Inhibition of protein kinase D by resveratrol

Biochemical Pharmacology

Volumn 62, Issue 12, 2001, Pages 1647-1651

  Haworth, Robert S ^a   Avkiran, Metin ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

COS 7 cell; Phorbol ester; Protein kinase D; Resveratrol

Indexed keywords

ENZYME ANTIBODY; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN KINASE; PROTEIN KINASE D; PROTEIN KINASE INHIBITOR; RESVERATROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CELL FUNCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; IC 50; MONKEY; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; COS CELLS; ENZYME INHIBITORS; PHOSPHORYLATION; PROTEIN KINASE C; SERINE; STILBENES;

EID: 0035894173     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00807-3     Document Type: Article

References (18)

1. Molecular cloning and characterisation of protein kinase D: A target for diacylglycerol and phorbol esters with a distinctive catalytic domain
2. Protein kinase D: A novel target for diacylglycerol and phorbol esters
3. PKCμ is a novel, atypical member of the protein kinase C family
4. Expression and characterisation of PKD, a phorbol ester and diacylglycerol-stimulated serine protein kinase
5. Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway
6. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
7. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells
8. Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer
9. Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases
10. + exchanger activity
11. Protein kinase Cμ (PKCμ) associates with the B cell antigen receptor complex and regulates lymphocyte signaling
12. Co-transfection with protein kinase D confers phorbol-ester-mediated inhibition on glucagon-stimulated cAMP accumulation in COS cells transfected to overexpress glucagon receptors
13. 1-adrenergic receptor- and protein kinase C-mediated regulation
14. Characterization of serine 916 as an in vivo autophosphorylation site for protein kinase D/protein kinase Cμ
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16. Identification of in vivo phosphorylation sites required for protein kinase D activation
17. Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways
18. Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2