Prediction of aryl hydrocarbon receptor-mediated enzyme induction of drugs and chemicals by mRNA quantification

Chemical Research in Toxicology

Volumn 11, Issue 12, 1998, Pages 1447-1452

  Frötschl, Roland ^a   Chichmanov, Lubomir ^a   Kleeberg, Ullrich ^b   Hildebrandt, Alfred G ^b   Roots, Ivar ^a   Brockmöller, Jürgen ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Fed Inst Drugs and Med Devices   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; AROMATIC HYDROCARBON RECEPTOR; BENZIMIDAZOLE DERIVATIVE; BENZO[A]PYRENE; BETA NAPHTHOFLAVONE; DOMPERIDONE; EFAROXAN; ETHOXYRESORUFIN DEETHYLASE; INDINAVIR; ISOSAFROLE; LANSOPRAZOLE; LOSARTAN; LOSARTAN POTASSIUM; MEBENDAZOLE; MESSENGER RNA; MICONAZOLE; NELFINAVIR; OMEPRAZOLE; PANTOPRAZOLE; PHENYTOIN; PRIMAQUINE; PROTEINASE INHIBITOR; RESVERATROL; RITONAVIR; SAQUINAVIR; XENOBIOTIC AGENT;

ARTICLE; CARCINOGENICITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG POTENCY; ENZYME INDUCTION; HELA CELL; HUMAN; HUMAN CELL; INTOXICATION; RNA ANALYSIS;

EID: 0032410633     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx980164h     Document Type: Article

References (3)

1. Ha, H. R., Chen, J., Leuenberger, P. M., Freiburghaus, A. U., and Follath, F. (1995) In vitro inhibition of midazolam and quinidine metabolism by flavonoids. Eur. J. Clin. Pharmacol. 48, 367-71.
2. Rost, K. L., and Roots, I. (1994) Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios: coincidence with plasma clearance and breath test. Clin. Pharmacol. Ther. 55, 402-11.
3. Swanson, H. I., and Bradfield, C. A. (1993) The AH-receptor: genetics, structure and function. Pharmacogenetics 3, 213-30.