Targeting JAK3 and BTK tyrosine kinases with rationally-designed inhibitors

Current Drug Targets

Volumn 7, Issue 3, 2006, Pages 327-343

  Vassilev, Alexei O ^a,b   Tibbles, Heather E ^a,b   DuMez, Darin ^a,b   Venkatachalam, Taracad K ^a,b   Uckun, Fatih M ^a,b  

^a Parker Hughes Cancer Center   (United States)

^b Ikaros Enterprises   (United States)

Author keywords

BTK; Inhibitors; JAK3; Rational drug design; Tyrosine kinases

Indexed keywords

4 (4 HYDROXYANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 [N [1 (2 CYANO 1 OXOETHYL) 4 METHYL 3 PIPERIDINYL] N METHYLAMINO]PYRROLO[2,3 D]PYRIMIDINE; ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTILEUKEMIC AGENT; ASPARAGINASE; AZATHIOPRINE; BRUTON TYROSINE KINASE INHIBITOR; CALCINEURIN INHIBITOR; CP 550; CP 690; CYCLOSPORIN A; DIPYRIDAMOLE; ENZYME INHIBITOR; FUSIDATE SODIUM; IMMUNOSUPPRESSIVE AGENT; JANUS KINASE 3 INHIBITOR; LFM A13; METHOTREXATE; METHYLPREDNISOLONE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NC 1153; PNU 156804; PREDNISOLONE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR; RAPAMYCIN; ROQUINIMEX; TACROLIMUS; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE; AGAMMAGLOBULINAEMIA TYROSINE KINASE; JAK3 PROTEIN, HUMAN; JANUS KINASE 3; PROTEIN TYROSINE KINASE;

ANEMIA; ANTINEOPLASTIC ACTIVITY; ASTHMA; BLEEDING; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; COLORECTAL CANCER; DEEP VEIN THROMBOSIS; DRUG DESIGN; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; GRAFT VERSUS HOST REACTION; HEMATOPOIESIS; HUMAN; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; LEUKEMIA; LEUKEMOGENESIS; LEUKOPENIA; LUNG EMBOLISM; METASTASIS INHIBITION; NEPHROTOXICITY; NEUROTOXICITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PROTEIN FUNCTION; REVIEW; THROMBOCYTOPENIA; THROMBOEMBOLISM; ANIMAL; AUTOIMMUNE DISEASE; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; INSULIN DEPENDENT DIABETES MELLITUS; NEOPLASM; ORGAN TRANSPLANTATION; PHYSIOLOGY;

ANIMALS; AUTOIMMUNE DISEASES; DIABETES MELLITUS, TYPE 1; DRUG DELIVERY SYSTEMS; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; JANUS KINASE 3; NEOPLASMS; ORGAN TRANSPLANTATION; PROTEIN-TYROSINE KINASES;

EID: 33645835168     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945006776054997     Document Type: Review

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