Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma

EMBO Reports

Volumn 4, Issue 11, 2003, Pages 1067-1071

  Talora, Claudio ^a   Campese, Antonio F ^a   Bellavia, Diana ^a   Pascucci, Monica ^a   Checquolo, Saula ^a   Groppioni, Manuela ^a   Frati, Luigi ^a,b   von Boehmer, Harald ^c   Gulino, Alberto ^a,b   Screpanti, Isabella ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b IRCCS NEUROMED   (Italy)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; NOTCH RECEPTOR; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; LYMPHOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; T CELL LYMPHOMA; T LYMPHOCYTE; THYMOCYTE; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS;

EID: 0348133609     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.embor.7400013     Document Type: Article

References (23)

1. Abraham, K.M., Levin, S.D., Marth, J.D., Forbush, K.A. & Perlmutter, R.M. (1991) Thymic tumorigenesis induced by overexpression of p56lck. Proc. Natl Acad. Sci. USA, 88, 3977-3981.
2. 2+ mobilization and activation of NF-κB and NFAT. Nature Immunol., 2, 403-409.
3. Allenspach, E.J., Maillard, I., Aster, J.C. & Pear, W.S. (2002) Notch signaling in cancer. Cancer Biol. Ther., 1, 466-476.
4. Artavanis-Tsakonas, S., Rand, M.D. & Lake, R.J. (1999) Notch signaling: cell fate control and signal integration in development. Science, 284, 770-776.
5. Bain, C., Engel, I., Robanus Maandag, E.C., te Riele, H.P., Voland, J.R., Sharp, L.L., Chun, J., Huey, B., Pinkel, D. & Murre, C. (1997) E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas. Mol. Cell. Biol., 17, 4782-4791.
6. Bain, G., Cravatt, C.B., Loomans, C., Alberola-Ila, J., Hedrick, S.M. & Murre, C. (2001) Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nature Immunol., 2, 165-171.
7. Bellavia, D., Campese, A.F., Alesse, E., Vacca, A., Felli, M.P., Balestri, A., Stoppacciaro, A., Tiveron, C., Tatangelo, L., Giovarelli, M. et al. (2000) Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice. EMBO J., 19, 3337-3348.
8. Bellavia, D., Campese, A.F., Checquolo, S., Balestri, A., Biondi, A., Cazzaniga, G., Lendahl, U., Fehling, H.J., Hayday, A.C., Frati, L. et al. (2002) Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis. Proc. Natl Acad. Sci. USA, 99, 3788-3793.
9. Bettini, M., Xi, H., Milbrandt, J. & Kersh, G.J. (2002) Thymocyte development in early growth response gene 1-deficient mice. J. Immunol., 169, 1713-1720.
10. Ellisen, L.W., Bird, J., West, D.C., Soreng, A.L., Reynolds, T.C., Smith, S.D. & Sklar, J. (1991) TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell, 66, 649-661.
11. Engel, I. & Murre, C. (2001) The function of E- and Id proteins in lymphocyte development. Nature Rev. Immunol., 1, 193-199.
12. Engel, I. & Murre, C. (2002) Disruption of pre-TCR expression accelerates lymphomagenesis in E2A-deficient mice. Proc. Natl Acad. Sci. USA, 99, 11322-11327.
13. Felli, M.P., Maroder, M., Mitsiadis, T.A., Campese, A.F., Bellavia, D., Vacca, A., Mann, R.S., Frati, L., Lendahl, U., Gulino, A. et al. (1999) Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. Int. Immunol., 11, 1017-1025.
14. Greenbaum, S. & Zhuang, Y. (2002) Regulation of early lymphocyte development by E2A family proteins. Semin. Immunol., 14, 405-414.
15. Murphy, L.O., Smith, S., Chen, R.H., Fingar, D.C. & Blenis, J. (2002) Molecular interpretation of ERK signal duration by immediate early gene products. Nature Cell Biol., 4, 556-564.
16. Park, S.T., Nolan, G.P. & Sun, X.H. (1998) Growth inhibition and apoptosis due to restoration of E2A activity in T cell acute lymphoblastic leukemia cells. J. Exp. Med., 189, 501-508.
17. Persson, P., Jogi, A., Grynfeld, A., Pahlman, S. & Axelson, H. (2000) HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex. Biochem. Biophys. Res. Commun., 274, 22-31.
18. Petersson, K., Ivars, F. & Sigvardsson, M. (2002) The pTα promoter and enhancer are direct targets for transactivation by E box-binding proteins. Eur. J. Immunol., 32, 911-920.
19. Primi, D., Clynes, R.A., Jouvin-Marche, E., Marolleau, J.P., Barbier, E., Cazenave, P.A. & Marcu, K.B. (1988) Rearrangement and expression of T cell receptor and immunoglobulin loci in immortalized CD4-CD8-T cell lines. Eur. J. Immunol., 18, 1101-1109.
20. Reizis, B. & Leder, P. (2002) Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev., 16, 295-300.
21. Rohn, J.L., Lauring, A.S., Linenberger, M.L. & Overbaugh, J. (1996) Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma. J. Virol., 70, 8071-8080.
22. Screpanti, I., Bellavia, D., Campese, A.F., Frati, L. & Gulino, A. (2003) Notch, a unifying target in T-cell acute lymphoblastic leukemia? Trends Mol. Med., 9, 30-35.
23. von Boehmer, H. & Fehling, H.J. (1997) Structure and function of the pre-T cell receptor. Annu. Rev. Immunol., 15, 433-452.