Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor κB

Molecular Pharmacology

Volumn 66, Issue 4, 2004, Pages 870-879

  Storz, Peter ^a   Döppler, Heike ^a   Toker, Alex ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; ANTIOXIDANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE D; PROTEIN SERINE KINASE; RESVERATROL; TYROSINE;

ARTICLE; CONCENTRATION RESPONSE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION;

ALLELES; ANTIOXIDANTS; BIOLOGICAL TRANSPORT; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HUMANS; NF-KAPPA B; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; PROTO-ONCOGENE PROTEINS C-ABL; SERINE; SRC-FAMILY KINASES; STILBENES;

EID: 4844224721     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.000687     Document Type: Article

References (40)

1. Ashikawa K, Majumdar S, Banerjee S, Bharti AC, Shishodia S, and Aggarwal BB (2002) Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. J Immunol 169:6490-6497.
2. Baron CL and Malhotra V (2002) Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane. Science (Wash DC) 295:325-328.
3. Bauer B, Krumbock N, Fresser F, Hochholdinger F, Spitaler M, Simm A, Uberall F, Schraven B, and Baier G (2001) Complex formation and cooperation of protein kinase Cθ and Akt1/protein kinase Bα in the NF-κB transactivation cascade in Jurkat T cells. J Biol Chem 276:31627-31634.
4. Brandlin I, Hubner S, Eiseler T, Martinez-Moya M, Horschinek A, Hausser A, Link G, Rupp S, Storz P, Pfizenmaier K, et al. (2002) Protein kinase C (PKC)η-mediated PKC μ activation modulates ERK and JNK signal pathways. J Biol Chem 277: 6490-6496.
5. Cal C, Garban H, Jazirehi A, Yeh C, Mizutani Y, and Bonavida B (2003) Resveratrol and cancer: chemoprevention, apoptosis and chemo-immunosensitizing activities. Curr Med Chem Anti-Canc Agents 3:77-93.
6. Dorrie J, Gerauer H, Wachter Y, and Zunino SJ (2001) Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res 61:4731-4739.
7. Estrov Z, Shishodia S, Faderl S, Harris D, Van Q, Kantarjian HM, Talpaz M, and Aggarwal BB (2003) Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest and induces apoptosis of acute myeloid leukemia cells. Blood 102:987-995.
8. Fremont L (2000) Biological effects of resveratrol. Life Sci 66:663-673.
9. Hausser A, Storz P, Link G, Stoll H, Liu YC, Altman A, Pfizenmaier K, and Johannes FJ (1999) Protein kinase C μ is negatively regulated by 14-3-3 signal transduction proteins. J Biol Chem 274:9258-9264.
10. Haworth RS and Avkiran M (2001) Inhibition of protein kinase D by resveratrol. Biochem Pharmacol 62:1647-1651.
11. Hirano M, Hirai S, Mizuno K, Osada S, Hosaka M, and Ohno S (1995) A protein kinase C isozyme, nPKC epsilon, is involved in the activation of NF-kappa B by 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat 3Y1 fibroblasts. Biochem Biophys Res Commun 206:429-436.
12. Iglesias T, Waldron RT, and Rozengurt E (1998) Identification of in vivo phosphorylation sites required for protein kinase D activation. J Biol Chem 273:27662-27667.
13. Joe AK, Liu H, Suzui M, Vural ME, Xiao D, and Weinstein IB (2002) Resveratrol induces growth inhibition, S-phase arrest, apoptosis and changes in biomarker expression in several human cancer cell lines. Clin Cancer Res 8:893-903.
14. Johannes FJ, Hausser A, Storz P, Truckenmuller L, Link G, Kawakami T, and Pfizenmaier K (1999) Bruton's tyrosine kinase (Btk) associates with protein kinase C mu. FEBS Lett 461:68-72.
15. Johannes FJ, Horn J, Link G, Haas E, Siemienski K, Wajant H, and Pfizenmaier K (1998) Protein kinase Cmu downregulation of tumor-necrosis-factor- induced apoptosis correlates with enhanced expression of nuclear-factor-kappaB- dependent protective genes. Eur J Biochem 257:47-54.
16. Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, and Burgering BM (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature (Lond) 419:316-321.
17. Leitges M, Sanz L, Martin P, Duran A, Braun U, Garcia JF, Camacho F, Diaz-Meco MT, Rennert PD, and Moscat J (2001) Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Mol Cell 8:771-780.
18. Li N and Karin M (1999) Is NF-kappaB the sensor of oxidative stress? FASEB J 13:1137-1143.
19. Manna SK, Mukhopadhyay A, and Aggarwal BB (2000) Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1 and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol 184:6509-6519.
20. Martindale JL and Holbrook NJ (2002) Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 192:1-15.
21. Matthews SA, Iglesias T, Rozengurt E, and Cantrell D (2000) Spatial and temporal regulation of protein kinase D (PKD). EMBO (Eur Mol Biol Organ) J 19:2935-2945.
22. Matthews SA, Rozengurt E, and Cantrell D (1999) Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/Protein kinase Cmu. J Biol Chem 274:26543-26549.
23. Mercurio F and Manning AM (1999) NF-kappaB as a primary regulator of the stress response. Oncogene 18:6163-6171.
24. Rey O, Young SH, Cantrell D, and Rozengurt E (2001) Rapid protein kinase D translocation in response to G protein-coupled receptor activation. Dependence on protein kinase C. J Biol Chem 276:32616-32626.
25. Shrivastava A and Aggarwal BB (1999) Antioxidants differentially regulate activation of nuclear factor-kappa B, activator protein-1, c-jun amino-terminal kinases and apoptosis induced by tumor necrosis factor: evidence that JNK and NF-kappa B activation are not linked to apoptosis. Antioxid Redox Signal 1:181-191.
26. Slater SJ, Seiz JL, Cook AC, Stagliano BA, and Buzas CJ (2003) Inhibition of protein kinase C by resveratrol. Biochim Biophys Acta 1637:59-69.
27. Soltoff SP (2001) Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cδ tyrosine phosphorylation. J Biol Chem 276:37986-37992.
28. Stewart JR, Christman KL, and O'Brian CA (2000) Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation. Biochem Pharmacol 60:1355-1359.
29. Stewart JR, Ward NE, Ioannides CG, and O'Brian CA (1999) Resveratrol preferentially inhibits protein kinase C-catalyzed phosphorylation of a cofactor-independent, arginine-rich protein substrate by a novel mechanism. Biochemistry 38:13244-13251.
30. Storz P, Doppler H, Johannes FJ, and Toker A (2003) Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation. J Biol Chem 278:17969-17976.
31. Storz P, Doppler H, and Toker A (2004) Protein kinase cdelta selectively regulates protein kinase d-dependent activation of NF-kappaB in oxidative stress signaling. Mol Cell Biol 24:2614-2626.
32. Storz P, Hausser A, Link G, Dedio J, Ghebrehiwet B, Pfizenmaier K, and Johannes FJ (2000) Protein kinase Cμ is regulated by the multifunctional chaperon protein p32. J Biol Chem 275:24601-24607.
33. Storz P and Toker A (2003) Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. EMBO (Eur Mol Biol Organ) J 22:109-120.
34. Sun Z, Arendt CW, Ellmeier W, Schaeffer EM, Sunshine MJ, Gandhi L, Annes J, Petrzilka D, Kupfer A, Schwartzberg PL, et al. (2000) PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature (Lond) 404:402-407.
35. Tinhofer I, Bernhard D, Senfter M, Anether G, Loeffler M, Kroemer G, Kofler R, Csordas A, and Greil R (2001) Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2. FASEB J 15:1613-1615.
36. Uhle S, Medalia O, Waldron R, Dumdey R, Henklein P, Bech-Otschir D, Huang X, Berse M, Sperling J, Schade R, et al. (2003) Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. EMBO (Eur Mol Biol Organ) J 22:1302-1312.
37. Vancurova I, Miskolci V, and Davidson D (2001) NF-kappa B activation in tumor necrosis factor alpha-stimulated neutrophils is mediated by protein kinase Cδ. Correlation to nuclear IκBα. J Biol Chem 276:19746-19752.
38. Van Lint J, Rykx A, Maeda Y, Vantus T, Sturany S, Malhotra V, Vandenheede JR, and Seufferlein T (2002) Protein kinase D: an intracellular traffic regulator on the move. Trends Cell Biol 12:193-200.
39. Waldron RT and Rozengurt E (2003) Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain. J Biol Chem 278:154-163.
40. Yu R, Hebbar V, Kim DW, Mandlekar S, Pezzuto JM, and Kong AN (2001) Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways. Mol Pharmacol 60:217-224.