Myc-induced T cell leukemia in transgenic zebrafish

Science

Volumn 299, Issue 5608, 2003, Pages 887-890

  Langenau, David M ^a   Traver, David ^b   Ferrando, Adolfo A ^a   Kutok, Jeffery L ^c   Aster, Jon C ^c   Kanki, John P ^a   Lin, Shuo ^d   Prochownik, Ed ^e   Trede, Nikolaus S ^b   Zon, Leonard I ^b   Look, A Thomas ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLONING; PROTEINS; TUMORS;

CARCINOGENESIS;

DISEASES;

GREEN FLUORESCENT PROTEIN; PROTEIN; RAG2 PROTEIN;

CANCER; FISH; GENETICS;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER MODEL; CANCER RESEARCH; CARCINOGENESIS; CELL INFILTRATION; CHIMERA; CLONAL VARIATION; CONTROLLED STUDY; GENE EXPRESSION; GENE INDUCTION; GENE MUTATION; GENETIC SCREENING; IN SITU HYBRIDIZATION; LYMPHOBLAST; NONHUMAN; ONCOGENE MYC; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; T CELL LEUKEMIA; THYMUS; TRANSGENE; TRANSGENIC ANIMAL; TUMOR SUPPRESSOR GENE; ZEBRA FISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL LINEAGE; CELL TRANSFORMATION, NEOPLASTIC; CLONE CELLS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FEMALE; FERTILIZATION IN VITRO; GENE EXPRESSION PROFILING; GENES, MYC; GREEN FLUORESCENT PROTEINS; KIDNEY; LEUKEMIA, T-CELL, ACUTE; LEUKEMIC INFILTRATION; LUMINESCENT PROTEINS; MALE; MICE; MUTATION; NEOPLASM TRANSPLANTATION; OLFACTORY BULB; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; SPLEEN; T-LYMPHOCYTES; THYMUS GLAND; TRANSGENES; ZEBRAFISH;

ANIMALIA; DANIO RERIO;

EID: 0347785481     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1080280     Document Type: Article

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27. We thank Y. Yang and M. Loda for paraffin sectioning and in situ analysis; J. Gilbert for editorial review; R. DePinho for the mouse myc cDNA; A. Winzeler for help with irradiation protocols; J. Morris for help with in vitro fertilization protocols; J. Vinokur, G. Kourkoulis, and W. Saganic for fish care and husbandry; and D. Dodson for manuscript preparation. Supported by NIH grants CA-68484 (A.T.L.) and CA-06516 (J.L.K. and J.C.A.). D.M.L. is an NSF predoctoral fellow, D.T. is supported by the Irvington Institute for Immunological Research, and A.A.F. is a fellow of the Leukemia and Lymphoma Society.