Resveratrol as a chemopreventive agent: A promising molecule for fighting cancer

Current Drug Targets

Volumn 7, Issue 4, 2006, Pages 423-442

  Delmas, Dominique ^a   Lançon, Allan ^a   Colin, Didier ^a   Jannin, Brigitte ^a   Latruffe, Norbert ^a  

^a UNIVERSITÉ DE BOURGOGNE   (France)

Author keywords

Bioavailability; Cancer; Chemoprevention; Resveratrol; Sensitization

Indexed keywords

CYCLOSPORIN; CYCLOSPORIN A; CYTOTOXIC AGENT; DOXORUBICIN; FLUOROURACIL; GUAIACOL; HYDROXYUREA; INDOMETACIN; NITRIC OXIDE; PACLITAXEL; PHENYLBUTAZONE; PHYTOALEXIN; POLYAMINE; REACTIVE OXYGEN METABOLITE; RESVERATROL; ANTINEOPLASTIC AGENT; RADIOSENSITIZING AGENT; STILBENE DERIVATIVE;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; APOPTOSIS; CANCER; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER PREVENTION; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CORONARY ARTERY DISEASE; CYTOTOXICITY; DEGENERATIVE DISEASE; DNA REPAIR; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MEGADOSE; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SENSITIZATION; DRUG STRUCTURE; ENTEROHEPATIC CIRCULATION; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; HUMAN; LIVER CARCINOMA; LOW DRUG DOSE; LUNG CANCER; METASTASIS INHIBITION; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; RADIOSENSITIZATION; REVIEW; SCAVENGING SYSTEM; STRUCTURE ACTIVITY RELATION; TUMOR PROMOTION; VASCULAR DISEASE; VIRUS INFECTION; ANIMAL; CELL CYCLE; CHEMISTRY; DRUG EFFECT; NEOPLASM;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE; HUMANS; NEOPLASMS; RADIATION-SENSITIZING AGENTS; STILBENES;

EID: 33646068410     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945006776359331     Document Type: Review

References (262)

1. Lanz, T., Tropf, S., Marner, F.J., Schroder, J. and Schroder, G. (1991) J. Biol. Chem., 266(15), 9971-9976.
2. Fremont, L. (2000) Life Sci., 66(8), 663-673.
3. Kris-Etherton, P.M. and Keen, C.L. (2002) Curr. Opin. Lipidol., 13(1), 41-49.
4. Russo, A., Palumbo, M., Aliano, C., Lempereur, L., Scoto, G. and Renis, M. (2003) Life Sci., 72(21), 2369-2379.
5. Surh, Y. (1999) Mutat Res., 428(1-2), 305-327.
6. Latruffe, N., Delmas, D., Jannin, B., Malki, M.C., Passilly-Degrace, P. and Berlot, J.P. (2002) Int. J. Mol. Med., 10(6), 755-760.
7. Howitz, K.T., Bitterman, K.J., Cohen, H.Y., Lamming, D.W., Lavu, S., Wood, J.G., Zipkin, R.E., Chung, P., Kisielewski, A., Zhang, L.L., Scherer, B. and Sinclair, D.A. (2003) Nature, 425(6954), 191-196.
8. Renaud, S.C., Gueguen, R., Schenker, J. and d'Houtaud, A. (1998) Epidemiology, 9(2), 184-188.
9. Bagchi, D., Das, D.K., Tosaki, A., Bagchi, M. and Kothari, S.C. (2001) Drugs Exp. Clin. Res., 27(5-6), 233-248.
10. Berge, G., Overbo, S., Botnen, I.V., Hewer, A., Phillips, D.H., Haugen, A. and Mollerup, S. (2004) Br. J. Cancer, 91, 333-338.
11. Li, H., Cheng, Y., Wang, H., Sun, H., Liu, Y., Liu, K. and Peng, S. (2003) Appl. Radiat. Isot., 58(3), 291-298.
12. Ignatowicz, E., Balana, B., Vulimiri, S.V., Szaefer, H. and Baer-Dubowska, W. (2003) Toxicology, 189(3), 199-209.
13. Szaefer, H., Cichocki, M., Brauze, D. and Baer-Dubowska, W. (2004) Nutr. Cancer, 48(1), 70-77.
14. Ciolino, H.P., Daschner, P.J. and Yeh, G.C. (1998) Cancer Res., 58(24), 5707-5712.
15. Casper, R.F., Quesne, M., Rogers, I.M., Shirota, T., Jolivet, A., Milgrom, E. and Savouret, J.F. (1999) Mol. Pharmacol., 56(4), 784-790.
16. Singh, S.U., Casper, R.F., Fritz, P.C., Sukhu, B., Ganss, B., Girard, B., Jr., Savouret, J.F. and Tenenbaum, H.C. (2000) J. Endocrinol., 167(1), 183-195.
17. Jang, M., Cai, L., Udeani, G.O., Slowing, K.V., Thomas, C.F., Beecher, C.W., Fong, H.H., Farnsworth, N.R., Kinghorn, A.D., Mehta, R.G., Moon, R.C. and Pezzuto, J.M. (1997) Science, 275(5297), 218-220.
18. Lee, J.E. and Safe, S. (2001) Biochem. Pharmacol., 62(8), 1113-1124.
19. Guengerich, F.P. and Shimada, T. (1998) Mutat. Res., 400(1-2), 201-213.
20. Frotschl, R., Chichmanov, L., Kleeberg, U., Hildebrandt, A.G., Roots, I. and Brockmoller, J. (1998) Chem. Res. Toxicol., 11(12), 1447-1452.
21. Le Ferrec, E., Lagadic-Gossmann, D., Rauch, C., Bardiau, C., Maheo, K., Massiere, F., Le Vee, M., Guillouzo, A. and Morel, F. (2002) J. Biol. Chem., 277(27), 24780-24787.
22. Yueh, M.F., Kawahara, M. and Raucy, J. (2005) Toxicol. In Vitro, 19(2), 275-287.
23. Mollerup, S., Ovrebo, S. and Haugen, A. (2001) Int. J. Cancer, 92(1), 18-25.
24. Ciolino, H.P. and Yeh, G.C. (1999) Mol. Pharmacol., 56(4), 760-767.
25. Pantuck, E.J., Hsiao, K.C., Maggio, A., Nakamura, K., Kuntzman, R. and Conney, A.H. (1974) Clin. Pharmacol. Ther., 15(1), 9-17.
26. Chun, Y.J., Kim, M.Y. and Guengerich, F.P. (1999) Biochem. Biophys. Res. Commun., 262(1), 20-24.
27. Teel, R.W. and Huynh, H. (1998) Cancer Lett., 133(2), 135-141.
28. Chen, Z.H., Hurh, Y.J., Na, H.K., Kim, J.H., Chun, Y.J., Kim, D.H., Kang, K.S., Cho, M.H. and Surh, Y.J. (2004) Carcinogenesis, 25, 2005-2013.
29. Chan, W.K. and Delucchi, A.B. (2000) Life Sci., 67(25), 3103-3112.
30. Piver, B., Berthou, F., Dreano, Y. and Lucas, D. (2001) Toxicol. Lett., 125(1-3), 83-91.
31. Chang, T.K. and Yeung, R.K. (2001) Can. J. Physiol. Pharmacol., 79(3), 220-226.
32. Revel, A., Raanani, H., Younglai, E., Xu, J., Rogers, I., Han, R., Savouret, J.F. and Casper, R.F. (2003) J. Appl. Toxicol., 23(4), 255-261.
33. Revel, A., Raanani, H., Younglai, E., Xu, J., Han, R., Savouret, J.F. and Casper, R.F. (2001) Reprod. Toxicol., 15(5), 479-486.
34. Berge, G., S, O.V., Eilertsen, E., Haugen, A. and Mollerup, S. (2004) Br. J. Cancer, 91(7), 1380-1383.
35. Damianaki, A., Bakogeorgou, E., Kampa, M., Notas, G., Hatzoglou, A., Panagiotou, S., Gemetzi, C., Kouroumalis, E., Martin, P.M. and Castanas, E. (2000) J. Cell Biochem., 78(3), 429-441.
36. Sgambato, A., Ardito, R., Faraglia, B., Boninsegna, A., Wolf, F.I. and Cittadini, A. (2001) Mutat Res., 496(1-2), 171-180.
37. Afaq, F., Adhami, V.M., Ahmad, N. and Mukhtar, H. (2002) Front Biosci., 7d784-792.
38. Leonard, S.S., Xia, C., Jiang, B.H., Stinefelt, B., Klandorf, H., Harris, G.K. and Shi, X. (2003) Biochem. Biophys. Res. Commun., 309(4), 1017-1026.
39. Awad, A.B., Burr, A.T. and Fink, C.S. (2005) Prostaglandins Leukot. Essent. Fatty Acids, 72(3), 219-226.
40. Cadenas, S. and Barja, G. (1999) Free Radic. Biol. Med., 26(11-12), 1531-1537.
41. Afaq, F., Adhami, V.M. and Ahmad, N. (2003) Toxicol. Appl. Pharmacol., 186(1), 28-37.
42. Dubuisson, J.G., Dyess, D.L. and Gaubatz, J.W. (2002) Cancer Lett., 182(1), 27-32.
43. Otake, Y., Nolan, A.L., Walle, U.K. and Walle, T. (2000) J. Steroid Biochem. Mol. Biol., 73(5), 265-270.
44. Gerhauser, C., Klimo, K., Heiss, E., Neumann, I., Gamal-Eldeen, A., Knauft, J., Liu, G.Y., Sitthimonchai, S. and Frank, N. (2003) Mutat Res., 523-524 163-172.
45. Yen, G.C., Duh, P.D. and Lin, C.W. (2003) Free Radic. Res., 37(5), 509-514.
46. Sainz, R.M., Mayo, J.C., Tan, D.X., Lopez-Burillo, S., Natarajan, M. and Reiter, R.J. (2003) Biochem. Biophys. Res. Commun., 302(3), 625-634.
47. Lopez-Burillo, S., Tan, D.X., Mayo, J.C., Sainz, R.M., Manchester, L.C. and Reiter, R.J. (2003) J. Pineal Res., 34(4), 269-277.
48. Losa, G.A. (2003) Eur. J. Clin. Invest., 33(9), 818-823.
49. Jang, M. and Pezzuto, J.M. (1998) Cancer Lett., 134(1), 81-89.
50. Kong, A.N., Yu, R., Hebbar, V., Chen, C., Owuor, E., Hu, R., Ee, R. and Mandlekar, S. (2001) Mutat. Res., 480-481 231-241.
51. Yang, S.H., Kim, J.S., Oh, T.J., Kim, M.S., Lee, S.W., Woo, S.K., Cho, H.S., Choi, Y.H., Kim, Y.H., Rha, S.Y., Chung, H.C. and An, S.W. (2003) Int. J. Oncol., 22(4), 741-750.
52. Wang, Z., Hsieh, T.C., Zhang, Z., Ma, Y. and Wu, J.M. (2004) Biochem. Biophys. Res. Commun., 323(3), 743-749.
53. Huang, C., Ma, W.Y., Goranson, A. and Dong, Z. (1999) Carcinogenesis, 20(2), 237-242.
54. Chakraborty, S., Roy, M. and Bhattacharya, R.K. (2004) J. Environ. Pathol. Toxicol. Oncol., 23(3), 215-226.
55. Uenobe, F., Nakamura, S. and Miyazawa, M. (1997) Mutat. Res., 373(2), 197-200.
56. Bhat, K.P., Lantvit, D., Christov, K., Mehta, R.G., Moon, R.C. and Pezzuto, J.M. (2001) Cancer Res., 61(20), 7456-7463.
57. Banerjee, S., Bueso-Ramos, C. and Aggarwal, B.B. (2002) Cancer Res., 62(17), 4945-4954.
58. Li, Z.G., Hong, T., Shimada, Y., Komoto, I., Kawabe, A., Ding, Y., Kaganoi, J., Hashimoto, Y. and Imamura, M. (2002) Carcinogenesis, 23(9), 1531-1536.
59. Garcia-Garcia, J., Micol, V., de Godos, A. and Gomez-Fernandez, J.C. (1999) Arch. Biochem. Biophys., 372(2), 382-388.
60. Jayatilake, G.S., Jayasuriya, H., Lee, E.S., Koonchanok, N.M., Geahlen, R.L., Ashendel, C.L., McLaughlin, J.L. and Chang, C.J. (1993) J. Nat. Prod., 56(10), 1805-1810.
61. Slater, S.J., Seiz, J.L., Cook, A.C., Stagliano, B.A. and Buzas, C.J. (2003) Biochim. Biophys. Acta, 1637(1), 59-69.
62. Shih, A., Zhang, S., Cao, H.J., Boswell, S., Wu, Y.H., Tang, H.Y., Lennartz, M.R., Davis, F.B., Davis, P.J. and Lin, H.Y. (2004) Mol. Cancer Ther., 3(11), 1355-1364.
63. Stewart, J.R., Ward, N.E., Ioannides, C.G. and O'Brian, C.A. (1999) Biochemistry, 38(40), 13244-13251.
64. Atten, M.J., Attar, B.M., Milson, T. and Holian, O. (2001) Biochem. Pharmacol., 62(10), 1423-1432.
65. Woo, J.H., Lim, J.H., Kim, Y.H., Suh, S.I., Min do, S., Chang, J.S., Lee, Y.H., Park, J.W. and Kwon, T.K. (2004) Oncogene, 23(10), 1845-1853.
66. Uhle, S., Medalia, O., Waldron, R., Dumdey, R., Henklein, P., Bech-Otschir, D., Huang, X., Berse, M., Sperling, J., Schade, R. and Dubiel, W. (2003) EMBO J., 22(6), 1302-1312.
67. Stewart, J.R., Christman, K.L. and O'Brian, C.A. (2000) Biochem. Pharmacol., 60(9), 1355-1359.
68. Haworth, R.S. and Avkiran, M. (2001) Biochem. Pharmacol., 62(12), 1647-1651.
69. Storz, P., Doppler, H. and Toker, A. (2004) Mol. Pharmacol., 66(4), 870-879.
70. Manna, S.K., Mukhopadhyay, A. and Aggarwal, B.B. (2000) J. Immunol., 164(12), 6509-6519.
71. Yu, R., Hebbar, V., Kim, D.W., Mandlekar, S., Pezzuto, J.M. and Kong, A.N. (2001) Mol. Pharmacol., 60(1), 217-224.
72. Niles, R.M., McFarland, M., Weimer, M.B., Redkar, A., Fu, Y.M. and Meadows, G.G. (2003) Cancer Lett., 190(2), 157-163.
73. She, Q.B., Huang, C., Zhang, Y. and Dong, Z. (2002) Mol. Carcinog, 33(4), 244-250.
74. She, Q.B., Bode, A.M., Ma, W.Y., Chen, N.Y. and Dong, Z. (2001) Cancer Res., 61(4), 1604-1610.
75. Lin, H.Y., Shih, A., Davis, F.B., Tang, H.Y., Martino, L.J., Bennett, J.A. and Davis, P.J. (2002) J. Urol., 168(2), 748-755.
76. Shih, A., Davis, F.B., Lin, H.Y. and Davis, P.J. (2002) J. Clin. Endocrinol. Metab., 87(3), 1223-1232.
77. Kundu, J.K., Chun, K.S., Kim, S.O. and Surh, Y.J. (2004) Biofactors, 21(1-4), 33-39.
78. Reagan-Shaw, S., Afaq, F., Aziz, M.H. and Ahmad, N. (2004) Oncogene.
79. Stewart, J.R. and O'Brian, C.A. (2004) Invest. New Drugs, 22(2), 107-117.
80. Schneider, Y., Vincent, F., Duranton, B., Badolo, L., Gosse, F., Bergmann, C., Seiler, N. and Raul, F. (2000) Cancer Lett., 158(1), 85-91.
81. Wolter, F., Turchanowa, L. and Stein, J. (2003) Carcinogenesis, 24(3), 469-474.
82. Aziz, M.H., Afaq, F. and Ahmad, N. (2005) Photochem. Photobiol., 81(1), 25-31.
83. Pena, A., Reddy, C.D., Wu, S., Hickok, N.J., Reddy, E.P., Yumet, G., Soprano, D.R. and Soprano, K.J. (1993) J. Biol. Chem., 268(36), 27277-27285.
84. Goodwin, J.S. and Ceuppens, J. (1983) J. Clin. Immunol., 3(4), 295-315.
85. MacCarrone, M., Lorenzon, T., Guerrieri, P. and Agro, A.F. (1999) Eur. J. Biochem., 265(1), 27-34.
86. Knight, J., Taylor, G.W., Wright, P., Clare, A.S. and Rowley, A.F. (1999) Biochim. Biophys. Acta, 1436(3), 467-478.
87. Eling, T.E., Thompson, D.C., Foureman, G.L., Curtis, J.F. and Hughes, M.F. (1990) Annu. Rev. Pharmacol. Toxicol., 301-45.
88. Kulmacz, R.J. and Wang, L.H. (1995) J. Biol. Chem., 270(41), 24019-24023.
89. Maccarrone, M., Putti, S. and Finazzi Agro, A. (1997) FEBS Lett., 410(2-3), 470-476.
90. Pace-Asciak, C.R., Hahn, S., Diamandis, E.P., Soleas, G. and Goldberg, D.M. (1995) Clin. Chim. Acta, 235(2), 207-219.
91. Martinez, J. and Moreno, J.J. (2000) Biochem. Pharmacol., 59(7), 865-870.
92. Moreno, J.J. (2000) J. Pharmacol. Exp. Ther., 294(1), 333-338.
93. Kimura, Y., Okuda, H. and Arichi, S. (1985) Biochim. Biophys. Acta, 834(2), 275-278.
94. Rotondo, S., Rajtar, G., Manarini, S., Celardo, A., Rotillo, D., de Gaetano, G., Evangelista, V. and Cerletti, C. (1998) Br. J. Pharmacol., 123(8), 1691-1699.
95. Kimura, Y., Okuda, H. and Kubo, M. (1995) J. Ethnopharmacol., 45(2), 131-139.
96. Johnson, J.L. and Maddipati, K.R. (1998) Prostaglandins Other Lipid Mediat., 56(2-3), 131-143.
97. Jang, M. and Pezzuto, J.M. (1999) Drugs Exp. Clin. Res., 25(2-3), 65-77.
98. Waffo-Teguo, P., Hawthorne, M.E., Cuendet, M., Merillon, J.M., Kinghorn, A.D., Pezzuto, J.M. and Mehta, R.G. (2001) Nutr. Cancer, 40(2), 173-179.
99. Rimando, A.M., Cuendet, M., Desmarchelier, C., Mehta, R.G., Pezzuto, J.M. and Duke, S.O. (2002) J. Agric. Food Chem., 50(12), 3453-3457.
100. Shin, N.H., Ryu, S.Y., Lee, H., Min, K.R. and Kim, Y. (1998) Planta Med., 64(3), 283-284.
101. Szewczuk, L.M., Forti, L., Stivala, L.A. and Penning, T.M. (2004) J. Biol. Chem.
102. Murias, M., Handler, N., Erker, T., Pleban, K., Ecker, G., Saiko, P., Szekeres, T. and Jager, W. (2004) Bioorg. Med. Chem., 12(21), 5571-5578.
103. Subbaramaiah, K., Chung, W.J., Michaluart, P., Telang, N., Tanabe, T., Inoue, H., Jang, M., Pezzuto, J.M. and Dannenberg, A.J. (1998) J. Biol. Chem., 273(34), 21875-21882.
104. Subbaramaiah, K., Michaluart, P., Chung, W.J., Tanabe, T., Telang, N. and Dannenberg, A.J. (1999) Ann. N Y Acad. Sci., 889 214-223.
105. Subbaramaiah, K. and Dannenberg, A.J. (2001) Adv. Exp. Med. Biol., 492 147-157.
106. Mutoh, M., Takahashi, M., Fukuda, K., Matsushima-Hibiya, Y., Mutoh, H., Sugimura, T. and Wakabayashi, K. (2000) Carcinogenesis, 21(5), 959-963.
107. Wyke, S.M., Russell, S.T. and Tisdale, M.J. (2004) Br. J. Cancer, 91(9), 1742-1750.
108. Shen, F., Chen, S.J., Dong, X.J., Zhong, H., Li, Y.T. and Cheng, G.F. (2003) J. Asian Nat. Prod. Res., 5(2), 151-157.
109. O'Leary, K.A., de Pascual-Tereasa, S., Needs, P.W., Bao, Y.P., O'Brien, N.M. and Williamson, G. (2004) Mutat Res., 551(1-2), 245-254.
110. Ziegler, C.C., Rainwater, L., Whelan, J. and McEntee, M.F. (2004) J. Nutr., 134(1), 5-10.
111. Sale, S., Tunstall, R.G., Ruparelia, K.C., Potter, G.A., Steward, W.P. and Gescher, A.J. (2005) Int. J. Cancer, 115(2), 194-201.
112. Pinto, M.C., Garcia-Barrado, J.A. and Macias, P. (1999) J. Agric. Food Chem., 47(12), 4842-4846.
113. Pinto Mdel, C., Garcia-Barrado, J.A. and Macias, P. (2003) J. Agric. Food Chem., 51(6), 1653-1657.
114. Pace-Asciak, C.R. (1993) Gen. Pharmacol., 24(4), 805-810.
115. Gentilli, M., Mazoit, J.X., Bouaziz, H., Fletcher, D., Casper, R.F., Benhamou, D. and Savouret, J.F. (2001) Life Sci., 68(11), 1317-1321.
116. Morgan, D.O. (1995) Nature, 374(6518), 131-134.
117. Buchkovich, K., Duffy, L.A. and Harlow, E. (1989) Cell, 58(6), 1097-1105.
118. Sherr, C.J. (1993) Cell, 73(6), 1059-1065.
119. Adhami, V.M., Afaq, F. and Ahmad, N. (2003) Neoplasia, 5(1), 74-82.
120. Ahmad, N., Adhami, V.M., Afaq, F., Feyes, D.K. and Mukhtar, H. (2001) Clin Cancer Res., 7(5), 1466-1473.
121. Hsieh, T.C. and Wu, J.M. (1999) Exp. Cell Res., 249(1), 109-115.
122. Luzi, C., Brisdelli, F., Cinque, B., Cifone, G. and Bozzi, A. (2004) Biochem. Pharmacol., 68(10), 2019-2030.
123. Adhami, V.M., Afaq, F. and Ahmad, N. (2001) Biochem. Biophys. Res. Commun., 288(3), 579-585.
124. Kawada, N., Seki, S., Inoue, M. and Kuroki, T. (1998) Hepatology, 27(5), 1265-1274.
125. Kim, Y.A., Choi, B.T., Lee, Y.T., Park, D.I., Rhee, S.H., Park, K.Y. and Choi, Y.H. (2004) Oncol. Rep., 11(2), 441-446.
126. Takada, Y., Bhardwaj, A., Potdar, P. and Aggarwal, B.B. (2004) Oncogene, 23(57), 9247-9258.
127. Harbour, J.W. and Dean, D.C. (2000) Genes Dev., 14(19), 2393-2409.
128. Kim, Y.A., Lee, W.H., Choi, T.H., Rhee, S.H., Park, K.Y. and Choi, Y.H. (2003) Int. J. Oncol., 23(4), 1143-1149.
129. Wolter, F., Akoglu, B., Clausnitzer, A. and Stein, J. (2001) J. Nutr., 131(8), 2197-2203.
130. Liontas, A. and Yeger, H. (2004) Anticancer Res., 24(2B), 987-998.
131. Fulda, S. and Debatin, K.M. (2004) Cancer Res., 64(1), 337-346.
132. Mnjoyan, Z.H. and Fujise, K. (2003) Biochem. Biophys. Res. Commun., 311(2), 546-552.
133. Ragione, F.D., Cucciolla, V., Criniti, V., Indaco, S., Borriello, A. and Zappia, V. (2003) J. Biol. Chem., 278(26), 23360-23368.
134. Bernhard, D., Tinhofer, I., Tonko, M., Hubl, H., Ausserlechner, M.J., Greil, R., Kofler, R. and Csordas, A. (2000) Cell Death Differ., 7(9), 834-842.
135. Bartek, J. and Lukas, J. (2001) FEBS Lett., 490(3), 117-122.
136. Takada, Y., Bhardwaj, A., Potdar, P. and Aggarwal, B.B. (2004) Oncogene, 23(57), 9247-9258.
137. Jeong, W.S., Kim, I.W., Hu, R. and Kong, A.N. (2004) Pharm. Res., 21(4), 649-660.
138. Hsieh, T., Halicka, D., Lu, X., Kunicki, J., Guo, J., Darzynkiewicz, Z. and Wu, J. (2002) Biochem. Biophys. Res. Commun., 297(5), 1311-1317.
139. Kuwajerwala, N., Cifuentes, E., Gautam, S., Menon, M., Barrack, E.R. and Reddy, G.P. (2002) Cancer Res., 62(9), 2488-2492.
140. Chen, Y., Tseng, S.H., Lai, H.S. and Chen, W.J. (2004) Surgery, 136(1), 57-66.
141. Delmas, D., Passilly-Degrace, P., Jannin, B., Malki, M.C. and Latruffe, N. (2002) Int. J. Mol. Med., 10(2), 193-199.
142. Bhat, K.P. and Pezzuto, J.M. (2001) Cancer Res., 61(16), 6137-6144.
143. Estrov, Z., Shishodia, S., Faderl, S., Harris, D., Van, Q., Kantarjian, H.M., Talpaz, M. and Aggarwal, B.B. (2003) Blood, 102(3), 987-995.
144. Castello, L. and Tessitore, L. (2005) Oncol. Rep., 13(1), 133-137.
145. Park, J.W., Choi, Y.J., Jang, M.A., Lee, Y.S., Jun, D.Y., Suh, S.I., Baek, W.K., Suh, M.H., Jin, I.N. and Kwon, T.K. (2001) Cancer Lett., 163(1), 43-49.
146. Ragione, F.D., Cucciolla, V., Borriello, A., Pietra, V.D., Racioppi, L., Soldati, G., Manna, C., Galletti, P. and Zappia, V. (1998) Biochem. Biophys. Res. Commun., 250(1), 53-58.
147. Surh, Y.J., Hurh, Y.J., Kang, J.Y., Lee, E., Kong, G. and Lee, S.J. (1999) Cancer Lett., 140(1-2), 1-10.
148. Kim, S., Min, S.Y., Lee, S.K. and Cho, W.J. (2003) Chem. Pharm. Bull. (Tokyo), 51(5), 516-521.
149. Shenouda, N.S., Zhou, C., Browning, J.D., Ansell, P.J., Sakla, M.S., Lubahn, D.B. and Macdonald, R.S. (2004) Nutr. Cancer, 49(2), 200-208.
150. Pagano, M., Pepperkok, R., Lukas, J., Baldin, V., Ansorge, W., Bartek, J. and Draetta, G. (1993) J. Cell Biol., 121(1), 101-111.
151. O'Connor, P.M., Ferris, D.K., Pagano, M., Draetta, G., Pines, J., Hunter, T., Longo, D.L. and Kohn, K.W. (1993) J. Biol. Chem., 268(11), 8298-8308.
152. O'Connor, P.M., Ferris, D.K., Hoffmann, I., Jackman, J., Draetta, G. and Kohn, K.W. (1994) Proc. Natl. Acad. Sci. USA, 91(20), 9480-9484.
153. Hunter, T. and Pines, J. (1994) Cell, 79(4), 573-582.
154. Nurse, P. (1997) Cell, 91(7), 865-867.
155. Hsieh, T.C., Juan, G., Darzynkiewicz, Z. and Wu, J.M. (1999) Cancer Res., 59(11), 2596-2601.
156. Larrosa, M., Tomas-Barberan, F.A. and Espin, J.C. (2003) J. Agric. Food Chem., 51(16), 4576-4584.
157. Yu, L., Sun, Z.J., Wu, S.L. and Pan, C.E. (2003) World J. Gastroenterol., 9(10), 2341-2343.
158. Wolter, F., Clausnitzer, A., Akoglu, B. and Stein, J. (2002) J. Nutr., 132(2), 298-302.
159. Fontecave, M., Lepoivre, M., Elleingand, E., Gerez, C. and Guittet, O. (1998) FEBS Lett., 421(3), 277-279.
160. Elleingand, E., Gerez, C., Un, S., Knupling, M., Lu, G., Salem, J., Rubin, H., Sauge-Merle, S., Laulhere, J.P. and Fontecave, M. (1998) Eur. J. Biochem., 258(2), 485-490.
161. Stivala, L.A., Savio, M., Carafoli, F., Perucca, P., Bianchi, L., Maga, G., Forti, L., Pagnoni, U.M., Albini, A., Prosperi, E. and Vannini, V. (2001) J. Biol. Chem., 276(25), 22586-22594.
162. Sun, N.J., Woo, S.H., Cassady, J.M. and Snapka, R.M. (1998) J. Nat. Prod., 61(3), 362-366.
163. Tsan, M.F., White, J.E., Maheshwari, J.G. and Chikkappa, G. (2002) Leuk. Lymphoma, 43(5), 983-987.
164. Delmas, D., Jannin, B., Malki, M.C. and Latruffe, N. (2000) Oncol. Rep., 7(4), 847-852.
165. Matsuoka, A., Furuta, A., Ozaki, M., Fukuhara, K. and Miyata, N. (2001) Mutat. Res., 494(1-2), 107-113.
166. Matsuoka, A., Lundin, C., Johansson, F., Sahlin, M., Fukuhara, K., Sjoberg, B.M., Jenssen, D. and Onfelt, A. (2004) Mutat. Res., 547(1-2), 101-107.
167. Matsuoka, A., Takeshita, K., Furuta, A., Ozaki, M., Fukuhara, K. and Miyata, N. (2002) Mutat. Res., 521(1-2), 29-35.
168. Liang, Y.C., Tsai, S.H., Chen, L., Lin-Shiau, S.Y. and Lin, J.K. (2003) Biochem. Pharmacol., 65(7), 1053-1060.
169. Ferry-Dumazet, H., Garnier, O., Mamani-Matsuda, M., Vercauteren, J., Belloc, F., Billiard, C., Dupouy, M., Thiolat, D., Kolb, J.P., Marit, G., Reiffers, J. and Mossalayi, M.D. (2002) Carcinogenesis, 23(8), 1327-1333.
170. Carbo, N., Costelli, P., Baccino, F.M., Lopez-Soriano, F.J. and Argiles, J.M. (1999) Biochem. Biophys. Res. Commun., 254(3), 739-743.
171. Hsieh, T.C., Burfeind, P., Laud, K., Backer, J.M., Traganos, F., Darzynkiewicz, Z. and Wu, J.M. (1999) Int. J. Oncol., 15(2), 245-252.
172. Roman, V., Billard, C., Kern, C., Ferry-Dumazet, H., Izard, J.C., Mohammad, R., Mossalayi, D.M. and Kolb, J.P. (2002) Br. J. Haematol., 117(4), 842-851.
173. Billard, C., Izard, J.C., Roman, V., Kern, C., Mathiot, C., Mentz, F. and Kolb, J.P. (2002) Leuk. Lymphoma, 43(10), 1991-2002.
174. Delmas, D., Rebe, C., Lacour, S., Filomenko, R., Athias, A., Gambert, P., Cherkaoui-Malki, M., Jannin, B., Dubrez-Daloz, L., Latruffe, N. and Solary, E. (2003) J. Biol. Chem., 278(42), 41482-41490.
175. Zhou, H.B., Yan, Y., Sun, Y.N. and Zhu, J.R. (2003) World J. Gastroenterol., 9(3), 408-411.
176. Kaneuchi, M., Sasaki, M., Tanaka, Y., Yamamoto, R., Sakuragi, N. and Dahiya, R. (2003) Int. J. Oncol., 23(4), 1167-1172.
177. Zhou, H.B., Chen, J.J., Wang, W.X., Cai, J.T. and Du, Q. (2005) World J. Gastroenterol., 11(2), 280-284.
178. Tinhofer, I., Bernhard, D., Senfter, M., Anether, G., Loeffler, M., Kroemer, G., Kofler, R., Csordas, A. and Greil, R. (2001) FASEB J., 15(9), 1613-1615.
179. Jazirehi, A.R. and Bonavida, B. (2004) Mol. Cancer Ther., 3(1), 71-84.
180. Nakagawa, H., Kiyozuka, Y., Uemura, Y., Senzaki, H., Shikata, N., Hioki, K. and Tsubura, A. (2001) J. Cancer Res. Clin. Oncol., 127(4), 258-264.
181. Kim, Y.A., Rhee, S.H., Park, K.Y. and Choi, Y.H. (2003) J. Med. Food, 6(4), 273-280.
182. Mahyar-Roemer, M., Kohler, H. and Roemer, K. (2002) BMC Cancer, 2(1), 27.
183. Wei, M.C., Zong, W.X., Cheng, E.H., Lindsten, T., Panoutsakopoulou, V., Ross, A.J., Roth, K.A., MacGregor, G.R., Thompson, C.B. and Korsmeyer, S.J. (2001) Science, 292(5517), 727-730.
184. Tessitore, L., Davit, A., Sarotto, I. and Caderni, G. (2000) Carcinogenesis, 21(8), 1619-1622.
185. Du, C., Fang, M., Li, Y., Li, L. and Wang, X. (2000) Cell, 102(1), 33-42.
186. Srinivasula, S.M., Datta, P., Fan, X.J., Fernandes-Alnemri, T., Huang, Z. and Alnemri, E.S. (2000) J. Biol. Chem., 275(46), 36152-36157.
187. Hayashibara, T., Yamada, Y., Nakayama, S., Harasawa, H., Tsuruda, K., Sugahara, K., Miyanishi, T., Kamihira, S., Tomonaga, M. and Maita, T. (2002) Nutr. Cancer, 44(2), 193-201.
188. Miyashita, T., Krajewski, S., Krajewska, M., Wang, H.G., Lin, H.K., Liebermann, D.A., Hoffman, B. and Reed, J.C. (1994) Oncogene, 9(6), 1799-1805.
189. Narayanan, N.K., Narayanan, B.A. and Nixon, D.W. (2004) Cancer Detect. Prev., 28(6), 443-452.
190. Narayanan, B.A., Narayanan, N.K., Re, G.G. and Nixon, D.W. (2003) Int. J. Cancer, 104(2), 204-212.
191. Fulda, S. and Debatin, K.M. (2004) Oncogene, 23(40), 6702-6711.
192. Zhang, S., Cao, H.J., Davis, F.B., Tang, H.Y., Davis, P.J. and Lin, H.Y. (2004) Br. J. Cancer, 91(1), 178-185.
193. Haider, U.G., Sorescu, D., Griendling, K.K., Vollmar, A.M. and Dirsch, V.M. (2003) Mol. Pharmacol., 63(4), 925-932.
194. Mahyar-Roemer, M., Katsen, A., Mestres, P. and Roemer, K. (2001) Int. J. Cancer, 94(5), 615-622.
195. Mahyar-Roemer, M. and Roemer, K. (2001) Oncogene, 20(26), 3387-3398.
196. Clement, M.V., Hirpara, J.L., Chawdhury, S.H. and Pervaiz, S. (1998) Blood, 92(3), 996-1002.
197. Dorrie, J., Gerauer, H., Wachter, Y. and Zunino, S.J. (2001) Cancer Res., 61(12), 4731-4739.
198. Kuo, P.L., Chiang, L.C. and Lin, C.C. (2002) Life Sci., 72(1), 23-34.
199. Tsan, M.F., White, J.E., Maheshwari, J.G., Bremner, T.A. and Sacco, J. (2000) Br. J. Haematol., 109(2), 405-412.
200. Wang, Q., Li, H., Wang, X.W., Wu, D.C., Chen, X.Y. and Liu, J. (2003) Neurosci. Lett., 351(2), 83-86.
201. Micheau, O., Solary, E., Hammann, A. and Dimanche-Boitrel, M.T. (1999) J. Biol. Chem., 274(12), 7987-7992.
202. Grassme, H., Jekle, A., Riehle, A., Schwarz, H., Berger, J., Sandhoff, K., Kolesnick, R. and Gulbins, E. (2001) J. Biol. Chem., 276(23), 20589-20596.
203. Delmas, D., Rebe, C., Micheau, O., Athias, A., Gambert, P., Grazide, S., Laurent, G., Latruffe, N. and Solary, E. (2004) Oncogene, 23(55), 8979-8986.
204. Nielsen, M., Ruch, R.J. and Vang, O. (2000) Biochem. Biophys. Res. Commun., 275(3), 804-809.
205. Liu, X.H., Connolly, J.M. and Rose, D.P. (1996) Clin. Exp. Metastasis, 14(2), 145-152.
206. Reich, R. and Martin, G.R. (1996) Prostaglandins, 51(1), 1-17.
207. Kozuki, Y., Miura, Y. and Yagasaki, K. (2001) Cancer Lett., 167(2), 151-156.
208. Jadeski, L.C., Hum, K.O., Chakraborty, C. and Lala, P.K. (2000) Int. J. Cancer, 86(1), 30-39.
209. Yagihashi, N., Kasajima, H., Sugai, S., Matsumoto, K., Ebina, Y., Morita, T., Murakami, T. and Yagihashi, S. (2000) Virchows Arch., 436(2), 109-114.
210. Tsai, S.H., Lin-Shiau, S.Y. and Lin, J.K. (1999) Br. J. Pharmacol., 126(3), 673-680.
211. Holmes-McNary, M. and Baldwin, A.S., Jr. (2000) Cancer Res., 60(13), 3477-3483.
212. Xie, Q.W., Kashiwabara, Y. and Nathan, C. (1994) J. Biol. Chem., 269(7), 4705-4708.
213. Coussens, L.M. and Werb, Z. (2002) Nature, 420(6917), 860-867.
214. Takigawa, M., Enomoto, M., Nishida, Y., Pan, H.O., Kinoshita, A. and Suzuki, F. (1990) Cancer Res., 50(13), 4131-4138.
215. Takahashi, Y., Mai, M. and Nishioka, K. (2000) Int. J. Cancer, 85(2), 243-247.
216. Ignatenko, N.A., Zhang, H., Watts, G.S., Skovan, B.A., Stringer, D.E. and Gerner, E.W. (2004) Mol. Carcinog., 39(4), 221-233.
217. Babbar, N., Ignatenko, N.A., Casero, R.A., Jr. and Gerner, E.W. (2003) J. Biol. Chem., 278(48), 47762-47775.
218. Aggarwal, B.B., Takada, Y. and Oommen, O.V. (2004) Expert Opin. Investig. Drugs, 13(10), 1327-1338.
219. Cao, Z., Fang, J., Xia, C., Shi, X. and Jiang, B.H. (2004) Clin. Cancer Res., 10(15), 5253-5263.
220. Aggarwal, B.B., Bhardwaj, A., Aggarwal, R.S., Seeram, N.P., Shishodia, S. and Takada, Y. (2004) Anticancer Res., 24(5A), 2783-2840.
221. Kimura, Y. and Okuda, H. (2001) J. Nutr., 131(6), 1844-1849.
222. Lin, M.T., Yen, M.L., Lin, C.Y. and Kuo, M.L. (2003) Mol. Pharmacol., 64(5), 1029-1036.
223. Brakenhielm, E., Cao, R. and Cao, Y. (2001) FASEB J., 15(10), 1798-1800.
224. Sternlicht, M.D. and Werb, Z. (2001) Annu. Rev. Cell Dev. Biol., 17463-516.
225. Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E. and Seiki, M. (1994) Nature, 370(6484), 61-65.
226. Sato, H. and Seiki, M. (1993) Oncogene, 8(2), 395-405.
227. Godichaud, S., Krisa, S., Couronne, B., Dubuisson, L., Merillon, J.M., Desmouliere, A. and Rosenbaum, J. (2000) Hepatology, 31(4), 922-931.
228. Cao, Y., Fu, Z.D., Wang, F., Liu, H.Y. and Han, R. (2005) J. Asian Nat. Prod. Res., 7(3), 205-213.
229. Ahn, K.S., Kim, J.H., Oh, S.R., Ryu, S.Y. and Lee, H.K. (2000) Planta Med., 66(7), 641-644.
230. Ferrero, M.E., Bertelli, A.E., Fulgenzi, A., Pellegatta, F., Corsi, M.M., Bonfrate, M., Ferrara, F., De Caterina, R., Giovannini, L. and Bertelli, A. (1998) Am. J. Clin. Nutr., 68(6), 1208-1214.
231. Asensi, M., Medina, I., Ortega, A., Carretero, J., Bano, M.C., Obrador, E. and Estrela, J.M. (2002) Free Radic. Biol. Med., 33(3), 387-398.
232. Klinge, C.M., Blankenship, K.A., Risinger, K.E., Bhatnagar, S., Noisin, E.L., Sumanasekera, W.K., Brey, D.M. and Keynton, R.S. (2004) J. Biol. Chem.
233. Su, J.L., Lin, M.T., Hong, C.C., Chang, C.C., Shiah, S.G., Wu, C.W., Chen, S.T., Chau, Y.P. and Kuo, M.L. (2005) Carcinogenesis, 26(1), 1-10.
234. Yu, L., Wu, S.L., Zhang, M. and Pan, C.E. (2003) Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 19(6), 549-551.
235. Kubota, T., Uemura, Y., Kobayashi, M. and Taguchi, H. (2003) Anticancer Res., 23(5A), 4039-4046.
236. Sun, Z.J., Pan, C.E., Liu, H.S. and Wang, G.J. (2002) World J. Gastroenterol., 8(1), 79-81.
237. Fuggetta, M.P., D'Atri, S., Lanzilli, G., Tricarico, M., Cannavo, E., Zambruno, G., Falchetti, R. and Ravagnan, G. (2004) Melanoma Res., 14(3), 189-196.
238. Zoberi, I., Bradbury, C.M., Curry, H.A., Bisht, K.S., Goswami, P.C., Roti Roti, J.L. and Gius, D. (2002) Cancer Lett., 175(2), 165-173.
239. Baatout, S., Derradji, H., Jacquet, P., Ooms, D., Michaux, A. and Mergeay, M. (2004) Int. J. Mol. Med., 13(6), 895-902.
240. Andlauer, W., Kolb, J., Siebert, K. and Furst, P. (2000) Drugs Exp. Clin. Res., 26(2), 47-55.
241. Gescher, A.J. and Steward, W.P. (2003) Cancer Epidemiol. Biomarkers Prev., 12(10), 953-957.
242. Kaldas, M.I., Walle, U.K. and Walle, T. (2003) J. Pharm. Pharmacol., 55(3), 307-312.
243. Henry, C., Vitrac, X., Decendit, A., Ennamany, R., Krisa, S. and Merillon, J.M. (2005) J. Agric. Food Chem., 53(3), 798-803.
244. Bertelli, A., Bertelli, A.A., Gozzini, A. and Giovannini, L. (1998) Drugs Exp. Clin. Res., 24(3), 133-138.
245. Goldberg, D.M., Yan, J. and Soleas, G.J. (2003) Clin. Biochem., 36(1), 79-87.
246. Walle, T., Hsieh, F., DeLegge, M.H., Oatis, J.E. Jr. and Walle, U.K. (2004) Drug Metab. Dispos., 32(12), 1377-1382.
247. Crowell, J.A., Korytko, P.J., Morrissey, R.L., Booth, T.D. and Levine, B.S. (2004) Toxicol. Sci., 82(2), 614-619.
248. Potter, G.A., Patterson, L.H., Wanogho, E., Perry, P.J., Butler, P.C., Ijaz, T., Ruparelia, K.C., Lamb, J.H., Farmer, P.B., Stanley, L.A. and Burke, M.D. (2002) Br. J. Cancer, 86(5), 774-778.
249. Piver, B., Fer, M., Vitrac, X., Merillon, J.M., Dreano, Y., Berthou, F. and Lucas, D. (2004) Biochem. Pharmacol., 68(4), 773-782.
250. De Santi, C., Pietrabissa, A., Spisni, R., Mosca, F. and Pacifici, G.M. (2000) Xenobiotica, 30(6), 609-617.
251. de Santi, C., Pietrabissa, A., Mosca, F. and Pacifici, G.M. (2000) Xenobiotica, 30(11), 1047-1054.
252. Aumont, V., Krisa, S., Battaglia, E., Netter, P., Richard, T., Merillon, J.M., Magdalou, J. and Sabolovic, N. (2001) Arch. Biochem. Biophys., 393(2), 281-289.
253. Yu, C., Shin, Y.G., Chow, A., Li, Y., Kosmeder, J.W., Lee, Y.S., Hirschelman, W.H., Pezzuto, J.M., Mehta, R.G. and van Breemen, R.B. (2002) Pharm. Res., 19(12), 1907-1914.
254. Bertelli, A.A., Giovannini, L., Stradi, R., Urien, S., Tillement, J.P. and Bertelli, A. (1996) Int. J. Clin. Pharmacol. Res., 16(4-5), 77-81.
255. Vitrac, X., Desmouliere, A., Brouillaud, B., Krisa, S., Deffieux, G., Barthe, N., Rosenbaum, J. and Merillon, J.M. (2003) Life Sci., 72(20), 2219-2233.
256. Lancon, A., Delmas, D., Osman, H., Thenot, J.P. and Latruffe, B.J. (2004) Biochem. Biophys. Res. Commun., 316(4), 1132-1137.
257. Jannin, B., Menzel, M., Berlot, J.P., Delmas, D., Lancon, A. and Latruffe, N. (2004) Biochem. Pharmacol., 68(6), 1113-1118.
258. Sale, S., Verschoyle, R.D., Boocock, D., Jones, D.J., Wilsher, N., Ruparelia, K.C., Potter, G.A., Farmer, P.B., Steward, W.P. and Gescher, A.J. (2004) Br. J. Cancer, 90(3), 736-744.
259. Meng, X., Maliakal, P., Lu, H., Lee, M.J. and Yang, C.S. (2004) J. Agric. Food Chem., 52(4), 935-942.
260. Lorenz, P., Roychowdhury, S., Engelmann, M., Wolf, G. and Horn, T.F. (2003) Nitric Oxide, 9(2), 64-76.
261. Schneider, Y., Fischer, B., Coelho, D., Roussi, S., Gosse, F., Bischoff, P. and Raul, F. (2004) Cancer Lett., 211(2), 155-161.
262. Schneider, Y., Chabert, P., Stutzmann, J., Coelho, D., Fougerousse, A., Gosse, F., Launay, J.F., Brouillard, R. and Raul, F. (2003) Int. J. Cancer, 107(2), 189-196.