and autologous BMT: A GOELAMS trial
    • Hunault, M. et al. Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high-dose therapy and autologous BMT: a GOELAMS trial. Blood 104, 3028-3037 (2004).
    • (2004) Blood , vol.104 , pp. 3028-3037
    • Hunault, M.1
  • 6
    • 27244440324 scopus 로고    scopus 로고
    • Molecular genetics of acute lymphoblastic leukemia
    • Armstrong, S. A. & Look, A. T. Molecular genetics of acute lymphoblastic leukemia. J. Clin. Oncol. 23, 6306-6315 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 6306-6315
    • Armstrong, S.A.1    Look, A.T.2
  • 7
    • 37049182717 scopus 로고
    • Deregulation of c-myc by translocation of the α-locus of the T-cell receptor in T-cell leukemias
    • Erikson, J. et al. Deregulation of c-myc by translocation of the α-locus of the T-cell receptor in T-cell leukemias. Science 232, 884-886 (1986).
    • (1986) Science , vol.232 , pp. 884-886
    • Erikson, J.1
  • 8
    • 27644497232 scopus 로고    scopus 로고
    • Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia
    • Meng, Y. S., Khoury, H., Dick, J. E. & Minden, M. D. Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia. Leukemia 19, 1941-1947 (2005).
    • (2005) Leukemia , vol.19 , pp. 1941-1947
    • Meng, Y.S.1    Khoury, H.2    Dick, J.E.3    Minden, M.D.4
  • 9
    • 0027759976 scopus 로고
    • TAL1, TAL2 and LYL1: A family of basic helix-loop-helix proteins implicated in T cell acute leukaemia
    • Baer, R. TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia. Semin. Cancer Biol. 4, 341-347 (1993).
    • (1993) Semin. Cancer Biol. , vol.4 , pp. 341-347
    • Baer, R.1
  • 10
    • 0030752361 scopus 로고    scopus 로고
    • E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas
    • Bain, G. et al. E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas. Mol. Cell. Biol. 17, 4782-4791 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4782-4791
    • Bain, G.1
  • 11
    • 0030666853 scopus 로고    scopus 로고
    • High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice
    • Yan, W. et al. High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice. Mol. Cell. Biol. 17, 7317-7327 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 7317-7327
    • Yan, W.1
  • 12
    • 0035963295 scopus 로고    scopus 로고
    • The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice
    • O'Neil, J., Billa, M., Oikemus, S. & Kelliher, M. The DNA binding activity of TAL-1 is not required to induce leukemia/lymphoma in mice. Oncogene 20, 3897-3905 (2001).
    • (2001) Oncogene , vol.20 , pp. 3897-3905
    • O'Neil, J.1    Billa, M.2    Oikemus, S.3    Kelliher, M.4
  • 13
    • 0033043388 scopus 로고    scopus 로고
    • Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: Parallels with E2A-deficient mice
    • Chervinsky, D. S. et al. Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice. Mol. Cell. Biol. 19, 5025-5035 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5025-5035
    • Chervinsky, D.S.1
  • 14
    • 17144474314 scopus 로고    scopus 로고
    • Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia
    • Ferrando, A. A. et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 1, 75-87 (2002). This study represents one of the first attempts to use gene-expression profiling for the classification of T-ALL subtypes, identification of novel oncogenic factors and the prognostic relevance of gene profiles.
    • (2002) Cancer Cell , vol.1 , pp. 75-87
    • Ferrando, A.A.1
  • 15
    • 10744222734 scopus 로고    scopus 로고
    • Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia
    • Ferrando, A. A. et al. Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia. Lancet 363, 535-536 (2004).
    • (2004) Lancet , vol.363 , pp. 535-536
    • Ferrando, A.A.1
  • 16
    • 1442307956 scopus 로고    scopus 로고
    • Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia
    • Ferrando, A. A. et al. Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Blood 103, 1909-1911 (2004).
    • (2004) Blood , vol.103 , pp. 1909-1911
    • Ferrando, A.A.1
  • 17
    • 0027973545 scopus 로고
    • Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia
    • Wadman, I. et al. Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. EMBO J. 13, 4831-4839 (1994).
    • (1994) EMBO J. , vol.13 , pp. 4831-4839
    • Wadman, I.1
  • 18
    • 0027980311 scopus 로고
    • The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells
    • Valge-Archer, V. E. et al. The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Proc. Natl Acad. Sci. USA 91, 8617-8621 (1994).
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8617-8621
    • Valge-Archer, V.E.1
  • 19
    • 0030658039 scopus 로고    scopus 로고
    • Oncogenic transcription factors in the human acute leukemias
    • Look, A. T. Oncogenic transcription factors in the human acute leukemias. Science 278, 1059-1064 (1997).
    • (1997) Science , vol.278 , pp. 1059-1064
    • Look, A.T.1
  • 20
    • 20144363957 scopus 로고    scopus 로고
    • A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias
    • Speleman, F. et al. A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias. Leukemia 19, 358-366 (2005).
    • (2005) Leukemia , vol.19 , pp. 358-366
    • Speleman, F.1
  • 21
    • 22044457152 scopus 로고    scopus 로고
    • HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL)
    • Soulier, J. et al. HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL). Blood 106, 274-286 (2005).
    • (2005) Blood , vol.106 , pp. 274-286
    • Soulier, J.1
  • 22
    • 0037082446 scopus 로고    scopus 로고
    • HOX-A10 regulates hematopoietic lineage commitment: Evidence for a monocyte-specific transcription factor
    • Taghon, T. et al. HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor. Blood 99, 1197-1204 (2002).
    • (2002) Blood , vol.99 , pp. 1197-1204
    • Taghon, T.1
  • 23
    • 0038040548 scopus 로고    scopus 로고
    • Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: Implications for human T-cell development
    • Taghon, T. et al. Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development. Leukemia 17, 1157-1163 (2003).
    • (2003) Leukemia , vol.17 , pp. 1157-1163
    • Taghon, T.1
  • 24
    • 0038240453 scopus 로고    scopus 로고
    • Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: Dominance of HOX dysregulation
    • Ferrando, A. A. et al. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood 102, 262-268 (2003).
    • (2003) Blood , vol.102 , pp. 262-268
    • Ferrando, A.A.1
  • 25
    • 0028335821 scopus 로고
    • Hox11 controls the genesis of the spleen
    • Roberts, C. W., Shutter, J. R. & Korsmeyer, S. J. Hox11 controls the genesis of the spleen. Nature 368, 747-749 (1994).
    • (1994) Nature , vol.368 , pp. 747-749
    • Roberts, C.W.1    Shutter, J.R.2    Korsmeyer, S.J.3
  • 26
    • 0141613827 scopus 로고    scopus 로고
    • T(5;14)/HOX11 L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Croupe Francais de Cytogenetique Hematologique (GFCH)
    • Berger, R. et al. t(5;14)/HOX11 L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Croupe Francais de Cytogenetique Hematologique (GFCH). Leukemia 17, 1851-1857 (2003).
    • (2003) Leukemia , vol.17 , pp. 1851-1857
    • Berger, R.1
  • 27
    • 0036682493 scopus 로고    scopus 로고
    • HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis
    • Ballerini, P. et al. HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis. Blood 100, 991-997 (2002).
    • (2002) Blood , vol.100 , pp. 991-997
    • Ballerini, P.1
  • 28
    • 9144253121 scopus 로고    scopus 로고
    • Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: Results of EORTC studies 58881 and 58951
    • Cave, H. et al. Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951. Blood 103, 442-450 (2004).
    • (2004) Blood , vol.103 , pp. 442-450
    • Cave, H.1
  • 29
    • 0029953937 scopus 로고    scopus 로고
    • The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family
    • Dreyling, M. H. et al. The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. Proc. Natl Acad. Sci. USA 93, 4804-4809 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4804-4809
    • Dreyling, M.H.1
  • 30
    • 0041743184 scopus 로고    scopus 로고
    • CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRγδ lineage
    • Asnafi, V. et al. CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRγδ lineage. Blood 102, 1000-6 (2003).
    • (2003) Blood , vol.102 , pp. 1000-1006
    • Asnafi, V.1
  • 31
    • 0037226808 scopus 로고    scopus 로고
    • A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein
    • Wechsler, D. S. et al. A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein. Genes Chromosomes Cancer 36, 26-36 (2003).
    • (2003) Genes Chromosomes Cancer , vol.36 , pp. 26-36
    • Wechsler, D.S.1
  • 32
    • 0029130257 scopus 로고
    • The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene
    • Chaplin, T. et al. The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene. Blood 86, 2073-2076 (1995).
    • (1995) Blood , vol.86 , pp. 2073-2076
    • Chaplin, T.1
  • 33
    • 6944252248 scopus 로고    scopus 로고
    • Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia
    • Graux, C. et al. Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. Nature Genet. 36, 1084-1089 (2004).
    • (2004) Nature Genet. , vol.36 , pp. 1084-1089
    • Graux, C.1
  • 34
    • 20444378917 scopus 로고    scopus 로고
    • Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32)
    • De Keersmaecker, K. et al. Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32). Blood 105, 4849-4852 (2005).
    • (2005) Blood , vol.105 , pp. 4849-4852
    • De Keersmaecker, K.1
  • 35
    • 0035150370 scopus 로고    scopus 로고
    • Molecular cytogenetic and clinical findings in ETV6-ABL1-positive leukemia
    • Van Limbergen, H. et al. Molecular cytogenetic and clinical findings in ETV6-ABL1-positive leukemia. Genes Chromosomes Cancer 30, 274-282 (2001).
    • (2001) Genes Chromosomes Cancer , vol.30 , pp. 274-282
    • Van Limbergen, H.1
  • 36
    • 0032533257 scopus 로고    scopus 로고
    • Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr-abl-transduced bone marrow
    • Pear, W. S. et al. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr-abl-transduced bone marrow. Blood 92, 3780-3792 (1998).
    • (1998) Blood , vol.92 , pp. 3780-3792
    • Pear, W.S.1
  • 37
    • 15444339209 scopus 로고    scopus 로고
    • A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
    • Lacronique, V. et al. A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278, 1309-1312 (1997).
    • (1997) Science , vol.278 , pp. 1309-1312
    • Lacronique, V.1
  • 38
    • 0034660270 scopus 로고    scopus 로고
    • TEL-JAK2 transgenic mice develop T-cell leukemia
    • Carron, C. et al. TEL-JAK2 transgenic mice develop T-cell leukemia. Blood 95, 3891-3899 (2000).
    • (2000) Blood , vol.95 , pp. 3891-3899
    • Carron, C.1
  • 39
    • 0025950015 scopus 로고
    • Chromosomal translocations joining LCK and TCRB loci in human T cell leukemia
    • Tycko, B., Smith, S. D. & Sklar, J. Chromosomal translocations joining LCK and TCRB loci in human T cell leukemia. J. Exp. Med. 174, 867-873 (1991).
    • (1991) J. Exp. Med. , vol.174 , pp. 867-873
    • Tycko, B.1    Smith, S.D.2    Sklar, J.3
  • 40
    • 0028353897 scopus 로고
    • Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia
    • Wright, D. D., Sefton, B. M. & Kamps, M. P. Oncogenic activation of the Lck protein accompanies translocation of the LCK gene in the human HSB2 T-cell leukemia. Mol. Cell. Biol. 14, 2429-2437 (1994).
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 2429-2437
    • Wright, D.D.1    Sefton, B.M.2    Kamps, M.P.3
  • 41
    • 0025254225 scopus 로고
    • N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis
    • Lubbert, M. et al. N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis. Blood 75, 1163-1169 (1990).
    • (1990) Blood , vol.75 , pp. 1163-1169
    • Lubbert, M.1
  • 42
    • 0031870590 scopus 로고    scopus 로고
    • Mutational analysis of the N-ras gene in acute lymphoblastic leukemia: A study of 125 Japanese pediatric cases
    • Yokota, S. et al. Mutational analysis of the N-ras gene in acute lymphoblastic leukemia: a study of 125 Japanese pediatric cases. Int. J. Hematol. 67, 379-387 (1998).
    • (1998) Int. J. Hematol. , vol.67 , pp. 379-387
    • Yokota, S.1
  • 43
    • 0028922510 scopus 로고
    • Mutations of the p53 and ras genes in childhood t(1;19)-acute lymphoblastic leukemia
    • Kawamura, M. et al. Mutations of the p53 and ras genes in childhood t(1;19)-acute lymphoblastic leukemia. Blood 85, 2546-2552 (1995).
    • (1995) Blood , vol.85 , pp. 2546-2552
    • Kawamura, M.1
  • 44
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    • Ellisen, L. W. et al. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66, 649-661 (1991). Describes the identification of the first human Notch gene (NOTCH 1). It also indicates, for the first time, a causative role of activated Notch signalling in human neoplasms.
    • (1991) Cell , vol.66 , pp. 649-661
    • Ellisen, L.W.1
  • 45
    • 0000674913 scopus 로고
    • The theory of the gene
    • Morgan, T. H. The theory of the gene. Am. Nat. 51, 513-544 (1917).
    • (1917) Am. Nat. , vol.51 , pp. 513-544
    • Morgan, T.H.1
  • 46
    • 0022289842 scopus 로고
    • Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing ECF-like repeats
    • Wharton, K. A., Johansen, K. M., Xu, T. & Artavanis-Tsakonas, S. Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing ECF-like repeats. Cell 43, 567-581 (1985).
    • (1985) Cell , vol.43 , pp. 567-581
    • Wharton, K.A.1    Johansen, K.M.2    Xu, T.3    Artavanis-Tsakonas, S.4
  • 47
    • 1642382833 scopus 로고    scopus 로고
    • Notch signaling: Control of cell communication and cell fate
    • Lai, E. C. Notch signaling: control of cell communication and cell fate. Development 131, 965-973 (2004).
    • (2004) Development , vol.131 , pp. 965-973
    • Lai, E.C.1
  • 49
    • 0036467663 scopus 로고    scopus 로고
    • Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway
    • Reizis, B. & Leder, P. Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev. 16, 295-300 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 295-300
    • Reizis, B.1    Leder, P.2
  • 50
    • 0036070308 scopus 로고    scopus 로고
    • Inactivation of Notch 1 impairs VDJβ rearrangement and allows pre-TCR-independent survival of early αβ lineage thymocytes
    • Wolfer, A. et al. Inactivation of Notch 1 impairs VDJβ rearrangement and allows pre-TCR-independent survival of early αβ lineage thymocytes. Immunity 16, 869-879 (2002).
    • (2002) Immunity , vol.16 , pp. 869-879
    • Wolfer, A.1
  • 51
    • 2442522357 scopus 로고    scopus 로고
    • Regulation of αβ/γδ cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling
    • Tanigaki, K. et al. Regulation of αβ/γδ cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. Immunity 20, 611-622 (2004).
    • (2004) Immunity , vol.20 , pp. 611-622
    • Tanigaki, K.1
  • 52
    • 2142654263 scopus 로고    scopus 로고
    • Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation
    • Ciofani, M. et al. Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. J. Immunol. 172, 5230-5239 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 5230-5239
    • Ciofani, M.1
  • 53
    • 0033136717 scopus 로고    scopus 로고
    • Deficient T cell fate specification in mice with an induced inactivation of Notch 1
    • Radtke, R et al. Deficient T cell fate specification in mice with an induced inactivation of Notch 1. Immunity 10, 547-558 (1999). Documents the requirement for Notch 1 activity in T-cell development. A lack of Notch 1 function results in B-cell specification at the expense of T-cells.
    • (1999) Immunity , vol.10 , pp. 547-558
    • Radtke, R.1
  • 54
    • 0035477668 scopus 로고    scopus 로고
    • Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus
    • Wilson, A., MacDonald, H. R. & Radtke, F. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J. Exp. Med. 194, 1003-1012 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 1003-1012
    • Wilson, A.1    MacDonald, H.R.2    Radtke, F.3
  • 55
    • 0037370310 scopus 로고    scopus 로고
    • Notch 1 functions as a tumor suppressor in mouse skin
    • Nicolas, M. et al. Notch 1 functions as a tumor suppressor in mouse skin. Nature Genet. 33, 416-421 (2003).
    • (2003) Nature Genet. , vol.33 , pp. 416-421
    • Nicolas, M.1
  • 56
    • 0023201213 scopus 로고
    • Mammary tumorigenesis in feral mice: Identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors
    • Gallahan, D. & Callahan, R. Mammary tumorigenesis in feral mice: identification of a new int locus in mouse mammary tumor virus (Czech II)-induced mammary tumors. J. Virol. 61, 66 (1987).
    • (1987) J. Virol. , vol.61 , pp. 66
    • Gallahan, D.1    Callahan, R.2
  • 57
    • 0036734148 scopus 로고    scopus 로고
    • Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells
    • Weijzen, S. et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nature Med. 8, 979-986 (2002). Shows that the sustained presence of activated Notch 1 signalling is required for the manifestation of neoplastic properties in culture.
    • (2002) Nature Med. , vol.8 , pp. 979-986
    • Weijzen, S.1
  • 58
    • 0029078323 scopus 로고
    • Alterations in Notch signaling in neoplastic lesions of the human cervix
    • Zagouras, P. et al. Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc. Natl. Acad. Sci. USA 92, 6414-6418 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 6414-6418
    • Zagouras, P.1
  • 59
    • 20544447734 scopus 로고    scopus 로고
    • Notch signals control the fate of immature progenitor cells in the intestine
    • Fre, S. et al. Notch signals control the fate of immature progenitor cells in the intestine. Nature 435, 964-968 (2005).
    • (2005) Nature , vol.435 , pp. 964-968
    • Fre, S.1
  • 60
    • 20544460148 scopus 로고    scopus 로고
    • Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
    • van Es, J. H. et al. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435, 959-963 (2005).
    • (2005) Nature , vol.435 , pp. 959-963
    • Van Es, J.H.1
  • 61
    • 16044362074 scopus 로고    scopus 로고
    • Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
    • Joutel, A. et al. Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature 383, 707-710 (1996).
    • (1996) Nature , vol.383 , pp. 707-710
    • Joutel, A.1
  • 62
    • 0038875342 scopus 로고    scopus 로고
    • Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch 1
    • Li, L. et al. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch 1. Nature Genet. 16, 243-251 (1997).
    • (1997) Nature Genet. , vol.16 , pp. 243-251
    • Li, L.1
  • 63
    • 0030914459 scopus 로고    scopus 로고
    • Mutations in the human Jagged1 gene are responsible for Alagille syndrome
    • Oda, T. et al. Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nature Genet. 16, 235-242 (1997).
    • (1997) Nature Genet. , vol.16 , pp. 235-242
    • Oda, T.1
  • 64
    • 30444454357 scopus 로고    scopus 로고
    • Developmental and molecular characterization of emerging β- and γδ-selected pre-T cells in the adult mouse thymus
    • Taghon, T. et al. Developmental and molecular characterization of emerging β- and γδ-selected pre-T cells in the adult mouse thymus. Immunity 24, 53-64 (2006).
    • (2006) Immunity , vol.24 , pp. 53-64
    • Taghon, T.1
  • 65
    • 22144487402 scopus 로고    scopus 로고
    • Notch signaling controls the generation and differentiation of early T lineage progenitors
    • Sambandam, A. et al. Notch signaling controls the generation and differentiation of early T lineage progenitors. Nature Immunol. 6, 663-670 (2005).
    • (2005) Nature Immunol. , vol.6 , pp. 663-670
    • Sambandam, A.1
  • 66
    • 25644445324 scopus 로고    scopus 로고
    • Making waves in cancer research: New models in the zebrafish
    • Berghmans, S. et al. Making waves in cancer research: new models in the zebrafish. Biotechniques 39, 227-237 (2005).
    • (2005) Biotechniques , vol.39 , pp. 227-237
    • Berghmans, S.1
  • 67
    • 13544250491 scopus 로고    scopus 로고
    • Notch ligands Delta1 and Jagged1 transmit distinct signals to T-cell precursors
    • Lehar, S. M., Dooley, J., Farr, A. G. & Bevan, M. J. Notch ligands Delta1 and Jagged1 transmit distinct signals to T-cell precursors. Blood 105, 1440-1447 (2005).
    • (2005) Blood , vol.105 , pp. 1440-1447
    • Lehar, S.M.1    Dooley, J.2    Farr, A.G.3    Bevan, M.J.4
  • 68
    • 0035988246 scopus 로고    scopus 로고
    • Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision
    • Man, H. et al. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int. Immunol. 14, 637-645 (2002).
    • (2002) Int. Immunol. , vol.14 , pp. 637-645
    • Man, H.1
  • 69
    • 18344388633 scopus 로고    scopus 로고
    • Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch 1
    • Izon, D. J. et al. Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch 1. Immunity 16, 231-243 (2002).
    • (2002) Immunity , vol.16 , pp. 231-243
    • Izon, D.J.1
  • 70
    • 4444328365 scopus 로고    scopus 로고
    • Mastermind critically regulates Notch-mediated lymphoid cell fate decisions
    • Maillard, I. et al. Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood 104, 1696-1702 (2004).
    • (2004) Blood , vol.104 , pp. 1696-1702
    • Maillard, I.1
  • 71
    • 0034599854 scopus 로고    scopus 로고
    • Notch 1 deficiency dissociates the intrathymic development of dendritic cells and T cells
    • Radtke, F. et al. Notch 1 deficiency dissociates the intrathymic development of dendritic cells and T cells. J. Exp. Med. 191, 1085-1094 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 1085-1094
    • Radtke, F.1
  • 72
    • 20244389684 scopus 로고    scopus 로고
    • Notch 1 expression in early lymphopoiesis influences B versus T lineage determination
    • Pui, J. C. et al. Notch 1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity 11, 299-308 (1999).
    • (1999) Immunity , vol.11 , pp. 299-308
    • Pui, J.C.1
  • 73
    • 0035476891 scopus 로고    scopus 로고
    • Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation
    • Jaleco, A. C. et al. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J. Exp. Med. 194, 991-1002 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 991-1002
    • Jaleco, A.C.1
  • 74
    • 0036916440 scopus 로고    scopus 로고
    • Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro
    • Schmitt, T. M. & Zuniga-Pflucker, J. C. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17, 749-756 (2002).
    • (2002) Immunity , vol.17 , pp. 749-756
    • Schmitt, T.M.1    Zuniga-Pflucker, J.C.2
  • 75
    • 0032054238 scopus 로고    scopus 로고
    • Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice
    • Jiang, R. et al. Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev. 12, 1046-1057 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 1046-1057
    • Jiang, R.1
  • 76
    • 0031001247 scopus 로고    scopus 로고
    • Notch activity influences the αβ versus γδ cell lineage decision
    • Washburn, T. et al. Notch activity influences the αβ versus γδ cell lineage decision. Cell 88, 833-843 (1997).
    • (1997) Cell , vol.88 , pp. 833-843
    • Washburn, T.1
  • 77
    • 0347951391 scopus 로고    scopus 로고
    • + cell-dependent mechanism
    • + cell-dependent mechanism. J. Clin. Invest. 112, 1741-1750 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 1741-1750
    • Wong, K.K.1
  • 78
    • 0242493801 scopus 로고    scopus 로고
    • Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells
    • Yvon, E. S. et al. Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells. Blood 102, 3815-3821 (2003).
    • (2003) Blood , vol.102 , pp. 3815-3821
    • Yvon, E.S.1
  • 79
    • 0042834334 scopus 로고    scopus 로고
    • Notch signaling augments T cell responsiveness by enhancing CD25 expression
    • Adler, S. H. et al. Notch signaling augments T cell responsiveness by enhancing CD25 expression. J. Immunol. 171, 2896-2903 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 2896-2903
    • Adler, S.H.1
  • 81
    • 0041331708 scopus 로고    scopus 로고
    • TCR-mediated notch signaling regulates proliferation and IFN-γ production in peripheral T cells
    • Palaga, T., Miele, L., Golde, T. E. & Osborne, B. A. TCR-mediated notch signaling regulates proliferation and IFN-γ production in peripheral T cells. J. Immunol. 171, 3019-3024 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 3019-3024
    • Palaga, T.1    Miele, L.2    Golde, T.E.3    Osborne, B.A.4
  • 82
    • 8644225027 scopus 로고    scopus 로고
    • A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development
    • Hadland, B. K. et al. A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood 104, 3097-3105 (2004).
    • (2004) Blood , vol.104 , pp. 3097-3105
    • Hadland, B.K.1
  • 83
    • 0038404519 scopus 로고    scopus 로고
    • Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells
    • Kumano, K. et al. Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells. Immunity 18, 699-711 (2003).
    • (2003) Immunity , vol.18 , pp. 699-711
    • Kumano, K.1
  • 84
    • 0033694305 scopus 로고    scopus 로고
    • Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling
    • Varnum-Finney, B. et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nature Med. 6, 1278-1281 (2000).
    • (2000) Nature Med. , vol.6 , pp. 1278-1281
    • Varnum-Finney, B.1
  • 85
    • 0037370834 scopus 로고    scopus 로고
    • Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability
    • Varnum-Finney, B., Brashem-Stein, C. & Bernstein, I. D. Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood 101, 1784-1789 (2003).
    • (2003) Blood , vol.101 , pp. 1784-1789
    • Varnum-Finney, B.1    Brashem-Stein, C.2    Bernstein, I.D.3
  • 86
    • 0036529989 scopus 로고    scopus 로고
    • Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome
    • Stier, S. et al. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood 99, 2369-2378 (2002).
    • (2002) Blood , vol.99 , pp. 2369-2378
    • Stier, S.1
  • 87
    • 20144370145 scopus 로고    scopus 로고
    • Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
    • Duncan, A. W. et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nature Immunol. 6, 314-322 (2005).
    • (2005) Nature Immunol. , vol.6 , pp. 314-322
    • Duncan, A.W.1
  • 88
    • 0031043087 scopus 로고    scopus 로고
    • The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis
    • Wettstein, D. A., Turner, D. L. & Kintner, C. The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis. Development 124, 693-702 (1997).
    • (1997) Development , vol.124 , pp. 693-702
    • Wettstein, D.A.1    Turner, D.L.2    Kintner, C.3
  • 89
    • 0028988990 scopus 로고
    • Masking of the CBF1/RBPJ κ transcriptional repression domain by Epstein-Barr virus EBNA2
    • Hsieh, J. J. & Hayward, S. D. Masking of the CBF1/RBPJ κ transcriptional repression domain by Epstein-Barr virus EBNA2. Science 268, 560-563 (1995).
    • (1995) Science , vol.268 , pp. 560-563
    • Hsieh, J.J.1    Hayward, S.D.2
  • 90
    • 0028674212 scopus 로고
    • Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch
    • Aster, J. et al. Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. Cold Spring Harb. Symp. Quant. Biol. 59, 125-136 (1994).
    • (1994) Cold Spring Harb. Symp. Quant. Biol. , vol.59 , pp. 125-136
    • Aster, J.1
  • 91
    • 0029942842 scopus 로고    scopus 로고
    • Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
    • Pear, W. S. et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J. Exp. Med. 183, 2283-2291 (1996). This is the first documentation of the oncogenic potential of human TAN1 in the haematopoietic system of a murine model.
    • (1996) J. Exp. Med. , vol.183 , pp. 2283-2291
    • Pear, W.S.1
  • 92
    • 0033796150 scopus 로고    scopus 로고
    • Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1
    • Aster, J. C. et al. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1. Mol. Cell. Biol. 20, 7505-7515 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 7505-7515
    • Aster, J.C.1
  • 93
    • 0035796488 scopus 로고    scopus 로고
    • Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells
    • Allman, D. et al. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells. J. Exp. Med. 194, 99-106 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 99-106
    • Allman, D.1
  • 94
    • 0030297895 scopus 로고    scopus 로고
    • An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
    • Robey, E. et al. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell 87, 483-492 (1996).
    • (1996) Cell , vol.87 , pp. 483-492
    • Robey, E.1
  • 95
    • 0037103148 scopus 로고    scopus 로고
    • A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development
    • Fowlkes, B. J. & Robey, E. A. A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development. J. Immunol. 169, 1817-1821 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 1817-1821
    • Fowlkes, B.J.1    Robey, E.A.2
  • 96
    • 0043171113 scopus 로고    scopus 로고
    • Radiation-induced deletions in the 5′ end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas
    • Tsuji, H. et al. Radiation-induced deletions in the 5′ end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas. Carcinogenesis 24, 1257-1268 (2003).
    • (2003) Carcinogenesis , vol.24 , pp. 1257-1268
    • Tsuji, H.1
  • 97
    • 30444436343 scopus 로고    scopus 로고
    • Activating Notch1 mutations in mouse models of T-ALL
    • O'Neil, J. et al. Activating Notch1 mutations in mouse models of T-ALL. Blood 107, 781-785 (2005).
    • (2005) Blood , vol.107 , pp. 781-785
    • O'Neil, J.1
  • 98
    • 33644756556 scopus 로고    scopus 로고
    • Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma
    • Lin, Y. W., Nichols, R. A., Letterio, J. J. & Aplan, P. D. Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma. Blood 107, 2540-2543 (2005).
    • (2005) Blood , vol.107 , pp. 2540-2543
    • Lin, Y.W.1    Nichols, R.A.2    Letterio, J.J.3    Aplan, P.D.4
  • 99
    • 0033397647 scopus 로고    scopus 로고
    • Cytogenetics and molecular genetics of childhood leukemia
    • Ma, S. K., Wan, T. S. & Chan, L. C. Cytogenetics and molecular genetics of childhood leukemia. Hematol. Oncol. 17, 91-105 (1999).
    • (1999) Hematol. Oncol. , vol.17 , pp. 91-105
    • Ma, S.K.1    Wan, T.S.2    Chan, L.C.3
  • 100
    • 0036566557 scopus 로고    scopus 로고
    • Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma
    • Jundt, F. et al. Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood 99, 3398-3403 (2002).
    • (2002) Blood , vol.99 , pp. 3398-3403
    • Jundt, F.1
  • 101
    • 0037133497 scopus 로고    scopus 로고
    • Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis
    • Bellavia, D. et al. Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc. Natl Acad. Sci. USA 99, 3788-3793 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 3788-3793
    • Bellavia, D.1
  • 102
    • 0037441471 scopus 로고    scopus 로고
    • Differential regulation of Notch signal transduction in leukaemia and lymphoma cells in culture
    • Chiaramonte, R. et al. Differential regulation of Notch signal transduction in leukaemia and lymphoma cells in culture. J. Cell Biochem. 88, 569-577 (2003).
    • (2003) J. Cell Biochem. , vol.88 , pp. 569-577
    • Chiaramonte, R.1
  • 103
    • 0037218811 scopus 로고    scopus 로고
    • Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling
    • Weng, A. P. et al. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol. Cell. Biol. 23, 655-664 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 655-664
    • Weng, A.P.1
  • 104
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng, A. P. et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306, 269-271 (2004). Demonstrates the causative role of somatic activating mutations in NOTCH1 in the development of human T-ALL.
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.P.1
  • 105
    • 6344251643 scopus 로고    scopus 로고
    • Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats
    • Sanchez-Irizarry, C. et al. Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol. Cell. Biol. 24, 9265-9273 (2004).
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 9265-9273
    • Sanchez-Irizarry, C.1
  • 106
    • 0032525964 scopus 로고    scopus 로고
    • LIN-12/Notch signaling: Lessons from worms and flies
    • Greenwald, I. LIN-12/Notch signaling: lessons from worms and flies. Genes Dev. 12, 1751-1162 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 1751-11162
    • Greenwald, I.1
  • 107
    • 0031030361 scopus 로고    scopus 로고
    • Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors
    • Berry, L. W., Westlund, B. & Schedl, T. Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors. Development 124, 925-936 (1997).
    • (1997) Development , vol.124 , pp. 925-936
    • Berry, L.W.1    Westlund, B.2    Schedl, T.3
  • 108
    • 0035860804 scopus 로고    scopus 로고
    • Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
    • Gupta-Rossi, N. et al. Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J. Biol. Chem. 276, 34371-34378 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 34371-34378
    • Gupta-Rossi, N.1
  • 109
    • 0034284471 scopus 로고    scopus 로고
    • A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice
    • Feldman, B. J., Hampton, T. & Cleary, M. L. A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. Blood 96, 1906-1913 (2000).
    • (2000) Blood , vol.96 , pp. 1906-1913
    • Feldman, B.J.1    Hampton, T.2    Cleary, M.L.3
  • 110
    • 0034024722 scopus 로고    scopus 로고
    • Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice
    • Hoemann, C. D. et al. Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice. Mol. Cell. Biol. 20, 3831-3842 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3831-3842
    • Hoemann, C.D.1
  • 111
    • 0033681301 scopus 로고    scopus 로고
    • Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
    • Deftos, M. L. et al. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. Immunity 13, 73-84 (2000).
    • (2000) Immunity , vol.13 , pp. 73-84
    • Deftos, M.L.1
  • 112
    • 1642576036 scopus 로고    scopus 로고
    • The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells
    • Sade, H., Krishna, S. & Sarin, A. The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells. J. Biol. Chem. 279, 2937-2944 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 2937-2944
    • Sade, H.1    Krishna, S.2    Sarin, A.3
  • 113
    • 9144229104 scopus 로고    scopus 로고
    • Requirement for cyclin D3 in lymphocyte development and T cell leukemias
    • Sicinska, E. et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 4, 451-461 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 451-461
    • Sicinska, E.1
  • 114
    • 0842285394 scopus 로고    scopus 로고
    • E2A proteins enforce a proliferation checkpoint in developing thymocytes
    • Engel, I. & Murre, C. E2A proteins enforce a proliferation checkpoint in developing thymocytes. EMBO J. 23, 202-211 (2004).
    • (2004) EMBO J. , vol.23 , pp. 202-211
    • Engel, I.1    Murre, C.2
  • 115
    • 0242556813 scopus 로고    scopus 로고
    • Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities
    • Nie, L., Xu, M., Vladimirova, A. & Sun, X. H. Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. EMBO J. 22, 5780-5792 (2003).
    • (2003) EMBO J. , vol.22 , pp. 5780-5792
    • Nie, L.1    Xu, M.2    Vladimirova, A.3    Sun, X.H.4
  • 116
    • 0037143763 scopus 로고    scopus 로고
    • Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice
    • Engel, I. & Murre, C. Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice. Proc. Natl Acad. Sci. USA 99, 11322-11327 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 11322-11327
    • Engel, I.1    Murre, C.2
  • 117
    • 0348133609 scopus 로고    scopus 로고
    • Pre-TCR-triggered ERK signalling-dependent down regulation of E2A activity
    • Talora, C. Pre-TCR-triggered ERK signalling-dependent down regulation of E2A activity. EMBO Rep. 4, 1067-1072 (2003).
    • (2003) EMBO Rep. , vol.4 , pp. 1067-1072
    • Talora, C.1
  • 118
    • 0031923281 scopus 로고    scopus 로고
    • Notch inhibition of E47 supports the existence of a novel signaling pathway
    • Ordentlich, P. et al. Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol. Cell. Biol. 18, 2230-2239 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 2230-2239
    • Ordentlich, P.1
  • 119
    • 33646374372 scopus 로고    scopus 로고
    • Notch1 promotes survival of E2A-deficient T cell lymphomas through Pre-T cell receptor dependent and independent mechanisms
    • 31 Jan doi:10.1182/blood-2005-09-3551
    • Reschly, E. J. et al. Notch1 promotes survival of E2A-deficient T cell lymphomas through Pre-T cell receptor dependent and independent mechanisms. Blood 31 Jan 2006 (doi:10.1182/blood-2005-09-3551).
    • (2006) Blood
    • Reschly, E.J.1
  • 120
    • 23844446044 scopus 로고    scopus 로고
    • Suppression of p53 by Notch in lymphomagenesis: Implications for initiation and regression
    • Beverly, L. J., Felsher, D. W. & Capobianco, A. J. Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression. Cancer Res. 65, 7159-7168 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 7159-7168
    • Beverly, L.J.1    Felsher, D.W.2    Capobianco, A.J.3
  • 121
    • 0033556251 scopus 로고    scopus 로고
    • Cutting edge: Protective effects of notch-1 on TCR-induced apoptosis
    • Jehn, B. M., Bielke, W., Pear, W. S. & Osborne, B. A. Cutting edge: protective effects of notch-1 on TCR-induced apoptosis. J. Immunol. 162, 635-638 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 635-638
    • Jehn, B.M.1    Bielke, W.2    Pear, W.S.3    Osborne, B.A.4
  • 122
    • 0032442040 scopus 로고    scopus 로고
    • Correlating notch signaling with thymocyte maturation
    • Deftos, M. L., He, Y. W., Ojala, E. W. & Bevan, M. J. Correlating notch signaling with thymocyte maturation. Immunity 9, 777-786 (1998).
    • (1998) Immunity , vol.9 , pp. 777-786
    • Deftos, M.L.1    He, Y.W.2    Ojala, E.W.3    Bevan, M.J.4
  • 123
    • 0036745068 scopus 로고    scopus 로고
    • Orphan nuclear receptors in T lymphocyte development
    • He, Y. W. Orphan nuclear receptors in T lymphocyte development. J. Leukoc. Biol. 72, 440-446 (2002).
    • (2002) J. Leukoc. Biol. , vol.72 , pp. 440-446
    • He, Y.W.1
  • 124
    • 0029808295 scopus 로고    scopus 로고
    • Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis
    • Girard, L. et al. Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis. Genes Dev. 10, 1930-1944 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 1930-1944
    • Girard, L.1
  • 125
    • 0037710256 scopus 로고    scopus 로고
    • Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis
    • Beverly, L. J. & Capobianco, A. J. Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis. Cancer Cell 3, 551-564 (2003).
    • (2003) Cancer Cell , vol.3 , pp. 551-564
    • Beverly, L.J.1    Capobianco, A.J.2
  • 126
    • 33645227683 scopus 로고    scopus 로고
    • Notch activation is an early and critical event during t-cell leukemogenesis in Ikaros-deficient mice
    • Dumortier, A. et al. Notch activation is an early and critical event during t-cell leukemogenesis in Ikaros-deficient mice. Mol. Cell. Biol. 26, 209-220 (2006).
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 209-220
    • Dumortier, A.1
  • 127
    • 22444431606 scopus 로고    scopus 로고
    • Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system
    • Dupuy, A. J. et al. Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature 436, 221-226 (2005).
    • (2005) Nature , vol.436 , pp. 221-226
    • Dupuy, A.J.1
  • 128
    • 19044399684 scopus 로고    scopus 로고
    • Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling
    • Yeoh, E. J. et al. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 1, 133-143 (2002).
    • (2002) Cancer Cell , vol.1 , pp. 133-143
    • Yeoh, E.J.1
  • 129
    • 0030662043 scopus 로고    scopus 로고
    • Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis
    • Garces, C. et al. Notch-1 controls the expression of fatty acid-activated transcription factors and is required for adipogenesis. J. Biol. Chem. 272, 29729-29734 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 29729-29734
    • Garces, C.1
  • 130
    • 0035005101 scopus 로고    scopus 로고
    • New protease inhibitors prevent γ-secretase-mediated production of αβ40/42 without affecting Notch cleavage
    • Petit, A. et al. New protease inhibitors prevent γ-secretase-mediated production of αβ40/42 without affecting Notch cleavage. Nature Cell Biol. 3, 507-511 (2001).
    • (2001) Nature Cell Biol. , vol.3 , pp. 507-511
    • Petit, A.1
  • 131
    • 0036727125 scopus 로고    scopus 로고
    • γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
    • Fortini, M. E. γ-Secretase-mediated proteolysis in cell-surface-receptor signalling. Nature Rev. Mol. Cell Biol. 3, 673-84 (2002).
    • (2002) Nature Rev. Mol. Cell Biol. , vol.3 , pp. 673-684
    • Fortini, M.E.1
  • 132
    • 11144355129 scopus 로고    scopus 로고
    • Chronic treatment with the γ-secretase inhibitor LY-411,575 inhibits β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation
    • Wong, G. T. et al. Chronic treatment with the γ-secretase inhibitor LY-411,575 inhibits β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J. Biol. Chem. 279, 12876-12882 (2004). The first report that documents the long-term effects of oral administration of GSIs in mice. The authors provide evidence that significant side effects are due to inhibition of Notch signalling, including arrest of T-cell development and aberrant differentiation of gut epithelium.
    • (2004) J. Biol. Chem. , vol.279 , pp. 12876-12882
    • Wong, G.T.1
  • 133
    • 22144492615 scopus 로고    scopus 로고
    • Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21
    • Minter, L. M. et al. Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nature Immunol. 6, 680-688 (2005).
    • (2005) Nature Immunol. , vol.6 , pp. 680-688
    • Minter, L.M.1
  • 134
    • 2942579675 scopus 로고    scopus 로고
    • TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB
    • O'Neil, J. et al. TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB. Cancer Cell 5, 587-596 (2004).
    • (2004) Cancer Cell , vol.5 , pp. 587-596
    • O'Neil, J.1
  • 135
    • 0034284471 scopus 로고    scopus 로고
    • A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice
    • Feldman, B. J., Hampton, T. & Cleary, M. L. A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. Blood 96, 1906-1913 (2000).
    • (2000) Blood , vol.96 , pp. 1906-1913
    • Feldman, B.J.1    Hampton, T.2    Cleary, M.L.3
  • 136
    • 0037235453 scopus 로고    scopus 로고
    • Retroviral insertional mutagenesis: Tagging cancer pathways
    • Mikkers, H. & Berns, A. Retroviral insertional mutagenesis: tagging cancer pathways. Adv. Cancer Res. 88, 53-99 (2003).
    • (2003) Adv. Cancer Res. , vol.88 , pp. 53-99
    • Mikkers, H.1    Berns, A.2
  • 137
    • 22444444402 scopus 로고    scopus 로고
    • Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse
    • Collier, L. S. et al. Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature 436, 272-276 (2005).
    • (2005) Nature , vol.436 , pp. 272-276
    • Collier, L.S.1
  • 138
    • 0347785481 scopus 로고    scopus 로고
    • Myc-induced T cell leukemia in transgenic zebrafish
    • Langenau, D. M. et al. Myc-induced T cell leukemia in transgenic zebrafish. Science 299, 887-890 (2003).
    • (2003) Science , vol.299 , pp. 887-890
    • Langenau, D.M.1
  • 139
    • 2442599273 scopus 로고    scopus 로고
    • In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish
    • Langenau, D. M. et al. In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc. Natl Acad. Sci. USA 101, 7369-7374 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 7369-7374
    • Langenau, D.M.1
  • 140
    • 17844403755 scopus 로고    scopus 로고
    • Crellox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia
    • Langenau, D. M. et al. Crellox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Proc. Natl Acad. Sci. USA 102, 6068-6073 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 6068-6073
    • Langenau, D.M.1
  • 141
    • 14844355836 scopus 로고    scopus 로고
    • Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding
    • Okajima, T., Xu, A., Lei, L. & Irvine, K. D. Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding. Science 307, 1599-1603 (2005).
    • (2005) Science , vol.307 , pp. 1599-1603
    • Okajima, T.1    Xu, A.2    Lei, L.3    Irvine, K.D.4
  • 142
    • 0041355557 scopus 로고    scopus 로고
    • Notch and Presenilin: Regulated intramembrane proteolysis links development and degeneration
    • Selkoe, D. & Kopan, R. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu. Rev. Neurosci. 26, 565-597 (2003).
    • (2003) Annu. Rev. Neurosci. , vol.26 , pp. 565-597
    • Selkoe, D.1    Kopan, R.2
  • 143
    • 23744491374 scopus 로고    scopus 로고
    • Nicastrin functions as a γ-secretase-substrate receptor
    • Shah, S. et al. Nicastrin functions as a γ-secretase-substrate receptor. Cell 122, 435-447 (2005).
    • (2005) Cell , vol.122 , pp. 435-447
    • Shah, S.1
  • 144
    • 0038079817 scopus 로고    scopus 로고
    • Structural requirements for assembly of the CSL-intracellular Notch1-Mastermind-like 1 transcriptional activation complex
    • Nam, Y., Weng, A. P., Aster, J. C. & Blacklow, S. C. Structural requirements for assembly of the CSL-intracellular Notch1-Mastermind-like 1 transcriptional activation complex. J. Biol. Chem. 278, 21232-21239 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 21232-21239
    • Nam, Y.1    Weng, A.P.2    Aster, J.C.3    Blacklow, S.C.4
  • 145
    • 1642344776 scopus 로고    scopus 로고
    • Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data
    • Lubman, O. Y., Korolev, S. V. & Kopan, R. Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. Mol. Cell 13, 619-626 (2004).
    • (2004) Mol. Cell , vol.13 , pp. 619-626
    • Lubman, O.Y.1    Korolev, S.V.2    Kopan, R.3
  • 146
    • 0036606776 scopus 로고    scopus 로고
    • Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex
    • Fryer, C. J. et al. Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev. 16, 1397-1411 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 1397-1411
    • Fryer, C.J.1
  • 147
    • 0036840497 scopus 로고    scopus 로고
    • p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro
    • Wallberg, A. E., Pedersen, K., Lendahl, U. & Roeder, R. G. p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol. Cell. Biol. 22, 7812-7819 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 7812-7819
    • Wallberg, A.E.1    Pedersen, K.2    Lendahl, U.3    Roeder, R.G.4
  • 148
    • 0036096912 scopus 로고    scopus 로고
    • Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line
    • Jeffries, S., Robbins, D. J. & Capobianco, A. J. Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line. Mol. Cell. Biol. 11, 3927-3941 (2002).
    • (2002) Mol. Cell. Biol. , vol.11 , pp. 3927-3941
    • Jeffries, S.1    Robbins, D.J.2    Capobianco, A.J.3
  • 149
    • 0036696444 scopus 로고    scopus 로고
    • The endocytic protein α-Adaptin is required for numb-mediated asymmetric cell division in Drosophila
    • Berdnik, D., Torok, T., Gonzalez-Gaitan, M. & Knoblich, J. A. The endocytic protein α-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev. Cell 3, 221-231 (2002).
    • (2002) Dev. Cell , vol.3 , pp. 221-231
    • Berdnik, D.1    Torok, T.2    Gonzalez-Gaitan, M.3    Knoblich, J.A.4
  • 150
    • 0037663379 scopus 로고    scopus 로고
    • Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain
    • McGill, M. A. & McGlade, C. J. Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J. Biol. Chem. 278, 23196-23203 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 23196-23203
    • McGill, M.A.1    McGlade, C.J.2
  • 151
    • 0029047609 scopus 로고
    • Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
    • Matsuno, K. et al. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development 121, 2633-2644 (1995).
    • (1995) Development , vol.121 , pp. 2633-2644
    • Matsuno, K.1
  • 152
    • 0037154292 scopus 로고    scopus 로고
    • Protein degradation: Four E3s for the notch pathway
    • Lai, E. C. Protein degradation: four E3s for the notch pathway. Curr. Biol. 12, R74-R78 (2002).
    • (2002) Curr. Biol. , vol.12
    • Lai, E.C.1
  • 153
    • 8844229536 scopus 로고    scopus 로고
    • Mastermind recruits CycC-CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
    • Fryer, C. J., White, J. B. & Jones, K. A. Mastermind recruits CycC-CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol. Cell 16, 509-520 (2004).
    • (2004) Mol. Cell , vol.16 , pp. 509-520
    • Fryer, C.J.1    White, J.B.2    Jones, K.A.3
  • 154
    • 0025785081 scopus 로고
    • The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein
    • Lu, M., Gong, Z. Y., Shen, W. F. & Ho, A. D. The tcl-3 proto-oncogene altered by chromosomal translocation in T-cell leukemia codes for a homeobox protein. EMBO J. 10, 2905-2910 (1991).
    • (1991) EMBO J. , vol.10 , pp. 2905-2910
    • Lu, M.1    Gong, Z.Y.2    Shen, W.F.3    Ho, A.D.4
  • 155
    • 0025894715 scopus 로고
    • Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia
    • Hatano, M. et al. Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. Science 253, 79-82 (1991).
    • (1991) Science , vol.253 , pp. 79-82
    • Hatano, M.1
  • 156
    • 0026046616 scopus 로고
    • HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24
    • Kennedy, M. A. et al. HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. Proc. Natl Acad. Sci. USA 88, 8900-8904 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8900-8904
    • Kennedy, M.A.1
  • 157
    • 0025748060 scopus 로고
    • A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)
    • Dube, I. D. et al. A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14). Blood 78, 2996-3003 (1991).
    • (1991) Blood , vol.78 , pp. 2996-3003
    • Dube, I.D.1
  • 158
    • 0036849635 scopus 로고    scopus 로고
    • Disruption of the RanBP17/Hox11L2 region by recombination with the TCRδ locus in acute lymphoblastic leukemias with t(5;14)(q34;q11)
    • Hansen-Hagge, T. E. et al. Disruption of the RanBP17/Hox11L2 region by recombination with the TCRδ locus in acute lymphoblastic leukemias with t(5;14)(q34;q11). Leukemia 16, 2205-2212 (2002).
    • (2002) Leukemia , vol.16 , pp. 2205-2212
    • Hansen-Hagge, T.E.1
  • 159
    • 0034724344 scopus 로고    scopus 로고
    • The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene
    • Wang, J. et al. The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene. Proc. Natl Acad. Sci. USA 97, 3497-3502 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 3497-3502
    • Wang, J.1
  • 160
    • 0024308990 scopus 로고
    • lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif
    • Mellentin, J. D., Smith, S. D. & Cleary, M. L. lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. Cell 58, 77-83 (1989).
    • (1989) Cell , vol.58 , pp. 77-83
    • Mellentin, J.D.1    Smith, S.D.2    Cleary, M.L.3
  • 161
    • 0004328021 scopus 로고
    • Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor δ-chain diversity region and results in a previously unreported fusion transcript
    • Begley, C. G. et al. Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor δ-chain diversity region and results in a previously unreported fusion transcript. Proc. Natl Acad. Sci. USA 86, 2031-2035 (1989).
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2031-2035
    • Begley, C.G.1
  • 162
    • 0025014636 scopus 로고
    • The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein
    • Chen, Q. et al. The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J. 9, 415-424 (1990).
    • (1990) EMBO J. , vol.9 , pp. 415-424
    • Chen, Q.1
  • 163
    • 0026352831 scopus 로고
    • TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia
    • Xia, Y. et al. TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. Proc. Natl Acad. Sci. USA 88, 11416-11420 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 11416-11420
    • Xia, Y.1
  • 164
    • 0022972786 scopus 로고
    • A common mechanism of chromosomal translocation in T- and B-cell neoplasia
    • Finger, L. R. et al. A common mechanism of chromosomal translocation in T- and B-cell neoplasia. Science 234, 982-985 (1986).
    • (1986) Science , vol.234 , pp. 982-985
    • Finger, L.R.1
  • 165
    • 0022972448 scopus 로고
    • Molecular cloning of the breakpoint junction of a human chromosomal 8;14 translocation involving the T-cell receptor α-chain gene and sequences on the 3′ side of MYC
    • McKeithan, T. W. et al. Molecular cloning of the breakpoint junction of a human chromosomal 8;14 translocation involving the T-cell receptor α-chain gene and sequences on the 3′ side of MYC. Proc. Natl Acad. Sci. USA 83, 6636-6640 (1986).
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 6636-6640
    • McKeithan, T.W.1
  • 166
    • 0022530613 scopus 로고
    • Gene encoding the α chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia
    • Shima, E. A. et al. Gene encoding the α chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia. Proc. Natl Acad. Sci. USA 83, 3439-3443 (1986).
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 3439-3443
    • Shima, E.A.1
  • 167
    • 0025276687 scopus 로고
    • Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system
    • Greenberg, J. M. et al. Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system. Nature 344, 158-160 (1990).
    • (1990) Nature , vol.344 , pp. 158-160
    • Greenberg, J.M.1
  • 168
    • 0024564420 scopus 로고
    • The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein
    • McGuire, E. A. et al. The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. Mol. Cell. Biol. 9, 2124-2132 (1989).
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 2124-2132
    • McGuire, E.A.1
  • 169
    • 0025759278 scopus 로고
    • The rhombotin family of cysteine-rich LIM-domain oncogenes: Distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13
    • Boehm, T. et al. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc. Natl Acad. Sci. USA 88, 4367-4371 (1991).
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 4367-4371
    • Boehm, T.1
  • 170
    • 0025933456 scopus 로고
    • TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)
    • Royer-Pokora, B., Loos, U. & Ludwig, W. D. TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene 6, 1887-1893 (1991).
    • (1991) Oncogene , vol.6 , pp. 1887-1893
    • Royer-Pokora, B.1    Loos, U.2    Ludwig, W.D.3
  • 171
    • 0033568581 scopus 로고    scopus 로고
    • The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia
    • Hussey, D. J. et al. The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia. Blood 94, 2072-2079 (1999).
    • (1999) Blood , vol.94 , pp. 2072-2079
    • Hussey, D.J.1
  • 172
    • 0033978155 scopus 로고    scopus 로고
    • Identification and molecular characterization of CALM-AF10 fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia
    • Carlson, K. M. et al. Identification and molecular characterization of CALM-AF10 fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia. Leukemia 14, 100-104 (2000).
    • (2000) Leukemia , vol.14 , pp. 100-104
    • Carlson, K.M.1
  • 173
    • 0033788513 scopus 로고    scopus 로고
    • Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia
    • Ferrando, A. A. & Look, A. T. Clinical implications of recurring chromosomal and associated molecular abnormalities in acute lymphoblastic leukemia. Semin. Hematol. 37, 381-395 (2000).
    • (2000) Semin. Hematol. , vol.37 , pp. 381-395
    • Ferrando, A.A.1    Look, A.T.2
  • 175


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