Notch signaling in leukemia

Current Opinion in Hematology

Volumn 8, Issue 4, 2001, Pages 237-244

  Aster, Jon C ^a   Pear, Warren S ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; CANCER RISK; CELL MATURATION; CHROMOSOME TRANSLOCATION; HUMAN; LEUKEMOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REVIEW; RISK ASSESSMENT; SIGNAL TRANSDUCTION; T CELL LEUKEMIA;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; HEMATOPOIETIC STEM CELLS; HUMANS; LEUKEMIA, EXPERIMENTAL; LEUKEMIA, T-CELL, ACUTE; MEMBRANE PROTEINS; MICE; MODELS, BIOLOGICAL; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSCRIPTION FACTORS;

EID: 0034888060     PISSN: 10656251     EISSN: None     Source Type: Journal    
DOI: 10.1097/00062752-200107000-00010     Document Type: Review

References (68)

1. Notch signaling: Cell fate control and signal integration in development
2. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
3. Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region
4. Notch1 and Notch2 inhibit myeloid differentiation in response to different cytokines
5. Notch signaling: From the outside in
6. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)
7. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
8. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
9. Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5
10. Signalling downstream of activated mammalian Notch
11. LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway
12. MAML1, a human homologue of drosophila mastermind, is a transcriptional co-activator for Notch receptors
13. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
14. Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans
15. SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchlC to facilitate NotchlC function
16. Lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H)
17. Oncogenic forms of Notch1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription
18. Suppressor of hairless-independent events in Notch signaling imply novel pathway elements
19. Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway
20. Neoplastic transformation by Notch requires nuclear localization
21. Neoplastic transformation by Notch is independent of transcriptional activation by RBP-J signaling
22. Notch inhibition of E47 supports the existence of a novel signaling pathway
23. Human deltex is a conserved regulator of Notch signaling
24. LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes
25. Modulated expression of notch1 during thymocyte development
26. Notch1 signaling promotes the maturation of CD4 and CD8 thymocytes
27. Exclusive development of T-cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
28. Notch1 expression in early lymphopoiesis influences B versus T lineage determination
29. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by Notch1
30. Deficient T cell fate specification in mice with an induced inactivation of Notch1
31. Cutting edge: An essential role for notch-1 in the development of both thymus-independent and -dependent T cells in the gut
32. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells
33. Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength
34. Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development
35. A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice
36. D/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis
37. Two distinct Notch1 mutant alleles are involved in the induction of T-cell leukemia in c-myc transgenic mice
38. Correlating notch signaling with thymocyte maturation
39. Protective effects of notch-1 on TCR-induced apoptosis
40. MHC recognition in thymic development: Distinct, parallel pathways for survival and lineage commitment
41. A recombinant retrovirus encoding alkaline phosphatase confirms clonal boundary assignment in lineage analysis of murine retina
42. Cell proliferation control by Notch signaling in Drosophila development
43. Cell cycle arrest and apoptosis induced by notch1 in B cells
44. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive notch1 signaling
45. Inhibition of granulocytic differentiation by mNotch1
46. Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics
47. Suppression of erythroid but not megakaryocytic differentiation of human K562 erythroleukemic cells by Notch-1
48. Notch signaling via RBP-J promotes myeloid differentiation
49. Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma
50. Evidence that an IRES within the Notch2 coding region can direct expression of a nuclear form of the protein
51. Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice
52. The Notch 3 intracellular domain represses Notch 1-mediated activation through Hairy/Enhancer of Split (HES) promoters
53. Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor
54. Transcription factor regulation of B lineage commitment
55. E2A deficiency leads to abnormalities in alphabeta T-celL development and to rapid development of T-cell lymphomas
56. Constitutive expression of the Id1 gene impairs mouse B cell development
57. Two mammalian helix-loop-helix factors structurally related to Drosophila Hairy and Enhancer of Split
58. The v-rel oncogene promotes malignant T-cell leukemia/lymphoma in transgenic mice
59. NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa
60. T-cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells
61. EBNA-2 upregulation of Epstein-Barr virus latency promoters and the cellular CD23 promoter utilizes a common targeting intermediate, CBF1
62. Epstein-Barr virus EBNA3A and EBNA3C proteins both repress RBP-J kappa-EBNA2-activated transcription by inhibiting the binding of RBP-J kappa to DNA
63. The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJ(kappa)
64. Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei
65. A presenilin-1-dependent-secretase-like protease mediates release of Notch intracellular domain
66. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
67. Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development
68. NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to Notch-1