Akt-dependent cytokine production in mast cells

Journal of Experimental Medicine

Volumn 192, Issue 5, 2000, Pages 729-739

  Kitaura, Jiro ^a   Asai, Koichi ^a   Maeda Yamamoto, Mari ^b   Kawakami, Yuko ^a   Kikkawa, Ushio ^c   Kawakami, Toshiaki ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b FOOD RESEARCH INSTITUTE   (Japan)

^c KOBE UNIVERSITY   (Japan)

Author keywords

Btk; Fc RI; Lyn; NF B; Signal transduction

Indexed keywords

CYTOKINE; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; NUCLEAR FACTOR; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CYTOKINES; DNA-BINDING PROTEINS; ENZYME PRECURSORS; INTERLEUKIN-2; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAST CELLS; MICE; MICE, INBRED C57BL; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, IGE; SRC-FAMILY KINASES; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034605120     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.5.729     Document Type: Article

References (96)

1. Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily
2. Molecular cloning and characterization of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
3. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
4. PI3K: Downstream AKTion blocks apoptosis
5. PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
6. Mechanisms and consequences of activation of protein kinase B/Akt
7. Akt signaling: Linking membrane events to life and death decisions
8. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
9. AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphoryiation
10. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
11. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
12. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
13. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
14. A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain
15. Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors
16. Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase
17. Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase
18. 2 and heat shock through distinct mechanisms dependent and independent of phosphatidylinositol 3-kinase
19. Allergy
20. Fc receptors
21. Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor
22. Src homlogy 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor
23. Syk protein-tyrosine kinase is regulated by tyrosine-phoshorylated Igα/Igβ immunoreceptor tyrosine activation motif binding and autophosphorylation
24. New nomenclature for the Reth motif (or ARH1/TAM/ARAM/ARAM/YXXL)
25. Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation
26. Conformational changes induced in the protein tyrosine kinase p72(syk) by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides
27. Syk kinase activation by a src kinase-initiated activation loop phosphorylation chain reaction
28. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-γ2
29. 2+ following B-cell receptor activation
30. The role of protein kinase C in cell surface signal transduction and tumour promotion
31. Protein kinase C and lipid signaling for sustained cellular responses
32. 2+ and purified isozymes in washed permeabilized cells
33. Activation of multiple protein kinases including a MAP kinase upon FcεRI cross-linking
34. 2 pathway in a rat mast cell line
35. Activation of MAP kinases, pp90(rsk) and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or FcεRI: Rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells
36. Stimulation of mitogen-activated protein kinase activity by different secretory stimuli in rat basophilic leukemia cells
37. Aggregation of the FcεRI on mast cells stimulates c-Jun amino-terminal kinase activity. A response inhibited by wortmannin
38. Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity
39. 2 pathway by FεeRI is not shared by a G protein-coupled receptor
40. Regulation of protein kinase CβI by two protein-tyrosine kinases, btk and Syk
41. The regulation of AP-1 activity by mitogen-activated protein kinases
42. Identification of a putative regulator of early T cell activation genes
43. Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation
44. Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor α gene promoter
45. Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp
46. Cell-type-specific regulation of the human tumor necrosis factor alpha gene in B cells and T cells by NFATp and ATF-2/ JUN
47. Transcription factors of the NFAT family: Regulation and function
48. Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of nuclear factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
49. MAP3K-related kinase invoved in NF-κB induction by TNF, CD95 and IL-1
50. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-κB acting through the NF-κB-inducing kinase and IκB kinases
51. Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
52. MEKK1 activates both IκB kinase α and IκB kinase β
53. Coordinate regulation of IκB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-κB-inducing kinase
54. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-κB through IκB kinase-α and IκB kinase-β
55. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
56. Identification and characterization of an IκB kinase
57. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation
58. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK
59. IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation
60. NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
61. Independent and opposing roles for Btk and Lyn in B and myeloid signaling pathways
62. Tyrosine phosphorylation is required for mast cell activation by FcεRI cross-linking
63. Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells
64. Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt
65. Bruton's tyrosine kinase-mediated interleukin-2 gene activation in mast cells. Dependence on the c-Jun N-terminal kinase activation pathway
66. Molecular cloning of rat RAC protein kinase α and β and their association with protein kinase C ζ
67. The Kit receptor promotes cell survival via activation of PI3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136
68. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts
69. Suppression of TNF-α-induced apoptosis by NF-κB
70. Molecular determinants of NF-κB-inducing kinase action
71. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3
72. The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes
73. The B cell antigen receptor activates the Akt (protein kinase B)/ glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase
74. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells
75. Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases
76. FoεRI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 ra tumor mast cells
77. Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon FcεRI cross-linking
78. Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation
79. Redundant and opposing functions of two tyrosine kinases, btk and lyn, in mast cell activation
80. Involvement of Bruton's tyrosine kinase in FcεRI-dependent mast cell degranulation and cytokine production
81. NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase
82. Glycogen synthase kinase 3 phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells
83. Regulation of mast cell growth and proliferation
84. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
85. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
86. Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: Involveme of MEK upstream of Bad phosphorylation
87. Cytokine-induced protein kinase B activation and Bad phosphorylation do not correlate with cell survival of hemopoietic cells
88. Regulation and function of protein kinase B and MAP kinase activation by the IL-5/GM-CSF/IL-3 receptor
89. Regulation of cell death protease caspase-9 by phosphorylation
90. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
91. Direct control of the Forkhead transcription factor AFX by protein kinase B
92. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
93. The high-affinity IgE receptor (FcεRI) blocks apoptosis in normal human monocytes
94. Bruton's tyrosine kinase links the B cell receptor to nuclear factor κB activation
95. Bruton's tyrosine kinase is required for activation of IκB kinase and nuclear factor κB in response to B cell receptor engagement
96. NF-κB is a target of AKT in anti-apoptotic PDGF signalling