Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells

Cancer Research

Volumn 61, Issue 12, 2001, Pages 4731-4739

  Dorrie J ^a   Gerauer, H ^a   Wachter, Y ^a   Zunino, S J ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 9; CASPASE INHIBITOR; FAS ANTIGEN; FAS LIGAND; RESVERATROL;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL MEMBRANE DEPOLARIZATION; CELL STRAIN HL 60; CONTROLLED STUDY; DEPOLARIZATION; DRUG CYTOTOXICITY; DRUG MECHANISM; EMISSION TOMOGRAPHY; HUMAN; HUMAN CELL; LIGAND BINDING; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTIGENS, CD95; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 9; CASPASES; ENZYME ACTIVATION; FAS LIGAND PROTEIN; HUMANS; INTRACELLULAR MEMBRANES; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, PRE-B-CELL; LEUKOCYTES, MONONUCLEAR; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIALS; MITOCHONDRIA; STILBENES; TRANSLOCATION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0035874886     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Resveratrol: A molecule whose time has come? And gone?
2. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
3. DNA polymerase and topoisomerase II inhibitors from Psorealea corylifolia
4. Resveratrol, a remarkable inhibitor of ribonucleotide reductase
5. Human ICE/CED-3 protease nomenclature
6. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
7. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
8. Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis
9. CPP32/apopain is a key interleukin 1 β converting enzyme-like protease involved in Fas-mediated apoptosis
10. Caspases: The executioners of apoptosis
11. Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells
12. Comparison of apoptosis in wild-type and Fas-resistant cells: Chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions
13. Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells
14. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis
15. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells
16. Differential CD95 expression and function in T and B lineage acute lymphoblastic leukemia cells
17. The acute lymphoblastic leukaemia cell line SEM with t(4;11) chromosomal rearrangement is biphenotypic and responsive to interleukin-7
18. Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics
19. Growth factor requirements of childhood acute leukemia: Establishment of GM-CSF-dependent cell lines
20. Regulation of CD95 expression and CD95-mediated cell death by interferon-γ in acute lymphoblastic leukemia with chromosomal translocation t(4;11)
21. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
22. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
23. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V
24. Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model
25. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells
26. Mitochondrial modifications during rat thymocyte apoptosis: A study at the single cell level
27. Clinical significance of cytogenetic abnormalities in adult acute lymphoblastic leukemia
28. Resveratrol induces Fas signalling-independent apoptosis in THP-1 human monocytic leukaemia cells
29. Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cells
30. Mitochondria and apoptosis
31. Piceatannol, a stilbene phytochemical, inhibits mitochondrial FOF1-ATPase activity by targeting the F1 complex
32. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
33. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner