Protein degradation: Four E3s for the Notch pathway

Current Biology

Volumn 12, Issue 2, 2002, Pages

  Lai, Eric C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; NOTCH RECEPTOR; UBIQUITIN;

ANIMAL; GENETICS; HYDROLYSIS; METABOLISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; HYDROLYSIS; MEMBRANE PROTEINS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 0037154292     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00679-0     Document Type: Review

References (33)

1. A new ticket for entry into budding vesicles-ubiquitin
2. The ubiquitin system
3. Dominant-negative mutation in the β2 and β6 proteasome-subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage
4. The constitution of the germinal material in relation to heredity
5. Deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster
6. Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus
7. The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice
8. The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase
9. Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of Notch signaling
10. Recognition and ubiquitination of Notch by Itch, a HECT-type E3 ubiquitin ligase
11. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats
12. The WWE domain: A common interaction module in protein ubiquitination and ADP ribosylation
13. Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans
14. Sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins
15. Sel-10 is an inhibitor of Notch signaling that targets Notch for ubiquitin-mediated rotein degradation
16. The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
17. Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
18. The Drosophila neuralized gene encodes a C3HC4 zinc finger
19. The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons
20. Neuralized functions cell-autonomously to regulate a subset of Notch-dependent processes during adult Drosophila development
21. Neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development
22. Neuralized functions cell autonomously to regulate Drosophila sense organ development
23. Neuralized functions as an E3 ubiquitin ligase during Drosophila development
24. Drosophila Neuralized is a ubiquitin ligase that promotes the internalization and degradation of Delta
25. Xenopus Neuralized is a ubiquitin ligase that interacts with X-Delta1 and regulates Notch signaling
26. Neuralized encodes a peripheral membrane protein involved in Delta signaling and endocytosis
27. Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells
28. Only a subset of the binary cell fate decisions mediated by Numb/Notch signaling in Drosophila sensory organ lineage requires Suppressor of hairless
29. Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetrical localization in Drosophila neural and muscle progenitors
30. LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin dependent degradation
31. The mammalian numb phosphotyrosine-binding domain
32. Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin
33. Nrarp is a novel intracellular component of the Notch signaling pathway