Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia

Nature Genetics

Volumn 36, Issue 10, 2004, Pages 1084-1089

  Graux, C ^a   Cools, J ^a,b   Melotte, C ^a   Quentmeier, H ^c   Ferrando, A ^d   Levine, R ^d   Vermeesch, J R ^a   Stul, M ^a   Dutta, B ^b   Boeckx, N ^a   Bosly, A ^e   Heimann, P ^f   Uyttebroeck, A ^a   Mentens, N ^a,b   Somers, R ^a,b   MacLeod, R A R ^c   Drexler, H G ^c   Look, A T ^d   Gilliland, D G ^d,g,h   Michaux, L ⁱ   Vandenberghe, P ^a   Wlodarska, I ^a   Marynen, Peter ^a,b   Hagemeijer, Anne ^a   more..

^a UNIVERSITY OF LEUVEN   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c LEIBNIZ INSTITUTE DSMZ GERMAN COLLECTION OF MICROORGANISMS AND CELL CULTURES   (Germany)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY HOSPITAL OF MONT GODINNE   (Belgium)

^f ERASME HOSPITAL   (Belgium)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

^h HOWARD HUGHES MEDICAL INSTITUTE   (United States)

ⁱ NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMATINIB; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR; DNA; ENZYME INHIBITOR; NUCLEOPORIN; NUP214 PROTEIN, HUMAN; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ABL1 GENE; ACUTE LYMPHOBLASTIC LEUKEMIA; AMPLICON; ARTICLE; CHROMOSOME 9Q; CHROMOSOME BAND; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; CYTOGENETICS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EPISOME; GENE FUSION; GENE REARRANGEMENT; HUMAN; NUP214 GENE; ONCOGENE; PATHOGENESIS; PRIORITY JOURNAL; T LYMPHOCYTE; AMINO ACID SEQUENCE; CHROMOSOME 9; DRUG ANTAGONISM; ENZYMOLOGY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PLASMID; T CELL LEUKEMIA; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ARTIFICIAL GENE FUSION; BASE SEQUENCE; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 9; DNA, NEOPLASM; ENZYME INHIBITORS; GENE AMPLIFICATION; GENES, ABL; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, T-CELL, ACUTE; MOLECULAR SEQUENCE DATA; NUCLEAR PORE COMPLEX PROTEINS; PIPERAZINES; PLASMIDS; PROTEIN-TYROSINE KINASES; PYRIMIDINES;

EID: 6944252248     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1425     Document Type: Article

References (27)

1. Ferrando, A.A. et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 1, 75-87 (2002).
2. Pui, C.H., Relling, M.V. & Downing, J.R. Acute lymphoblastic leukemia. N. Engl. J. Med. 350, 1535-1548 (2004).
3. Paietta, E. et al. Activating FLT3 mutations in CD117/KIT positive T-cell acute lymphoblastic leukemias. Blood 104, 558-560 (2004).
4. Maurer, B.J., Lai, E., Hamkalo, B.A., Hood, L. & Attardi, G. Novel submicroscopic extrachromosomal elements containing amplified genes in human cells. Nature 327, 434-437 (1987).
5. de Klein, A. et al. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature 300, 765-767 (1982).
6. von Lindern, M. et al. The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. Mol. Cell Biol. 12, 1687-1697 (1992).
7. Capdeville, R., Buchdunger, E., Zimmermann, J. & Matter, A. Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug. Nat. Rev. Drug Discov. 1, 493-502 (2002).
8. Druker, B.J. et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N. Engl. J. Med. 344, 1038-1042 (2001).
9. Hebert, J., Cayuela, J.M., Berkeley, J. & Sigaux, F. Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias. Blood 84, 4038-4044 (1994).
10. de Klein, A. et al. bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia. Blood 68, 1369-1375 (1986).
11. Hahn, P.J. Molecular biology of double-minute chromosomes. Bioessays 15, 477-484 (1993).
12. Carroll, S.M. et al. Double minute chromosomes can be produced from precursors derived from a chromosomal deletion. Mol. Cell Biol. 8, 1525-1533 (1988).
13. Kraemer, D., Wozniak, R.W., Blobel, G. & Radu, A. The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm. Proc. Natl. Acad. Sci. USA 91, 1519-1523 (1994).
14. Golub, T.R. et al. Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia. Mol. Cell Biol. 16, 4107-4116 (1996).
15. Oda, T. et al. CrkI is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia. J. Biol. Chem. 269, 22925-22928 (1994).
16. Nieborowska-Skorska, M., Slupianek, A. & Skorski, T. Progressive changes in the leukemogenic signaling in BCR/ABL-transformed cells. Oncogene 19, 4117-4124 (2000).
17. Kelly, L.M. & Gilliland, D.G. Genetics of myeloid leukemias. Annu. Rev. Genomics Hum. Genet. 3, 179-198 (2002).
18. Nagel, S., Kaufmann, M., Drexler, H.G. & MacLeod, R.A. The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35.1;q32.2). Cancer Res. 63, 5329-5334 (2003).
19. Barber, K.E. et al. Amplification of the ABL gene in T-cell acute lymphoblastic leukemia. Leukemia 18, 1153-1156 (2004).
20. Cools, J. et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N. Engl. J. Med. 348, 1201-1214 (2003).
21. Mitelman, F. ISCN(1995): Guidelines for Cancer Cytogenetics. Supplement to an International System for Human Nomenclature (Karger, Basel, 1995).
22. Dierlamm, J. et al. Successful use of the same slide for consecutive fluorescence in situ hybridization experiments. Genes Chromosomes Cancer 16, 261-264 (1996).
23. Fiegler, H. et al. DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. Genes Chromosomes Cancer 36, 361-374 (2003).
24. Van Buggenhout, G. et al. The mild Wolf-Hirschhorn syndrome: microarray CGH analysis of atypical 4p16.3 deletions enables refinement of the genotype-phenotype map. J. Med. Genet. 41, 691-698 (2004).
25. Fornerod, M. et al. Relocation of the carboxyterminal part of CAN from the nuclear envelope to the nucleus as a result of leukemia-specific chromosome rearrangements. Oncogene 10, 1739-1748 (1995).
26. Cools, J. et al. Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13). Blood 94, 1820-1824 (1999).
27. Bene, M.C. et al. Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia 9, 1783-1786 (1995).